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| 1 | Relationship between intestinal microbiota and ulcerative colitis:Mechanisms and clinical application of probiotics and fecal microbiota transplantation显示文摘Ulcerative colitis(UC) is an inflammatory disease that mainly affects the colon and rectum. It is believed that genetic factors, host immune system disorders, intestinal microbiota dysbiosis, and environmental factors contribute to the pathogenesis of UC. however, studies on the role of intestinal microbiota in the pathogenesis of UC have been inconclusive. Studies have shown that probiotics improve intestinal mucosa barrier function and immune system function and promote secretion of anti-inflammatory factors, thereby inhibiting the growth of harmful bacteria in the intestine. Fecal microbiota transplantation(FMT) can reduce bowel permeability and thus the severity of disease by increasing the production of short-chain fatty acids, especially butyrate, which help maintain the integrity of the epithelial barrier. FMT can also restore immune dysbiosis by inhibiting Th1 differentiation, activity of T cells, leukocyte adhesion, and production of inflammatory factors. Probiotics and FMT are being increasingly used to treat UC, but their use is controversial because of uncertain efficacy. Here, we briefly review the role of intestinal microbiota in thepathogenesis and treatment of UC. | Zhao-hua Shen Chang-xin Zhu Yong-sheng Quan Zhen-yu Yang Shuai Wu Wei-wei Luo Bei Tan Xiao-yan Wang | 2018 | World Journal of Gastroenterology2018，24，1： | 111 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 3 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 4 | Geomorphologic evidence of phased uplift of the northeastern Qinghai-Tibet Plateau since 14 million years ago显示文摘A typical sequence of fluvial terraces and aeolian deposits overlying these terraces were multidisciplinary investigated. New evidences for uplift process of the northeastern Qinghai-Tibetan Plateau in the past 14 million years were obtained. At least 11 river terraces along Huangshui, the first-class tributary of Yellow River, at the Xining-Huzhu region are identified. While the first one (T1) is classified as an accumulation terrace, the others are all basement river terraces, which consist of the Tertiary sandstone and siltstone bedrock, fluvial gravel and pebbles and the overlying aeolian loess-Red Clay deposit. Samples from the aeolian deposits were examined for paleomagnetic stratigraphic reconstruction (1030 samples), luminescence dating (16 samples), magnetic susceptibility and grain-size distribution (more than 4000 samples). The luminescence dating and stratigraphic correlation suggest that terraces of T11, T10,T8, T7, T3, T2, T1 were formed at 14, 11.3, 1.55, 1.2, 0.15, 0.07 and 0.01 million years ago, respectively. Sedimentological analysis and geomorphological observation indicate that formation and evolution of these terraces were mainly driven by tectonic uplift. Therefore, the terrace sequence provides an ideal geological record of the uplift process of the northeastern Qinghai-Tibet during the past 14 million years, and the timings of the terraces formation are regarded as the timings of tectonic uplift. The significant uplifting events took place at 14, 11.3, 1.2 and 0.15 million years ago, respectively. The fluvial incision at the Xining-Huzhu region is less than 100 m during a period of ~12 million years in the Miocene era (between the T11 and T9), while the Huangshui River had incised 432 m during the past 1.2 million years (from T7 to the present floodplain). The river incision process clearly demonstrates that accelerated