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| 1 | P wave velocity structure of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions显示文摘The three-dimensional P wave velocity structures of upper and middle crust beneath the Three Gorges reservoir dam and adjacent regions were reconstructed by means of the seismic tomography, using the absolute P-arrivals from the events observed by the Three Gorges seismic network. Our preliminary study of the deep structure shows: (1) the lithology of the Huangling anticline, integral and highly so-lidified, exhibits a uniformity. Down to a depth of 20 km, the Huangling anticline still shows high- velocity anomalies. Note that the characteristics of the velocity images with the different depths are not the same; (2) the depth of the sedimentary rocks beneath the entire Zigui basin is not constant, which is less than 6 km; (3) the top boundary of the crystalline basement varies from 0 to 7 km, whereas the bottom one between 14 and 16 km; (4) the partially molten substances of the upper mantle are located in the Badong-Zigui and its adjacent regions as well as nearby Peishi area. The development and evo-lution of the current tectonics are associated with the cooling and solidifying process of the molten substances within the upper mantle; (5) the different velocity structures of the deep crust in both east and west side of the Jiuwanxi fault are to be investigated in order to understand the origin of gravita-tional gradient zone in the Three Gorge areas; and (6) the velocities within the upper crust would be affected by reservoir water permeability. | LI Qiang ZHAO Xu CAI JinAn LIU RuiFeng LONG GuiHua AN YanRu | 2009 | Science China Earth Sciences2009，52，4： | 11 |
| 2 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 3 | Quantitative trait loci for Fusarium head blight resistance in wheat cultivars Yangmai 158 and Zhengmai 9023显示文摘Fusarium head blight(FHB)is one of the prevalent fungal diseases of wheat worldwide.Exploring new FHB resistance quantitative trait loci(QTL)in adapted wheat cultivars is a critical step for breeding new FHB-resistant cultivars.In this study,we developed a population of 236 F5:7 recombinant inbred lines(RILs)using two popular Chinese wheat cultivars,Yangmai 158 and Zhengmai 9023,with moderate FHB resistance to identify the QTL for FHB type II resistance.This population was evaluated for percentage of symptomatic spikelets per spike(PSS)using single floret injection in repeated greenhouse experiments.Mean PSSs were 33.2%for Yangmai 158 and 30.3%for Zhengmai 9023.A genetic linkage map of 1002 single nucleotide polymorphisms(SNPs)generated by genotyping-by-sequencing(GBS)was constructed for the RIL population.Six QTL were identified for FHB resistance,and three of them were repeatable in the both experiments.Zhengmai 9023 contributed the resistance allele at one repeatable QTL,designated as Qfhb.7D,whereas Yangmai 158 contributed the resistance alleles at the other two repeatable QTL,Qfhb.3AL and Qfhb.2DS.The additional QTL,Qfhb.4AS was significant in the mean PSS,and Qfhb.2DL and Qfhb.7AS were significant in only one experiment.Replacement of each allele individually at the three repeatable QTL significantly changed PSSs.Qfhb.3AL,Qfhb.2DS,and Qfhb.7D explained 8.35%to 9.89%,5.13%to 7.43%,and 6.15%to 9.32%of the phenotypic variations,respectively.The three repeatable QTL contributed by the two parents were additive and stacking the resistance alleles from all the three repeatable QTL showed the highest level of resistance in the current RIL population.Ten SNPs in the QTL regions of Qfhb.3AL,Qfhb.2DS,and Qfhb.7D were converted into KBioscience competitive allele-specific PCR(KASP)assays.One KASP marker for Qfhb.3AL was validated in a panel of wheat cultivars from China.Some of these KASP markers could be useful for marker-assisted selection to stack these QTL. | Pingping Zhang Chenjin Guo Zhao Liu Amy Bernardo Hongxiang Maa Hongxiang Ma Peng Jiang Guicheng Song Guihua Bai | 2021 | The Crop Journal2021，9，1： | 8 |
