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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | A Control Strategy for Grid-connected Inverters With LCL Filters显示文摘把LCL滤波器作为电压源型并网逆变器与电网的接口已受到广泛关注。与单电感L滤波器相比,利用电感值较小的LCL滤波器对入网电流的高次谐波具有显著的衰减效果,特别是在低开关频率的大功率并网逆变系统应用中更具明显优势,但是仅采用直接入网电流控制时,LCL滤波器接口的并网逆变器系统存在稳定性问题。该文采用电网侧电感电流和逆变侧电感电流双闭环控制策略对并网电流进行直接控制,电网侧电感电流作为外环更容易抑制并网电流的谐波因素,且可以直接控制入网电流的单位功率因数,采用逆变器侧电感电流作为内环可以增加系统阻尼,从而可抑制系统振荡,增加系统稳定性。对该方案进行系统建模,并深入分析了滤波器参数、控制器参数及系统稳定性之间的精确量化关系。仿真和实验结果表明,该控制策略既可有效抑制入网电流谐振和实现进网电流的高功率因数运行,同时又具有良好的稳态和动态性能。 | HU Xuefeng WEI Zheng CHEN Yihan GONG Chunying ZHANG Jiayan | 2012 | 中国电机工程学报2012，32，27： | 37 |
| 3 | Characteristics of paleoflood deposits archived in unit T0403 of Yuxi Site in the Three Gorges reservoir areas,China显示文摘Based on the detailed analyses,multi-proxies such as AMS 14 C dating,grain size,component and morphology of heavy minerals,micromorphology of zircon,magnetic susceptibility,Rb/Sr and Hg content are used to research the paleoflood sediments archived in the Yuxi Site.The research indicates that, since 7.6 kaBP,at least 16 times of paleoflood with water level above Wusong Elevation 147.024 m(a.s.l.) left deposits in the Neolithic layers of unit T0403 from the Yuxi Site.The results are induced from the following aspects:(1)The plaeoflood sediments take on great similarities with modern flood sediments in the Yuxi Site and Zhongba Site in probability cumulative curves which mainly show a pattern of 3 segments in fluvial pattern.(2)There is some resemblance between the heavy mineral components and the zircon shape characteristics of paleoflood deposits and those of modern flood deposits.(3) Magnetic susceptibility values(40.44―70.10SI)are lower than those of sediments from cultural layers (59.59―188.68SI).(4)Hg values(290.71―742.51 ng/g)are lower than those of sediments from cultural layers(344.16―10518.17 ng/g).(5)Rb/Sr values are higher than those of sediments from cultural layers, while those of the 4th,5th,6th,7th,8th cultural layers are high,which shows that they are inundated by paleoflood.The reason for many flood deposits existing is related to the site situated on the first terrace where the Yuxi River joins with the Yangtze River.As there are some similarities between the plaeoflood sediments and those of the Zhongba Site,it is feasible to confirm the existence of paleoflood sediments based on the above points. | ZHU Cheng MA ChunMei XU WeiFeng BAI JiuJiang ZHENG ChaoGui ZHU GuangYao WANG HuiLin CHEN Ye LU XueFeng | 2008 | Chinese Science Bulletin2008，53，S1： | 16 |
| 4 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 5 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 6 | Potential association of hyperhomocysteinemia with the progression of IgA nephropathy: a retrospective study显示文摘 | Duan Shuwei Liu Shuwen Sun Xuefeng Zheng Ying Liu Linchang Yao Feixiang Wu Jie | 2014 | Chinese Medical Journal2014，，10： | 11 |
| 7 | Heavy metal removal from aqueous solutions by chitosan-based magnetic composite flocculants显示文摘In this study,three magnetic flocculants with different chelating groups,namely,carboxymethyl chitosan-modified Fe_(3)O_(4)flocculant(MC),acrylamide-grafted magnetic carboxymethyl chitosan flocculant(MCM),and 2-acrylamide-2-methylpropanesulfonic acid copolyacrylamide-grafted magnetic carboxymethyl chitosan flocculant(MCAA)were prepared,synthesized,and characterized by photopolymerization technology.They were applied to the flocculation removal of Cr(Ⅲ),Co(Ⅱ),and Pb(Ⅱ).The effect of flocculation condition on the removal performance of Cr(Ⅲ),Co(Ⅱ),and Pb(Ⅱ)was studied.Characterization results show that the three magnetic carboxymethyl chitosan-based flocculants have been successfully prepared with good magnetic induction properties.Flocculation results show that the removal rates of MC,MCM,and MCAA on Cr(Ⅲ)are 51.79%,82.33%,and 91.42%,respectively,under the conditions of 80 mg/L flocculant,pH value of 6,reaction time of 1.5 hr,G value of 200 s^(-1),and precipitation magnetic field strength of 120 mT.The removal rates of Co(Ⅱ)by MC,MCM,and MCAA are 54.33%,84.99%,and 90.49%,respectively.The removal rates of Pb(Ⅱ)by MC,MCM,and MCAA are 61.54%,91.32%,and 95.74%,respectively.MCAA shows good flocculation performance in composite heavy metal-simulated wastewater.The magnetic carboxymethyl chitosan-based flocculant shows excellent flocculation performance in removing soluble heavy metals.This research provides guidance and ideas for the development of efficient and low-cost flocculation technology to remove heavy metals in wastewater. | Xuefeng Xiao Yuanyuan Yu Yongjun Sun Xing Zheng Aowen Chen | 2021 | Journal of Environmental Sciences2021，33，10： | 9 |
