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| 1 | The Phenotypic Characterization of Naturally Occurring Regulatory CD4^+CD25^+T Cells显示文摘免疫系统的动态平衡取决于在对自我抗原的对入侵的病原体和有免疫力的忍耐的有免疫力的反应之间的平衡。中央、外部的忍耐是为 T 房间忍耐的正式就职和维护的重要机制。最近,许多注意对规章的 T 房间(Treg ) 被给予了,它在维持外部有免疫力的忍耐起一个重要作用。到目前为止,关于 Treg 房间的表面标记没有令人满意的进展,因为任何一个都不为 Treg 房间是唯一的。在这评论,我们总结在自然地发生的CD4+CD25+ Treg 房间( nTreg )表示的一些重要分子,包括 forkhead/winged-helix 家庭 transcriptional 抑压者 p3 ( Foxp3 ),肿瘤坏死因素受体( TNFR )家庭, CD28/CTLA4 分子, chemokine 受体,像使用费的受体( TLR ), membranebound TGF-和其它分子例如 neuropilin-1 ,淋巴细胞激活 gene-3 (落后) -3 和 granzyme.This 评论在 nTreg | Huanfa Yi Yu Zhen Lingling Jiang Jialin Zheng Yong Zhao | 2006 | Cellular & Molecular Immunology2006，3，3： | 31 |
| 2 | Pollution characteristics of organic and elemental carbon in PM_(2.5) in Xiamen,China显示文摘Xiamen,located on the southeastern coastal line of China,is undergoing rapid urbanization and industrialization,so its air quality has a trend of degradation.However,studies on level,temporal and spatial changes of fine particles (PM 2.5) and their carbonaceous fractions are scarce.In this article,abundance,sources,seasonal and spatial variations,distribution of organic carbon (OC) and elemental carbon (EC) in PM 2.5,were studied at suburban,urban and industrial sites in Xiamen during four season-representative months in 2009-2010.PM 2.5 samples were collected with middle volume sampler and were analyzed for OC and EC with thermal optical transmittance (TOT) method.Results showed that the annual average PM 2.5 concentrations were 63.88-74.80 μg/m 3 at three sites.While OC and EC concentrations were in the range of 15.81-19.73 μg/m 3 and 2.74-3.49 μg/m 3,respectively,and clearly presented the summerminima and winter maxima in this study.The carbonaceous aerosol accounted for 42.8%-47.3% of the mass of PM 2.5.The annual average of secondary organic carbon (SOC) concentrations in Xiamen were 9.23-11.36 μg/m 3,accounting for approximately 56% of OC.Strong correlations between OC and EC was found in spring (R 2=0.50) and autumn (R 2=0.73),suggesting that there were similar emission and transport processes for carbonaceous aerosols in these two seasons,while weak correlations were found in summer (R 2=0.33) and winter (R 2=0.41).The OC/EC ratios in PM 2.5 varied from 2.1 to 8.7 with an annual average of 5.7,indicating that vehicle exhaust,coal smoke and biomass burning were main source apportionments of carbonaceous fractions in Xiamen. | Fuwang Zhang Jinping Zhao Jinsheng Chen Ya Xu Lingling Xu | 2011 | Journal of Environmental Sciences2011，23，8： | 27 |
| 3 | Chemical characteristics of PM_(2.5) during haze episodes in the urban of Fuzhou,China显示文摘Atmospheric fine particles(PM_(2.5)) were collected in this study with middle volume samplers in Fuzhou,China,during both normal days and haze days in summer(September 2007) and winter(January 2008).The concentrations,distributions,and sources of polycyclic aromatic hydrocarbons(PAHs),organic carbon(OC),elemental carbon(EC),and water soluble inorganic ions(WSIIs) were determinated.The results showed that the concentrations of PM2.5,PAHs,OC,EC,and WSIIs were in the orders of haze > normal and winter > summer.The dominant PAHs of PM2.5 in Fuzhou were Fluo,Pyr,Chr,BbF,BkF,BaP,BghiP,and IcdP,which represented about 80.0%of the total PAHs during different sampling periods.The BaPeq concentrations of ∑PAHs were 0.78,0.99,1.22,and 2.43 ng/m3 in summer normal,summer haze,winter normal,and winter haze,respectively.Secondary pollutants(SO_4^(2-),NO_3^-,NH_4^+.and OC) were the major chemical compositions of PM2.5,accounting for 69.0%,55.1%,63.4%,and 64.9%of PM2.5 mass in summer normal,summer haze,winter normal,and winter haze,respectively.Correspondingly,secondary organic carbon(SOC) in Fuzhou accounted for 20.1%,48.6%,24.5%,and 50.5%of OC.The average values