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| 1 | 长春市儿童医院1998~2001年婴幼儿杯状病毒腹泻流行病学研究显示文摘人类杯状病毒(humancalicivirus,HuCV)是引起儿童和成人非菌性胃肠炎的主要病原之一。为了掌握HuCV在我国的流行情况,1998年7月至2001年6月,从长春市儿童医院2343例5岁以下腹泻患儿中共收集粪便标本1264份,其中1056份来自2135例住院患儿。对轮状病毒检测为阴性的588份标本,经多价酶免疫试验(EIA)和两组引物反转录-聚合酶链反应(RT-PCR)检测HuCV,202份为阳性,其中住院患儿标本178份,HuCV检出率为16 9%。HuCV腹泻以2岁以下儿童为主(占96%),流行高峰季节为11月至次年3月。选择17株HuCV进行分子鉴定,15株属GⅡ 4群,1株属GⅡ 3群,另1株属GⅠ 2群,表明GⅡ 4群HuCV是我国流行的优势株。根据HuCV住院患儿的监测资料初步估计,HuCV腹泻住院率约为0 5‰~2 4‰。讨论了长春地区HuCV的流行趋势和疾病负担。以上结果为我国HuCV腹泻的预防和控制提供了科学依据。 | 谢华萍 方肇寅 王光 孙利炜 吕红霞 Zhong WM Tai JH 林思恩 童志礼 章青 Glass RI Jiang X | 2002 | 病毒学报2002，18，4： | 75 |
| 2 | Research on the dynamics of the South China Sea opening:Evidence from analogue modeling显示文摘Independent of Indochina extrusion, the South China Sea experienced a process from passive continental rifting to marginal sea drifting. According to the fault patterns in the Beibu Gulf basin and the Pearl River Mouth basin, the continental rifting and early spreading stage from 32 to 26 Ma were controlled by extensional stress field, which shifted clockwise from southeastward to south southeastward. From 24 Ma on, the sea spread in NW-SE direction and ceased spreading at around 15.5 Ma. Integrated geological information with the assumption that the South China Sea developed along a pre-Cenozoic weakness zone, we did analogue experiments on the South China Sea evolu- tion. Experiments revealed that the pre-existing weakness zone goes roughly along the uplift zone between the present Zhu-1 and Zhu-2 depression. The pre-existing weakness zone is composed of three segments trending NNE, roughly EW and NEE, respectively. The early opening of the South China Sea is accompanied with roughly 15° clockwise rotation, while the SE sub-sea basin opened with SE extension. Tinjar fault was the western boundary of the Nansha block (Dangerous Ground), while Lupar fault was the eastern boundary of the Indochina, NW-trending rift belt known as Zengmu basin developed between above two faults due to block divergent of Indochina from Nansha. In the experiment, transtensional flower structures along NW-trending faults are seen, and slight inversion occurs along some NE-dipping faults. The existence of rigid massifs changed the orientations of some faults and rift belt, and also led to deformation concentrate around the massifs. The rifting and drifting of the South China Sea might be caused by slab pull from the proto South China Sea subducting toward Borneo and/or mantle flow caused by India-Asia collision. | SUN Zhen1,2, ZHOU Di1, ZHONG Zhihong3, XIA Bin2, QIU Xuelin1, ZENG Zuoxun4 & JIANG Jianqun5 1. CAS Key Laboratory of Marginal Sea Geology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2. CAS Key Laboratory of Marginal Sea Geology, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China 3. Department of Technology, Shenzhen Branch of CNOOC, Guangzhou 510240, China 4. Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 5. Hainan Oil & Gas Exploration Company, Liaohe Oilfield PetroChina, Panjin 124010, China | 2006 | Science China Earth Sciences2006，49，10： | 45 |