| 4 | Sorghum Insect Problems and Management显示文摘Sorghum (Sorghum bicolor) has high levels of starch,sugar,and fiber and is one of the most important energy crops in the world.Insect damage is one of the challenges that impacts sorghum biomass production.There are at least 150 insect species that can infest sorghum varieties worldwide.These insects can complete several generations within a growing season,they target various parts of sorghum plants at developmental stages,and they cause significant biomass losses.Genetic research has revealed the existence of resistant genetics in sorghum and insect tolerant sorghum varieties have been identified.Various control methods have been developed,yet more effective management is needed for increasing sorghum biomass production.Although there are no transgenic sorghum products on the market yet,biotechnology has been recognized as an important tool for controlling insect pests and increasing sorghum production. | Chunshan Guo Wei Cui Xue Feng Jianzhou Zhao Guihua Lu | 2011 | Journal of Integrative Plant Biology2011，53，3： | 3 |
| 5 | Development and identification of a dwarf wheat-Leymus mollis double substitution line with resistance to yellow rust and Fusarium head blight显示文摘Leymus mollis (Trin.) Pilger (2n = 4x = 28, NsNsXmXm,), a wild relative of common wheat, possesses many potentially valuable traits for genetic improvement of wheat, including strong, short stems, long spikes with numerous spikelets, tolerance to drought and cold stresses, and resistance to many fungal and bacterial diseases. In the present study, a wheat-L. mollis double substitution line DM96 was selected from a F6 progeny of a cross between M842-16 (an octoploid Tritileymus line) and D4286 (a Triticum durum line) using genomic in situ hybridization (GISH), simple sequence repeat (SSR) markers, and expressed sequence tagged sequence site (EST-STS) markers. Chromosome analysis at mitosis and meiosis showed that DM96 had a chromosome constitution of 2n = 42 = 21II. GISH analysis indicated that DM96 carried 38 chromosomes from wheat and two homologous pairs of Ns chromosomes from L. mollis. Fluorescent in situ hybridization (FISH) showed that chromosomes 2Ns and 3Ns from L. mollis had replaced wheat chromosomes 2D and 3D in DM96, which was confirmed by SSR and STS markers. The newly developed substitution line DM96 has shorter height, longer spikes and more kernels than its parents and showed high resistance to stripe rust and Fusarium head blight (FHB). Thus, this line is a new bridge material for the production of useful translocation lines for wheat genetic research and genetic improvement of wheat yield and disease resistance in breeding programs. | Jixin Zhao Yang Liu Xueni Cheng Yuhui Pang Jiachuang Li Zhenqi Su Jun Wu Qunhui Yang Guihua Bai Xinhong Chen | 2019 | The Crop Journal2019，7，4： | 2 |
| 6 | Cellular prion protein released on exosomes from macrophages binds to Hsp70显示文摘Prion 疾病是传染、致命的 neurodegenerative 混乱。变换成 prion 蛋白质(PrPSc ) 的错误褶层 isoform 的细胞的 prion 蛋白质(PrPC ) 为 prion 疾病感染负责。免疫系统在从圆周便于 prion 感染的传播到中央神经系统起一个重要作用。巨噬细胞被认为与 PrPSc 的交通和复制联系了。那么,在巨噬细胞理解 PrPC trafficking 是重要的为 PrPSc 探索运输机制。这里,我们从 Ana-1 巨噬细胞房间线的文化媒介孤立 exosomes 并且由西方的弄污, immunoelectron 显微镜学,和 co-immunoprecipitation 在分泌 exosomes 由 exosomes 和和 Hsp70 的 PrPC 的相互作用调查了 PrPC trafficked。结果证明从巨噬细胞的文化媒介的孤立的泡被 exosomes 和讨厌的人 PrPC 描绘。并且 PrPC 在细胞内部的环境两个都跳了到 Hsp70 并且分泌了 exosomes。相反, PrPC 没与 exosomes, Tag101 和 Flotillin-1 的标记蛋白质有相互作用。这些结果建议在细胞外的空间在场的 PrPC 可能是通过从巨噬细胞的分泌 exosomes 的 externalized,并且 Hsp70 可以在经由分泌 exosomes 释放的 PrPC 的过程起作用。 | Guihua Wang Xiangmei Zhou Yu Bai Zhongqiu Zhang Deming Zhao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 2 |
