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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | From Golden Rice to aSTARice:Bioengineering Astaxanthin Biosynthesis in Rice Endosperm显示文摘Carotenoids are important phytonutrients with antioxidant properties,and are widely used in foods and feedstuffs as Supplements.Astaxanthin,a red-colored ketocarotenoid,has strong antioxidant activity and thus can benefit human health.However,astaxanthin is not produced in most higher plants.Here we report the bioengineering of astaxanthin biosynthesis in rice endosperm by introducing four synthetic genes,sZmPSY1,sPaCrtl,sCrBKT,and sHpBHY,which encode the enzymes phytoene synthase,phytoene desaturase,β-carotene ketolase,and β-carotene hydroxylase,respectively.Transgneic overexpression of two (sZmPSY1 and sPaCrtl),three (sZmPSY1,sPaCrtl and sCrBKT),and all these four genes driven by rice endosperm-specific promoters established the Carotenoid/ketocarotenoid/astaxanthin biosynthetic pathways in the endosperm and thus resulted in various types of germplasm,from the yellow-grained β-caro- tene-enriched Golden Rice to orange-red-grained Canthaxanthin Rice and Astaxanthin Rice,respectively. Grains Of Astaxanthin Rice were enriched with astaxanthin in the endosperm and had higher antioxidant activity.These results proved that introduction of a minimal set of four transgenes enables de novo biosynthesis of astaxanthin in therice endosperm.This work provides a Successful example for synthetic biology in plants and biofortification in crops;the biofortified rice products generated by this study could be consumed as health-promoting foods and processed tO produce dietary supplements. | Qinlong Zhu Dongchang Zeng Suize Yu Chaojun Cui Jiamin Li Heying Li Junyu Chen Runzhao Zhang Xiucai Zhao Letian Chen Yao-Guang Liu | 2018 | Molecular Plant2018，11，12： | 35 |
| 3 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 4 | Wireless Communications with Programmable Metasurface:Transceiver Design and Experimental Results显示文摘Metasurfaces have drawn significant attentions due to their superior capability in tailoring electromagnetic waves with a wide frequency range, from microwave to visible light. Recently, programmable metasurfaces have demonstrated the ability of manipulating the amplitude or phase of electromagnetic waves in a programmable manner in real time, which renders them especially appealing in the applications of wireless communications. In this paper, we present the fundamental principle of applying programmable metasurface as transmitter for wireless communications. Then, we establish a prototype system of metasurface-based transmitter to conduct several experiments and measurements over the air, which practically demonstrate the feasibility of using programmable metasurfaces in future communication systems. By exploiting the dynamically controllable property of programmable metasurface, the design, implementation and experimental evaluation of the proposed metasurface-based wireless communication system are presented with the prototype, which realizes single carrier quadrature phase shift keying(QPSK) transmission over the air. In the developed prototype, the phase of the reflected electromagnetic wave of programma-ble metasurface is directly manipulated in real time according to the baseband control signal, which achieves 2.048 Mbps data transfer rate with video streaming transmission over the air. In addition, experimental result is provided to compare the performance of the proposed metasurface-based architecture against the conventional one. With the slight increase of the transmit power by 5 dB, the same bit error rate(BER) performance can be achieved as the conventional system in the absence of channel coding. Such a result is encouraging considering that the metasurface-based system has the advantages of low hardware cost and simple structure, thus leading to a promising new architecture for wireless communications. | Wankai Tang Xiang Li Jun Yan Dai Shi Jin Yong Zeng Qiang Cheng Tie Jun Cui | 2019 | China Communications2019，16，5： | 23 |
