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| 1 | The Interaction of Population,Industry and Land in Process of Urbanization in China:A Case Study in Jilin Province显示文摘Urbanization is a complex process that covers a wide range of topics, of which population, industry and land urbanization are three important aspects. Jilin Province is an important agricultural province in China. The contradiction between population, industry and land urbanization is especially prominent here, and its coupling development is of great practical significance. In this paper, the coupling degree of population-industry-land urbanization in Jilin Province in 1990, 2000 and 2010 is measured by coupling mode. The spatial pattern of the coupling degree is analyzed by trend surface analysis and global and local spatial autocorrelation. The influence factors and their spatial differentiation are discussed using multiple linear regression(MLR) model and geographic weighted regression(GWR) model. The results show that: 1) the coupling degree of population-industry-land urbanization in Jilin Province is at a low level. Judging from the change of time scale, the urbanization of most research units is becoming more and more coordinated. From the comparison of spatial scales, there is significant spatial difference in the research units of different administrative levels. 2) Judging from the global change trend, the coupling degree of population-industry-land urbanization in the central region is higher than that in western and eastern regions. The coordination of urbanization in the central region is relatively good, and the distribution of the cold and hot spots is basically the same as that overall. 3) The spatial pattern of the coupling degree is related to the cold and hot spot distribution of the influence coefficient of urban population density and per capita urban construction land. The variation of the coupling degree spatial pattern is synchronous with the spatial change of the urban population density influence coefficient. 4) The degree of agglomeration of the urban population is the main factor promoting the coupling pattern of population-industry-land urbanization in Jilin Province, and the extent of its influence is gradually increasing. In addition, the level of city administrative, the efficiency of urban expansion and the capacity of market consumption also have an important influence on the coupling pattern. | LIU Yanjun ZHOU Guolei LIU Degang YU Huisheng ZHU Liyuan ZHANG Jing | 2018 | Chinese Geographical Science2018，28，3： | 12 |
| 2 | Study on reservoir operation optimization of Ertan Hydropower Station considering GFS forecasted precipitation显示文摘The medium-term runoff forecasting provided new information for forecast of medium and long term runoff and optimal hydroelectric power generation.According to the actual runoff and hydropower generating characteristics of Ertan Hydropower Station,we studied the decade runoff quantitatively and grade forecast model based on Global Forecasting System(GFS) precipitation forecast information in wet season,then used the posteriori runoff transition probability and measurable probability of runoff forecast to research the uncertain runoff description based on runoff forecast;finally on the basis of the runoff description and the grading forecast accuracy of GFS-based next 10 days'total forecast precipitation,we studied the uncertain optimal operating model of Ertan Hydropower Station considering runoff forecast.The results showed that the runoff forecast considering GFS forecast precipitation and uncertainty has significantly improved the existing runoff description and operating optimization model,and obviously raised the hydropower generation efficiency of Ertan Reservoir. | PENG Yong 1,WANG GuoLi 1,TANG GuoLei 1,ZHOU HuiCheng 1,WANG YaJun 2 & JIAN DePing 2 1 Institute of Water Resources and Flood Control,Dalian University of Technology,Dalian 116023,China 2 Ertan Hydropower Development Co.,Ltd.,Chengdu 610021,China | 2011 | Science China(Technological Sciences)2011，54，S1： | 8 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Process-scheme-driven automatic construction of NC machining cell for aircraft structural parts显示文摘In order to enhance the NC programming effciency and quality of aircraft structural parts(ASPs),an intelligent NC programming pattern driven by process schemes is presented.In this pattern,the NC machining cell is the minimal organizational structure in the technological process,consisting of an operation machining volume cell,and the type and parameters of the machining operation.After the machining cell construction,the fnal NC program can be easily obtained in a CAD/CAM system by instantiating the machining operation for each machining cell.Accordingly,how to automatically establish the machining cells is a key issue in intelligent NC programming.On the basis of the NC machining craft of ASP,the paper aims to make an in-depth research on this issue.Firstly,some new terms about the residual volume and the machinable volume are defned,and then,the technological process is modeled with a process scheme.Secondly,the approach to building the machining cells is introduced,in which real-time complement machining is mainly considered to avoid interference and overcutting.Thirdly,the implementing algorithm is designed and applied to the Intelligent NC Programming System of ASP.Finally,the developed algorithm is validated through two case studies. | Chen Shulin Zheng Guolei Zhou Min Du Baorui Chu Hongzhen | 2013 | Chinese Journal of Aeronautics2013，26，5： | 4 |
| 5 | Influential Intensity of Urban Agglomeration on Evolution of Ecoenvironmental Pressure:A Case Study of Changchun,China显示文摘In this paper,we study the interactive relationship between the agglomeration of urban elements and the evolution of eco-environmental pressure.We build an index system for evaluating the agglomeration of urban elements and eco-environmental pressure.Using the entropy method and response intensity model,we analyze how urban elements agglomeration influenced eco-environmental pressure in Changchun from 1990 to 2012,eliciting the changing features and influential factors.Ultimately,we conclude there is a significant interactive relationship between the agglomeration of urban elements and the evolution of eco-environmental pressure in Changchun.This is inferred from the degree of this agglomeration in Changchun having increased since 1990,with the degree of eco-environmental pressure first decreasing and then increasing.Alongside this,the impact of urban elements agglomeration on eco-environmental pressure has changed from negative to positive.The main reasons behind this shift are arguably the rapid growth of urban investment and ongoing urbanization. | LIU Yanjun ZHANG Jing LI Chenggu ZHOU Guolei FU Zhanhui LIU Degang | 2017 | Chinese Geographical Science2017，27，4： | 2 |