| 8 | Prediction of nitrogen and phosphorus contents in citrus leaves based on hyperspectral imaging显示文摘The nutritional status of citrus leaves is very important to the determining of fertilization plans.The spectrum technique is a quick,un-injured method and is becoming widely used for plant nutrient estimation.The possibility and method of using spectrum technique to estimate the nutrient of citrus leaf was explored in this study.A total amount of 135 leaves from the mature spring shoots of navel orange trees(C.sinensis Osbeck,“Newhall”)were collected and randomly grouped into two sets of samples:100 leaves for the calibration set and 35 leaves for the prediction set.The hyperspectral images were scanned upper and lower side of each leaf and then the total nitrogen(N)and phosphorus(P)contents of each leaf were measured.The raw spectra data were extracted to generate average spectra curves,preprocessed with five different methods,and was used to build N and P content prediction models.The performances of the five preprocessing methods,i.e.,Savitzky-Golay smoothing(SGS),standard normal variate(SNV),multiplicative scatter correction(MSC),first-derivative(1-Der)and second-derivative(2-Der),were tested with linear partial least squares(PLS)models and nonlinear least squares-support vector machine(LS-SVM)models.The results showed that the SG-PLS and PLS were the best for the N predicting(Rp=0.9049,RMSEP=0.1041)and P(Rp=0.9235,RMSEP=0.0514)in citrus leaves,respectively;the hyperspectral image data from leaf‟s upper side predicting better for the contents of N and P.The study suggested that the hyperspectral image data from the upper side of the citrus leaves are suitable for nondestructive estimation of nutrient content. | Liu Yanli Lyu Qiang He Shaolan Yi Shilai Liu Xuefeng Xie Rangjin Zheng Yongqiang Deng Lie | 2015 | International Journal of Agricultural and Biological Engineering2015，8，2： | 5 |
| 9 | Compositions of aliphatic des-A-triterpenes in the Hani peat deposit,Northeast China and its biological significance显示文摘Aliphatic des-A-triterpenes,the degradation products of pentacyclic triterpenes have been tentatively assigned in samples taken from a 963-cm-thick peat sequence from the Hani region of Northeast China using gas chromatography-mass spectrometry(GC-MS)in order to understand and identify these des-A-triterpenes response to climate and ecology.The study indicates that aliphatic des-A-triterpenes are abundant in the Hani peat bog.The high relative abundance of the total des-A-triterpenes mainly occurs at the Holocene periods and is corresponding to the low sedimentation rate.The mechanism of des-A-triterpenes accumulation is not consistent with the previous studies.It is proposed that the biological community is also one influence factor.The obvious stage variations of the total des-A-triterpenes in the whole sequence reveal the different biological(microbes and plants) processes and responses,possibly revealing the four large replacements of biological community and functional composition in the swamp environment over the 16000 cal a BP.The low total des-A-triterpenes values occur at about 10200,8700,7700,6600,4480-3940 and 3040 cal a BP,reflecting the multiple millennial micro-environment oscillations under the macro-environment of the swamp during the Holocene.The ratios of diene and monoene des-A-triterpenes(DT/MT),des-A-lupane and diene and monoene des-A-triterpenes(DL/(DT+MT)),ratios ofindividual compounds exhibit vertical opposite to the total des-A-triterpenes. Namely,these ratios are high during the last deglaciation and late Holocene whereas they are low at other periods,indicating different compounds have different responses to micro-environment and microbial activities.This study discusses the diversity of biological community and biological functional composition response to micro-environment,which not only provides the complement in Northeast China,but also bears important fundamental information for the implication to ecological environment in the future. | ZHENG YanHong ZHOU WeiJian LIU Zhao CHEN QingMin YU XueFeng LIU XiaoMin | 2010 | Chinese Science Bulletin2010，55，21： | 5 |