| 5 | Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer显示文摘渗入肿瘤的 Tregs 的起源,肿瘤免疫力的抑制的批评调停人,是不清楚的。这里,,我们证明在人的乳癌的渗入肿瘤的天真的 CD4 + T 房间和 Tregs 有重叠 TCR 全部剧目几乎别与传播 Tregs 重叠,建议 intratumoral Tregs 主要在 situ 而非从招募的 Tregs 从天真的 T 房间发展。而且,许多天真的 CD4 + T 房间和 Tregs 密切被相关,两个显示的穷人为乳癌病人的预后。天真的 CD4 + T 房间与许多生产 CCL18 巨噬细胞成比例遵守肿瘤片。而且,采纳地转移的人的天真的 CD4 + T 房间以一种 CCL18 依赖的方式渗入人的乳癌 orthotopic 异种皮移植。在在人性化的鼠标的人的乳癌异种皮移植,由将 PITPNM3 的表达式击倒堵住天真的 CD4 + T 房间的招募进肿瘤, CCL18 受体,显著地减少 intratumoral Tregs 并且禁止肿瘤前进。这些调查结果建议那个乳房渗入肿瘤的 Tregs 从在 situ 区分进 Tregs 的传播天真的 CD4 + T 房间的趋化性产生。由防碍 CCL18 的 PITPNM3 识别禁止天真的 CD4 + T 房间招募进肿瘤可以是为 anticancer 免疫疗法的吸引人的策略。 | Shicheng Su Jianyou Liao Jiang Liu Di Huang Chonghua He Fei Chen LinBing Yang Wei Wu Jianing Chen Ling Lin Yunjie Zeng Nengtai Ouyang Xiuying Cui Herui Yao Fengxi Su Jian-dong Huang Judy Lieberman Qiang Liu Erwei Song | 2017 | Cell Research2017，27，4： | 19 |
| 6 | YAP promotes osteogenesis and suppresses adipogenic differentiation by regulatingβ-catenin signaling显示文摘YAP(yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis.YAP is selectively expressed in osteoblast(OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs(bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis. | Jin-Xiu Pan Lei Xiong Kai Zhao Peng Zeng Bo Wang Fu-Lei Tang Dong Sun Hao-han Guo Xiao Yang Shun Cui Wen-Fang Xia Lin Mei Wen-Cheng Xiong | 2018 | Bone Research2018，6，2： | 19 |
| 7 | Chinese expert consensus statement on the diagnosis and treatment of fulminant myocarditis显示文摘Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis. | Daowen Wang Sheng Li Jiangang Jiang Jiangtao Yan Chunxia Zhao Yan Wang Yexin Ma Hesong Zeng Xiaomei Guo Hong Wang Jiarong Tang Houjuan Zuo Li Lin Guanglin Cui Section of Precision Medicine Group of Chinese Society of Cardiology,Editorial Board of Chinese Journal of Cardiology &Working Group of Adult Fulminant Myocarditis | 2019 | Science China(Life Sciences)2019，62，2： | 18 |
| 8 | Fabrication of the Superhydrophobic Surface on Magnesium Alloy and Its Corrosion Resistance显示文摘The superhydrophobic surface was fabricated on the AZ31 alloy by the combination of the hydrothermal treatment method and post modification with stearic acid. The superhydrophobic surface showed a static water contact angle of 157.6°. The characteristics of the coatings were characterized by scanning electron microscopy(SEM), X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR). The corrosion resistance of the superhydrophobic coatings was investigated by potentiodynamic polarization test and electrochemical impedance spectroscopy(EIS). The results revealed that the superhydrophobic coatings, characterized by petal-like structure significantly improved the corrosion resistance of the AZ31 alloy. | Fen Zhang Changlei Zhang Liang Song Rongchang Zeng Shuoqi Li Hongzhi Cui | 2015 | Journal of Materials Science & Technology2015，31，11： | 17 |
| 9 | Corrosion resistance of in-situ growth of nano-sized Mg(OH)2 on micro-arc oxidized magnesium alloy AZ31—Influence of EDTA显示文摘One of the major obstacles for the clinical use of biodegradable magnesium(Mg)-based materials is their high corrosion rate. Micro-arc oxidation(MAO) coatings on Mg alloys provide mild corrosion protection owing to their porous structure. Hence, in this study a dense Mg(OH)2 film was fabricated on MAO-coated Mg alloy AZ31 in an alkaline electrolyte containing ethylenediamine tetraacetic acid disodium(EDTA-2 Na) to reinforce the protection. Surface morphology, chemical composition and growth process of the MAO/Mg(OH)2 hybrid coating were examined using field-emission scanning electron microscopy, energy dispersive X-ray spectrometer, X-ray diffraction, X-ray photoelectron spectroscopy and Fourier transform