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| 1 | Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus显示文摘 | Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng | 2014 | Chinese Medical Journal2014，，18： | 12 |
| 2 | Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus显示文摘长期的无法预言的温和压力淫液模型是消沉的一个广泛地使用的试验性的模型。在马头鱼尾的怪兽的外长的导致压力的 neuronal 房间死亡仔细与消沉的致病被联系。过多、延长的 endoplasmic 蜂窝胃嗯压力扳机房间死亡。氢硫化物 H 2 S,第三内长的发信号 gasotransmitter,作为 neuromodulator 和 neuroprotectant 在大脑功能起一个重要作用。我们假设了内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力可能涉及导致淫液的像消沉的行为。因此,集中于是否达到高潮的现在的学习扰乱内长的 H 2 S 和起来调整嗯在马头鱼尾的怪兽的应力并且是否外长的 H 2 S 阻止导致淫液的象压抑一样行为。结果证明对待淫液的老鼠展出像消沉的行为并且海马趾嗯包括调整葡萄糖的蛋白质的起来调整的层次的压力回答 78, CCAAT/enhancer 有约束力的蛋白质相应蛋白质,和劈开的 caspase-12 表示,当时 H 2 在马头鱼尾的怪兽的 S 在对待淫液的老鼠被压制。而且,外长的 H 2 S 阻止导致淫液的像消沉的行为。这些数据显示导致淫液的像消沉的行为与内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力并且建议了那内长的 H 2 S 并且嗯应力是消沉的新奇处理目标。 | Huiying Tan Wei Zou Jiamei Jiang Ying Tian Zhifang Xiao Lili Bi Haiying Zeng Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 8 |
| 3 | Comparison of the short-term and long-term outcomes of laparoscopic hysterectomies and of abdominal hysterectomies: a case study of 4,895 patients in the Guangxi Zhuang Autonomous Region, China显示文摘Background: To evaluate the short-term and long-term outcomes after laparoscopic hysterectomy(LH) compared with abdominal hysterectomy(AH) in case of benign gynecological disease. Methods: A multi-center cohort retrospective comparative study of population among 4,895 hysterectomies(3,539 LH vs.1,356 AH) between 2007 and 2013 was involved. Operative time(OT), estimated blood loss(EBL), intra-operative and post-operative complications, passing flatus; days with indwelling catheter, questionnaires covering pelvic floor functions and sexual functions were assessed.Results: The EBL(174.1±157.4 vs. 263.1±183.2 cc, LH and AH groups, respectively), passing flatus(38.7±14.1 vs. 48.1±13.2 hours), days with indwelling catheter(1.5±0.6 vs. 2.2±0.8 days), use of analgesics(6.5% vs. 73.1%), intra-operative complication rate(2.4% vs. 4.1%), post-operative complication rate(2.3% vs. 5.7%), post-operative constipation(12.1% vs. 24.6%), mild and serious stress urinary incontinence(SUI) post-operative(P<0.001; P=0.014), and proportion of Female Sexual Functioning Index(FSFI) total score <26.55 post-operative(P<0.001) of the LH group were significantly less than those of AH group. There wereno significant differences in OT(106.5±34.5 vs. 106.2±40.3 min) between the two groups.Conclusions: LH is a safe and efficient operation for improving patients' long-term quality of life(Qo L), and LH is a cost-effectiveness procedure for treating benign gynecological disease. LH is superior to AH due to reduced EBL, reduced post-operative pain and earlier passing flatus. | Hongying He Zhijun Yang Dingyuan Zeng Jiangtao Fan Xiaoxia Hu Yuan Ye Hua Bai YanmingJiang Zhong Lin Zhiying Lei Xinlin Li Lian Li Jinghua Gan Ying Lan Xiongzhi Tang Danxia Wang Junsong Jiang Xiaoyan Wu Meiying Li Xiaoqing Ren Xiaomin Yang Mei Liu Qinmei Wang Fuyan jiang Li Li | 2016 | Chinese Journal of Cancer Research2016，28，2： | 6 |
