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| 1 | I-IBV life cycle is restricted in mouse hepatocytes .~xpressing human NTCP显示文摘 | Hanjie Li Qiuyu Zhuang Yuze Wang Tianyi'ng Zhang Jinghua Zhao Yali Zhang Junfang Zhang Yi Lin Quan Yuan Ningshao Xia Jiahuai Han | 2014 | Cellular & Molecular Immunology2014，11，2： | 14 |
| 2 | A novel catalytic application of heteropolyacids:chemical transformation of major ginsenosides into rare ginsenosides exemplified by Rg1显示文摘High performance liquid chromatography coupled with quadruple-time-of-flight mass spectrometry(HPLC-Q-TOF-MS)method was developed for analyzing the hydrolytic mixtures of ginsenoside R_(g1) in acidic conditions(pH 3). Three catalysts, a heteropolyacid(H_4SiW_(12)O_(40), SiW_(12) for short), its complex with γ-CD(SiW_(12)/γ-CD for short) and formic acid, were used for comparison. The chemical transformation products were identified based on the accurate mass measurement and the fragment ions obtained from tandem mass spectrometry. It was concluded that the catalytic efficiency of SiW_(12)(≈SiW_(12)/γ-CD) is ca. 410 times higher than that of formic acid, thus becoming the most efficient catalyst for chemical transformations of ginsenosides. | Jie Cao Chang Liu Qianqian Wang Yuze Li Qing Yu | 2017 | Science China Chemistry2017，60，6： | 5 |
| 3 | A post-GWAS confirming the genetic effects and functional polymorphisms of AGPAT3 gene on milk fatty acids in dairy cattle显示文摘Background: People are paying more attention to the healthy and balanced diet with the improvement of their living standards. Milk fatty acids(FAs) have been reported that they were related to some atherosclerosis and coronary heart diseases in human. In our previous genome-wide association study(GWAS) on milk FAs in dairy cattle, 83 genomewide significant single nucleotide polymorphisms(SNPs) were detected. Among them, two SNPs, ARS-BFGL-NGS-109493 and BTA-56389-no-rs associated with C18 index(P = 0.0459), were located in the upstream of 1-acylglycerol-3-phosphate O-acyltransferase 3(AGPAT3) gene. AGPAT3 is involved in glycerol-lipid, glycerol-phospholipid metabolism and phospholipase D signaling pathways. Hence, it was inferred as a candidate gene for milk FAs. The aim of this study was to further confirm the genetic effects of the AGPAT3 gene on milk FA traits in dairy cattle.Results: Through re-sequencing the complete coding region, and 3000 bp of 5′ and 3′ regulatory regions of the AGPA T3 gene, a total of 17 SNPs were identified, including four in 5′ regulatory region, one in 5′ untranslated region(UTR),three in introns, one in 3′ UTR, and eight in 3′ regulatory region. By the linkage disequilibrium(LD) analysis with Haploview4.1 software, two haplotype blocks were observed that were formed by four and 12 identified SNPs,respectively. Using SAS9.2, we performed single locus-based and haplotype-based association analysis on 24 milk FAs in 1065 Chinese Holstein cows, and discovered that all the SNPs and the haplotype blocks were significantly associated with C6:0, C8:0 and C10:0(P < 0.0001–0.0384). Further, with Genomatix, we predicted that four SNPs in 5′ regulatory region(g.146702957 G > A, g.146704373 A > G, g.146704618 A > G and g.146704699 G > A) changed the transcription factor binding sites(TFBSs) for transcription factors SMARCA3, REX1, VMYB, BRACH, NKX26, ZBED4, SP1, USF1, ARNT and FOXA1. Out of them, two SNPs were validated to impact transcriptional activity by performing luciferase assay that the alleles A of both SNPs, g.146704373 A > G and g.146704618 A > G, increased the transcriptional activities of AGPAT3 promoter compared with alleles G(P = 0.0004).Conclusions: In conclusion, our findings first demonstrated the significant genetic associations of the AGPAT3 gene with milk FAs in dairy cattle, and two potential causal mutations were detected. | Lijun Shi Xin Wu Yuze Yang Zhu Ma Xiaoqing Lv Lin Liu Yanhua Li Feng Zhao Bo Han Dongxiao Sun | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 4 | Ultrasensitive polarization-dependent terahertz modulation in hybrid perovskites plasmoninduced transparency devices显示文摘Active control of metamaterial properties with high tunability of both resonant intensity and frequency is