| 10 | HIV Prevention and Health Poverty Alleviation-Liangshan Prefecture,Sichuan Province,China,2017-2020显示文摘BACKGROUND Liangshan,officially the Liangshan Yi Autonomous Prefecture,is an autonomous prefecture occupying much of the southern portion of Sichuan Province.It has been a remote and deeply impoverished area and also has the largest population of ethnic Yi people in China(1).For many years,due to geographical environment conditions,traffic conditions,and other historic restrictions,the human immunodeficiency virus(HIV)epidemic in Liangshan Prefecture has become the focus of HIV prevention and control in China since the first acquired immunodeficiency syndrome(AIDS)case was reported in this area in 1995(2-3). | Zhongfu Liu Xuefeng Tang Yufen Liu Linglin Zhang Yihui Yang Yongli Zheng Weixin Liu Chunnong Jike Hong Mai Heying Fan Gang Yu Mengjie Han George F.Gao | 2021 | China CDC weekly2021，3，48： | 4 |
| 11 | Frontiers in circularly polarized luminescence:molecular design,self-assembly,nanomaterials,and applications显示文摘The research in circularly polarized luminescence has attracted wide interest in recent years.Efforts on one side are directed toward the development of chiral materials with both high luminescence efficiency and dissymmetry factors,and on the other side,are focused on the exploitations of these materials in optoelectronic applications.This review summarizes the recent frontiers(mostly within five years)in the research in circularly polarized luminescence,including the development of chiral emissive materials based on organic small molecules,compounds with aggregation-induced emissions,supramolecular assemblies,liquid crystals and liquids,polymers,metal-ligand coordination complexes and assemblies,metal clusters,inorganic nanomaterials,and photon upconversion systems.In addition,recent applications of related materials in organic light-emitting devices,circularly polarized light detectors,and organic lasers and displays are also discussed. | Zhong-Liang Gong Xuefeng Zhu Zhonghao Zhou Si-Wei Zhang Dong Yang Biao Zhao Yi-Pin Zhang Jianping Deng Yixiang Cheng You-Xuan Zheng Shuang-Quan Zang Hua Kuang Pengfei Duan Mingjian Yuan Chuan-Feng Chen Yong Sheng Zhao Yu-Wu Zhong Ben Zhong Tang Minghua Liu | 2021 | Science China Chemistry2021，64，12： | 3 |
| 12 | Gastrointestinal toxicities associated with immune checkpoint inhibitors: a disproportionality analysis leveraging VigiBase,the WHO Adverse Drug Reaction Database显示文摘With the improvement of people's living standards, gastrointestinal adverse reactions caused by various adverse factors have attracted more and more people's attention. A recent study has indicated that coronavirus disease 2019(COVID-19) could also invade the gastrointestinal tract, leading to gastrointestinal adverse reactions(Song et al., 2020). In recent years, immunotherapy has provided certain effects for some patients with advanced malignant tumors. | Sifu HUANG Xuefeng BAI Taiyong FANG Yanta GUO Kainan ZHENG Xiahong LIN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，2： | 3 |
| 13 | Proton irradiation effects on HVPE GaN显示文摘GaNs grown by hydride vapor phase epitaxy(HVPE) were irradiated by protons with different fluences.The changes of surface topography of as-grown and irradiated samples were characterized by atomic force microscopy(AFM).The crystal quality and optical properties of GaN films were examined by the variations of the micro-Raman and photoluminescence(PL) spectra with proton fluence.It was observed that the surface became a little more rough after irradiation.The Raman spectra indicated that the strain of materials and carrier concentration were not affected by the proton injection.The full-width at half-maximum(FWHM) of E 2 high phonon mode narrowed,which was consistent with the FWHM of PL near-band-edge emission(BE).The spectra of yellow luminescence and blue luminescence normalized to the intensity of BE demonstrated a little increase of Ga vacancy and a large decrease of O N,which may be the main reason for the change of optical properties. | LU Ling HAO Yue ZHENG XueFeng ZHANG JinCheng XU ShengRui LIN ZhiYu AI Shan MENG FanNa | 2012 | Science China(Technological Sciences)2012，55，9： | 2 |
