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| 1 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 2 | Soil erosion and its response to the changes of precipitation and vegetation cover on the Loess Plateau显示文摘土壤侵蚀是对我们的陆上的生态系统和一个重要全球环境问题的主要威胁。在中国的黄土高原是承受了在过去的十年温暖并且弄干的更严重的土壤侵蚀和经历的气候的区域之一。命名 Grain-to-Green 节目现在一直在操作超过 10 年了的植被恢复。估计土壤侵蚀的变化和降水和植被恢复的反应在黄土高原上玷污侵蚀是必要的。在学习,修订通用土壤损失方程(RUSLE ) 被使用评估走水路引起侵蚀的年度土壤损失。结果如下出现了。在 2000 和 2010 之间的黄土高原上的土壤侵蚀为 15.2 t hm2 a1 平均并且为价值作为光被描绘不到 25 t hm2 a1。比 25 t hm2 a1 高的严重土壤侵蚀主要在溪谷和多山的区域被散布在中央,西南,并且黄土高原上的地球岩石的多山的区域的一些散布区域。黄土高原上的土壤侵蚀在最近的十年显示出一个死亡趋势并且以率减少了更多在承受严重土壤损失的区域的超过 1 t hm2 a1。得益于改进植被盖子和生态的建设,黄土高原上的土壤侵蚀显著地被拒绝特别在 Yulin 的东方,最在山西省在 Luliang 和 Linfen 府的 Shaanxi 省,和西方 Yanan 府分开在多山并且溪谷区域。植被盖子反应在这些区域玷污侵蚀的变化比降水显示出相对更高的贡献。然而,在在 Gansu 省的 Qingyang 和 Dingxi 府和在 Ningxia Hui 自治区域的 Guyuan 的大多数区域是主要与降水有关。 | SUN Wenyi SHAO Quanqin LIU Jiyuan | 2013 | Journal of Geographical Sciences2013，23，6： | 32 |
| 3 | Classification and regionalization of the forming environment of windblown sand disasters along the Tarim Desert Highway显示文摘Through the systematic field survey and observations, the factor quantification as well as setting the criteria, the sand disaster-forming environment along the Tarim Desert Highway can be divided into four grades by the classification and regionalization based on fuzzy mathematics. The length of the regions with significant sand disaster accounted for 37.1% of the total highway length. Particularly, the area along the Tarim Desert Highway, based on the sand disaster-forming environment classification as well as the difference in the five basic landform units along the highway, combined with the difference of wind regime, can be divided into five regions, in which the length of the regions suffering severe sand damage occupied 64.3% of the total highway length. In addition, the index of disaster formation grade along the highway decreased from north to south, showing a repeated spatial pattern in small length scales. | LEI JiaQiang LI ShengYu FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo LIU Shang DU WenYi YAN ZengHui WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 4 | Effects of natural covers on soil evaporation of the shelterbelt along the Tarim Desert Highway显示文摘The control of soil evaporation is one of important approaches to save water. The artificially simulated evaporation experiments have been conducted in the hinterland of the Taklimakan Desert to reveal the effects of the natural covers on the soil evaporation of the Tarim Desert Highway shelterbelt as well as provide some insights in the efficient utilization of water resources and optimization of irrigation systems. The results showed that (1) All the covers, including the sand deposit, the salt crust, the litter, the sand-litter mixed layer and so on, can significantly inhibit the soil water evaporation. Specifically, the daily evaporation, the total evaporation, and the evaporation rate in covered sands were much smaller than that of sands without cover. The cover inhibition effects increased with the cover thickness. Particularly, the soil evaporation of the covered sands was less affected by external and internal factors than that of the bare sands. Moreover, the variation of daily evaporation of covered sands was smaller than that of bare sands. The cumulative evaporation varied linearly with time in the covered sands whereas it varied logarithmically in the bare sands. In addition, the soil evaporation in the bare sands showed significantly different characteristics in the early and late stages of the evaporation. (2) All the covers exhibited the significant inhibiting effect on the soil evaporation, and the inhibition efficiency increased logarithmically with the cover thickness. However, as the cover thickness was above a certain value, the increase in the inhibition efficiency was slow. Particularly, at a cover thickness of 2 cm, there was no obvious difference in the inhibition efficiency among all kinds of covers. The maximum inhibition efficiency as calculated from the daily evaporation on the first day of irrigation was: sand-litter mixed layer (79.92%) > litter layer (78.96%) > salt crust (75.58%) > sand bed (74.11%), whereas the average inhibiting efficiency as calculated from the cumulative soil evaporation at the end of an irrigation cycle (the fourth day) was: salt crust (67.78%) > sand-litter mixed layer (66.72%) > sand deposit (63.28%) > litter layer (61.74%). | ZHOU HongWei LI ShengYu SUN ShuGuo XU XinWen LEI JiaQiang LIU Shang DU WenYi YAN Zeng WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 5 | dentification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma显示文摘 | Fei Li Zhaoyuan Fang Jian Zhang Chen Li Hongyan Liu Jufeng Xia Hongwen Zhu Chenchen auo Zhen Qin Fuming Li Xiangkun Han Yuetong Wang Yan Feng Ye Wang Wenjing Zhang Zuoyun Wang Yujuan Jin Yihua Sun Wenyi Wei Rong Zeng Haiquan Chen Hongbin Ji | 2016 | Cell Research2016，26，10： | 9 |