infrared spectrophotometer. Corrosion resistance of the coatings was evaluated via potentiodynamic polarization curves and hydrogen evolution tests. Results manifested that the Mg(OH)2 coating possesses a porous nano-sized structure and completely seals the micro-pores and micro-cracks of the MAO coating.The intermetallic compound of AlMn phase in the substrate plays a key role in the growth of Mg(OH)2 film. The current density of Mg(OH)2-MAO composite coating decreases three orders of magnitude in comparison with that of bare substrate, indicating excellent corrosion resistance. The Mg(OH)2-MAO composite coating is beneficial to the formation of calcium phosphate corrosion products on the surface of Mg alloy AZ31, demonstrating a great promise for orthopaedic applications. | Chang-Yang Li Xiao-Li Fan Rong-Chang Zeng Lan-Yue Cui Shuo-Qi Li Fen Zhang Qing-Kun He M. Bobby Kannan Hong-Wei (George) Jiang Dong-Chu Chen Shao-Kang Guan | 2019 | Journal of Materials Science & Technology2019，35，6： | 16 |
| 10 | Dynamic Calibration of the Cutting Temperature Sensor of NiCr/NiSi Thin-film Thermocouple显示文摘In high-speed cutting, natural thermocouple, artificial thermocouple and infrared radiation temperature measurement are usually adopted for measuring cutting temperature, but these methods have difficulty in measuring transient temperature accurately of cutting area on account of low response speed and limited cutting condition. In this paper, NiCr/NiSi thin-film thermocouples(TFTCs) are fabricated according to temperature characteristic of cutting area in high-speed cutting by means of advanced twinned microwave electro cyclotron resonance(MW-ECR) plasma source enhanced radio frequency(RF) reaction non-balance magnetron sputtering technique, and can be used for transient cutting temperature measurement. The time constants of the TFTCs with different thermo-junction film width are measured at four kinds of sampling frequency by using Ultra-CFR short pulsed laser system that established. One-dimensional unsteady heat conduction model is constructed and the dynamic performance is analyzed theoretically. It can be seen from the analysis results that the NiCr/NiSi TFTCs are suitable for measuring transient temperature which varies quickly, the response speed of TFTCs can be obviously improved by reducing the thickness of thin-film, and the area of thermo-junction has little influence on dynamic response time. The dynamic calibration experiments are made on the constructed dynamic calibration system, and the experimental results confirm that sampling frequency should be larger than 50 kHz in dynamic measurement for stable response time, and the shortest response time is 0.042 ms. Measurement methods and devices of cutting heat and cutting temperature measurement are developed and improved by this research, which provide practical methods and instruments in monitoring cutting heat and cutting temperature for research and production in high-speed machining. | CUI Yunxian YANG Deshun JIA Ying ZENG Qiyong SUN Baoyuan | 2011 | Chinese Journal of Mechanical Engineering2011，24，1： | 15 |
| 11 | In vitro corrosion resistance and antibacterial performance of noveltin dioxide-doped calcium phosphate coating on degradable Mg-1Li-1Ca alloy显示文摘A SnO_2-doped calcium phosphate(Ca-P-Sn) coating was constructed on Mg-1 Li-1 Ca alloy by a hydrothermal process. The fabricated functional coatings were investigated using scanning electron microscopy(SEM), X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR). A triple-layered structure, which is composed of Ca_3(PO_4)_2,(Ca, Mg)_3(PO_4)_2, SnO_2, and MgHPO_4·3 H_2O, is evident and leads to the formation of Ca_(10)(PO_4)_6(OH)_2 in Hank's solution. Electrochemical measurements, hydrogen evolution tests and plating counts reveal that the corrosion resistance and antibacterial activity were improved through the coating treatment. The embedded SnO_2 nanoparticles enhanced crystallisation of the coating.The formation and degradation mechanisms of the coating were discussed. | Lan-Yue Cui Guang-Bin Wei Zhuang-Zhuang Han Rong-Chang Zeng Lei Wang Yu-Hong Zou Shuo-Qi Li Dao-Kui Xu Shao-Kang Guan | 2019 | Journal of Materials Science & Technology2019，35，3： | 14 |