of nitrogen oxidation ratio(NOR) and sulfur oxidation ratio(SOR) were higher in haze days(0.08 and 0.27) than in normal days(0.05 and 0.22).Higher OC/EC ratios were also found in haze days(5.0) than in normal days(3.3).Correlation analysis demonstrated that visibility had positive correlations with wind speed,and negative correlations with relative humidity and major air pollutants.Overall,the enrichments of PM_(2.5),OC,EC,SO_4^(2-),and NO_3^- promoted haze formation.Furthermore,the diagnostic ratios of IcdP/(IcdP + BghiP),IcdP/BghiP,OC/EC,and NO_3^-/SO_4^(2-) indicated that vehicle exhaust and coal consumption were the main sources of pollutants in Fuzhou. | Fuwang Zhang Lingling Xu Jinsheng Chen Xiaoqiu Chen Zhenchuan Niu Tong Lei Chunming Li Jinping Zhao | 2013 | Particuology2013，11，3： | 19 |
| 4 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 5 | Multichannel vectorial holographic display and encryption显示文摘Since its invention,holography has emerged as a powerful tool to fully reconstruct the wavefronts of light including all the fundamental properties(amplitude,phase,polarization,wave vector,and frequency).For exploring the full capability for information storage/display and enhancing the encryption security of metasurface holograms,smart multiplexing techniques together with suitable metasurface designs are highly demanded.Here,we integrate multiple polarization manipulation channels for various spatial phase profiles into a single birefringent vectorial hologram by completely avoiding unwanted cross-talk.Multiple independent target phase profiles with quantified phase relations that can process significantly different information in different polarization states are realized within a single metasurface.For our metasurface holograms,we demonstrate high fidelity,large efficiency,broadband operation,and a total of twelve polarization channels.Such multichannel polarization multiplexing can be used for dynamic vectorial holographic display and can provide triple protection for optical security.The concept is appealing for applications of arbitrary spin to angular momentum conversion and various phase modulation/beam shaping elements. | Ruizhe Zhao Basudeb Sain Qunshuo Wei Chengchun Tang Xiaowei Li Thomas Weiss Lingling Huang Yongtian Wang Thomas Zentgraf | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 6 | UAV Online Path Planning Algorithm in a Low Altitude Dangerous Environment显示文摘UAV online path-planning in a low altitude dangerous environment with dense obstacles, static threats(STs)and dynamic threats(DTs), is a complicated, dynamic, uncertain and real-time problem. We propose a novel method to solve the problem to get a feasible and safe path. Firstly STs are modeled based on intuitionistic fuzzy set(IFS) to express the uncertainties in STs. The methods for ST assessment and synthesizing are presented. A reachability set(RS) estimator of DT is developed based on rapidly-exploring random tree(RRT) to predict the threat of DT. Secondly a subgoal selector is proposed and integrated into the planning system to decrease the cost of planning, accelerate the path searching and reduce threats on a path. Receding horizon(RH) is introduced to solve the online path planning problem in a dynamic and partially unknown environment. A local path planner is constructed by improving dynamic domain rapidly-exploring random tree(DDRRT) to deal with complex obstacles. RRT* is embedded into the planner to optimize paths. The results of Monte Carlo simulation comparing the traditional methods prove that our algorithm behaves well on online path planning with high successful penetration probability. | Naifeng Wen Lingling Zhao Xiaohong Su Peijun Ma | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，2： | 15 |