| 6 | Occurrence and infection risk of waterborne pathogens in Wanzhou watershed of the Three Gorges Reservoir, China显示文摘The Three Gorges Reservoir (TGR), formed by China's Yangtze Three Gorges Project, is the largest lake in the world, but there is too little information available about fecal contamination and waterborne pathogen impacts on this aquatic ecosystem. During two successive 1-year study periods (July 2009 to July 2011), the water quality in Wanzhou watershed of the TGR was tested with regard to the presence of fecal indicators and pathogens. According to Chinese and World Health Organization water quality standards, water quality in the mainstream was good but poor in backwater areas. Salmonella, Enterohemorrhagic Escherichia coli (EHEC), Giardia and Cryptosporidium were detected in the watershed. Prevalence and concentrations of the pathogens in the mainstream were lower than those in backwater areas. The estimated risk of infection with Salmonella, EHEC, Cryptosporidium, and Giardia per exposure event ranged from 2.9 × 10 -7 to 1.68 × 10-5 , 7.04 × 10-10 to 2.36 × 10-7 , 5.39 × 10-6 to 1.25 × 10-4 and 0 to 1.2 × 10-3 , respectively, for occupational divers and recreational swimmers exposed to the waters. The estimated risk of infection at exposure to the 95% upper confidence limit concentrations of Salmonella, Cryptosporidium and Giardia may be up to 2.62 × 10-5 , 2.55 × 10-4 and 2.86 × 10-3 , respectively. This study provides useful information for the residents, health care workers and managers to improve the safety of surface water and reduce the risk of fecal contamination in the TGR. | Guosheng Xiao Zhaodan Wang Ji'an Chen Zhiqun Qiu Yanjie Li Junsheng Qi Wenyi Liu Weiqun Shu | 2013 | Journal of Environmental Sciences2013，25，9： | 7 |
| 7 | Effects of Extrusion Speed on the Microstructure and Mechanical Properties of Mg-9Gd-3Y-1.5Zn-0.8Zr alloy显示文摘The effects of the extrusion speed on the microstructures,mechanical properties and aging hardening behaviors of Mg—9Gd—3Y—1.5Zn—0.8Zr alloy have been investigated.The microstructure evolution during hot extrusion has also been discussed.The microstructures of the extruded alloys mainly consist of the equiaxed dynamically recrystallized grains and fiber-like long period stacking ordered(LPSO)phase.The increasing extrusion speed results in grain coarsening and the mechanical properties deterioration.Meanwhile,it could also retard the aging hardening response.The extrudability of the investigated alloy is limited.Cracks nucleate and grow up rapidly when the extrusion speed is over 0.3 m/min.It should be closely related to the large amount of LPSO phase and the unique microstructure evolution.The rapidly precipitating fine lamella during extrusion could pin the dislocations and grain boundaries effectively.It could strengthen the alloy but also limit the extrudability of the investigated alloy. | Xuan Liu Zhiqiang Zhang Wenyi Hu Qichi Le Lei Bao Jianzhong Cui | 2016 | Journal of Materials Science & Technology2016，32，4： | 7 |
| 8 | Easily manageable prognostic factors in 152 Chinese elderly acute myeloid leukemia patients:a single-center retrospective study显示文摘We retrospectively investigated the prognostic factors of acute myeloid leukemia(AML) in 152 Chinese patients with de novo AML who were older than 60 years of age and who received treatment at our hospital.Log-rank test showed that 6 parameters including older age,higher white blood cell(WBC) counts,lactate dehydrogenase(LDH)and bone marrow(BM) blasts at diagnosis,unfavorable risk cytogenetics,and non-mutated CEBPα were significant adverse prognostic factors of overall survival(OS) for elderly AML patients(P = 0.0013,0.0358,0.0132,0.0242,0.0236 and 