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| 1 | LA-ICP-MS zircon U-Pb dating and phenocryst EPMA of dikes, Guocheng, Jiaodong Peninsula: Implications for North China Craton lithosphere evolution显示文摘Widespread dike swarm, including diorite-, monzonite-porphyry and lamprophyre, intruded in the al- tered breccia gold deposits along basin marginal faults, Guocheng, Jiaodong Peninsula. Petrography exhibits biotite enclaves in amphibole phenocrysts and the presence of acicular apatites in these dikes. Electron probe microanalyses (EPMA) show that the amphibole and clinopyroxene phenocryst’s mantle in diorite porphyry and lamprophyre respectively has sharply higher MgO (Mg#) and Cr2O3 contents in contrast to their cores. The plagioclase phenocryst in monzonite porphyry has reverse zoning. These results indicate that the magma mixing between mantle-derived mafic and crust-derived felsic magmas occurred in the original process of the dikes. Zircon cathodoluminescence (CL) images show well-developed magmatic oscillatory zones and the acquired LA-ICP-MS zircon U-Pb weighted mean 206Pb/238U ages are 114±2 Ma (MSDW=1.5) for monzonite porphyry (GS1) and 116±1 Ma (MSDW=0.8) for diorite porphyry (GS2), respectively. Earlier magmatic events in the northwest Jiaodong Peninsula represented by some inherited or captured zircons also occur in these dikes. Magmatic zircons from GS1 and GS2 display consistent chondrite-normalized REE patterns and Nb/Ta values, implying that they may share a similar or same source. HREE enrichment and obvious negative Eu anomalies of these zircons preclude garnet presented in their source. Our results, combined with preciously pub- lished data, indicate that dike intrusion and gold mineralization among quartz vein, altered tectonite and altered breccia gold deposits are broadly contemporaneous throughout the Jiaodong Peninsula. These also imply that the intensive crust-mantle interaction and asthenospheric underplating had oc- curred in the Early Cretaceous in the Peninsula, together with foundering of lower crust in the early Mesozoic, representing the different stages of lithosphere thinning in the North China Craton (NNC). | TAN Jun WEI JunHao GUO LingLi ZHANG KeQing YAO ChunLiang LU JianPei LI HongMei | 2008 | Science China Earth Sciences2008，51，10： | 23 |
| 2 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 3 | Effects of environmental factors on sulfamethoxazole photodegradation under simulated sunlight irradiation: Kinetics and mechanism显示文摘To advance the knowledge of the environmental fate of sulfamethoxazole(SMX),we systematically investigated the effects of natural water constituents and synthetic substances(i.e.,TiO2 nanoparticles(nTiO2) and Ti-doped β-Bi2O3(NTB)) on the photodegradation kinetics of SMX under xenon lamp irradiation.The photolysis of SMX in aqueous solution followed first-order kinetics.Our results showed that higher concentrations of SMX,fulvic acid,suspended sediments,NTB and higher pH value decreased the photodegradation rates of SMX,whereas H2O2 improved the SMX photodegradation.TiO2 nanoparticles had a dual effect on photodegradation due to their photocatalytic activity and photoabsorption of photons.No intermediates more toxic toward Vibrio fischeri than SMX were produced after direct photolysis and photocatalytic degradation for 3 hr.The photolysis of SMX involved three pathways:hydroxylation,cleavage of the sulfonamide bond,and fragmentation of the isoxazole ring.This study lays the groundwork for a better understanding of the environmental fate of SMX. | Junfeng Niu Lilan Zhang Yang Li Jinbo Zhao Sidan Lv Keqing Xiao | 2013 | Journal of Environmental Sciences2013，25，6： | 14 |
