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| 1 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 2 | m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure显示文摘Dear Editor,N6-methyladenosine(m6A)is the most common posttranscriptional mammalian mRNA modification involved in multiple biological processes and diseases.1 However,its role in cardiac energy metabolism changes during heart failure(HF)remains elusive.Here we explored the role of m6A demethylase fat mass and obesity-associated protein(FTO)in glucose metabolism during pressure overload-induced HF.Methylated RNA immunoprecipitation sequencing(MeRIP-seq)was performed to map transcriptome-wide m6A modifications in transverse aortic constriction(TAC)and sham hearts.The number of identified m6A peaks was higher in the TAC than in the sham hearts(Fig.1a).Consistent with previous reports,the m6A peaks were enriched in 3’-untranslated regions in both the TAC and sham hearts(Fig.1b).2 The m6A peaks were characterized by the canonical RGAAR(R=A or G)motif(Fig.1c). | Beijian Zhang Hao Jiang Jian Wu Yun Cai Zhen Dong Yongchao Zhao Qinfeng Hu Kai Hu Aijun Sun Junbo Ge | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 6 |
| 3 | A structural and data-driven approach to engineering a plant cytochrome P450 enzyme显示文摘Functional manipulation of biosynthetic enzymes such as cytochrome P450 s(or P450 s) has attracted great interest in metabolic engineering of plant natural products.Cucurbitacins and mogrosides are plant triterpenoids that share the same backbone but display contrasting bioactivities.This structural and functional diversity of the two metabolites can be manipulated by engineering P450 s.However,the functional redesign of P450 s through directed evolution(DE) or structure-guided protein engineering is time consuming and challenging,often because of a lack of high-throughput screening methods and crystal structures of P450 s.In this study,we used an integrated approach combining computational protein design,evolutionary information,and experimental data-driven optimization to alter the substrate specificity of a multifunctional P450(CYP87 D20)from cucumber.After three rounds of iterative design and evaluation of 96 protein variants,CYP87 D20,which is involved in the cucurbitacin C biosynthetic pathway,was successfully transformed into a P450 mono-oxygenase that performs a single specific hydroxylation at C11 of cucurbitadienol.This integrated P450-engineering approach can be further applied to create a de novo pathway to produce mogrol,the precursor of the natural sweetener mogroside,or to alter the structural diversity of plant triterpenoids by functionally manipulating other P450 s. | Dawei Li Yongshuo Ma Yuan Zhou Junbo Gou Yang Zhong Lingling Zhao Lida Han Sergey Ovchinnikov Ling Ma Sanwen Huang Per Greisen Yi Shang | 2019 | Science China(Life Sciences)2019，62，7： | 5 |
| 4 | Alda-1 treatment promotes the therapeutic effect of mitochondrial transplantation for myocardial ischemia-reperfusion injury显示文摘Mitochondrial damage is a critical driver in myocardial ischemia-reperfusion(I/R)injury and can be alleviated via the mitochondrial transplantation.The efficiency of mitochondrial transplantation is determined by mitochondrial vitality.Because aldehyde dehydrogenase 2(ALDH2)has a key role in regulating mitochondrial homeostasis,we aimed to investigate its potential therapeutic effects on mitochondrial transplantation via the use of ALDH2 activator,Alda-1.Our present study demonstrated that time-dependent internalization of exogenous mitochondria by cardiomyocytes along with ATP production were significantly increased in response to mitochondrial transplantation.Furthermore,Alda-1 treatment remarkably promoted the oxygen consumption rate and baseline mechanical function of cardiomyocytes caused by mitochondrial transplantation.Mitochondrial transplantation inhibited cardiomyocyte apoptosis induced by the hypoxia-reoxygenation exposure,independent of Alda-1 treatment.However,promotion of the mechanical function of cardiomyocytes exposed to hypoxia-reoxygenation treatment was only observed after mitochondrial Alda-1 treatment and transplantation.By using a myocardial I/R mouse model,our results revealed that transplantation of Alda-1-treated mitochondria into mouse myocardial tissues limited the infarction size after I/R injury,which was at least in part due to increased mitochondrial potential-mediated fusion.In conclusion,ALDH2 activation in mitochondrial transplantation shows great potential for the treatment of myocardial I/R injury. | Xiaolei Sun Rifeng Gao Wenjia Li Yongchao Zhao Heng Yang Hang Chen Hao Jiang Zhen Dong Jingjing Hu Jin Liu Yunzeng Zou Aijun Sun Junbo Ge | 2021 | Bioactive Materials2021，6，7： | 5 |