| 12 | In vitro corrosion resistance of layer-by-layer assembled polyacrylic acid multilayers induced Ca–P coating on magnesium alloy AZ31显示文摘Biodegradable magnesium(Mg)-based alloys have aroused great concern owing to their promising characteristics as temporary implants for orthopedic application.But their undesirably rapid corrosion rate under physiological conditions has limited the actual clinical application.This study reports the use of a novel biomimetic polyelectrolyte multilayer template,based on polyvinylpyrrolidone(PVP)and polyacrylic acid(PAA)via layerby-layer(LbL)assembly,to improve the corrosion resistance of the alloy.Surface characterization techniques(field-emission scanning electron microscopy,Fourier transform infrared(FTIR)spectrophotometer and X-ray diffractometer)confirmed the formation of biomineralized Ca–P coating on AZ31 alloy.Both hydrogen evolution and electrochemical corrosion tests demonstrated that the corrosion protection of the polyelectrolyte-induced Ca–P coating on AZ31 alloy.The formation mechanism of biomineralized Ca–P coating was proposed. | Lan-Yue Cui Shen-Cong Cheng Lu-Xian Liang Jing-Chao Zhang Shuo-Qi Li Zhen-Lin Wang Rong-Chang Zeng | 2020 | Bioactive Materials2020，5，1： | 13 |
| 13 | Corrosion resistance of a superhydrophobic micro-arc oxidation coating on Mg-4Li-1Ca alloy显示文摘A micro-arc oxidation(MAO)/zinc stearate(ZnSA) composite coating was fabricated via MAO processing and subsequent sealing with electrodeposition of a superhydrophobic ZnSA. The surface morphologies,chemical composition and corrosion resistance of the coatings were investigated using field-emission scanning electron microscopy, Fourier transform infrared, X-ray diffraction and electrochemical and hydrogen evolution measurements. Results indicated that the MAO coating was efficiently sealed by the following superhydrophobic ZnSA coating. The MAO/ZnSA composite coating significantly enhanced the corrosion resistance of Mg alloy Mg-4 Li-1 Ca due to its superhydrophobic function. Additionally, corrosion mechanism was suggested and discussed for the composite coating. | Lan-Yue Cui Han-Peng Liu Wen-Le Zhang Zhuang-Zhuang Han Mei-Xu Deng Rong-Chang Zeng Shuo-Qi Li Zhen-Lin Wang | 2017 | Journal of Materials Science & Technology2017，33，11： | 13 |
| 14 | Corrosion resistance of bioinspired DNA-induced Ca-P coating on biodegradable magnesium alloy显示文摘Bioinspired coatings with decreased corrosion rate and enhanced bond strength are at the core of future clinic applications on degradable magnesium(Mg)-based implants.The hybrid of organic and inorganic compounds offers a strategy to fabricate biodegradable,biocompatible and compact coatings on biomedical Mg alloys.Hereby,a comparison with and without DNA addition was made on the corrosion resistance and adhesion strength of Ca-P coatings fabricated on AZ31 alloy via hydrothermal deposition.The morphology,chemical composition,and crystallographic structure of the coatings were investigated by means of SEM,EDS and FTIR as well as XRD before and after corrosion tests.Corrosion resistance was evaluated via potentiodynamic polarization curves,electrochemical impedance spectroscopy(EIS)and hydrogen evolution tests in Hank’s solution.Results show that the coatings are mainly characterized by tricalcium phosphate(TCP),dicalcium phosphate anhydrous(DCPA)and calcium-deficient hydroxyapatite(CDHA).The presence of DNA leads to the formation of Ca-P coating with improved corrosion resistance and adhesion strength.Additionally,the formation mechanism for DNA-induced Ca-P coating is proposed.The DNA-induced Ca-P coating exhibits a promising future for controlling the corrosion rate of biodegradable Mg alloys.©2019 Published by Elsevier B.V.on behalf of Chongqing University. | Ping Liu Jia-Min Wang Xiao-Tong Yu Xiao-Bo Chen Shuo-Qi Li Dong-Chu Chen Shao-Kang Guan Rong-Chang Zeng Lan-Yue Cui | 2019 | Journal of Magnesium and Alloys2019，7，1： | 13 |