| 4 | Zircon U–Pb and Hf isotopic study of Neoproterozoic granitic gneisses from the Alatage area, Xinjiang:constraints on the Precambrian crustal evolution in the Central Tianshan Block显示文摘The architecture and growth history of Precambrian crustal basements in the Central Tianshan Block play a key role in understanding the tectonic evolution of the Chinese Tianshan Orogenic Belt.In this study,we present precise LA-ICP-MS zircon U–Pb dating and LAMC-ICPMS zircon Hf isotopic data for two granitic gneisses from Alatage area in the Central Tianshan Block.The magmatic zircons from both samples yield similar protolith ages of 945±6 and 942±6 Ma,indicating that the early Neoproterozoic magmatism is prevailed in the Alatage area.These zircons have crustal Hf model ages of1.82–2.22 and 1.70–2.03 Ga,respectively,which are significantly older than their crystallization ages.It indicates that their parental magmas were derived from the reworking of ancient crust.However,we suggest that these Paleoproterozoic Hf model ages might result from mixing of continental materials with different ages in the Neoproterozoic crust.The inherited(detrital)zircon cores not only yield a wide age range of ca.989–1617 Ma,but also exhibit large Hf-isotope variations with Hf model ages of1.54–2.30 Ga.In particular,some 1.4–1.6 Ga zircons show high initial176Hf/177Hf ratios,consistent with those of depleted mantle,which indicates that the Mesoproterozoic event involved both reworking of older crust and generation of juvenile crust.The Central Tianshan Block has different Precambrian crustal growth history from the Tarim Craton.Therefore,it would not be a fragment of the Precambrian basement of the Tarim Craton. | Botao Huang Zhenyu He Keqing Zong Zeming Zhang | 2014 | Chinese Science Bulletin2014，59，1： | 12 |
| 5 | Trace elemental records of short-lived heating during exhumation of the CCSD eclogites显示文摘Trace element compositions of garnet, omphacite and apatite in ultrahigh-pressure eclogites from the main hole of the Chinese Continental Scientific Drilling (CCSD) project were in situ analyzed by the LA-ICP-MS method. Although both garnet and omphacite have homogeneous major element composi-tions, their trace elements show zonations from core to rim in rare earth elements. In particular, middle rare earth elements in the garnet, heavy rare earth elements in the apatite and all rare earth elements in the omphacite increase from core to rim, respectively. Based on dependence of partition coefficients on temperature and pressure in these minerals, we suggest that the trace elemental zonations in these minerals may record a short-lived heating event during exhumation. | ZONG KeQing LIU YongSheng LIU XiaoMing ZHANG BinHui | 2007 | Chinese Science Bulletin2007，52，6： | 9 |
| 6 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 7 | Cyclometalated platinum(Ⅱ) complexes with sterically bulky camphor-derived groups as β-diketonate ancillary ligand:a new route to efficiently reducing π-π interactions and Pt-Pt interactions显示文摘A new series of mono-cyclometalated square planar platinum(Ⅱ) complexes have been synthesized and the single-crystal X-ray structures of complex 1 and 2 have been determined.The complexes have the general formula ppyPt(O^O),where ppy is 2-phenylpyridyl,and O^O is β-diketonate ancillary ligands with the acyl substituent group in position 3 of(D)-(+)-camphor.Although,like the many Pt(Ⅱ) complexes with square-planar geometry,these complexes have plane stacking modes in crystal structure,the sterically bulky camphor-derived groups compel extensive slipping of the molecular stacking planes,resulting in the negligible overlapping of the aromatic ring fragments between molecules and the considerable Pt-Pt distance.The resolved spectra and a little shifted emission in solid state of complexes show that there is significant reduction of π-π interactions and Pt-Pt interactions,and suggest these complexes may be good candidates for doped phosphorescent organic light emitting diodes(PhOLEDs) and even for nondoped PhOLEDs. | LUO KaiJun,XIE Yu,XU LingLing,WANG JiangWei,ZHANG LiFang & ZHAO KeQing College of Chemistry and Materials Science,Sichuan Normal University,Chengdu 610068,China | 2010 | Science China Chemistry2010，53，1： | 5 |
