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| 1 | A Facile One-Step Synthesis of TiOe/Graphene Composites for Photodegradation of Methyl Orange显示文摘 | Haijiao Zhang Panpan Xu Guidong Du Zhiwen Chen Kokyo Oh Dengyu Pan Zheng Jiao | 2011 | Nano Research2011，4，3： | 21 |
| 2 | Rocky Desertification Risk Zone Delineation in Karst Plateau Area:A Case Study in Puding County,Guizhou Province显示文摘Karst rocky desertification is a geo-ecological problem in Southwest China.The rocky desertification risk zone delineation could be used as a guide for the regional and hierarchical rocky desertification management and prevention.We chose the middle and lower reaches of the Houzhai underground basin on the karst plateau in Puding County, Guizhou Province, China as the study area and selected land use type, elevation, slope, aspect, lithology and settlement buffer as the main driving factors of the rocky desertification.The potential risk of rocky desertification was quantified with the factor-weights union method and statistical analysis method.Five grades of rocky desertification risk were delineated based on Geographic Information System.The extremely low, low, moderate, high and extremely high rocky desertification risk zones accounted for 5.01%, 44.17%, 33.92%, 15.59% and 1.30%, respectively.As a whole, the rocky desertification risk level was moderate because the area of low and moderate rocky desertification risk zones occupied 78.09% of the study area.However, more than half of the area(about 50.81%) was predicted to have moderate rocky desertification risk and above, indicating that the study area was subject to rocky desertification.Rocky desertification risk was higher in the southeast and lower in the northwest of the study area.Distinct differences in the distribution of rocky desertification risk zones corresponding to different factors have been found. | ZHANG Panpan HU Yuanman XIAO Duning LI Xiuzhen YIN Jie HE Hong S | 2010 | Chinese Geographical Science2010，20，1： | 15 |
| 3 | Assessment of diurnal variation of summer precipitation over the Qilian Mountains based on an hourly merged dataset from 2008 to 2014显示文摘调查日报在在向东北西藏的高原的 Qilian 山的夏天降水的变化,时时,为这个区域的降水数量在 0.1 点用一个时时合并的降水产品在 2008-2014 的夏天期间被分析 ? 湵慦潶慲汢? 諟D禎澞?汣浩瑡 ? 档湡敧椠?? | LIU Xuemei ZHANG Mingjun WANG Shengjie WANG Jie ZHAO Peipei ZHOU Panpan | 2017 | Journal of Geographical Sciences2017，27，3： | 14 |
| 4 | Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors显示文摘Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosafety Level-4(BSL-4) facilities, which have restricted the development of anti-filovirus vaccines and drugs.An HIV-based pseudovirus cell infection assay is widely used for viral entry studies in BSL-2 conditions. Here,we successfully constructed nine in vitro pseudo-filovirus models covering all filovirus genera and three in vivo pseudo-filovirus-infection mouse models using Ebola virus, Marburg virus, and Lloviu virus as representative viruses. The pseudo-filovirus-infected mice showed visualizing bioluminescence in a dose-dependent manner. A bioluminescence peak in mice was reached on day 5 post-infection for Ebola virus and Marburg virus and on day4 post-infection for Lloviu virus. Two known filovirus entry inhibitors, clomiphene and toremiphene, were used to validate the model. Collectively, our study shows that all genera of filoviruses can be well-pseudotyped and are infectious in vitro. The pseudo-filovirus-infection mouse models can be used for in vivo activity evaluation of anti-filovirus drugs. This sequential in vitro and in vivo evaluation system of filovirus entry inhibitors provides a secure and efficient platform for screening and assessing anti-filovirus agents in BSL-2 facilities. | Qing Chen Ke Tang Xiaoyu Zhang Panpan Chen Ying Guo | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 10 |