| 5 | Three Dimensional Laser Point Cloud Slicing Method for Calculating Irregular Volume显示文摘Volume parameter is the basic content of a spatial body object morphology analysis.However,the challenge lies in the volume calculation of irregular objects.The point cloud slicing method proposed in this study effectively works in calculating the volume of the point cloud of the spatial object obtained through three-dimensional laser scanning(3DLS).In this method,a uniformly spaced sequent slicing process is first conducted in a specific direction on the point cloud of the spatial object obtained through 3DLS.A series of discrete point cloud slices corresponding to the point cloud bodies are then obtained.Subsequently,the outline boundary polygon of the point cloud slicing is searched one by one in accordance with the slicing sequence and areas of the polygon.The point cloud slice is also calculated.Finally,the individual point cloud section volume is calculated through the slicing areas and the adjacent slicing gap.Thus,the total volume of the scanned spatial object can be calculated by summing up the individual volumes.According to the results and analysis of the calculated examples,the slice-based volume-calculating method for the point cloud of irregular objects obtained through 3DLS is correct,concise in process,reliable in results,efficient in calculation methods,and controllable on accuracy.This method comes as a good solution to the volume calculation of irregular objects. | Bin LI Xiaofa ZHAO Yong CHEN Junbo WEI Lu WANG Bochao MA | 2019 | Journal of Geodesy and Geoinformation Science2019，2，4： | 5 |
| 6 | Distributed Real-time State Estimation for Combined Heat and Power Systems显示文摘This paper proposes a distributed real-time state estimation(RTSE)method for the combined heat and power systems(CHPSs).First,a difference-based model for the heat system is established considering the dynamics of heat systems.This heat system model is further used along with the power system steady-state model for holistic CHPS state estimation.A cubature Kalman filter(CKF)-based RTSE is developed to deal with the system nonlinearity while integrating both the historical and present measurement information.Finally,a multi-timescale asynchronous distributed computation scheme is designed to enhance the scalability of the proposed method for largescale systems.This distributed implementation requires only a small amount of information exchange and thus protects the privacy of different energy systems.Simulations carried out on two CHPSs show that the proposed method can significantly improve the estimation efficiency of CHPS without loss of accuracy compared with other existing models and methods. | Tingting Zhang Wen Zhang Qi Zhao Yaxin Du Jian Chen Junbo Zhao | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，2： | 5 |
| 7 | Recent progress in stability of perovskite solar cells显示文摘Perovskite solar cells have attracted significant attention in just the past few years in solar cell research fields,where the power conversion efficiency was beyond 22.1%.Now,the most important challenge for perovskite solar cells in practical applications is the stability issue.In this mini-review,we will summarize the degradation mechanism of perovskite solar cells,including the perovskite material itself and also the interfaces.While we also provide our opinion on improving the stability of perovskite solar cells. | Xiaojun Qin Zhiguo Zhao Yidan Wang Junbo Wu Qi Jiang Jingbi You | 2017 | Journal of Semiconductors2017，38，1： | 4 |
| 8 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 9 | Unified optimal power flow model for AC/DC grids integrated with natural gas systems considering gas-supply uncertainties显示文摘A unified optimal power flow(OPF) model for AC/DC grids integrated with natural gas systems is proposed for the real-time scheduling of power systems.Herein, the primary physical couplings underlying this coordinated system are modeled and investigated. In addition, the uncertainties of gas loads are considered when studying the role of gas supply for gas-fired units in power system operations. The nonlinear gas system constraints are converted to the second-order cone forms that allow for the use of the Benders decomposition techniques and the interior-point method to obtain the optimal solution. The numerical results of the modified IEEE 118-bus test system that integrates the Belgium 20-node natural gas system demonstrate the effectiveness of the proposed model. The effects of gas demand uncertainties on the optimal schedule of thermal generators are investigated as well. | Jiale FAN Xiaoyang TONG Junbo ZHAO | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 3 |