| 3 | Induction of apoptosis by arsenic trioxide and hydroxycamptothecin in gastric cancer cells in vitro显示文摘AIM To study the effects of arsenic trioxide andHCPT on different degrees of differentiated gastriccancer cells(SGC-7901,MKN-45,MKN-28)withrespect to both cytotoxicity and induction ofapoptosis in vitro.METHODS The cytotoxicity of As2O3 and HCPTon gastric cancer cells was determined by MTTassay.Morphologic changes of apoptosis ofgastric cancer cells were observed by lightmicroscopy and transmission electron microscopy.Apoptosis and cell cycle changes of gastric cancercells induced by HCPT and As2O3 were investigatedby TUNEL method and flow cytometry.RESULTS As2O3 and HCPT had remarkablecytotoxic effects on different degrees ofdifferentiated gastric cancer cells.The IC50ofAs2O3 on well differentiated gastric cancer cellMKN-28,moderately differentiated gastric cancercell SGC-7901,and poorly differentiated gastriccancer cell MKN-28 were 8.91 μmol/L,10.57μmol/L,and 11.65 μmol/L,respectively.The IC50of HCPT on MKN-28,SGC-7901,and MKN-45 were9.35 mg/L,10.21 mg/L,and 12.63 mg/Lrespectively after 48 h treatment.After 12 h ofexposure to both drugs,gastric cancer cellsexhibited morphologic features of apoptosis,including cell shrinkage,nuclear condensation, and formation of apoptotic bodies.A typicalsubdiploid peak before G0/G1 phase was observedby flow cytometry.The apoptotic rates of SGC-7901,MKN-45,and MKN-28 were 13.84%,22.52%,and 9.68%,respectively after 48 hexposure to 10 μmol/L As2O3.The apoptotic ratesof SGC-7901,MKN-45,and MKN-28 were 21.88%,12.35%,and 30.26%,respectively after 48 hexposure to 10 mg/L HCPT.The apoptotic indicewere 7%-15% as assessed by TUNEL method.The effect of As2O3 on SGC-7901 showedremarkable cell cycle specificity,which inducedcell death in G1 phase,and blocked G2/M phase.HCPT also showed a remarkable cell cyclespecificity,by inducing cell death and apoptosis inG1 phase and arrest of proliferation at S phase.CONCLUSION As2O3 and HCPT exhibitsignificant cytotoxicity on gastric cancer cells byinduction of apoptosis.As2O3 and HCPT mighthave a promising prospect in the treatment ofgastric cancer,which needs to be further studied. | Tu SP Zhong J Tan JH Jiang XH Qiao MM Wu YX Jiang SH | 2000 | World Journal of Gastroenterology2000，6，4： | 43 |
| 4 | 河北省卢龙县1999~2001年婴幼儿杯状病毒腹泻流行病学研究显示文摘目的 研究河北省卢龙县 5岁以下婴幼儿杯状病毒腹泻的流行特点。方法 应用酶联免疫吸附试验 (ELISA)和逆转录 聚合酶链反应 (RT PCR)方法检测人类杯状病毒 (HuCVs)。部分阳性标本的PCR产物经克隆测序 ,结合参考毒株相应的核苷酸序列进行进化分析。利用住院腹泻患者粪便样本中HuCVs的检出率 ,估计HuCVs腹泻住院率。结果 HuCVs检出率为 31.6 % ,住院患者HuCVs阳性率为 17.5 % ,主要分布在 3~ 17月龄婴幼儿 ,发病主要集中在冬季。 11株测序病毒之间的核苷酸序列同源性为 5 5 .1%~ 10 0 % ,均属于诺瓦克病毒 (NLV)GⅡ遗传组。卢龙县 2 0 0 0年HuCVs流行株为NLVGⅡ 4和GⅡ 7,2 0 0 1年为NLVGⅡ 3和GⅡ 7。初步估计HuCVs腹泻患者住院率为 3.6‰。结论 河北省卢龙县婴幼儿中存在不同基因型杯状病毒感染 ,以NLVGⅡ组毒株为主 ,其疾病负担仅次于轮状病毒。 | 吕红霞 方肇寅 谢华萍 唐景裕 胡海宽 郑丽舒 叶青 章青 ZHONG Wei-min JIANG Xi | 2003 | 中华流行病学杂志2003，24，12： | 47 |
| 5 | Colorectal cancer in Guangdong Province of China:A demographic and anatomic survey显示文摘AIM:To determine the basic demographic features of colorectal cancer (CRC) in five hospitals located in four different areas of Guangdong Province,China.METHODS:A review of patient records from 1986 to 2006 from five hospitals was conducted. Patient data was obtained,including age,gender,location of le-sions,staging and histological type of CRC. The Chi-square test was used to assess differences in rates and a significance level of 0.05 was used. Univariate com-parisons were made via Fisher's exact tests.RESULTS:Analysis was carried out on 8172 CRC patents,6.1% (499/8172) of the patients were aged ≤ 30 years. The peak incidence was between the ages 61-70 years (27.8%). The mean age at CRC diagnosis increased from 52 years (1986-1988) to 60 years(2004-2006) and the proportion of young CRC patients decreased from 8.0% to 5.9% over the same period. Of 8172 lesions,4434 (54.3%) were located in rectum and 3738 (45.7%) in colon. The incidence of rectal cancer decreased significantly from 59.4% (1989-1991) to 51.8% (2004-2006) and right sided colon cancer increased from 40.6% to 48.2%. The