rising of the northeastern Qinghai-Tibet Plateau during the late Cenozoic, and provides new evidence of previous thoughts. There was a significant readjustment of the fluvial catchment during 1.55-1.2 million years ago: before this time, the paleoriver flowed to southwest. After this time the Huangshui River flows to southeast. A tectonic movement dominates reorganization of this fluvial system. | LU Huayu1, WANG Xiaoyong1, AN Zhisheng1, MIAO Xiaodong1, ZHU Rixiang3, MA Haizhou2, LI Zhen4, TAN Hongbing2 & WANG Xianyan1 1. State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075 China 2. Qinghai Institute of Salt Lakes, Chinese Academy of Sciences. Xining 810008, China 3. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 4. Department of Geography, Qinghai Normal University, Xining 810008, China | 2004 | Science China Earth Sciences2004，47，9： | 51 |
| 5 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 6 | GS6, A Member of the GRAS Gene Family,Negatively Regulates Grain Size in Rice显示文摘Grain size is an important yield related trait in rice.Intensive arti cial selection for grain size during domestication is evidenced by the larger grains of most of today’s cultivars compared with their wild relatives.However,the molecular genetic control of rice grain size is still not well characterized.Here,we report the identi cation and cloning of Grain Size 6(GS6),which plays an important role in reducing grain size in rice.A premature stop at the t348 position in the coding sequence(CDS)of GS6 increased grain width and weight signi cantly.Alignment of the CDS regions of GS6 in 90 rice materials revealed three GS6alleles.Most japonica varieties(95%)harbor the Type I haplotype,and 62.9%of indica varieties harbor the Type II haplotype.Association analysis revealed that the Type I haplotype tends to increase the width and weight of grains more than either of the Type II or Type III haplotypes.Further investigation of genetic diversity and the evolutionary mechanisms of GS6showed that the GS6gene was strongly selected in japonica cultivars.In addition,a'ggc'repeat region identi ed in the region that encodes the GRAS domain of GS6 played an important historic role in the domestication of grain size in rice.Knowledge of the function of GS6might aid efforts to elucidate the molecular mechanisms that control grain development and evolution in rice plants,and could facilitate the genetic improvement of rice yield. | Lianjun Sun Xiaojiao Li Yongcai Fu Zuofeng Zhu Lubin Tan Fengxia Liu Xianyou Sun Xuewen Sun Chuanqing Sun | 2013 | Journal of Integrative Plant Biology2013，55，10： | 44 |
| 7 | Development of "Purple Endosperm Rice" by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System显示文摘Anthocyanins 在主食庄稼的 anthocyanin 生合成的高抗氧化剂活动,和工程例如米饭(Oryza sativa L.) ,能为改进人的健康提供支持健康的食物。然而,为 biofortification 设计新陈代谢的小径仍然保持困难,并且因为它的 biosynthetic 小径的复杂基因规章的网络,在米饭内乳设计 anthocyanin 生产的以前的尝试失败了。在这研究,我们为叠的 transgene 开发了一个高效率的向量系统并且使用了它在米饭内乳设计 anthocyanin 生合成。我们做了包含内乳特定的倡导者驾驶的八 anthocyanin 相关的基因(从从薄荷科植物的玉米和六结构的基因 ?的二规章的基因) 的构造,加为标记切除的一个可选的标记和基因。有这构造的米饭的转变产生了新奇 biofortified germplasm 紫色内乳瑞斯(用汉语的叫的 Zijingmi ) ,它在内乳有高 anthocyanin 内容和抗氧化剂活动。这 anthocyanin 生产源于 transgenes 和产生激活的表示(或改进) 13 内长的 anthocyanin 生合成基因的表示,那是 silenced 或在野类型的米饭内乳在底层表示。这研究为叠的 transgene 提供一个有效、万用的工具箱并且为一条复杂生物小径的成功的工程表明它的使用,建议为在工厂的农学的特点的合成生物学和改进的这个工具箱的潜在的用途。 | Qinlong Zhu Suize Yu Dongchang Zeng Hongmei Liu Huicong Wang Zhongtang Yang Xianrong Xie Rongxin Shen Jiantao Tan Heying Li Xiucai Zhao Qunyu Zhang Yuanling Chen Jingxing Guo Letian Chen Yao-Guang Liu | 2017 | Molecular Plant2017，10，7： | 47 |