essential for advanced terahertz(THz) applications, ranging from spectroscopy and sensing to communications.Among varied metamaterials, plasmon-induced transparency(PIT) has enabled active control with giant sensitivity by embedding semiconducting materials. However, there is still a stringent challenge to achieve dynamic responses in both intensity and frequency modulation. Here, an anisotropic THz active metamaterial device with an ultrasensitive modulation feature is proposed and experimentally studied. A radiative-radiative-coupled PIT system is established, with a frequency shift of 0.26 THz in its sharp transparent windows by polarization rotation. Enabled by high charge-carrier mobility and longer diffusion lengths, we utilize a straightforwardly spincoated MAPbI3 film acting as a photoactive medium to endow the device with high sensitivity and ultrafast speed.When the device is pumped by an ultralow laser fluence, the PIT transmission windows at 0.86 and 1.12 THz demonstrate a significant reduction for two polarizations, respectively, with a full recovery time of 561 ps. In addition, we numerically prove the validity that the investigated resonator structure is sensitive to the optically induced conductivity. The hybrid system not only achieves resonant intensity and frequency modulations simultaneously, but also preserves the all-optical-induced switching merits with high sensitivity and speed, which enriches multifunctional subwavelength metamaterial devices at THz frequencies. | JUNHU ZHOU YUZE HU TIAN JIANG HAO OUYANG HAN LI YIZHEN SUI HAO HAO JIE YOU XIN ZHENG ZHONGJIE XU XIANG’AI CHENG | 2019 | Photonics Research2019，7，9： | 3 |
| 5 | Fine-Tuning Contact via Complexation for High-Performance Organic Solar Cells显示文摘For organic optoelectronic devices,precise tuning of the electrical property of both active layers and interfaces is crucial to achieve enhanced device performance.Herein,we developed a facile method using complexation to modify the work function and energy levels of cathode contact layers in organic solar cells(OSCs)to achieve suitable work function and energy levels while retaining relatively good conductivity.Compared with the control devices with neat(N,Ndimethyl-ammonium N-oxide)propyl perylene diimide(PDINO)contacts,the tris(pentafluorophenyl)borane(BCF)-complexed PDINO cathode contacts showed enhanced power conversion efficiencies(PCEs),which is independent of the composition of the active layer.More specifically,single-junction OSCs employing PDINO cathode contact with 2 wt%BCF-additive achieved an average PCE of 17.7%.Based on experimental data and theoretical modeling,we found that the boron cores of BCF coordinate with the amino N-oxide terminal substituent of PDINO after generating BCF–H2O/methanol complexes.BCF segments with a strong electron-withdrawing property can effectively reduce the energy levels of the PDINO–BCF complex,and thus enhance device PCE when it is used as a cathode contact in OSCs.This strategy can be extended to other types of photovoltaic devices,photodetectors,and light-emitting diodes. | Yawen Li Zhenzhen Zhang Xiaona Han Tao Li Yuze Lin | 2022 | CCS Chemistry2022，4，3： | 2 |
| 6 | Enhancing photovoltaic performance via aggregation dynamics control in fused-ring electron acceptor显示文摘A new fused-ring electron acceptor FNIC3 with dynamics controlled aggregation behavior was synthesized.FNIC3 shows strong absorption in 600–900 nm,HOMO/LUMO energy levels of−5.59/−4.04 eV,and electron mobility of 1.2×10^(−3) cm^(2) V^(−1) s^(−1).The aggregation of FNIC3 shows strong dependency on film formation time.Prolongation of film formation time promotes the crystallization of FNIC3,leading to improved crystallinity and enlarged aggregate sizes.Aggregation of FNIC3 significantly influences the photovoltaic device parameters.Appropriate aggregation red-shifts the absorption and improves the mobilities of the blend,which contributes to high photocurrent and fill factor thus high power conversion efficiency(PCE).Overaggregation leads to increased nonradiative energy loss and insufficient charge generation,resulting in decreased open-circuit voltage and short-circuit current density.The blends based on PM6:FNIC3 fabricated under proper film formation time exhibit a PCE of 12.3%,higher than those fabricated under short and long film formation time(10.0–10.5%). | Jiayu Wang Runyu Zhu Shijie Wang Yawen Li Boyu Jia Jiadong Zhou Peiyao Xue Susanne Seibt Yuze Lin Zengqi Xie Wei Ma Xiaowei Zhan | 2021 | Aggregate2021，2，3： | 1 |