| 7 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 8 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 9 | Evapotranspiration estimation methods in hydrological models显示文摘实际土壤水分蒸发蒸腾损失总量是水文学周期和连接陆地表面水平衡和陆地表面精力平衡的一个唯一的术语的一个关键过程。土壤水分蒸发蒸腾损失总量在在水文学模型模仿土壤水分蒸发蒸腾损失总量评价方法的气候变化,和评论的水文学效果起一个关键作用具有重要重要性。这篇论文第一总结方法在水文学模型使用了的土壤水分蒸发蒸腾损失总量评价然后分类他们进由他们的机制收集方法的综合变换方法和分类。综合变换方法通常在水文学模型被使用,二差别在他们之中存在:一个人在潜在的蒸发评价方法,当时其它在为定义在潜在的蒸发和实际土壤水分蒸发蒸腾损失总量之间的关系的功能。由于 Penman-Monteith 方法和存在数据无常的更高的信息要求,简化了实验方法因为精明的潜在、实际的土壤水分蒸发蒸腾损失总量广泛地在水文学模型被使用。不同土壤水分蒸发蒸腾损失总量计算方法被使用取决于水文学模型,和重要性的复杂性,在最合适的土壤水分蒸发蒸腾损失总量方法的选择的困难被讨论。最后,这份报纸指出在水文学建模估计方法的土壤水分蒸发蒸腾损失总量的未来的发展趋势。 | ZHAO Lingling XIA Jun XU Chong-yu WANG Zhonggen SOBKOWIAKLeszek LONG Cangrui | 2013 | Journal of Geographical Sciences2013，23，2： | 10 |
| 10 | Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation显示文摘Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide with H3K27me3, and is the functional homolog of Polycomb protein. This raises the question whether genuine HP1 homologs exist in plants. Here, we report on the discovery of ADCP1, a plant-specific triple tandem Agenet protein, as a multivalent H3K9me reader in Arabidopsis, and establish that ADCP1 is essential for heterochromatin formation and transposon silencing through modulating H3K9 and DNA methylation levels. Structural studies revealed the molecular basis underlying H3K9me-specific recognition by tandem Agenet of ADCP1. Similar to human HP1α and fly HP1a, ADCP1 mediates heterochromatin phase separation. Our results demonstrate that despite its distinct domain compositions, ADCP1 convergently evolves as an HP1-equivalent protein in plants to regulate heterochromatin formation. | Shuai Zhao Lingling Cheng Yifei Gao Baichao Zhang Xiangdong Zheng Liang Wang Pilong Li Qianwen Sun Haitao Li | 2019 | Cell Research2019，29，1： | 10 |
| 11 | Characteristics of secondary inorganic aerosol and sulfate species in size-fractionated aerosol particles in Shanghai显示文摘Sulfate, nitrate and ammonium(SNA) are the dominant species in secondary inorganic aerosol, and are considered an important factor in regional haze formation. Size-fractionated aerosol particles for a whole year were collected to study the size distribution of SNA as well as their chemical species in Shanghai. SNA mainly accumulated in fine particles and the highest average ratio of SNA to particulate matter(PM) was observed to be 47% in the fine size fraction(0.49–0.95 μm). Higher sulfur oxidation ratio and nitrogen oxidation ratio values were observed in PM of fine size less than 0.95 μm. Ion balance calculations indicated that more secondary sulfate and nitrate would be generated in PM of fine size(0.49–0.95 μm). Sulfur K-edge X-ray absorption near-edge structure(XANES) spectra of typical samples were analyzed. Results revealed that sulfur mainly existed as sulfate with a proportion(atomic basis) more than 73% in all size of PM and even higher at 90% in fine particles. Sulfate mainly existed as(NH4)2SO4 and gypsum in PM of Shanghai. Compared to non-haze days, a dramatic increase of(NH4)2SO4 content was found in fine particles on haze days only, which suggested the promoting impact of(NH4)2SO4 on haze formation. According to the result of air mass backward trajectory analysis, more(NH4)2SO4 would be generated during the periods of air mass stagnation. Based on XANES, analysis of sulfate species in size-fractionated aerosol particles can be an effective way to evaluate the impact of sulfate aerosols on regional haze formation. | Shilei Long Jianrong Zeng Yan Li Liangman Bao Lingling Cao Ke Liu Liang Xu Jun Lin Wei Liu Guanghua Wang Jian Yao Chenyan Ma Yidong Zhao | 2014 | Journal of Environmental Sciences2014，26，5： | 10 |