| 6 | FBXL19-AS1 promotes cell proliferation and inhibits cell apoptosis via miR-876-5p/FOXM1 axis in breast cancer显示文摘As the most common cancer and one of the leading causes of cancer-associated mortality,breast cancer continues to need more key molecules to regulate its progression.F-box and leucine-rich repeat protein 19 antisense RNA 1(known as FBXL19-AS1)is a long non-coding RNA(lncRNA)which has been reported as an oncogene in several types of human cancers.However,the specific downstream targets of FBXL19-AS1 remain unknown.In this study,we set out to find more reliable downstream molecules of FBXL19-AS1 in breast cancer.FBXL19-AS1 was expressed at a high level in breast cancer cells.Loss-of-function experiments revealed that silencing FBXL19-AS1 could impair cell proliferation and induce cell apoptosis in breast cancer.In addition,the location of FBXL19-AS1 in the cytoplasm was detected by fluorescent in situ hybridization assay,while FBXL19-AS1 regulated the expression of Forkhead box M1(FOXM1)by directly absorbing miR-876-5p.Through rescue assays,it was observed that FOXM1 overexpression recovered the inhibited tumor growth caused by FBXL19-AS1 downregulation.We affirmed the function of FBXL19-AS1 in breast cancer and described the mechanism of the FBXL19-AS1/miR-876-5p/FOXM1 axis.The current work presents the molecular mechanism which underlies FBXL19-AS1 in breast cancer and suggests a comprehensive,feasible FBXL19-AS1-mediated therapeutic approach for treating breast cancer. | Guolei Dong Teng Pan Dongdong Zhou Chunyan Li Jingjing Liu Jin Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 1 |
| 7 | Matching of Residential and Commercial Space in Shrinking Cities from the Perspective of Supply and Demand:A Case Study of Yichun City,China显示文摘Urban shrinkage is becoming an increasingly common phenomenon in China.The research focus has been the identification,origin,and pattern of shrinking cities.Nevertheless,attention has also been paid to the problems associated with urban shrinkage.The present study examines one typical shrinking city in China,specifically the Yichun District in Yichun City.To explore the matching relationship between residential and commercial spaces,this study analyzes supply and demand data,electricity consumption data and multi-source points of interest(POI)of residents.The results showed that the occupancy rate is not reduced in the context of urban shrinkage,and that the supply level of various commercial facilities is not in decline.Apart from leisure and entertainment facilities,the supply levels of catering,shopping and supporting facilities for life were noted to have improved.In reference to urban shrinkage,the matching relationship between residential and commercial space in the 5-min,10-min,and 15-min living circles mainly shifted to a highlevel equilibrium.The matching relationships between residential space and different types of commercial spaces change in both direction and magnitude.From the perspective of supply and demand,the spatial and temporal changes in the relationship relate to multiple factors,such as the level of economic development,the buiding age pattern,public transportation accessibility,aging,and residents’willingness to move.This study provides relevant data for managing urban shrinkage.It also helps improve the relationships between residential and commercial spaces and works to optimize the layout and structure of functional urban spaces. | ZHANG Yining ZHOU Guolei LIU Yanjun FU Hui SUN Hongri | 2022 | Chinese Geographical Science2022，32，3： | 0 |
| 8 | Enhancing alkyne semi-hydrogenation through engineering metal-support interactions of Pd on oxides显示文摘Supported Pd catalysts show superior activities for olefin productions from alkynes through semi-hydrogenation reactions,but over-hydrogenation into alkanes highly decreases olefin selectivity.Using phenylacetylene semi-hydrogenation as a model reaction,here we explore the optimization approaches toward better Pd catalysts for alkyne semi-hydrogenation through investigating support effect and metal-support interactions.The results show that the states of Pd with supports can be tuned by varying oxide reducibility,loading ratios,and post-treatments.In our system,0.06 wt.%Pd on rutile-TiO_(2) nanorods shows the highest activity owing to the synergistic effects of single-atoms and clusters.Support reducibility can change the filling degrees of Pd 4d orbitals through varying interfacial bonding strengths,which further affect catalytic activity and selectivity. | Yuefeng Wu Xiaotong Lu Pengfei Cui Wenyu Jia Jun Zhou Yuan Wang Hussain Zahid Yuxin Wu Muhammad Umer Rafique Xiong Yin Baoshan Li Leyu Wang Guolei Xiang | 2024 | Nano Research2024，17，5： | 0 |
| 9 | Housing vacancy identification in shrinking cities based on multi-source data:A case study of Fushun city in Northeast China显示文摘Urban shrinkage has attracted the attention of many geographers and urban planners in recent years.However,there are fewer studies on vacant housing in shrinking cities.Therefore,this study combines multi-source remote sensing images and urban building data to assess the spatiotemporal variation patterns of housing vacancy in a typical shrinking city in China.The following points were obtained:(1)We developed an evaluation model to identify vacant residential buildings in shrinking cities by removing the contribution of nighttime lights from roads and non-residential buildings;(2)The residential building vacancy rate in Fushun city significantly increased from 2013 to 2020,resulting in a significant high-value clustering effect.The impact of urban shrinkage on vacant residential buildings was higher than that on vacant non-residential buildings;(3)The World Pop population data demonstrated consistent spatial distribution and trend of population change in Fushun with the residential building vacancy rate results,suggesting good reliability of the constructed evaluation model in this study.Identifying housing vacancies can help the local government to raise awareness of the housing vacancy problem in shrinking cities and to propose reasonable renewal strategies. | SUN Hongri ZHOU Guolei LIU Yanjun FU Hui JIN Yu | 2024 | Journal of Geographical Sciences2024，34，1： | 0 |
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