| 4 | Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase显示文摘Diabetes have been shown to cause progressive neuronal injury with pain and numbness via advanced glycation end-products(AGEs)-induced neuronal cell apoptosis;however, the valuable drug targets for diabetic neuropathy have been poorly reported so far. In this study, we discovered a natural small-molecule schisandrol A(SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis. ATP6V0D1, a major subunit of vacuolar-type ATPase(V-ATPase) in lysosome was identified as a crucial cellular target of SolA. Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification.Interestingly, SolA-induced lysosome pH downregulation resulted in a mitochondrial-lysosomal crosstalk by selectively promoting mitochondrial BH3-only protein BIM degradation, thereby preserving mitochondrial homeostasis and neuronal cells survival. Collectively, our findings reveal ATP6V0D1 is a valuable pharmacological target for diabetes-associated neuronal injury via controlling lysosomal acidification, and also provide the first small-molecule template allosterically activating V-ATPase for preventing diabetic neuropathy. | Xiaoqing Zhou Shaoyang Zhao Tingting Liu Lu Yao Meimei Zhao Xiaoming Ye Xiaowen Zhang Qiang Guo Pengfei Tu Kewu Zeng | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 5 | Enhancing hydrogen evolution on the basal plane of transition metal dichacolgenide van der Waals heterostructures显示文摘Recent years have seen a surge in the use of low-dimensional transition metal dichacolgenides,such as MoS_(2),as catalysts for the electrochemical hydrogen evolution reaction.In particular,sulfur vacancies in MoS_(2)can activate the inert basal plane,but that requires an unrealistically high defect concentration(~9%)to achieve optimal activity.In this work,we demonstrate by firstprinciples calculations that assembling van der Waals heterostructures can enhance the catalytic activity of MoS_(2)with low concentrations of sulfur vacancies.We integrate MoS_(2)with various two-dimensional nanostructures,including graphene,h-BN,phosphorene,transition metal dichacolgenides,MXenes,and their derivatives,aiming to fine-tune the free energy of atomic hydrogen adsorption.Remarkably,an optimal free energy can be achieved for a low sulfur vacancy concentration of~2.5%in the MoS_(2)/MXene-OH heterostructure,as well as high porosity and tunability.These results demonstrate the potential of combining two-dimensional van der Waals assembly with defect engineering for efficient hydrogen production. | Faling Ling Wei Kang Huirong Jing Wen Zeng Yankun Chen Xiaoqing Liu Yixin Zhang Lin Qi Liang Fang Miao Zhou | 2019 | npj Computational Materials2019，，1： | 2 |
| 6 | Deformation behavior and dynamic recrystallization of a Mg–Zn–Y–Zr alloy显示文摘 | Ya Zhang Xiaoqing Zeng Chen Lu Wenjiang Ding | 2006 | Materials Science & Engineering A2006，，1： | 2 |
| 7 | Antagonism between coral pathogen Vibrio coralliilyticus and other bacteria in the gastric cavity of scleractinian coral Galaxea fascicularis显示文摘Scleractinian corals host numerous microbial symbionts with different types of interactions. The gastric cavity of scleractinian coral, as a semiclosed subenvironment with distinct chemical characteristics(e.g., dissolved O2, pH, alkalinity, and nutrients), harbors a distinct microbial community and a diverse array of bacteria that can be pathogenic or beneficial. Galaxea fascicularis is one of the dominant massive scleractinian coral species on inshore fringing reefs in the northern South China Sea.Although the abundance of coral-associated bacteria has been investigated in G. fascicularis, less is known about the microorganisms in the gastric cavity. In this study, we specially isolated cultivable bacterial strains from the gastric cavity of G.fascicularis collected from Hainan Island using a noninvasive sampling approach. Among the 101 representative bacterial strains, one Vibrio coralliilyticus strain, SCSIO 43001, was found to be a temperature-dependent opportunistic pathogen of G.fascicularis. The antagonistic