| 10 | Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells显示文摘转变生长因素 --(TGF-) 在恶意的细胞的各种各样的类型上施加 apoptotic 效果,包括肝癌症细胞。然而, TGF- 由导致 apoptosis 的精确机制仍然保持糟糕已知。在现在的学习,我们显示出那 threonine 32 (Thr32 ) FoxO3 的残余是批评的让 TGF- 在 hepatocarcinoma Hep3B 房间经由 Bim 导致 apoptosis。我们的数据证明 TGF- 在 Thr32 通过特定的 de-phosphorylation 导致了 FoxO3 激活。TGF -- 激活的 FoxO3 与 Smad2/3 合作了调停 Bim 起来规定和 apoptosis。在 Thr32 的 FoxO3 (de ) phosphorylation 被酷蛋白 kinase 调整我 --(CKI-) 。由小分子 D4476 的 CKI 抑制能废除 TGF -- 导致的 FoxO/Smad 激活,反向的 Bim 起来规定,和块顺序的 apoptosis。更重要地, CKI- 和 p32FoxO3 的 deregulated 层次在人的恶意的肝纸巾被发现。一起拿,我们的调查结果建议可能有 FoxO3 的 Thr32 为 TGF 是枢轴的一台 CKI-FoxO/Smad-Bim 在引擎 -- 导致的 apoptosis,为肝癌症治疗使它成为一个潜在的治疗学的目标。 | Xiangxuan Zhao Yong Liu Lei Du Leya He Biyun Ni Junbo Hu Dahai Zhu Quan Chen | 2015 | Protein & Cell2015，6，2： | 3 |
| 11 | Kinetic study on the photo-catalytic degradation of pyridine in TiO2 suspension systems 显示文摘 | Zhao Hong Xu Suohong Zhong Junbo | 2004 | Catalysis Today2004，9，1： | 1 |
| 12 | Chemical engineering of the single-walled carbon nanotube-nylon 6 interface 显示文摘 | Junbo G Zhao B Itkis E M | 2006 | Journal of American Chemical Society2006，128，23： | 1 |
| 13 | Kinetic study on the photo - catalytic degradation of pyridine in TiO: suspen- sion systems 显示文摘 | Hong Zhao Suohong Xu Junbo Zhong | 2004 | Catalysis Today2004，9395，： | 1 |
| 14 | Chemical engineering of the single-walled carbon nanotube-nylon 6 Interface显示文摘 | Bin Zhao Mikhail E | 2006 | Journal of American Chemistry Society2006，128，23： | 1 |
| 15 | Chemical engineering of the single-walled carbon nanotube-nylon 6 interface显示文摘 | Junbo G Zhao B Itkis E M | 2006 | Journal of American Chemical Society2006，128，23： | 1 |
| 16 | Temperature and anion responsive self-assembly of ionic liquid block copolymers coating gold nanoparticles显示文摘 | Junbo LI Jianlong ZHAO Wenlan WU Ju LIANG Jinwu GUO Huiyun ZHOU Lijuan LIANG | 2016 | Frontiers of Materials Science2016，10，2： | 1 |
| 17 | Isolation of yellow catfish β-actin promoter and generation of transgenic yellow catfish expressing enhanced yellow fluorescent protein显示文摘 | Jiachun Ge Zhangji Dong Jingyun Li Zhiqiang Xu Wei Song Jie Bao Dong Liang Junbo Li Kui Li Wenshuang Jia Muzi Zhao Yongxiang Cai Jiaxin Yang Jianlin Pan Qingshun Zhao | 2012 | Transgenic Research2012，，5： | 1 |
| 18 | Failure analysis of the 304 stainless steel tube in a gas analyzer显示文摘 | Yongde Li Na Xu Xiaofeng Wu Junbo Shi Lili Zhang Mei Zhao Qishan Zang | 2011 | Engineering Failure Analysis2011，，： | 1 |
| 19 | Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety显示文摘 | HE Junbo WANG Xiaoguo ZHAO Xiaoqin | 2012 | Eur J Med Chem2012，54，： | 1 |
| 20 | Strain-sensitive ferromagnetic two-dimensional Cr_(2)Te_(3)显示文摘Searching for room temperature magnetic two-dimensional(2D)materials is a charming goal,but the number of satisfied materials is tiny.Strain can introduce considerable deformation into the lattice structure of 2D materials,and thus significantly modulate their intrinsic properties.In this work,we demonstrated a remarkable strain-modulated magnetic properties in the chemical vapor deposited Cr_(2)Te_(3) nanoflakes grown on mica substrate.We found the Curie temperature of Cr_(2)Te_(3) nanoflakes can be positively and negatively modulated under tensile and compressive strain respectively,with a maximum varied value of -40 and-90 K,dependent on the thickness of samples.Besides,the coercive field of Cr_(2)Te_(3) nanoflakes also showed a significant decrease under the applied strain,suggesting the decrease of exchange interaction or the change of the magnetization direction.This work suggests a promise to employ interfacial strain to accelerate the practical application of room temperature 2D magnetics. | Junchuan Zhong Mingshan Wang Teng Liu Yinghe Zhao Xiang Xu Shasha Zhou Junbo Han Lin Gan Tianyou Zhai | 2022 | Nano Research2022，15，2： | 1 |
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