| 12 | Identification of botanical origin of Chinese unifloral honeys by free amino acid profiles and chemometric methods显示文摘The amino acid contents of five floral sources Chinese honeys(jujube, rape, chaste, acacia, and lungan) were measured using reversed phase high-performance liquid chromatography(RP-HPLC). The results showed that proline was the main amino acid in most of the analyzed samples. Phenylalanine presents at the highest content in chaste honey samples, and the total amino acid contents of chaste honeys were also significantly higher than those of other honey samples. Based on the amino acid contents, honey samples were classified using chemometric methods(cluster analysis(CA), principal component analysis(PCA), and discriminant analysis(DA)). According to the CA results, chaste honeys could be separated from other honeys, while the remaining samples were correctly grouped together when the chaste honey data were excluded. By using DA, the overall correct classification rate reached 100%. The results revealed that amino acid contents could potentially be used as indicators to identify the botanical origin of unifloral honeys. | Zheng Sun Lingling Zhao Ni Cheng Xiaofeng Xue Liming Wu Jianbin Zheng Wei Cao | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 9 |
| 13 | WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation显示文摘The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1(WIP1) plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain unclear.Here, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury. | Dahu Li Lijun Zhang Xin Huang Lili Liu Yunling He Lun Xu Yiyao Zhang Tong Zhao Liying Wu Yongqi Zhao Kuiwu Wu Yan Wu Ming Fan Lingling Zhu | 2017 | Neuroscience Bulletin2017，33，3： | 9 |
| 14 | Rapid reconstitution of NK1 cells after allogeneic transplantation is associated with a reduced incidence of graft-versus-host disease显示文摘The balance between immunostimulation and immunoregulation in T cell immunity is achieved by maintaining specific ratios of Th1, Th2, Th3 and Tr1 cells. Here, we investigate levels of type 1(IFN-gamma; NK1), type 2(IL-13; NK2), type 3(TGF-beta;NK3) and regulatory(IL-10; NKr) cytokines in peripheral blood to assess the cytokine profiles of natural killer(NK) cells following human allogeneic hematopoietic stem cell transplantation(allo-HSCT). NK2 and NK3 cell expansion was observed after allo-HSCT; levels of NKr cells reached donor levels at day 15, though levels of NK1 cells were consistently lower than donor levels until day 60 after allo-HSCT. Multivariate analysis showed that a higher level of NK1 cells by day 15 was associated with a lower overall risk of acute graft-versus-host disease(GVHD)(HR 0.157, P=0.010) as well as II-IV acute GVHD(HR0.260, P=0.059). Furthermore, higher levels of NK1 cells by day 15 were correlated with lower rates of cytomegalovirus(CMV)reactivation(HR 0.040, 0.005–0.348, P=0.003). These results indicate that rapid reconstitution of NK cells, especially NK1 cells,can help prevent the development of GVHD as well as CMV reactivation after allogeneic transplantation. | Xingxing Yu Lingling Xu Yingjun Chang Xiaojun Huang Xiangyu Zhao | 2018 | Science China(Life Sciences)2018，61，8： | 9 |
| 15 | Synoptic-scale variation of δ^(18)O in summer monsoon rainfall at Lijiang, China显示文摘Based on the daily δ^(18)O data in June―September 2003 at Lijiang and the daily mean NCEP/ NCAR reanalysis data, synoptic-scale variation of δ^(18)O in summer monsoon rainfall was investigated. The 'precipitation amount effect' is obvious for the daily δ^(18)O variation, whereas the 'temperature effect' is insignificant. Alternate occurrences of active phase and break phase of the southwest monsoon probably influence the synoptic-scale δ^(18)O variation prominently. Moreover, the isotopic composition in precipitation during the late monsoon months is presumably influenced significantly by recycling of monsoon precipitation. Both the above factors disturb the 'amount effect' of isotopic variation in the monsoon region. This study also indicates that the synoptic-scale rainfall δ^(18)O variation at Lijiang in summer is domi-nated by the Indian monsoon depression (low pressure) system at large scale. These results are important for further studying the 'amount effect' and reconstructing paleoclimate in the monsoon region. | PANG Hongxi HE Yuanqing LU Aigang ZHAO Jingdong NING Baoying YUAN Lingling SONG Bo | 2006 | Chinese Science Bulletin2006，51，23： | 9 |