mean age,ana-tomic distribution,histological type and differentiation degree were significantly different among the four geographical areas (P < 0.05).CONCLUSION:The hospitalization rate for CRC has increased in Guangdong in recent years. The characteristics of CRC from the five hospitals located in the four different areas of Guangdong Province are also different. Further studies are needed to assess more recent trend in the incidence and prevalence of CRC as well as the respective roles of genetic and environ-mental factors in CRC. | Xu, An-Gao Yu, Zhi-Jin Jiang, Bo Wang, Xin-Ying Zhong, Xu-Hui Liu, Ji-Hong Lou, Qiu-Yun Gan, Ai-Hua | 2010 | World Journal of Gastroenterology2010，16，8： | 40 |
| 6 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 7 | Intelligent and connected vehicles: Current status and future perspectives显示文摘Intelligent connected vehicles(ICVs) are believed to change people's life in the near future by making the transportation safer,cleaner and more comfortable. Although many prototypes of ICVs have been developed to prove the concept of autonomous driving and the feasibility of improving traffic efficiency, there still exists a significant gap before achieving mass production of high-level ICVs. The objective of this study is to present an overview of both the state of the art and future perspectives of key technologies that are needed for future ICVs. It is a challenging task to review all related works and predict their future perspectives, especially for such a complex and interdisciplinary area of research. This article is organized to overview the ICV key technologies by answering three questions: what are the milestones in the history of ICVs; what are the electronic components needed for building an ICV platform; and what are the essential algorithms to enable intelligent driving? To answer the first question, the article has reviewed the history and the development milestones of ICVs. For the second question, the recent technology advances in electrical/electronic architecture, sensors, and actuators are presented. For the third question, the article focuses on the algorithms in decision making, as the perception and control algorithm are covered in the development of sensors and actuators. To achieve correct decision-making, there exist two different approaches: the principle-based approach and data-driven approach. The advantages and limitations of both approaches are explained and analyzed. Currently automotive engineers are concerned more with the vehicle platform technology, whereas the academic researchers prefer to focus on theoretical algorithms. However, only by incorporating elements from both worlds can we accelerate the production of high-level ICVs. | YANG DianGe JIANG Kun ZHAO Ding YU ChunLei CAO Zhong XIE ShiChao XIAO ZhongYang JIAO XinYu WANG SiJia ZHANG Kai | 2018 | Science China(Technological Sciences)2018，61，10： | 31 |
| 8 | Effect of Helicobacter pylori infection on gastric epithelial proliferation in progression from normal mucosa to gastric carcinoma显示文摘EfectofHelicobacterpyloriinfectionongastricepithelialproliferationinprogressionfromnormalmucosatogastriccarcinomaLIUWenZhon... | LIU Wen Zhong, ZHENG Xiong, SHI Yao, DONG Quan Jiang and XIAO Shu Dong | 1998 | World Journal of Gastroenterology1998，4，3： | 30 |