| 7 | The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis显示文摘Breast cancer is the most prevalent cancer worldwide,and metastasis is the leading cause of death in cancer patients.Human monocyte chemoattractant protein-1(MCP-1/CCL2)was isolated from the culture supernatants of not only mitogen-activated peripheral blood mononuclear leukocytes but also malignant glioma cells based on its in vitro chemotactic activity toward human monocytes.MCP-1 was subsequently found to be identical to a previously described tumor cell-derived chemotactic factor thought to be responsible for the accumulation of tumor-associated macrophages(TAMs),and it became a candidate target of clinical intervention;however,the role of TAMs in cancer development was still controversial at the time of the discovery of MCP-1.The in vivo role of MCP-1 in cancer progression was first evaluated by examining human cancer tissues,including breast cancers.Positive correlations between the level of MCP-1 production in tumors and the degree of TAM infiltration and cancer progression were established.The contribution of MCP-1 to the growth of primary tumors and metastasis to the lung,bone,and brain was examined in mouse breast cancer models.The results of these studies strongly suggested that MCP-1 is a promoter of breast cancer metastasis to the lung and brain but not bone.Potential mechanisms of MCP-1 production in the breast cancer microenvironment have also been reported.In the present manuscript,we review studies in which the role of MCP-1 in breast cancer development and progression and the mechanisms of its production were examined and attempt to draw a consensus and discuss the potential use of MCP-1 as a biomarker for diagnosis. | Teizo Yoshimura Chunning Li Yuze Wang Akihiro Matsukawa | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 8 | Take Bitcoin into your portfolio:a novel ensemble portfolio optimization framework for broad commodity assets显示文摘The emergence and growing popularity of Bitcoins have attracted the attention of the financial world.However,few empirical studies have considered the inclusion of the newly emerged commodity asset in the global commodity market.It is of great importance for investors and policymakers to take advantage of this asset and its potential benefits by incorporating it as a part of the broad commodity trading portfolio.In this study,we propose a novel ensemble portfolio optimization(NEPO)framework utilized for broad commodity assets,which integrates a hybrid variational mode decomposition-bidirectional long short-term memory deep learning model for future returns forecast and a reinforcement learning-based model for optimizing the asset weight allocation.Our empirical results indicate that the NEPO framework could effectively improve the prediction accuracy and trend prediction ability across various commodity assets from different sectors.In addition,it could effectively incorporate Bitcoins into the asset pool and achieve better financial performance compared to traditional asset allocation strategies,commodity funds,and indices. | Yuze Li Shangrong Jiang Yunjie Wei Shouyang Wang | 2021 | Financial Innovation2021，7，1： | 1 |
| 9 | Recovery of Li_(2)CO_(3)and FePO_(4)from spent LiFePO_(4)by coupling technics of isomorphic substitution leaching and solvent extraction显示文摘Efficient and low-cost recycling of spent lithium iron phosphate(LiFePO_(4),LFP)batteries has become an inevitable trend.In this study,an integrated closed-loop recycling strategy including isomorphic substitution leaching and solvent extraction process for spent LFP was proposed.An inexpensive FeCl_(3)was used as leaching agent to directly substitute Fe^(2+)from LFP.99%of Li can be rapidly leached in just 30 min,accompanied by 98%of FePO_(4)precipitated in lixivium.The tri-n-butyl phosphate(TBP)-sulfonated kerosene(SK)system was applied to extract Li from lixivium through a twelve-stage