| 5 | Broken Rotor Bar Fault Diagnosis of Induction Motors Using a Hybrid Bare-bones Particle Swarm Optimization Algorithm显示文摘在传统定子电流频谱分析中,感应电机转子断条故障特征经常被基波分量淹没而无法准确检测。针对该问题,提出一种基于混合骨干微粒群优化算法的转子断条故障诊断新方法。该方法首先根据电流信号与单位余弦基函数的内积最大准则,利用混合骨干微粒群算法强大的全局搜索能力,准确估计出基波波形参数;然后利用波形参数构造出基波表达式,并将其从原电流信号中剔除,达到突出故障特征的目的。针对微粒群算法在进化后期收敛缓慢的缺点,通过K–均值聚类方式,引入单纯形法对其进行改进,使整个算法的广度探索与深度开发能力得到了有效均衡。最后,对模拟数据和实测信号进行实验,结果验证了所提方法的有效性和优越性。 | WANG Panpan SHI Liping ZHANG Yong HAN Li | 2012 | 中国电机工程学报2012，32，30： | 10 |
| 6 | Association of cystatin C level and cardiovascular prognosis for patients with preexisting coronary heart disease:a meta-analysis显示文摘The association of circulating levels of cystatin C(CysC)and risk of recurrent cardiovascular events in patients with preexisting coronary heart disease are uncertain.To qualitatively and quantitatively address this issue,we performed a random meta-analysis of results from prospective studies on the topic.We searched electronic and printed sources(up to 16 October 2011)using keywords and retrieved articles for seven prospective studies according to the selection criteria.Data were abstracted and meta-analysis was performed using the random-effects model(RevMan 5.0.23 software).The cohorts involved 4,576 patients with preexisting coronary heart disease(CHD)and normal or mild chronic kidney disease,and follow-up ranged from 5.6 to 40.6 months.Highest versus lowest baseline CysC level was significantly associated with increased risk of cardiovascular events(OR 2.30,95%CI 1.80–2.94),all-cause mortality(OR 5.69,95%CI 3.70–8.74),but not with recurrent MI(OR 1.75,95%CI 0.77–4.00).In heterogeneity testing for studies reporting cardiovascular events and all-cause mortality,no significant heterogeneity was found,and exclusion of any single study did not alter the overall finding.For risk of recurrent MI,significant heterogeneity was found among the five trials(v2=13.16,P=0.01,I2=70%)and exclusion of the Taglieri et al.[12]study from the analysis resulted in a rise in relative risk(OR 2.36,95%CI 1.09–5.15).In conclusion,for patients with established CHD,high baseline level of CysC is associated with increased risk of cardiovascular events and all-cause death during long-term follow-up. | Ruijian Li Panpan Hao Yuguo Chen Yun Zhang | 2014 | Chinese Science Bulletin2014，59，5： | 8 |
| 7 | Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea显示文摘Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of S.erythraea.Herein,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in S.erythraea A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin biosynthesis.EMSA and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their transcription.Furthermore,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin production.Given demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial S.erythraea WB.Compared with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and ermE.When cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to WB.The strategy reported here will be useful to improve antibiotics production in other industrial actinomycete. | Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu Chengzhang Fu Rolf Muller David T.Weaver Lixin Zhang Buchang Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 7 |
| 8 | G protein-coupled receptor 183 facilitates endothelial-to- hematopoietic transition via Notch1 inhibition显示文摘 | Panpan Zhang Qiuping He Dongbo Chen Weixiao Liu Lu Wang Chunxia Zhang Dongyuan Ma Wei Li Bing Liu Feng Liu | 2015 | Cell Research2015，25，10： | 7 |