| 9 | The role of autophagy in cardiac hypertrophy显示文摘Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃, degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis,增加的 cardiomyocyte 尺寸,和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里, cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而,在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论,我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并且在心脏的肥大的 thedevelopment 提供卓见进 autophagy 的角色。我们断定未来研究应该强调在 autophagy andthe 之间的关系心脏的肥大的不同阶段,以及 autophagic 流动和选择 autophagy。Autophagy 将是为心脏的肥大的一个 potentialtherapeutic 目标。 | Lanfang Li Jin Xu Lu He Lijun Peng Qiaoqing Zhong Linxi Chen Zhisheng Jiang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 30 |
| 10 | Effect of Surface Mechanical Attrition Treatment on Corrosion Behavior of 316 Stainless Steel显示文摘The nanocrystalline microstructure of the surface of 316 stainless steel (316SS) induced by surface mechanical attrition treatment (SMAT) was determined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The technique of hydrogen embrittlement was first used to obtain the information of the brittleness cleavage plane. The effects of SMAT and the following annealing process on the corrosion behavior of 316SS were investigated by potentiodynamic polarization curves and potentiostatic critical pitting temperature measurements. The results demonstrated that the nanocrystalline layer with an average grain size of 19 nm was produced. However, there were lots of cracks on the surface, which led to the degradation in the corrosion resistance of 316SS after SMAT. Nevertheless, after annealing treatment, the corrosion resistance of the nanocrystalline surface had been improved greatly. The higher the annealing temperature, the better was the corrosion resistance. | HAO Yun-wei DENG Bo ZHONG Cheng JIANG Yi-ming LI Jin | 2009 | Journal of Iron and Steel Research(International)2009，16，2： | 26 |
| 11 | A Simple and Rapid Colloidal Gold-based Immunochromatogarpic Strip Test for Detection of FMDV Serotype A显示文摘A sandwich format immunochromatographic assay for detecting foot-and-mouth disease virus (FMDV) serotypes was developed. In this rapid test,affinity purified polyclonal antibodies from Guinea pigs which were immunized with sucking-mouse adapted FMD virus (A/AV88(L) strain) were conjugated to colloidal gold beads and used as the capture antibody,and affinity purified polyclonal antibodies from rabbits which were immunized with cell-culture adapted FMD virus (A/CHA/09 strain) were used as detector antibody. On the nitrocellulose membrane of the immunochromatographic strip,the capture antibody was laid on a sample pad,the detector antibody was printed at the test line(T) and goat anti-guinea pigs IgG antibodies were immobilized to the control line(C). The lower detection limit of the test for a FMDV 146S antigen is 11.7ng/ml as determined in serial tests after the strip device was assembled and the assay condition optimization. No cross reactions were found with FMDV serotype C,Swine vesicular disease (SVD),Vesicular stomatiti svirus (VSV) and vesicular exanthema of swine virus (VES) viral antigens with this rapid test. Clinically,the diagnostic sensitivity of this test for FMDV serotypes A was 88.7% which is as same as an indirect-sandwich ELISA. The specificity of this strip test was 98.2% and is comparable to the 98.7% obtained with indirect-sandwich ELISA. This rapid strip test is simple,easy and fast for clinical testing on field sites; no special instruments and skills are required,and the result can be obtained within 15 min. To our knowledge,this is the first rapid immunochromatogarpic assay for serotype A of FMDV. | Tao Jiang Zhong Liang Wei-wei Ren Juan Chen Xiao-ying Zhi Guang-yu Qi Xiang-tao Liu Xue-peng Cai | 2011 | Virologica Sinica2011，26，1： | 22 |