| 16 | IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass显示文摘Survival of children with chronic medical illnesses is leading to an increase in secondary osteoporosis due to impaired peak bone mass(PBM).Insulin-like growth factor type 1(IGF-1) levels correlate with the pattern of bone mass accrual and many chronic illnesses are associated with low IGF-1 levels.Reduced serum levels of IGF-1 minimally affect the integrity of the skeleton,whereas recent studies suggest that skeletal IGF-I regulates PBM.To determine the role of IGF-1 in postnatal bone mass accrual regardless of source,we established an inducible type 1 Igf receptor Cre/lox knockout mouse model,in which the type 1 Igf receptor was deleted inducibely in the mesenchymal stem cells(MSCs) from 3-7 weeks of age.The size of the mouse was not affected as knockout and wild type mice had similar body weights and nasoanal and femoral lengths.However,bone volume and trabecular bone thickness were decreased in the secondary spongiosa of female knockout mice relative to wild type controls,indicating that IGF-1 is critical for bone mass.IGF-1 signaling in MSCs in vitro has been implicated to be involved in both migration to the bone surface and differentiation into bone forming osteoblasts.To clarify the exact role of IGF-1 in bone,we found by immunohistochemical analysis that a similar number of Osterix-positive osteoprogenitors were on the bone perimeter,indicating migration of MSCs was not affected.Most importantly,56% fewer osteocalcin-positive mature osteoblasts were present on the bone perimeter in the secondary spongiosa in knockout mice versus wild type littermates.These in vivo data demonstrate that the primary role of skeletal IGF-1 is for the terminal differentiation of osteoprogenitors,but refute the role of IGF-1 in MSC migration in vivo.Additionally,these findings confirm that impaired IGF-1 signaling in bone MSCs is sufficient to impair bone mass acquisition. | Janet L. Crane Luo Zhao Joseph S. Frye Lingling Xian Tao Qiu Xu Cao | 2013 | Bone Research2013，1，2： | 8 |
| 17 | Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China显示文摘Monoclonal gammopathies are characterized by the presence of monoclonal immunoglobulin in patients with or without evidence of multiple myeloma (MM),macroglobulinemia,amyloidosis (AL),or a related plasma cell proliferative disorder. This study aims to evaluate laboratory diagnostic characters of monoclonal gammopathies and investigates the correlation between monoclonal gammopathies and transforming growth factor β1 (TGFβ1). Immunofixation electrophoresis (IFE),serum protein electrophoresis (SPE),nephelometry and urine light chain ELISA were used for laboratory identification of monoclonal immunoglobulins. Plasma TGFβ1 was detected with double-antibodies ELISA. Lightcycler was used for single nucleotide polymorphism (SNP) analysis. Totally 2,007 cases of monoclonal immunoglobulin (M protein) were identified in 10,682 samples. The isotypes of M protein were IgG type 47.1%,IgA 23.0%,IgM 8.7%,IgD 5.3%,free light chain κ 6.1%,λ 9.8%. In reference to IFE,the coherency of diagnosis was serum light chain ratio (κ/λ) 94.4%,quantitation of Igs 83%,light chain quantitation 80.9%,and urine light chain ratio (κ/λ) 58.0%. Plasma TGFβ1 was elevated significantly compared to normal control. The allelic frequency of codon 10 (C > T) was neither associated with the existence of the M protein nor with the M protein isotype. Monoclonal gammopathies can be identified with the combination of IFE,SPE,Igs quantitaion and urine light chain determination. Although TGFβ1,an important cytokine in immune regulation,was elevated in monoclonal gammopathies,the SNPs in coding region of TGFβ1 gene did not confer susceptibility to the development of monoclonal gammopathies in this study. | Hao Wang Chunfang Gao Lingling Xu Zaixing Yang Wenjing Zhao Xiantao Kong | 2008 | Cellular & Molecular Immunology2008，5，4： | 8 |