0.0130,respectively).Moreover,older age and higher LDH were significant adverse predictors for relapse-free survival(RFS)(P = 0.0447 and 0.0470,respectively).Univariate analysis revealed similar results for OS to those of the log-rank test and only higher LDH at diagnosis was a significant adverse predictor for RFS(P = 0.028,HR:1.979,95%CI:1.075-3.644).In multivariate analysis,we identified 2 trends towards independent prognostic factors for OS,including BM blasts at diagnosis(P = 0.057,HR:1.676,95%CI:0.984-2.854)and mutation status of CEBPα(P = 0.064,HR:4.173,95%CI:0.918-18.966).Our data indicated that older age,gender and a previous history of hematologic diseases resulted in lower complete remission rate(P = 0.012,0.051 and 0.086,respectively).We further developed an easy scoring system for predicting prognosis and response to induction therapy in older AML patients.Patients who had lower scores showed significantly longer OS and RFS(P = 0.0006 and 0.1001,respectively) and higher CR rate(P = 0.014).Our research is limited by its retrospective nature and the results from our study need to be further validated by prospective randomized clinical trials. | Jiadai Xu Tingmei Chen Yun Liu Huayuan Zhu Wei Wu WenYi Shen Bei Xu Sixuan Qian Jianyong Li Peng Liu | 2014 | The Journal of Biomedical Research2014，28，5： | 7 |
| 9 | Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery显示文摘在这个工作,新奇策略被开发了准备分散得好的 amine-functionalized SiO <潜水艇class=“ a-plus-plus ”> 2 nanodot涂的分层的双氢氧化物 nanocomposite ( NH <潜水艇class=“ a-plus-plus ”> 2 -SiO经由静电的相互作用和冷凝作用的 2 @LDH)( 3-aminopropyl ) triethoxysilane ( APTES )。这个 nanocomposite 系统很好在缓冲的文化媒介和磷酸盐被驱散盐,并且展出低 cytotoxicity 和好 biocompatibility。荧光显微镜学图象和流动 cytometry 数据显示那如此的 NH < 潜水艇 class= “ a-plus-plus ” > 2 -SiO 2 @LDH nanocomposite 能高效地交付小介入的 RNA (siRNA ) 进 U2OS 房间线禁止房间增长。因此, NH < 潜水艇 class= “ a-plus-plus ” > 2 -SiO 2 @LDH nanocomposite 为有效基因交货作为 nanocarrier 有一个大潜力。 | Li Li Wenyi Gu Jian Liu Shiyu Yan Zhi Ping Xu | 2015 | Nano Research2015，8，2： | 6 |
| 10 | A critical review on chemical constituents and pharmacological effects of Lilium显示文摘Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium. | Pengyu Wang Jian Li Fatma Alzahra K.Attia Wenyi Kang Jinfeng Wei Zhenhua Liu Changqin Li | 2019 | Food Science and Human Wellness2019，8，4： | 6 |
| 11 | Comparative analysis of antioxidant activities of essential oils and extracts of fennel(Foeniculum vulgare Mill.)seeds from Egypt and China显示文摘The present study was conducted to assay the antioxidant activities of essential oils and ethanol extracts of fennel(Foeniculum vulgare Mill.)seeds from Egypt and China.The major components of the Egyptian fennel essential oil were estragole(51.04%),limonene(11.45%),l-fenchone(8.19%)and trans-anethole(3.62%)by GC–MS analysis.Whereas,the major constituents of Chinese fennel essential oil were transanethole(54.26%),estragole(20.25%),l-fenchone(7.36%)and limonene(2.41%).The fennel seed extracts from Egypt and China contained appreciable levels of total phenolic contents(42.24 and 30.94 mg PE/g,respectively).The extracts exhibited good DPPH radical scavenging capacity with IC50(6.34 and 7.17 mg/g),respectively.A high variation in free radical scavenging activities of essential oils was observed.The Chinese fennel essential oil showed high activity in DPPH radical scavenging with IC50(15.66 mg/g).The Egyptian fennel essential oil showed very low activity with IC50(141.82 mg/g).The results of the present investigation demonstrated significant variations in the antioxidant activities of fennel essential oils and extracts from Egypt and China. | Adel F.Ahmed Mengjin Shi Cunyu Liu Wenyi Kang | 2019 | Food Science and Human Wellness2019，8，1： | 6 |
| 12 | Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method显示文摘This study was designed to elucidate the immunoregulation of Ganoderma lucidum.HPLC fingerprint and spectrum-effect relationship of G.lucidum were established to predict the active compounds and BP neural network model was established to predict the efficacy.Then the target compounds were identified by high resolution mass spectrometry.The results indicated that there are both enhanced immunity and immunosuppressive components in G.lucidum.BP neural network was trained with the common peak area and immune effi cacy index of G.lucidum fi ngerprint as samples,and a combined evaluation system of G.lucidum fi ngerprint effi cacy was established.The correlation coeffi cient R of BP network model was 0.98643,and the error of pharmacodynamic prediction results was in the ideal range.Eight compounds were identifi ed by high resolution mass spectrometry.The compounds related to immune activity in G.lucidum were determined in this study. | Changqin Li Yiping Cui Jie Lu Lijun Meng Changyang Ma Zhenhua Liu Yan Zhang Wenyi Kang | 2021 | Food Science and Human Wellness2021，10，3： | 6 |