| 12 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 13 | Association of hTcf-4 gene expression and mutation with clinicopathological characteristics of hepatocellular carcinoma显示文摘AIM: Hepatocellular carcinoma(HCC) is a significant healthproblem in China. But the molecular mechanisms of HCCremains unclear. APC/β-Catenin/Tcf signaling pathway, alsoknown as Wnt pathway, plays a critical role in thedevelopment and oncogenesis. As little is known about thealteration of human T-cell transcription factor-4 (hTcf-4) genein HCC, it is of interest to study the expression and mutationof hTcf-4 gene in HCC and the relationship between hTcf-4gene and progression of HCC.METHODS: Reverse transcription-polymerase chain reaction(RT-PCR) method was used to detect the expression of hTcf-4 mRNA in 32 HCC and para-cancerous tissues and 5 normalliver tissues. PCR-single strand conformation polymorphism(PCR-SSCP) method was used to detect the mutation ofhTcf-4 exons 1, 4, 9 and 15 in HCC. The correlation ofexpression and mutation of the hTcf-4 gene withclinicopathological characteristics of HCC was also analyzed.RESULTS: RT-PCR showed that the expression rate of hTcf-4 mRNA in HCC, para-cancerous tissues and normal livertissues was 90.6 %, 71.9 % and 80 %, respectively. Thegene expression level in tumor was 0.71±0.13, much higherthan that in para-cancerous liver 0.29±0.05 and normal liver0.26±0.05 (P<0.001), although there was no significantdifference in gene expression level between para-canceroustissues and normal liver (P>0.05). Furthermore, hTcf-4 geneexpression was closely associated with tumor capsule statusand intrahepatic metastasis of HCC. On SSCP, 2 of 32 casesof HCC (6.25 %) displayed characteristic mutational mobilityshifts in exon 15 of the hTcf-4 gene. No abnormal shiftingbands were observed in para-cancerous tissues.CONCLUSION: The high expression level of hTcf-4 in HCC,especially in tumors with metastasis, suggests that the over-expression of hTcf-4 gene may be closely associated withdevelopment and progression of HCC, but the mutation ofthis gene seemed to play less important role in this respect. | Ying Jiang Xin-Da Zhou Yin-Kun Liu Xin Wu Xiao-Wu Huang Liver Cancer Institute,Zhong Shah Hospital,Fudan University,Shanghai 200032,China | 2002 | World Journal of Gastroenterology2002，8，5： | 23 |
| 14 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 15 | β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling显示文摘β-Sitosterol(24-ethyl-5-cholestene-3-ol)is a common phytosterol Chinese medical plants that has been shown to possess antioxidant and anti-inflammatory activity.In this study we investigated the effects ofβ-sitosterol on influenza virus-induced inflammation and acute lung injury and the molecular mechanisms.We demonstrate thatβ-sitosterol(150–450μg/mL)dosedependently suppresses inflammatory response through NF-κB and p38 mitogen-activated protein kinase(MAPK)signaling in influenza A virus(IAV)-infected cells,which was accompanied by decreased induction of interferons(IFNs)(including Type I and III IFN).Furthermore,we revealed that the anti-inflammatory effect ofβ-sitosterol resulted from its inhibitory effect on retinoic acidinducible gene I(RIG-I)signaling,led to decreased STAT1 signaling,thus affecting the transcriptional activity of ISGF3(interferonstimulated gene factor 3)complexes and resulting in abrogation of the IAV-induced proinflammatory amplification effect in IFNsensitized cells.Moreover,β-sitosterol treatment attenuated RIG-I-mediated apoptotic injury of alveolar epithelial cells(AEC)via downregulation of pro-apoptotic factors.In