activity between the 100 strains and V. coralliilyticus SCSIO 43001 was tested using a modified Burkholder diffusion assay. Our results showed that V. coralliilyticus SCSIO 43001 inhibits the growth of Erythrobacter flavus and Sphingomonas yabuuchiae. Additionally, we found that three Pseudoalteromonas strains showed moderate to high antibacterial activity against V. coralliilyticus SCSIO 43001 and several other coral-associated Gram-negative bacterial strains.These results suggest that competition between the coral pathogen and other bacteria also occurs in the gastric cavity of coral, and Pseudoalteromonas strains in the gastric cavity of G. fascicularis may provide a protective role in the defense against coinhabiting coral pathogens at elevated temperature. | Kaihao TANG Waner ZHAN Yiqing ZHOU Tao XU Xiaoqing CHEN Weiquan WANG Zhenshun ZENG Yan WANG Xiaoxue WANG | 2020 | Science China Earth Sciences2020，63，1： | 2 |
| 8 | Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing显示文摘It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H_(2)is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C_(3)N_(4)nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H_(2)and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined’inside/outside-cooperation’will make a highway for treatment of deep-seated biofilm infection. | Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He | 2023 | National Science Review2023，10，5： | 2 |
| 9 | 显示文摘 | Zeng Xiaoqing Seoung J I Sang H J | 2006 | Journal of Luminescence2006，，121： | 1 |
| 10 | A study on variations of concentrations of particulate matter with different sizes in Lanzhou, China 显示文摘 | WANG Shigong FENG Xinyuan ZENG Xiaoqing | 2009 | Atmospheric Environ- ment2009，43，17： | 1 |
| 11 | VUV excitation properties of LnAl3B4O12:Re (Ln=Y,Gd; Re=Eu,Tb)显示文摘 | You Hongpeng Hong Guangyan Zeng Xiaoqing | 2000 | Journal of Physics and Chemistry of Solids2000，61，12： | 1 |
| 12 | Carbohydrate research显示文摘 | Lingyun Chen Yumin Du xiaoqing Zeng | 2003 | 338:333-3402003，338，： | 1 |
| 13 | Microstructure evolution of AZ31 Mg alloy during equal channel angular extrusion显示文摘 | LI Jin ZENG Xiaoqing MAO Dali | 2006 | Materials Science and Engineering2006，423，12： | 1 |
| 14 | EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma显示文摘 | Mengyan Wu Yingxia Liu Xiaoqing Di Haixian Kang Hua Zeng Yi Zhao Kangrong Cai Tianyun Pang Sen Wang Yunhong Yao Xinrong Hu | 2013 | Medical Oncology2013，，1： | 1 |
| 15 | Biodegradation of poly(butylene succinate-co-butylene adipate) by Aspergillus versicolor显示文摘 | Zhao Jianhao Wang Xiaoqing Zeng Jun | 2005 | Polymer Degradation and Stability2005，90，1： | 1 |
| 16 | VUV excitation properties of LnAl3B4O12∶Re(Ln=Y,Gd; Re=Eu,Tb)显示文摘 | YOU Hongpeng HONG Guangyan ZENG Xiaoqing | 2000 | J Phys Chem Solids2000，61，： | 1 |
| 17 | Infrared spectra and VUV excitation properties of BaLnB9O16∶Re(Ln=La,Gd; Re=Eu,Tb) 显示文摘 | YOU Hongpeng WU Xueyan ZENG Xiaoqing | 2001 | Mater Sci Eng B2001，86，： | 1 |
| 18 | Luminescent Properties of ( Y, Gd) BO3 : Bi^3+ , RE^3+ (RE = Eu, Tb) Phosphor under VUV/UV Excitation显示文摘 | Zeng Xiaoqing Im Seoung Jae Jang Sang Hun | 2006 | J Lumin2006，121，1： | 1 |
| 19 | 显示文摘 | Chen Lingyun Du yumin Zeng Xiaoqing | 2003 | Carbohydr Res2003，338，4： | 1 |
| 20 | Luminescent properties of (Y,Gd)BO 3 :Bi 3+ ,RE 3+ (RE=Eu, Tb) phosphor under VUV/UV excitation显示文摘 | Xiaoqing Zeng Seoung-Jae Im Sang-Hun Jang Young-Mo Kim Hyoung-Bin Park Seung-Hyun Son Hidekazu Hatanaka Gi-Young Kim Seul-Gi Kim | 2005 | Journal of Luminescence2005，，1： | 1 |
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