countercurrent process containing synchronous extraction and stepwise stripping of Li^(+)and Fe^(3+).80.81%of Li can be selectively enriched in stripping liquor containing 3.059 mol·L^(-1)of Li^(+)under optimal conditions.And the Fe stripping liquor was recovered for LFP re-leaching,of which,Fe^(2+)was oxidized to Fe^(3+)by appropriate H_(2)O_(2).Raffinate and lixivium were concentrated and entered into extraction process to accomplished closeloop recycling process.Overall,the results suggest that more than 99%of Li was recovered.FeCl_(3)holding in solution was directly regenerated without any pollutant emission.The sustainable mothed would be an alternative candidate for total element recycling of spent LFP batteries with industrial potential. | Yong Niu Xiaowu Peng Jinfeng Li Yuze Zhang Fugen Song Dong Shi Lijuan Li | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 1 |
| 10 | Thiazole- based organic semiconductors for organic electronics 显示文摘 | Lin Yuze Fan Haijun Li Yongfang | 2012 | Adv Mater2012，24，23： | 1 |
| 11 | SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA显示文摘HBV infection initiates hepatitis B and promotes liver cirrhosis and hepatocellular carcinoma.IFN-α is commonly used in hepatitis B therapy,but how it inhibits HBV is not fully understood.We screened 285 human interferon-stimulated genes(ISGs)for anti-HBV activity using a cell-based assay,which revealed several anti-HBV ISGs.Among these ISGs,SAMD4A was the strongest suppressor of HBV replication.We found the binding site of SAMD4A in HBV RNA,which was a previously unidentified Smaug recognition region(SRE)sequence conserved in HBV variants.SAMD4A binds to the SRE site in viral RNA to trigger its degradation.The SAM domain in SAMD4A is critical for RNA binding and the C-terminal domain of SAMD4A is required for SAMD4A anti-HBV function.Human SAMD4B is a homolog of human SAMD4A but is not an ISG,and the murine genome encodes SAMD4.All these SAMD4 proteins suppressed HBV replication when overexpressed in vitro and in vivo.We also showed that knocking out the Samd4 gene in hepatocytes led to a higher level of HBV replication in mice and AAV-delivered SAMD4A expression reduced the virus titer in HBVproducing transgenic mice.In addition,a database analysis revealed a negative correlation between the levels of SAMD4A/B and HBV in patients.Our data suggest that SAMD4A is an important anti-HBV ISG for use in IFN therapy of hepatitis B and that the levels of SAMD4A/B expression are related to HBV sensitivity in humans. | Yuze Wang Xinrui Fan Yunlong Song Yifei Liu Ruixin Liu Jianfeng Wu Xiaoling Li Quan Yuan Guo Fu Ningshao Xia Jiahuai Han | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 12 | A Solution‐Processable Electron Acceptor Based on Dibenzosilole and Diketopyrrolopyrrole for Organic Solar Cells显示文摘 | Yuze Lin Yongfang Li Xiaowei Zhan | 2013 | Adv Energy Mater2013，，6： | 1 |
| 13 | Enhancing Photovoltaic Performance of Asymmetric Fused-Ring Electron Acceptor by Expanding Pyrrole to Pyrrolo[3,2-b]pyrrole显示文摘We propose a strategy to improve performance of unidirectionally extended fused-ring electron acceptors by using pyrrolo[3,2-b]pyrrole to replace pyrrole ring, and design two asymmetric nonfullerene acceptors 1PIC and 2PIC. Replacing pyrrole in 1PIC with pyrrolo[3,2-b]pyrrole remarkably red-shifts absorption peak by 109 nm, elevates the HOMO and LUMO energy levels, and improves electron mobility. The photovoltaic devices based on blend of PM6 donor and 2PIC acceptor exhibit power conversion efficiency as high as 12.6%, which is much higher than that of PM6:1PIC (3.53%), due to more efficient exciton generation and dissociation, faster and more balanced carrier transport and less charge recombination. | Zemin Wang Guilong Cai Peiyao Xue Zesheng Liu Boyu Jia Nan Li Jiayu Wang Xinhui Lu Yuze Lin Guojie Wang Xiaowei Zhan | 2022 | Chinese Journal of Chemistry2022，40，24： | 1 |
| 14 | Obesity paradox: Clinical benefits not observed in obese patients with ST-segment elevation myocardial infarction: A multicenter, prospective, cohort study of the northern region of China显示文摘 | Yuze Li Chunwei Wu Yujiao Sun Daming Jiang Bo Zhang Lina Ren Yuan Gao Haijie Yu Guang Yang Qigang Guan Wen Tian Haishan Zhang Liang Guo Guoxian Qi | 2013 | International Journal of Cardiology2013，，： | 1 |