| 18 | Impact of urban landscape and environmental externalities on spatial differentiation of housing prices in Yangzhou City显示文摘在这研究,住房从时期为住宅区定价数据 20012012 被使用,全球区别索引(GDI ) 被建立在 Yangzhou 城市里在住房价格测量全面区别趋势,东方中国。然后,全球住房市场和住房 submarkets 的价格上的自然风景和环境的影响被快乐价格模型评估。结果如下被显示出。(1 ) 自从 2001,在那里在住房价格之中一直在增加差距。在这个时期,区别趋势显示出一个向上的变化,它被结合了住房价格的年度生长率。(2 ) 同质的价格的住宅区的空间分发变化了从在 2001 聚类进在 2012 分散了。(3 ) 自然风景和环境外表皮清楚地影响住房价格的空间区别。(4 ) 在不同住房, submarkets,自然风景的影响和环境外表皮被改变。自然风景特征在平常的商业房子和赔偿房子的住房价格上有重要影响,当时环境特征的影响在村庄和别墅的住房价格上有明显的影响。 | WANG Yang ZHAO Lingling SOBKOWIAK Leszek GUAN Xingliang WANG Shaojian | 2015 | Journal of Geographical Sciences2015，25，9： | 8 |
| 19 | Reemergent Cases of COVID-19--Dalian City,Liaoning Province,China,July 22,2020显示文摘From July 22-23,3 local COVID-19 cases were reported in Dalian City,Liaoning Province,China.All 3 patients reported that they did not leave Dalian 14 days before the onset of disease and had no COVID-19 case contact history and no foreign personnel contact history.Epidemiological investigation,medical isolation,and nucleic acid detection was immediately carried out in Dalian,and 12 asymptomatic infections were detected in close contacts of Patient 1.Because asymptomatic infections made up a large proportion of total infections,the outbreak was likely observed in the beginning stages. | Xiang Zhao Lingling Mao Jianqun Zhang Yong Zhang Yang Song Zhijian Bo Hong Wang Ji Wang Cao Chen Jinbo Xiao Tianjiao Ji Qian Yang Wenbo Xu Dayan Wang Wenqing Yao | 2020 | China CDC weekly2020，2，34： | 5 |
| 20 | A structural and data-driven approach to engineering a plant cytochrome P450 enzyme显示文摘Functional manipulation of biosynthetic enzymes such as cytochrome P450 s(or P450 s) has attracted great interest in metabolic engineering of plant natural products.Cucurbitacins and mogrosides are plant triterpenoids that share the same backbone but display contrasting bioactivities.This structural and functional diversity of the two metabolites can be manipulated by engineering P450 s.However,the functional redesign of P450 s through directed evolution(DE) or structure-guided protein engineering is time consuming and challenging,often because of a lack of high-throughput screening methods and crystal structures of P450 s.In this study,we used an integrated approach combining computational protein design,evolutionary information,and experimental data-driven optimization to alter the substrate specificity of a multifunctional P450(CYP87 D20)from cucumber.After three rounds of iterative design and evaluation of 96 protein variants,CYP87 D20,which is involved in the cucurbitacin C biosynthetic pathway,was successfully transformed into a P450 mono-oxygenase that performs a single specific hydroxylation at C11 of cucurbitadienol.This integrated P450-engineering approach can be further applied to create a de novo pathway to produce mogrol,the precursor of the natural sweetener mogroside,or to alter the structural diversity of plant triterpenoids by functionally manipulating other P450 s. | Dawei Li Yongshuo Ma Yuan Zhou Junbo Gou Yang Zhong Lingling Zhao Lida Han Sergey Ovchinnikov Ling Ma Sanwen Huang Per Greisen Yi Shang | 2019 | Science China(Life Sciences)2019，62，7： | 5 |
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