| 8 | A Doubly Parameterized Detector for Mismatched Signals显示文摘In this paper, we consider the problem of adaptive multichannel signal detection in the presence of signal mismatch, and introduce a novel tunable detector,which is parameterized by two tunable parameters. It has the Constant false alarm rate(CFAR) property and covers Kelly's generalized likelihood ratio test(KGLRT), Adaptive matched filter(AMF), and Adaptive coherence estimator(ACE) as its three special cases. The novel detector controls the mismatched signal by adjusting two tunable parameters. Remarkably, it can achieve improved detection performance for matched signals, enhanced rejection of seriously mismatched signals, and better robustness to slightly mismatched signals than its natural competitors. | LIU Weijian XIE Wenchong ZHANG Qianping LI Rongfeng DUAN Keqing WANG Yongliang | 2015 | Chinese Journal of Electronics2015，24，1： | 3 |
| 9 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 10 | Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy显示文摘Primary age-related tauopathy(PART) is characterized by tau neurofibrillary tangles(NFTs) in the absence of amyloid plaque pathology. In the present study,we analyzed the distribution patterns of phosphorylated43-kDa TAR DNA-binding protein(pTDP-43) in the brains of patients with PART. Immunohistochemistry and immunofluorescence double-labeling in multiple brain regions was performed on brain tissues from PART,Alzheimer's disease(AD), and aging control cases. We examined the regional distribution patterns of pTDP-43 intraneuronal inclusions in PART with Braak NFT stages[ 0 and B IV, and a Thal phase of 0(no beta-amyloid present). We found four stages which indicated potentially sequential dissemination of pTDP-43 in PART. Stage I was characterized by the presence of pTDP-43 lesions in the amygdala, stage II by such lesions in the hippocampus,stage III by spread of pTDP-43 to the neocortex, and stage IV by pTDP-43 lesions in the putamen, pallidum, and insular cortex. In general, the distribution pattern of pTDP-43 pathology in PART cases was similar to the early TDP-43 stages reported in AD, but tended to be more restricted to the limbic system. However, there were some differences in the distribution patterns of pTDP-43 between PART and AD, especially in the dentate gyrus of the hippocampus. Positive correlations were found in PART between the Braak NFT stage and the pTDP-43 stage and density. | Xiaoling Zhang Bing Sun Xing Wang Hui Lu Fangjie Shao Annemieke J.M.Rozemuller Huazheng Liang Chong Liu Jiadong Chen Manli Huang Keqing Zhu | 2019 | Neuroscience Bulletin2019，35，2： | 3 |
| 11 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 12 | In- duction of G1 cell cycle arrest and apoptosis by berberine in bladder cancer cells 显示文摘 | YAN KEQING ZHANG CHENG FENG JINBO | 2011 | European Journal of Pharmacolo- gy2011，661，13： | 1 |
| 13 | A “wire” signal smoothing device for laser ablation inductively coupled plasma mass spectrometry analysis显示文摘 | Zhaochu Hu Yongsheng Liu Shan Gao Shaoquan Xiao Laishi Zhao Detlef Günther Ming Li Wen Zhang Keqing Zong | 2012 | Spectrochimica Acta Part B: Atomic Spectroscopy2012，，： | 1 |