| 15 | New insights into the effect of Tris-HCl and Tris on corrosion of magnesium alloy in presence of bicarbonate,sulfate,hydrogen phosphate and dihydrogen phosphate ions显示文摘In vitro degradation is an important approach to screening appropriate biomedical magnesium(Mg) alloys at low cost. However, corrosion products deposited on Mg alloys exert a critical impact on corrosion resistance. There are no acceptable criteria on the evaluation on degradation rate of Mg alloys. Understanding the degradation behavior of Mg alloys in presence of Tris buffer is necessary. An investigation was made to compare the influence of Tris-HCl and Tris on the corrosion behavior of Mg alloy AZ31 in the presence of various anions of simulated body fluids via hydrogen evolution, p H value and electrochemical tests.The results demonstrated that the Tris-HCl buffer resulted in general corrosion due to the inhibition of the formation of corrosion products and thus increased the corrosion rate of the AZ31 alloy. Whereas Tris gave rise to pitting corrosion or general corrosion due to the fact that the hydrolysis of the amino-group of Tris led to an increase in solution p H value, and promoted the formation of corrosion products and thus a significant reduction in corrosion rate. In addition, the corrosion mechanisms in the presence of Tris-HCl and Tris were proposed. Tris-HCl as a buffer prevented the formation of precipitates of HCO_3^-, SO_4^(2-),HPO_4^(2-) and H_2PO_4^- ions during the corrosion of the AZ31 alloy due to its lower buffering p H value(x.x).Thus, both the hydrogen evolution rate and corrosion current density of the alloy were approximately one order of magnitude higher in presence of Tris-HCl than Tris and Tris-free saline solutions. | Lan-Yue Cui Yan Hu Rong-Chang Zeng Yong-Xin Yang Dan-Dan Sun Shuo-Qi Li Fen Zhang En-Hou Han | 2017 | Journal of Materials Science & Technology2017，33，9： | 12 |
| 16 | Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma显示文摘很少长期的发炎怎么贡献 hepatocellular 癌(HCC ) 的前进被知道,特别癌症的开始。揭开从长期的发炎的批评转变到在网络水平的 HCC 和分子的机制,我们用我们的动态网络 biomarker (DNB ) 分析了土拨鼠肝炎 virus/c-myc 鼠标和匹配年龄的 wt-C57BL/6 鼠标的时间系列 proteomic 数据模型。DNB 分析显示在转基因的老鼠的出生以后的第 5 月是癌症开始的批评时期,就在批评转变前,它与临床的症状一致。同时,联系 DNB 的网络在批评转变前后显示出蛋白质表示和 coexpression 层次的激烈的倒置。DNB, PLA2G6 和 CYP2C44 的二个成员,与他们的联系差别一起表示了蛋白质,被发现导致 arachidonic 酸新陈代谢的机能障碍,进一步通过短暂受体潜力隧道的煽动性的调停人规定激活煽动性的回答,并且最后导致肝 detoxification 和恶意的转变的缺陷到癌症。作为一个 c-Myc 目标, PLA2G6 断然在表示与 c-Myc 相关,显示出从减少到在 carcinogenesis 期间增加的一个趋势,与在批评转变的最小的点或付小费给的点。相应 PLA2G6 和 c-Myc 的如此的趋势也在人的 hepatocarcinogenesis 期间被观察,与在高级 dysplastic 小瘤(就在 carcinogenesis 前的一个阶段) 的最小的点。我们的学习暗示 PLA2G6 可能在 hepatocarcinogenesis 期间作为象著名 c-Myc 一样的 oncogene 工作,当 PLA2G6 和 c-Myc 的 downregulation 能是显示逼近的 carcinogenesis 的一个警告信号时。 | Meiyi Li Chen Li Wei-Xin Liu Conghui Liu Jingru Cui Qingrun Li Hong Ni Yingcheng Yang Chaochao Wu Chunlei Chen Xing Zhen Tao Zeng Mujun zhao Lei Chen Jiarui Wu Rong Zeng Luonan Chen | 2017 | Journal of Molecular Cell Biology2017，9，6： | 12 |