| 7 | Application of artificial intelligence in tongue diagnosis of traditional Chinese medicine:A review显示文摘Tongue diagnosis is an important process to non-invasively assess the condition of a patient’s internal organs in traditional Chinese medicine(TCM)and each part of the tongue is related to corresponding internal organs.Due to continuing computer technological advances,especially the artificial intelligence(AI)methods have achieved significant success in tackling tongue image acquisition,processing,and classification,novel AI methods are being introduced in traditional Chinese medicine tongue diagnosis medical practices.Traditional tongue diagnose depends on observations of tongue characteristics,such as color,shape,texture,moisture,etc.by traditional Chinese medicine physicians.The appearance of the tongue color,texture and coating reflects the improvement or deterioration of patient’s conditions.Moreover,AI can now distinguish patient’s condition through tongue images,texture or coating,which is all possible increasingly with help from traditional Chinese medicine physicians under the traditional Chinese medicine tongue theory.AI has enabled humans to do what was previously unimagined:traditional Chinese medicine tongue diagnosis with feeding a large amount of tongue image and tongue texture/coating data to train the AI modes.This review focuses on the research advances of AI in TCM tongue diagnosis thus far to identify the major scientific methods and prospects.In this article,we tried to review the AI application in resolving the tongue diagnosis of traditional Chinese medicine on color correction,tongue image extraction,tongue texture/coating segmentation. | Zhao Chen Xiaoyu Zhang Ruijin Qiu Yang Sun Rui Zheng Haie Pan Yin Jiang Changming Zhong Chen Zhao Guihua Tian Hongcai Shang | 2021 | TMR Modern Herbal Medicine2021，4，2： | 2 |
| 8 | The Role of Carotid Plaque Vulnerability and Inflammation in the Pathogenesis of Acute Ischemic Stroke显示文摘 | SHIFANG DING MEI ZHANG YUXIA ZHAO WENQIANG CHEN GUIHUA YAO CHENG ZHANG PENGFEI ZHANG YUN ZHANG | 2008 | The American Journal of the Medical Sciences2008，，1： | 1 |
| 9 | Effect of local hyperthermia induced by nanometer magnetic fluid on the rabbit VX2 liver tumor model显示文摘磁性的 nanoparticles 导致的过高热是为过高热和 thermoablation 的本地指向的一条最近的治疗学的途径并且是恶意的肿瘤的有希望的治疗。这研究的目的是在兔子 VX2 肝肿瘤模型上评估磁性的液体过高热的潜在、治疗学的效果。兔子适用肝肿瘤在肿瘤培植以后的 14 天随机各被划分成五组 10 个盒子,包括三个控制组和二过高热组织。过高热在单个 intratumoral 注射以后立即被执行非常 ated 以水为基的 Fe 3 在一个轮流出现的磁场下面的磁性的液体仅仅曾经作为其它当作了在 5 天以后的一个过高热组和重复过高热的 O 4 组。磁性的液体的分发被扫描的 CT 评估。所有动物 4 个星期在肿瘤培植以后被牺牲。治疗学的效果被肿瘤尺寸和肝肿瘤的宏观、病理学的检查决定。磁性的液体与包围织物相比扔的 intratumoral 的本地更高的密度成像被扫描的 CT 清楚地观察。在肿瘤培植以后的 28 天,肿瘤二过高热的最大的直径和肿瘤体积显著地是控制组的不到那些(P <
0.05 ) 。由与三个控制组相比的单个或重复的过高热的肿瘤体积抑制是 71.93 79.91% 和 92.34 94.46%(P <
0.05 ) 分别地。在一台显微镜下面,凝结坏死在激烈的区域被观察,它与包围织物有一根清楚的边界线。特别在坏死的区域,磁性的 nanoparticles 的 intratumoral 分发显得比在未经治疗的更同质。这研究证明磁性的液体的直接 intratumoral 注射导致的过高热能安全地被使用,并且没有加热的高 intratumoral 温度的一致得好的分布邻近正常织物能被完成。 | Lehui Du Jumei Zhou Xiaowen Wang Lin Sheng Guihua Wang Xiaoxue Xie Guoquan Xu Lingyun Zhao Yuping Liao Jingtian Tang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 1 |
| 10 | A highly selective ginsenoside Rb 1 -hydrolyzing β- d -glucosidase from Cladosporium fulvum显示文摘 | Juan Gao Xuesong Zhao Haibo Liu Yuying Fan Hairong Cheng Fei Liang Xingxing Chen Nan Wang Yifa Zhou Guihua Tai | 2010 | Process Biochemistry2010，，6： | 1 |