| 9 | Combination of anti-PD-1 antibody with P-GEMOX as a potentially effective immunochemotherapy for advanced natural killer/T cell lymphoma显示文摘Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available therapies.Here,we report the efficacy of anti-programmed death 1(PD-1)antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced NKTL.Nine patients underwent six 21-day cycles of anti-PD-1 antibody(day 1),pegaspargase 2000 U/m^(2)(day 1),gemcitabine 1 g/m^(2)(days 1 and 8)and oxaliplatin 130 mg/m^(2)(day 1),followed by anti-PD-1 antibody maintenance every 3 weeks.Programmed death-ligand 1(PD-L1)expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)analysis.Responses were assessed using 18F-fluorodeoxyglucose positron emission tomography(18FDG-PET)and computed tomography or magnetic resonance imaging.Eight patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 10.6 months,6/9 patients(66.7%)remained in complete remission.The most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and resolved.Immunochemotherapy produced a high response rate in patients with positive PD-L1 expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1 alterations and ARID1A mutation were associated with immunochemotherapy efficacy.Mutation in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1 might indicate a poor response to immunochemotherapy.In conclusion,the anti-PD-1 antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced NKTL.PD-L1 expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy. | Jun Cai Panpan Liu Huiqiang Huang Yajun Li Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan Gao Yi Xia Xuanye Zhang Hang Yang Lirong Li Qingqing Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 6 |
| 10 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 11 | A Hybrid Simplex Search and Modified Bare-bones Particle Swarm Optimization显示文摘 | WANG Panpan SHI Liping ZHANG Yong HAN Li | 2013 | Chinese Journal of Electronics2013，22，1： | 6 |
| 12 | Performance projections for ballistic carbon nanotube FinFET at circuit level显示文摘为碳 nanotube (CNT ) 的新奇三维的设备结构鳍地效果晶体管(FinFET ) 被建议并且评估。我们包括繁殖延期,全部的力量驱散,和精力延期产品(电子数据处理) 用三个表演度量标准在电路水平在一个 22-nm 节点与 Si FinFET 相比评估了 CNT FinFET 的潜力。与 Si FinFET 相比, CNT FinFET 处于在更高全部的功率驱散从它的几乎更大的当前的密度而且结果产生的速度和电子数据处理介绍明显的优点,特别在低阀值电压(V th = 1/3V dd ) 。在 V th 能有效地贡献漏电流和力量驱散的重要抑制,然后明显的优化处于速度与可接受的牺牲在 EDP 被获得。特别地,有优化阀值电压的 CNT FinFETs 能在低供应电压下面在 Si FinFETs 上提供约 50 次的一个电子数据处理优点(V dd = 0.4 V ) ,为 CNT 基于 FinFET 的集成电路建议大潜力。 | Panpan Zhang Chenguang Qiu Zhiyong Zhang Li Ding Bingyan Chen Lianmao Peng | 2016 | Nano Research2016，9，6： | 6 |
| 13 | Mapping stripe rust resistance genes by BSR-Seq:YrMM58 and YrHY1 on chromosome 2AS in Chinese wheat lines Mengmai 58 and Huaiyang 1 are Yr17显示文摘Stripe rust(yellow rust), caused by Puccinia striiformis f. sp. tritici(PST),is one of the most devastating fungal diseases in common wheat(Triticum aestivum L.) in China and worldwide. Resistance breeding is the most effective strategy to control diseases in crop plants. Chinese wheat lines Mengmai 58 and Huaiyang 1 are highly resistant to PST race CYR34(V26) at the adult plant stage. To genetically map the underlying resistance genes we developed segregating populations by crossing Mengmai 58 and Huaiyang 1 with the susceptible cultivar Nongda 399. The stripe rust resistances in Mengmai 58 and Huaiyang 1 were both controlled by single dominant genes, provisionally designated YrMM58 and YrHY1, respectively. Bulked segregant RNA-Seq(BSR-Seq) analysis showed that YrMM58 and YrHY1 were located in the same distal ~16 Mb region on chromosome 2 AS.Comparative genomics analysis with the physical map of Aegilops tauschii proved useful for developing additional markers to saturate the genetic linkage map. YrMM58 and YrHY1 were mapped to the distal end of chromosome arm 2 AS, with the closest marker WGGB148 being 7.7 cM and 3.8 cM from the resistance gene, which was considered to be Yr17. These markers can be used in marker-assisted selection. | Yong Wang Huaizhi Zhang Jingzhong Xie Bingmin Guo Yongxing Chen Huaiyu Zhang Ping Lu Qiuhong Wu Miaomiao Li Deyun Zhang Guanghao Guo Jian Yang Panpan Zhang Yan Zhang Xicheng Wang Hong Zhao Tingjie Cao Zhiyong Liu | 2018 | The Crop Journal2018，6，1： | 5 |