| 13 | Exponential Stability Analysis of the Solution of a Repairable Human-Machine System显示文摘 | Dongxu Liu Wenyi Si Zhe Yin | 2014 | 控制工程期刊(中英文版)2014，4，3： | 5 |
| 14 | Cholesterol-tuned liposomal membrane rigidity directs tumor penetration and anti-tumor effect显示文摘Recently, liposomes have been widely used in cancer therapeutics, but their anti-tumor effects are suboptimal due to limited tumor penetration. To solve this problem, researchers have made significant efforts to optimize liposomal diameters and potentials, but little attention has been paid to liposomal membrane rigidity. Herein, we sought to demonstrate the effects of cholesterol-tuned liposomal membrane rigidity on tumor penetration and anti-tumor effects. In this study, liposomes composed of hydrogenated soybean phospholipids(HSPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000](DSPE-PEG2000) and different concentrations of cholesterol were prepared. It was revealed that liposomal membrane rigidity decreased with the addition of cholesterol. Moderate cholesterol content conferred excellent diffusivity to liposomes in simulated diffusion medium, while excessive cholesterol limited the diffusion process. We concluded that the differences of the diffusion rates likely stemmed from the alterations in liposomal membrane rigidity, with moderate rigidity leading to improved diffusion. Next, the in vitro tumor penetration and the in vivo anti-tumor effects were analyzed. The results showed that liposomes with moderate rigidity gained excellent tumor penetration and enhanced anti-tumor effects. These findings illustrate a feasible and effective way to improve tumor penetration and therapeutic efficacy of liposomes by changing the cholesterol content, and highlight the importance of liposomal membrane rigidity. | Hangyi Wu Miaorong Yu Yunqiu Miao Shufang He Zhuo Dai Wenyi Song Yuan Liu Sha Song Ejaj Ahmad Dongkai Wang Yong Gan | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 15 | Composition and phase structure dependence of mechanical and magnetic properties for AlCoCuFeNi_x high entropy alloys显示文摘In this study, the effects of composition and phase constitution on the mechanical properties and magnetic performance of AlCoCuFeNix(x = 0.5, 0.8, 1.0, 1.5, 2.0, 3.0 in molar ratio) high entropy alloys(HEAs)were investigated. The results show that Ni element could lead to the evolution from face centered cubic(FCC), body centered cubic(BCC) and ordered BCC coexisting phase structure to a single FCC phase. The change of phase constitution enhances the plasticity but reduces the hardness and strength. One of the interesting points is the excellent soft magnetic properties of AlCoCuFeNixHEAs. Soft magnetic performance is dependent on composition and phase transition. AlCoCuFeNi1.5 alloy, achieving a better balance of mechanical and magnetic properties, could be applied as structure materials and soft magnetic materials(SMMs). High Curie temperature(>900 K) and strong phase stability below 1350 K of AlCoCuFeNi0.5 alloy confirm its practicability in a high-temperature environment. Atomic size difference(δ) is utilized as the critical parameter to explain the lattice strain and phase transformation induced by Ni addition. | Cong Liu Wenyi Peng C.S. Jiang Hongmin Guo Jun Tao Xiaohua Deng Zhaoxia Chen | 2019 | Journal of Materials Science & Technology2019，35，6： | 5 |