| 14 | Estimation of carbon and nitrogen contents in citrus canopy by low-altitude remote sensing显示文摘The study aimed to investigate the fast and nondestructive method for detecting carbon and nitrogen content in citrus canopy.The multispectral imagery of Tarocco blood orange(Citrus sinensis L.Osbeck)plant canopy was obtained by a multispectral camera array mounted at an eight-rotor unmanned aerial vehicle(UAV)flying at an altitude of 100 m above the canopy in Wanzhou District of Chongqing Municipality,China.Average spectral reflectance data of the whole canopy,mature leaf areas and young leaves areas were extracted from the imagery.Two spectral pre-processing methods,multiplicative scatter correction(MSC)and standard normal variable(SNV),and two modeling methods,the partial least squares(PLS)and the least squares support vector machine(LS-SVM),were adopted and compared for their prediction accuracy of total content of nitrogen,soluble sugar and starch in the leaves.The results showed that,based on the spectral data extracted from the mature leaves in the multispectral imagery,the PLS model based on the original spectrum obtained a Rp(correlation coefficient)of 0.6469 and RMSEP(root mean squares error of prediction)of 0.1296,suggested that it was the best for the prediction of total nitrogen content;the PLS model based on MSC(multiplicative scatter correction)spectrum pre-processing was the best for predicting total soluble sugar content(Rp=0.6398 and RMSEP=8.8891);and the LS-SVM model based on MSC was the best for the starch content prediction(Rp=0.6822 and RMSEP=14.9303).The prediction accuracy for carbon and nitrogen contents based on the spectral data extracted from the whole canopy and the young leaves were lower than that from the mature leaves.The results indicate that it is feasible to estimate the carbon and nitrogen contents by low-altitude airborne multispectral images. | Liu Xuefeng Lyu Qiang He Shaolan Yi Shilai Hu Deyu Wang Zhitao Xie Rangjin Zheng Yongqiang Deng Lie | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 2 |
| 15 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 16 | Prevalence, Awareness, Treatment, and Control of Hypertension in Elderly Adults with Chronic Kidney Disease: Results from the Survey of Prevalence, Awareness, and Treatment Rates in Chronic Kidney Disease Patients with Hypertension in China显示文摘 | Guangyan Cai Ying Zheng Xuefeng Sun Xiangmei Chen | 2013 | J Am Geriatr Soc2013，，12： | 2 |
| 17 | Impact of switching frequencies on the TID response of SiC power MOSFETs显示文摘Different switching frequencies are required when SiC metal-oxide-semiconductor field-effect transistors(MOSFETs)are switching in a space environment.In this study,the total ionizing dose(TID)responses of SiC power MOSFETs are investigated under different switching frequencies from 1 kHz to 10 MHz.A significant shift was observed in the threshold voltage as the frequency increased,which resulted in premature failure of the drain-source breakdown voltage and drain-source leakage current.The degradation is attributed to the high activation and low recovery rates of traps at high frequencies.The results of this study suggest that a targeted TID irradiation test evaluation method can be developed according to the actual switching frequency of SiC power MOSFETs. | Sheng Yang Xiaowen Liang Jiangwei Cui Qiwen Zheng Jing Sun Mohan Liu Dang Zhang Haonan Feng Xuefeng Yu Chuanfeng Xiang Yudong Li Qi Guo | 2021 | Journal of Semiconductors2021，42，8： | 2 |
| 18 | Hypocoagulation induced by broadspectrum antibiotics in extensive burn patients显示文摘Background:Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred.We describe the case of an extensive burn adult suffering from hypocoagulation not related to sepsis,but secondary to antibiotic treatment.Case presentation:Here,we report a case of an adult male patient suffering from flame burns of 45%total body surface area(40%full thickness)combined with inhalation injury.Hypocoagulopathy with soaring prolonged activated partial thromboplastin time value occurred on third week post-burn while systemic infection had been under control by application of broad-spectrum antibiotics.Investigations showed that not the infection but vitamin K-related coagulation factor deficiency were responsible for unexpected bleeding.However,supplemental vitamin K was not the key as we expected,which prompted us trying to decode the underlying cause of coagulation disturbance in this patient and pick out the most effective treatment for live-saving.After the withdrawal of highly suspected broad-spectrum antibiotic,Meropenem^(■),disturbed vitamin K related coagulation