| 14 | Study on ESS Control Strategy for Distribution Network with PV显示文摘Environmentally clean photovoltaic(PV)generation has found wider application,but the power f luctuation generated from PV can negatively impact the operation of power system.A properly designed energy storage system(ESS)can stabilize power system by absorbing and injecting instantaneous power.Suitable control strategy of ESS is studied in order to accommodate the power f luctuation.It adopts negative feedback which considers the relationship between real power and voltage in the distribution network because resistor is comparable to reactance of the lines in the distribution network.A universal model of ESS is established,the characteristic parameters such as time-delay of system response,limitation of charging and discharging and restraint of energy storage capacity are taken into account.The validity of the proposed model is verif ied by user-def ined modules in power system analysis software package(PSASP).The operation of PV generation at Wuhan Railway Station in both grid-connected mode and island mode at Wuhan Railway Station is analyzed in detail.The performances of the local distribution network with PV under different weather conditions are summarized,and the key parameter of ESS suitable for PV generation at Wuhan Railway Station is also recommended. | Li Yan Jing Panpan Yang Minjing Zhang Buhan Mao Chengxiong | 2014 | Electricity2014，25，4： | 5 |
| 15 | Geochronological Records of Oil-Gas Accumulations in the Permian Reservoirs of the Northeastern Ordos Basin显示文摘油气体累积(OGA ) 的地球年代学是在多周期的石油地质学的一个挑战性的题目附加的盆。由 K-Ar, authigenic illite (AI ) 和液体包括(FI ) 分析标明日期与磷灰石分裂轨道结合了(在船尾) 热建模,在东北 Ordos 盆(击) 抑制二叠的水库的 OGA 时间的案例研究在这份报纸被进行了。二叠的 oil-gas-bearing 沙岩核心样品标明日期的 AI 显示出 178108 妈的一个宽时间领域。AI 年龄的分发介绍主要 OGA 在二叠的水库处理的 2 阶段,它分别地与 165 妈和 130 妈的 2 山峰年龄在 175155 妈和 145115 妈的时间域发展了。现在二组织与的在船尾热的路径上的样品和他们的投射年龄的 FI 温度山峰不仅一低并且一座高山峰在 9078hallow 地下水的范围的温度能满足国家标准。(2 ) 从 coalbed 生产的水主要包含了 NaCl 獲漠 ? 慗整 ? 潃牰摯 ' 讚攥?潃污敢 ? 慇? 湡 ? 桓污潬 ? 片畯摮慷整 ? 湩 ? 畩楬? 潃污楦汥? 景 ? | CHEN Gang YANG Fu LI Shuheng ZHANG Huiruo HU Yanxu LEI Panpan | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 4 |
| 16 | Polydopamine and ammonium bicarbonate coated and doxorubicin loaded hollow cerium oxide nanoparticles for synergistic tumor therapy显示文摘The development of effective nanoplatforms is extremely necessary for cancer therapy.Herein,we prepared polydopamine(PDA)andammonium bicarbonate(NH4HCO3)coated and doxorubicin(Dox)loaded hollow cerium oxide(CeO2)NPs(PDAC NPs),which showedexcellent synergistic effect for photothermal therapy,chemotherapy and chemodynamic therapy.Under near infrared laser irradiation,PDA shell could absorb the incident light and convert it into heat,which could not only kill tumor cells with hyperthermia,but also trigger thedecomposition of NH4HCO3 into gaseous carbon dioxide and ammonia,leading to the destroy of PDA shell.The leakage of PDA furtheraccelerated Dox release and exposed CeO2 surface,in which Dox could enter into cell nucleus to induce chemotherapy,and CeO2 couldcatalyze cellular hydrogen peroxide into hydroxyl radical to present chemodynamic therapy.In fact,PDAC NPs showed an excellenttherapeutic efficacy both in vitro and in vivo.This design provides a new strategy for synergistic tumor therapy. | Keqiang Xu Yan Cheng Jiao Yan Yanlin Feng Runxiao Zheng Xiaqhig Wu Yanjing Wang Panpan Song Haiyuan Zhang | 2019 | Nano Research2019，12，12： | 4 |