| 16 | Antioxidant activity and total phenolic content of essential oils and extracts of sweet basil(Ocimum basilicum L.)plants显示文摘The present study was conducted to evaluate the chemical composition and antioxidant activity of the essential oils and ethanol extracts of Ocimum basilicum L.obtained from Assiut,Minia and BeniSuef of Egypt.The major constituents of sweet basil essential oils from three locations were linalool,estragole,methyl cinnamate,bicyclosesquiphellandrene,eucalyptol,-bergamotene,eugenol,-cadinene and germacrene D by the method of GC–MS.The relative concentration of these compounds varies.The basil extracts contained appreciable levels of total phenolic contents and exhibited good DPPH radical scavenging capacity higher than that of essential oils.The highest TPC(82.45 mg PE/g)and maximum radical scavenging activity with IC50 value(1.29 mg/mL)was obtained from Minia basil extract.High correlation between antioxidant activity and total phenolic contents of basil extracts was observed.High variation in free radical scavenging activity of essential oils was found.The essential oil from Minia basil showed high activity in DPPH radical scavenging with IC50(11.23 mg/mL)and contained the highest content of phenolic(41.3 mg PE/g).On contrary,low correlation between antioxidant activity and total phenolic contents of basil essential oils from different locations.The results of the present investigation demonstrated significant variations in the antioxidant activities of sweet basil essential oils and extracts from Egypt. | Adel F.Ahmed Fatma A.K.Attia Zhenhua Liu Changqin Li Jinfeng Wei Wenyi Kang | 2019 | Food Science and Human Wellness2019，8，3： | 4 |
| 17 | Deeply learned broadband encoding stochastic hyperspectral imaging显示文摘Many applications requiring both spectral and spatial information at high resolution benefit from spectral imaging.Although different technical methods have been developed and commercially available,computational spectral cameras represent a compact,lightweight,and inexpensive solution.However,the tradeoff between spatial and spectral resolutions,dominated by the limited data volume and environmental noise,limits the potential of these cameras.In this study,we developed a deeply learned broadband encoding stochastic hyperspectral camera.In particular,using advanced artificial intelligenee in filter design and spectrum reconstruction,we achieved 7000-11,000 times faster signal processing and〜10 times improvement regarding noise toleranee.These improvements enabled us to precisely and dynamically reconstruct the spectra of the entire field of view,previously unreachable with compact computational spectral cameras. | Wenyi Zhang Hongya Song Xin He Longqian Huang Xiyue Zhang Junyan Zheng Weidong Shen Xiang Hao Xu Liu | 2021 | Light(Science & Applications)2021，10，6： | 4 |
| 18 | Degrading proteins in animals:'PROTAC'tion goes in vivo显示文摘In a recent paper published in Cell Discovery, Sun et al. report a novel chemical approach to rapidly and reversibly deplete endogenous proteins globally in both small and large animals via the PROTAC (PROteolysis TArgeting Chimera) approach. This strategy not only provides a powerful tool for protein function studies in vivo, but also highlights the potential of using PROTAC in future human cancer therapies. | Jianping Guo Jing Liu Wenyi Wei | 2019 | Cell Research2019，29，3： | 3 |
| 19 | Numerical Analysis on Thermal Function of Clothing with PCM Microcapsules显示文摘To study the influences of phase change material(PCM)microcapsules in clothing on human thermal responses,a mathematical model is developed.The improved Stolwijk’s model is used to simulate human thermo-regulatory process,and the coupled heat and moisture transfer including the moisture sorption/desorption of fibers and effects of phase transition temperature range on the phase change processes of the PCM is considered in clothing model.Meanwhile,the theoretical predictions are validated by experimental data.Then,the interactions between human body thermal responses and the heat and moisture transfer in clothing are discussed by comparing the prediction results with PCMs and without PCMs.Also the effects of fiber hygroscopicity on clothing and human thermal responses are compared.The conclusion shows that the clothing with PCMs microcapsules can delay the human temperature variations and decrease the sweat accumulation rate on the skin surface and heat loss during changing of ambient conditions,and fiber hygroscopicity reduces the effect of PCM microcapsules on delaying garment temperature variations very significantly. | LIU Wenyi LI Fengzhi LIU Weihua | 2019 | Transactions of Nanjing University of Aeronautics and Astronautics2019，36，2： | 3 |
| 20 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
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