| 14 | Non-matrix-matched analysis of U-Th-Pb geochronology of bastn?site by laser ablation inductively coupled plasma mass spectrometry显示文摘Bastn?site is widespread in alkali granite, carbonatite and REE ore deposits. The U-Th-Pb ages of bastn?site can constrain the mineralization age. Currently, the lack of suitable in situ analysis reference material is the major obstacle of bastn?site U-Th-Pb geochronology. In this study, the matrix effects of U-Pb and Th-Pb age determination in bastn?site using glass NIST 610 as the external calibration reference were evaluated with the 193-nm excimer LA-ICP-MS analysis in normal and additional gases laser ablation modes. The obtained U-Th-Pb ages of bastn?site were approximately 7–11% lower than their reference values in the normal analytical mode(without additional gas). Fortunately, the determined systematic age biases in UTh-Pb dating were significantly reduced(less than 1–2%) with the addition of water vapor within the ablation chamber. This reduction may be attributed to the observed significant suppression of206 Pb/238 U and208 Pb/232 Th downhole fractionation in both NIST 610 glass and bastn?site by introducing a small quantity of water vapor in the ablation chamber. In addition, the obtained206 Pb/238 U and208 Pb/232 Th ages of bastn?site K-9, LZ1384, and MAD809 showed great consistency with their corresponding recommended values. The obtained results show that accurate and precise U-Th-Pb ages of bastn?site can be simultaneously obtained by using glass NIST 610 as the primary calibration standard in 193-nm LA-ICP-MS with the water vapor-assisted method. This simple and effective water vapor-assisted non-matrix-matched laser ablation method helps to promote the geological application of bastn?site U-Th-Pb geochronology. | Tao LUO He ZHAO Wen ZHANG Jingliang GUO Keqing ZONG Yongsheng LIU Junfeng ZHANG Zhaochu HU | 2021 | Science China Earth Sciences2021，64，4： | 1 |
| 15 | Simultaneously boostingtoughness and tensile strength for polyamide 6/montmorillonitenanocomposite by a pressure-induced flow field显示文摘 | Shu Zhu Han Keqing Zhang Sen | 2014 | Journal ofMacromolecular Science Part B2014，53，16： | 1 |
| 16 | Generation of localized surface waves at the interface between a linear dielectric and a biased photovoltaic–photorefractivecrystal显示文摘 | Keqing Lu Chunxiang Wang Pengyu Lu Weijun Chen Yiqi Zhang Yanpeng Zhang | 2013 | Optics Communications2013，，： | 1 |
| 17 | Electroretinographic Effects of an Intravitreal Injection of Triamcinolone in Rabbit Retina 显示文摘 | Dustin D Bo Lei Keqing Zhang | 2005 | Arch Ophthalmol2005，123，11： | 1 |
| 18 | Influence of melt temperature on structure of polyacrylonitrile in ionic liquids during plasticized melt spinning process显示文摘 | Tian Yincai Han Keqing Zhang Wenhui | 2012 | Appl Mech Mater2012，，： | 1 |
| 19 | Influence of residence time on the structure of polyacrylonitrile in ionic liquids during melt spinning process显示文摘 | Tian Yincai Han Keqing Zhang Wenhui | 2013 | Mater Lett2013，92，： | 1 |
| 20 | Endogenous cellulolytic enzyme systems in the longhorn beetle Mesosa myops (Insecta: Coleoptera) studied by transcriptomic analysis显示文摘Cerambycidae (长角牛甲壳虫) 是有食木的喂的习惯的翘目的一个大家庭。纤维素消化在这些喂木头的昆虫起一个重要作用。在这研究, transcriptomic 技术被用来获得一个 glycoside hydrolase 家庭 45 (GH45 ) 从 Mesosa myops 的绗维素酶和七 GH5 绗维素酶,典型长角牛甲壳虫。表达式动力学和进化关系的分析提供了对可加水分解纤维素的系统的完全的描述。与单个开发有关的表示动力学显示内长的 GH45 和 GH5 绗维素酶在 M 统治纤维素消化。myops。进化分析建议那 GH45 绗维素酶基因是在翘目亚目 Polyphaga 的一般基因。进化分析也显示在 Lamiinae 长角牛甲壳虫的 GH5 绗维素酶组仔细与木头喂被联系。这研究证明在 M 有一个复杂内长的可加水分解纤维素的系统。被属于二个 glycoside hydrolase 家庭的绗维素酶统治的 myops。 | Jie Liu Keqing Song Huajing Teng Bin Zhang Wenzhu Li Huaijun Xue Xingke Yang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 1 |
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