| 17 | Analysis of Evolution Trend of Water Resources Based on Spearman and R/S methods:A Case Study of Agricultural Water Source in Jinghui Irrigation Area显示文摘Based on the monitoring data of precipitation and runoff series from 1953 to 2013 and groundwater exploitation from 1977 to 2013 in Jinghui Irrigation Area,especially the evolution of water resources during the growth period of main crops,the trend test of precipitation and runoff series was carried out by using Spearman rank correlation test and R/S analysis.The results showed that the annual mean precipitation and runoff and the growth period of main crops showed a downward trend,and the changes in the future were similar to those in the past;the amount of groundwater exploitation has not changed much,which is about 150 million m^3.The research results can provide scientific basis for efficient utilization and reasonable allocation of water resources in irrigation area,and provide technical support for the development of modern agriculture. | ZHANG Panpan ZHANG Xianke | 2020 | Journal of Landscape Research2020，12，3： | 4 |
| 18 | Effect of Bionic Unit Shapes on Solid Particle Erosion Resistance of ZrO2-7wt%Y2O3 Thermal Barrier Coatings Processed by Laser显示文摘 | Panpan Zhang Fuhai Li Xiaofeng Zhang Zhihui Zhang Chaolin Tan Luquan Ren Yueliang Wang Wenyou Ma Min Liu | 2018 | Journal of Bionic Engineering2018，15，3： | 4 |
| 19 | Mendelian randomization studies on atherosclerotic cardiovascular disease: evidence and limitations显示文摘Epidemiological research has revealed a galaxy of biomarkers, such as genes, molecules or traits, which are associated with increased risk of atherosclerotic cardiovascular diseases(ASCVD). However, the etiological basis remains poorly characterized.Mendelian randomization(MR) involves the use of observational genetic data to ascertain the roles of disease-associated risk factors and, in particular, differentiate those reflecting the presence or severity of a disease from those contributing causally to a disease. Over the past decade, MR has evolved into a fruitful approach to clarifying the causal relation of a biomarker with ASCVD and to verifying potential therapeutic targets for ASCVD. In this review, we selected high-quality MR studies on ASCVD, examined the causal relationship of a series of biomarkers with ASCVD, and elucidated the role of MR in validating biomarkers as a therapeutic target by comparing the results from MR studies and randomized clinical trials(RCTs) for the treatment of ASCVD. The good agreement between the results derived by MR and RCTs suggests that MR could be performed as a screening process before novel drug development. However, when designing and interpreting a MR study, the assumptions and limitations inherent in this approach should be taken into account. Novel methodological developments, such as sensitivity analysis, will help to strengthen the validity of MR studies. | Qin Hu Panpan Hao Qiji Liu Mei Dong Yaoqin Gong Cheng Zhang Yun Zhang | 2019 | Science China(Life Sciences)2019，62，6： | 4 |
| 20 | Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence显示文摘Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in lipogenesis.Histological and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence. | Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen Jiahong Sun Frank J.Gonzalez Min Huang Huichang Bi | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 3 |
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