| 11 | Discovery of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging and omics显示文摘Migraine is one of the most prevalent and disabling neurological disease,but the current pharmacotherapies show limited efficacy and often accompanied by adverse effects.Acupuncture is a promising complementary therapy,but further clinical evidence is needed.The influence of acupuncture on migraine is not an immediate effect,and its mechanism remains unclear.This study aims to provide further clinical evidence for the anti-migraine effects of acupuncture and explore the mechanism involved.A randomized controlled trial was performed among 10 normal controls and 38 migraineurs.The migraineurs were divided into blank control,sham acupuncture,and acupuncture groups.Patients were subjected to two courses of treatment,and each treatment lasted for 5 days,with an interval of 1 day between the two courses.The effectiveness of treatment was evaluated using pain questionnaire.The functional magnetic resonance imaging(fMRI)data were analyzed for investigating brain changes induced by treatments.Blood plasma was collected for metabolomics and proteomics studies.Correlation and mediation analyses were performed to investigate the interaction between clinical,fMRI and omics changes.Results showed that acupuncture effectively relieved migraine symptoms in a way different from sham acupuncture in terms of curative effect,affected brain regions,and signaling pathways.The anti-migraine mechanism involves a complex network related to the regulation of the response to hypoxic stress,reversal of brain energy imbalance,and regulation of inflammation.The brain regions of migraineurs affected by acupuncture include the lingual gyrus,default mode network,and cerebellum.The effect of acupuncture on patients’metabolites/proteins may precede that of the brain. | Chong Li Xinyi Li Ke He Yang Wu Xiaoming Xie Jiju Yang Fan Zhang Yang Yue Huifeng Hao Shaokun Zhao Xin Li Guihua Tian | 2023 | Frontiers of Medicine2023，17，5： | 1 |
| 12 | Numerical solutions of stochastic differential delay equations with jumps 显示文摘 | ZHAO Guihua SONG Minghui LIU Mingzhu | 2009 | Int J Numer Anal Mod2009，6，： | 1 |
| 13 | Self-organization of unimolecular micelles in beam stream for functional mesoporous metal oxide nanofibers显示文摘The use of linear amphiphilic block copolymers as templates is an important method for the preparation of mesoporous materials.However,the obtained assemblies are usually sensitive to synthetic conditions,which impedes the preparation of such mesoporous materials in certain environments.Herein,we report a universal strategy applying an amphiphilic multiarm triblock copolymer in the preparation of mesoporous metal oxide nanofibers(NFs)using one metal oxide(TiO_(2),ZrO_(2),WO_(3),CeO_(2)),or two(TiO_(2)/WO 3,TiO_(2)/ZrO_(2),TiO_(2)/CeO_(2))and three(TiO_(2)/WO_(3)/CuO)metal oxides as composites.The template consists of modified β-cyclodextrin as the center of the macromolecule which is attached sequentially to a block of polystyrene,poly(acrylic acid),and poly(ethylene oxide).Under electrospinning conditions,stable unimolecular micelles are formed and effectively co-assemble with metal ions to form fibrous nanostructures.As indicated by various characterization methods,the synthesized TiO_(2) and its derived composite NFs maintain a straight and continuous fibrous structure after calcination,and TiO_(2) NFs exhibit uniform mesopores of 10.8 nm in diameter and a large Brunauer-Emmett-Teller surface area of 143.3 m^(2)g^(−1).Benefiting from the characteristic structure,still present after modification,Pt-decorated mesoporous TiO_(2) NFs display excellent ability in the visible-light photocatalytic degradation of tetracycline,which is superior to the commercial P25 catalyst.This study reveals a promising strategy for the preparation of fibrous mesoporous metal oxides. | Chongfei Gu Xiaoshan Fan Guihua Zhu Yuchi Fan Haifeng Wang Tao Zhao Qi Xiao Yuan Fang Xiaopeng Li Wan Jiang Lianjun Wang Pengpeng Qiu Wei Luo | 2022 | Fundamental Research2022，2，5： | 1 |