a mouse model of influenza,pre-administration ofβ-sitosterol(50,200 mg·kg−1·d−1,i.g.,for 2 days)dose-dependently ameliorated IAV-mediated recruitment of pathogenic cytotoxic T cells and immune dysregulation.In addition,pre-administration ofβ-sitosterol protected mice from lethal IAV infection.Our data suggest thatβ-sitosterol blocks the immune response mediated by RIG-I signaling and deleterious IFN production,providing a potential benefit for the treatment of influenza. | Bei-xian Zhou Jing Li Xiao-li Liang Xi-ping Pan Yan-bing Hao Pei-fang Xie Hai-ming Jiang Zi-feng Yang Nan-shan Zhong | 2020 | Acta Pharmacologica Sinica2020，41，9： | 20 |
| 16 | Endothelial Nitric Oxide Synthase Gene Intron 4, 27 bp Repeat Polymorphism and Essential Hypertension in the Kazakh Chinese Population显示文摘为了调查在 27 bp 之间的关系,在内含子 4in 重复多型性 endothelial 在 KazakhChinese 人口的氮的氧化物合酶( eNOS4 )基因和必要高血压,有必要高血压和 138 个健康的人的 151 个病人在 Xinjiang uygur 从 Shawan 区域的 Boertonggu 农村被选择中国 in2006 的自治区域。在二个组的 eNOS 的多型性与聚合酶链反应试金被检测,在每个组的遗传型频率是计算的跟随 Hardy-Weinberg 法律。Fourand 27 bp 重复的五辆双人脚踏车是被指明一 and “ b' 分别地。b/b, b/a 和 eNOS4 基因的 a/a 遗传型的频率在控制组是 84.06% , 15.22% 和 0.72% ,这被发现,并且 81.46% , 15.89% 和 2.65% 分别地在高血压组织。基因的频率一 and “ b' 在控制组是 91.67% 和 8.33% , 89.40% 和 10.60% 分别地在高血压组织。血浆 eNOS 活动没与 eNOS 基因的遗传型和等位基因被联系,这被发现。在高血压组的血浆 eNOS 活动显著地与控制组(P<0.01 ) 相比被减少。结果建议 eNOS4 基因多型性是不大可能的是为在 Xinjiang 哈萨克人口的必要高血压的主要基因危险性因素。然而,在血浆 eNOS 活动之间的一个积极协会和必要高血压被揭示了。 | Fengmei DENG Qinghua HU Bin TANG Fang HE Shuxia GUO Jiang CHEN Feng LI Xuehua WU Jun ZHANG Huimin ZHANG Juan ZHAO Hua ZHONG Ling HE Jun LI Le ZHANG Shuren WANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，5： | 18 |
| 17 | Surgical strategies for glioma involving language areas显示文摘gliomas 在的背景成功的处理或邻近语言区域组成主要挑战到神经外科。现在的学习被执行评估经由 intraoperative 印射直接外皮的电的刺激在下面的语言的过程当表现在 resective glioma surgery.Methods 以前时,唤醒麻醉有 gliomas 和左半球的优势的三十个病人并且,经历了经由 intraoperative 印射直接外皮的电的刺激在下面的语言在 resective glioma 外科前唤醒麻醉,回顾地被分析。所有病人有肿瘤在或邻近外皮的语言区域。大脑损害与语言功能的区域的保藏根据解剖功能的边界被移开。外科手术前、手术后的功能的调查结果是 evaluated.Results Intraoperative 语言区域在 20 个病人然而并非在四个病人被检测。为对麻醉或到 intracranial 压力的 intraoperative 增加可归因的原因印射失败的语言在在六月后续以后与中等或严重的语言赤字介绍的六个 cases.Seven 病人发生了。全部的切除术在四 cases.Conclusions Intraoperative 外皮的电的刺激在 14 种情况,在 12 种情况中的近总数的切除术和小计切除术中被完成是语言外皮的鉴定的一条精确、安全的途径。唤醒颅骨切开术 intraoperative 外皮的电的刺激,在有 presurgical 的联合识别肿瘤切除术的解剖功能的边界的神经病学的功能的成像,当保存正常语言功能并且最小化手术后的语言赤字的风险时,允许广泛的肿瘤切除。 | ZHANG Zhong JIANG Tao XIE Jian LIU Fu-sheng LI Shou-wei QIAO Hui WANG Zhong-cheng | 2008 | Chinese Medical Journal2008，，18： | 18 |
| 18 | A Novel 3D Non-Stationary UAV-MIMO Channel Model and Its Statistical Properties显示文摘The wireless communication systems based on Unmanned Aerial Vehicles(UAVs) have found a wide range of applications recently. In this paper, we propose a new three-dimensional(3 D) non-stationary multiple-input multiple-output(MIMO) channel model for the communication links between the UAV and mobile terminal(MT). The new model originates the traditional geometry-based stochastic models(GBSMs) but considers the non-stationary propagation environment due to the rapid movements of the UAV, MT, and clusters. Meanwhile, the upgrade time evolving algorithms of time-variant channel parameters, i.e., the path number based on birth-death processes of clusters, path delays, path powers, and angles of arrival and departure, are developed and optimized. In addition, the statistical properties of proposed GBSM including autocorrelation function(ACF), cross-correlation function(CCF), and Doppler power spectrum density(DPSD) are investigated and analyzed. Simulation results demonstrate that our proposed model provides a good agreement on the statistical properties with the corresponding derived theoretical ones, which indicates its usefulness for the performance evaluation and validation of the UAV based communication systems. | Qiuming Zhu Kaili Jiang Xiaomin Chen Weizhi Zhong Ying Yang | 2018 | China Communications2018，15，12： | 18 |