| 15 | A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch显示文摘A nanocomposite microneedle(ZCQ/MN)patch containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin(ZCQ)was developed as a combination therapy for androgenic alopecia(AGA).The degradable microneedle gradually dissolves after penetration into the skin and releases the ZCQ nanoparticles.ZCQ nanoparticles release quercetin(Qu),copper(Cu^(2+))and zinc ions(Zn^(2+))subcutaneously to synergistically promote hair follicle regeneration.The mechanism of promoting hair follicle regeneration mainly includes the regulation of the main pathophysiological phenomena of AGA such as inhibition of dihydrotestosterone,inhibition of inflammation,promotion of angiogenesis and activation of hair follicle stem cells by the combination of Cu^(2+)and Zn^(2+)ions and Qu.This study demonstrates that the systematic intervention targeting different pathophysiological links of AGA by the combination of organic drug and bioactive metal ions is an effective treatment strategy for hair loss,which provides a theoretical basis for development of biomaterial based anti-hair loss therapy. | Zhaowenbin Zhang Wenbo Li Di Chang Ziqin Wei Endian Wang Jing Yu Yuze Xu Yumei Que Yanxin Chen Chen Fan Bing Ma Yanling Zhou Zhiguang Huan Chen Yang Feng Guo Jiang Chang | 2023 | Bioactive Materials2023，，6： | 1 |
| 16 | Regional ecosystem health assessment using the GA-BPANN model:a case study of Yunnan Province,China显示文摘Background:Regional ecosystem health assessments are the basis for the sustainable development of society.However,an ecosystem is a complex integration of ecosystem mosaics and subsystems that influence each other,making it difficult to evaluate them using traditional assessment methods of linear and explicit functions.We introduce a back-propagation neural network model optimized by a genetic algorithm to evaluate ecosystem health in 16 districts in Yunnan Province.Result:(1)The model required fewer inputs to evaluate complex and nonlinear systems,avoided the need for subjective weights,and performed well in this practical application to regional ecosystem health assessment.(2)The ecosystem health in Yunnan Province was increasing,and there was a significant positive spatial autocorrelation during 2000-2020,showing that districts with high Ecosystem Health cluster together and the ecological protection policy of the region has produced a diffusion effect,leading to continuous improvement of the ecological health of the surrounding areas.High-low outlier areas of ecosystem health should be paid more attention,because of the increasing instability of local health levels.Conclusion:This study provides a methodological exploration for assessing spatial mosaics of different ecosystems at a regional scale. | Yuze Li Yuanxiang Wu Xiaoguang Liu | 2022 | Ecosystem Health and Sustainability2022，8，1： | 0 |
| 17 | Pore-Scale Investigation of Coupled Two-Phase and Reactive Transport in the Cathode Electrode of Proton Exchange Membrane Fuel Cells显示文摘A three-dimensional multicomponent multiphase lattice Boltzmann model(LBM)is established to model the coupled two-phase and reactive transport phenomena in the cathode electrode of proton exchange membrane fuel cells.The gas diff usion layer(GDL)and microporous layer(MPL)are stochastically reconstructed with the inside dynamic distribution of oxygen and liquid water resolved,and the catalyst layer is simplifi ed as a superthin layer to address the electrochemical reaction,which provides a clear description of the fl ooding eff ect on mass transport and performance.Diff erent kinds of electrodes are reconstructed to determine the optimum porosity and structure design of the GDL and MPL by comparing the transport resistance and per-formance under the fl ooding condition.The simulation results show that gradient porosity GDL helps to increase the reactive area and average concentration under fl ooding.The presence of the MPL ensures the oxygen transport space and reaction area because liquid water cannot transport through micropores.Moreover,the MPL helps in the uniform distribution of oxygen for an effi cient in-plane transport capacity.Crack and perforation structures can accelerate the water transport in the assembly.The systematic perforation design yields the best performance under fl ooding by separating the transport of liquid water and oxygen. | Shengjie Ye Yuze Hou Xing Li Kui Jiao Qing Du | 2023 | Transactions of Tianjin University2023，29，1： | 0 |