factors gradually restored to their optimal levels so as to maintain normal coagulation status.Therefore,surgical procedures without further risk of bleeding could be carried out in time for wound recovery.The patient was discharged on post-burn day 67 and transferred to a secondary hospital for his rehabilitation.Conclusion:Hypocoagulopathy may be devoted to different reasons other than sepsis in extensive burns.Early recognition of the cause for coagulation disturbance is critical to make appropriate treatment and save patients’lives.This case illustrated the importance of unveiling the mist cause for coagulation disturbance occurred in extensive burn patient,which paved the way for optimal life-saving treatments.And we also recommend burn surgeons to be alerted to antibiotic-induced vitamin K deficiency-related coagulopathy among critical burn patients. | Jian Liu Yiqing Liu Shengjun Liu Qin Zhang Jiexin Zheng Yiwen Niu Xuefeng Wang | 2019 | Burns & Trauma2019，7，1： | 2 |
| 19 | Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis显示文摘Impairment of glucose(Glu)uptake and storage by skeletal muscle is a prime risk factor for the development of metabolic diseases.Heterogeneous nuclear ribonucleoprotein A1(hnRNP Al)is a highly abundant RNA-binding protein that has been implicated in diverse cellular functions.The aim of this study was to investigate the function of hnRNP A1 on muscle tissue insulin sensitivity and systemic Glu homeostasis.Our results showed that conditional deletion of hnRNP Al in the muscle gave rise to a severe insulin resistance phenotype in mice fed a high-fat diet(HFD).Conditional knockout mice fed a HFD showed exacerbated obesity,insulin resistance,and hepatic steatosis.In vitro interference of hnRNP Al in C2C12 myotubes impaired insulin signal transduction and inhibited Glu uptake,whereas hnRNP Al overexpression in C2C12 myotubes protected against insulin resistance induced by supraphysiological concentrations of insulin.The expression and stability of glycogen synthase(gysl)mRNA were also decreased in the absence of hnRNP A l.Mechanistically,hnRNP Al interacted with gys l and stabilized its mRNA,thereby promoting glycogen synthesis and maintaining the insulin sensitivity in muscle tissue.Taken together,our findings are the first to show that reduced expression of hnRNP Al in skeletal muscle affects the metabolic properties and systemic insulin sensitivity by inhibiting glycogen synthesis. | Mingxia Zhao Lihong Shen Zijun Ouyang Manru Li Guoliang Deng Chenxi Yang Wei Zheng Lingdong Kong Xuefeng Wu Xudong Wu Wenjie Guo Ye Yin Qiang Xu Yang Sun | 2020 | Journal of Molecular Cell Biology2020，12，4： | 2 |
| 20 | A transformer-based Siamese network and an open optical dataset for semantic change detection of remote sensing images显示文摘Recent change detection(CD)methods focus on the extraction of deep change semantic features.However,existing methods overlook the fine-grained features and have the poor ability to capture long-range space–time information,which leads to the micro changes missing and the edges of change types smoothing.In this paper,a potential transformer-based semantic change detection(SCD)model,Pyramid-SCDFormer is proposed,which precisely recognizes the small changes and fine edges details of the changes.The SCD model selectively merges different semantic tokens in multi-head self-attention block to obtain multiscale features,which is crucial for extraction information of remote sensing images(RSIs)with multiple changes from different scales.Moreover,we create a well-annotated SCD dataset,Landsat-SCD with unprecedented time series and change types in complex scenarios.Comparing with three Convolutional Neural Network-based,one attention-based,and two transformer-based networks,experimental results demonstrate that the Pyramid-SCDFormer stably outperforms the existing state-of-the-art CD models and obtains an improvement in MIoU/F1 of 1.11/0.76%,0.57/0.50%,and 8.75/8.59%on the LEVIR-CD,WHU_CD,and Landsat-SCD dataset respectively.For change classes proportion less than 1%,the proposed model improves the MIoU by 7.17–19.53%on Landsat-SCD dataset.The recognition performance for small-scale and fine edges of change types has greatly improved. | Panli Yuan Qingzhan Zhao Xingbiao Zhao Xuewen Wang Xuefeng Long Yuchen Zheng | 2022 | International Journal of Digital Earth2022，15，1： | 2 |
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