| 19 | A drug-eluting Balloon for the trEatment of coronarY bifurcatiON lesions in the side branch:a prospective multicenter ranDomized (BEYOND)clinical trial in China显示文摘Background:Treatment of coronary bifurcation lesions remains challenging;a simple strategy has been preferred as of late,but the disadvantage is ostium stenosis or even occlusion of the side branch(SB).Only a few single-center studies investigating the combination of a drug-eluting stent in the main branch followed by a drug-eluting balloon in the SB have been reported.This prospective,multicenter,randomized study aimed to investigate the safety and efficacy of a paclitaxel-eluting balloon(PEB)compared with regular balloon angioplasty(BA)in the treatment of non-left main coronary artery bifurcation lesions.Methods:Between December 2014 and November 2015,a total of 222 consecutive patients with bifurcation lesions were enrolled in this study at ten Chinese centers.Patients were randomly allocated at a 1:1 ratio to a PEB group(n=113)and a BA group(n=109).The primary efficacy endpoint was angiographic target lesion stenosis at 9 months.Secondary efficacy and safety endpoints included target lesion revascularization,target vessel revascularization,target lesion failure,major adverse cardiac and cerebral events(MACCEs),all-cause death,cardiac death,non-fatal myocardial infarction,and thrombosis in target lesions.The main analyses performed in this clinical trial included case shedding analysis,base-value equilibrium analysis,effectiveness analysis,and safety analysis.SAS version 9.4 was used for the statistical analyses.Results:At the 9-month angiographic follow-up,the difference in the primary efficacy endpoint of target lesion stenosis between the PEB(28.7%±18.7%)and BA groups(40.0%±19.0%)was-11.3%(95%confidence interval:-16.3%to-6.3%,Psuperiority<0.0001)in the intention-to-treat analysis,and similar results were recorded in the per-protocol analysis,demonstrating the superiority of PEB to BA.Late lumen loss was significantly lower in the PEB group than in the BA group(-0.06±0.32 vs.0.18±0.34 mm,P<0.0001).For intention-to-treat,there were no significant differences between PEB and BA in the 9-month percentages of MACCEs(0.9%vs.3.7%,P=0.16)or non-fatal myocardial infarctions(0 vs.0.9%,P=0.49).There were no clinical events of target lesion revascularization,target vessel revascularization,target lesion failure,all-cause death,cardiac death or target lesion thrombosis in either group.Conclusions:In de novo non-left main coronary artery bifurcations treated with provisional T stenting,SB dilation with the PEB group demonstrated better angiographic results than treatment with regular BA at the 9-month follow-up in terms of reduced target lesion stenosis.Trial registration:ClinicalTrials.gov,NCT02325817;http://gffzzd3f38a9638994581svvxpouufoufb6vcb.ffgz.tsg.suse.edu.cn. | Quan-Min Jing Xin Zhao Ya-Ling Han Ling-Ling Gao Yang Zheng Zhan-Quan Li Ping Yang Hong-Liang Cong Chuan-Yu Gao Tie-Min Jiang Hui Li Jun-Xia Li Dong-Mei Wang Geng Wang Zhan-Chun Cong Zhong Zhang | 2020 | Chinese Medical Journal2020，，8： | 17 |
| 20 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
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