| 18 | The clutch size,incubation behavior of Reeves’s Pheasant(Syrmaticus reevesii) and their responses to ambient temperature and precipitation显示文摘Weather conditions play a pivotal role in embryo development and parental incubation costs,potentially impacting the clutch size and incubation behavior of birds.Understanding these effects is crucial for bird conservation.Reeves’ s Pheasant(Syrmaticus reevesii) is a threatened species endemic to China,which is characterized by female-only incubation.However,there is a lack of information regarding the impact of weather conditions on clutch size and incubation behavior in this species.Using satellite tracking,we tracked 27 wild female Reeves’ s Pheasants from 2020 to 2023 in Hubei Province,China.We explored their clutch size and incubation behavior,as well as their responses to ambient temperature and precipitation.Clutch size averaged 7.75 ±1.36,had an association with average ambient temperature and average daily precipitation during the egglaying period,and was potentially linked to female breeding attempts.Throughout the incubation period,females took an average of 0.73 ±0.46 recesses every 24 h,with an average recess duration of 100.80 ±73.37 min and an average nest attendance of 92.98 ±5.27%.They showed a unimodal recess pattern in which nest departures peaked primarily between 13:00 and 16:00.Furthermore,females rarely left nests when daily precipitation was high.Recess duration and nest attendance were influenced by the interaction between daily mean ambient temperature and daily precipitation,as well as day of incubation.Additionally,there was a positive correlation between clutch size and recess duration.These results contribute valuable insights into the lifehistory features of this endangered species. | Ting Jin Shuai Lu Yunqi Wang Junqin Hua Zhengxiao Liu Qian Hu Yating Liu Yuze Zhao Jianqiang Li Jiliang Xu | 2024 | Avian Research2024，15，1： | 0 |
| 19 | Experimental Investigations on NO_(x) Emission and Combustion Dynamics in an Axial Fuel Staging Combustor显示文摘Axial Fuel Staging(AFS)technology is an advanced low-emission combustion method in modem gas turbine,which divides the combustor into two axially arranged combustion zones.For revealing the characteristics of axial staged combustion,an industrial-grade combustor was designed and built.The distribution of temperature and velocity field in the combustor was presented with numerical simulation.And an Atmospheric Combustor Test Rig for axial staged combustion was built.The flow resistance characteristics of the combustor were measured at first.Then the effects of the equivalent ratio and the preheating temperature on the pollutant emission and combustion instability were investigated.The results show that the total pressure recovery coefficient in cold state is always above 98%;starting the secondary combustion at low load can reduce NO emissions by 50%,and can suppress the combustion oscillation amplitude of the combustor.At the design point with φ=0.62 and preheating temperature=400°C,NO emission and CO emission are 15.68 and 4.22 mg/m^(3)(@15%O_(2)). | LI Yuze JIA Yuliang JIN Ming ZHU Xutong GE Bing MAO Ronghai REN Lilei CHEN Mingmin JIAO Guangyun | 2022 | Journal of Thermal Science2022，31，1： | 0 |
| 20 | Complex system management in the post-COVID world:Five research directions显示文摘A complex system is composed of many interrelated elements,and the interaction between these elements makes the overall performance of the system greater than the sum of member performance[1-5].In the context of management,various forms of organizations,from micro enterprises to macroeconomic systems,can be seen as systems formed by a large number of interactive individuals acting on their own limited information. | Shouyang Wang Yuze Li | 2022 | Fundamental Research2022，2，5： | 0 |
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