| 14 | Preliminary Study on the Reinforcing Effect of Nanocellulose on Supercapacitor Membranes显示文摘In this study,six types of nanocellulose,as paper strengthening agents,were investigated for their reinforcing effects on a supercapacitor membrane by adding them to a slurry.The results indicated that adding 3%nanocellulose bacterial cellulose(BC)-B could effectively increase the tensile strength of the supercapacitor membrane by 36.5%without changing the pore structure of the membrane.Scanning electron microscopy images revealed that adding polyacrylamide to the supercapacitor membrane caused serious adhesion between fibers and affected the pore structure of the supercapacitor membrane,whereas adding BC-B did not produce similar effects. | Meng Wang Tao Zhao Zongjiu Mao Xiaoya Jiang Guihua Xiao Yuejiang Wang Xiu Du Xiaobo Yang Xuefeng Chen | 2022 | Paper And Biomaterials2022，7，4： | 1 |
| 15 | Sustainable electrical energy storage through the ferrocene/ferrocenium redox reaction in aprotic electrolyte显示文摘 | Zhao Yu Ding Yu Song Jie Li Gang Dong Guangbin Goodenough John B Yu Guihua | 2014 | Angewandte Chemie International Edition2014，53，11： | 1 |
| 16 | A reversible Br2/Br-redox couple in the aqueous phase as a high-performance catholyte for alkali-ion batteries显示文摘 | Zhao Yu Ding Yu Song Jie Peng Lele Goodenough John B Yu Guihua | 2014 | Energy&Environmental Science2014，7，6： | 1 |
| 17 | Exponential stability of Euler-Maruyama solutions for impulsive stochas- tic differential equations with delay显示文摘 | Zhao Guihua Song Minghui Liu Mingzhu | 2010 | Appl Math Comput2010，215，： | 1 |
| 18 | Papers published from 1995 to 2012 by six Traditional Chinese Medicine universities in China: a bibliometric analysis based on science citation index显示文摘OBJECTIVE: The quality and quantity of published research papers are important in both scientific and technology fields. Although there are several bibliometric studies based on citation analysis, very few have focused on research related to Traditional Chinese Medicine in China. METHODS: The bibliometric method used in this study included the following focuses: publication outputs for each year, paper type, language of publication, distribution of internationally collaborative countries, sources of funding, authorization number, distribution of institutes regarding collaborative publications, research fields, distribution of out-puts in journals, citation data, and h-index. RESULTS: A total of 3809 papers published from 1995 to 2012 were extracted from the science citation index(SCI). The cumulative number of papers from all six universities is constantly increasing. The United States attained the dominant position regarding complementary and alternative medicine research. The Chinese Academy of Sciences was the greatest participator in collaborative efforts. Research field analysis showed that the research mainly focused on pharmacology pharmacy, chemistry, integrative complementary medicine, plant sciences, and biochemistry molecular biology. The Shanghai University of Chinese Medicine had the most citations. CONCLUSION: In recent years, in terms of SCI papers, the six Traditional Chinese Medicine universities studied here have made great advances in scientific research. | Kuo Gao Guihua Tian Qing Ye Xing Zhai Jianxin Chen Tiegang Liu Kaifeng Liu Jingyi Zhao Shengyun Ding | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 1 |
| 19 | Behavior of calcium silicate hydrate in aluminate solution显示文摘 | LI Xiaobin ZHAO Zhou LIU Guihua | 2005 | Trans Nonferrous Met Soc China2005，15，5： | 1 |
| 20 | 显示文摘 | Li Changjun Cui Guihua Zhao Dazun | 2003 | Acta Optica Sinica2003，23，11： | 1 |
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