| 17 | Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12显示文摘Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis(OA).However,how subchondral bone formation is activated and the mechanism by which increased subchondral bone turnover promotes cartilage degeneration during OA remains unclear.Here,we show that the mechanistic target of rapamycin complex 1(mTORC1)pathway is activated in subchondral bone preosteoblasts(Osterix+)from OA patients and mice.Constitutive activation of mTORC1 in preosteoblasts by deletion of the mTORC1 upstream inhibitor,tuberous sclerosis 1,induced aberrant subchondral bone formation,and sclerosis with little-to-no effects on articular cartilage integrity,but accelerated posttraumatic OA development in mice.In contrast,inhibition of mTORC1 in preosteoblasts by disruption of Raptor(mTORC1-specific component)reduced subchondral bone formation and cartilage degeneration,and attenuated post-traumatic OA in mice.Mechanistically,mTORC1 activation promoted preosteoblast expansion and Cxcl12 secretion,which induced subchondral bone remodeling and cartilage degeneration during OA.A Cxcl12-neutralizing antibody reduced cartilage degeneration and alleviated OA in mice.Altogether,these findings demonstrate that mTORC1 activation in subchondral preosteoblasts is not sufficient to induce OA,but can induce aberrant subchondral bone formation and secrete of Cxcl12 to accelerate disease progression following surgical destabilization of the joint.Pharmaceutical inhibition of the pathway presents a promising therapeutic approach for OA treatment. | Chuangxin Lin Liangliang Liu Chun Zeng Zhong-Kai Cui Yuhui Chen Pinling Lai Hong Wang Yan Shao Haiyan Zhang Rongkai Zhang Chang Zhao Hang Fang Daozhang Cai Xiaochun Bai | 2019 | Bone Research2019，7，1： | 12 |
| 18 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 19 | Performance of a completely autotrophic nitrogen removal over nitrite process for treating wastewater with different substrates at ambient temperature显示文摘The stability and parameters of a bio-ceramic filter for completely autotrophic nitrogen removal were investigated.The completely autotrophic nitrogen removal over nitrite(CANON) reactor was fed with different concentrations of ammonia(400,300,and 200mg N/L) but constant influent ammonia load.The results showed that the CANON system can achieve good treatment performance at ambient temperature(15-23°C).The average removal rate and removal loading of NH4+-N and TN was 83.90%,1.26kg N/(m3·day),and 70.14%,1.09kg N/(m3·day),respectively.Among the influencing factors like pH,dissolved oxygen and alkalinity,it was indicated that the pH was the key parameter of the performance of the CANON system.Observing the variation of pH would contribute to better control of the CANON system in an intuitive and fast way.Denaturing gradient gel electrophoresis analysis of microorganisms further revealed that there were some significant changes in the community structure of ammonium oxidizing bacteria,which had low diversity in different stages,while the species of anaerobic ammonium oxidizing(anammox) bacteria were fewer and the community composition was relatively stable.These observations showed that anaerobic ammonia oxidation was more stable than the aerobic ammonia oxidation,which could explain that why the CANON system maintained a good removal efficiency under the changing substrate conditions. | Xiaoyan Chang Dong Li Yuhai Liang Zhuo Yang Shaoming Cui Tao Liu Huiping Zeng Jie Zhang | 2013 | Journal of Environmental Sciences2013，25，4： | 12 |
| 20 | Advance in Antibacterial Magnesium Alloys and Surface Coatings on Magnesium Alloys:A Review显示文摘Magnesium(Mg)alloys as a bioabsorbable light metal have shown great clinical potential as bone replacement implants.In this review,the categories,progress in cutting-edge preparation technologies and antibacterial mechanisms of Mg alloys and considerable numbers of corrosion-resistant and functional coatings are summarized.The relationship among the microstructure(grain size,intermetallic compounds),biocorrosion resistance and biocompatibility for antibacterial Mg alloys is discussed.The challenge and outlooks of biomedical Mg alloys and coatings are proposed from an antibacterial perspective. | Yang Shao Rong-Chang Zeng Shuo-Qi Li Lan-Yue Cui Yu-Hong Zou Shao-Kang Guan Yu-Feng Zheng | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，5： | 12 |
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