| 8 | Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis显示文摘AIM:To investigate the expression of co-stimulatorymolecule B7-H3 in gastric carcinoma and adenomatissue as well as normal gastric tissue and to explore therelationship between B7-H3 expression and pathologicalfeatures and prognosis of gastric carcinoma.METHODS:B7-H3 expression was detected in 102samples of human gastric carcinoma and 10 samples ofgastric adenoma and 10 samples of normal gastric tissueby immunohistochemical assay.Correlation betweenthe expression of B7-H3 and the patients'age,sex,gastric carcinoma locus,tumor size,tissue type,tumorinfiltration depth,differentiation degree,lymph nodemetastasis,and survival time was analyzed.RESULTS:B7-H3 was expressed in all gastric adenomasamples and in 58.8% samples of gastric carcinoma.B7-H3 expression in gastric carcinoma samples wasnot related with the patients'age,sex,lymph nodemetastasis,and tumor size(P>0.05),but with thesurvival time,infiltration depth of tumor and tissue type.CONCLUSION:Detection of B7-H3 expression in gastriccarcinoma tissue is beneficial to the judgment of theprognosis of gastric carcinoma patients and the choice oftreatment. | Chang-Ping Wu Jing-Ting Jiang Min Tan Yi-Bei Zhu Mei Ji Kuan-Feng Xu Jie-Min Zhao Guang-Bo Zhang Xue-Guang Zhang | 2006 | World Journal of Gastroenterology2006，12，3： | 38 |
| 9 | Using geoaccumulation index to study source profiles of soil dust in China显示文摘TSP (有空气动力学的 diameters<=100 亩 m 的大气的微粒事) 和 PM10 (有空气动力学的 diameters<=10 亩 m 的大气的微粒事) 的来源分配研究表明了土壤灰尘是在中国的这些微粒的重要来源。在这研究,土壤灰尘的污染通过一个 geoaccumulation 索引(I_(geo )) 的使用被估计。 17 个元素的集体集中侧面( Na , Mg ,艾尔, K , Ca , Ti , V , Cr , Mn , Fe ,公司, Ni , Cu , Zn , Br , Ba ,并且 Pb )被建立因为来自 15 个城市的土壤的城市的土壤 dusts.Geochemical 作文被用来代表背景城市的土壤作文。这研究的结果显示很多个城市被在两尺寸部分(TSP 和 PM10 ) 包含 Ca, Cr, Ni,和 Cu 的微粒严重地弄脏。有 Zn, Pb,公司,和 Br 的污染对中等严重(I_(geo )>2 ) 。艾尔和 Fe 集中不足够高让他们被认为沾染物。 | JI Yaqin FENG Yinchang WU Jianhui ZHU Tan BAI Zhipeng DUAN Chiqing | 2008 | Journal of Environmental Sciences2008，20，5： | 35 |
| 10 | Microclimate regimes following gap formation in a montane secondary forest of eastern Liaoning Province, China显示文摘以便在东北中国在一个第二等的森林里在物理环境上改进华盖洞 / 差距的角色的理解,案例研究被进行在里面;在一个山区的第二等的森林里的小不规则的差距附近。第二等的森林,大约 50 年以前被人严重地扰乱,被 Quercus 蒙古人集成通信适配器统治;Fraxinus rhynchophyllaan。在光合的光子流动密度(PPFD ) 的时间的变化,在在地面上面的 10 厘米的气温(T A ) ,土壤温度(T S ) ;土壤水分含量(SWC ) 在最高层(0 15 厘米) ;自从小差距的形成,亚层(15 30 厘米) 在第二年以后从 5 月被测量到 9 月(到看台高度的差距直径的比率是不到 0.5 ) 在 2006 分别地。结果显示 PPFD 的最高的价值发生在差距的北边,特别地在在 5 月的生长期的开始。在阳光充足的天, PPFD 的最高的价值在阴暗的天比那早出现了。最大;T A 的平均值在差距的北部分是更高的,;T A 的最小的价值在差距的南部的边。土壤温度从 1 ~ 8 ° C 与范围在差距显然变化了。T S 的最大的价值发生在差距的北部分,它显著地与 T A 的最大的价值被相关(R = 0.735, P<0.05 ) 。SWC 是更高的在最高层(0 15 厘米) 比那在里面亚层(15 30 厘米) ,而是他们的差别不是重要的(p>0.05 ) ,它可能被归因于小差距尺寸;效果未葬植被。从这些结果,在学习区域的 PPFD 的最大值在差距的北部分发生了,它与结果在北方半球观察了一致,但是出现时间与纬度的差别变化了。空气的最高的价值;因为他们被放射影响,土壤温度也发生在差距的北部分。然而,在 7 月的温度的变化由于差距尺寸的影响与另外的月不同。并且土壤水分含量的价值不在在湿季节的差距更高是任何一个也不在干旱期降低,它可能被差距尺寸影响;差距定位了的地形学。光的变化,土壤;气温,;在这小不规则的差距的土壤潮湿可能与效果有关微地点,它影响植物种类的新生。 | ZHU Jiao-jun TAN Hui LI Feng-qin CHEN Mei ZHANG Jin-xin | 2007 | Journal of Forestry Research2007，18，3： | 32 |
| 11 | Different treatment strategies and molecular features between right-sided and left-sided colon cancers显示文摘The colon is derived from the embryological midgut and hindgut separately,with the right colon and left colon having different features with regards to both anatomical and physiological characteristics.Cancers located in the right and left colon are referred to as right colon cancer(RCC) and left colon cancer(LCC),respectively,based on their apparent anatomical positions.Increasing evidence supports the notion that not only are there differences in treatment strategies when dealing with RCC and LCC,but molecular features also vary between them,not to mention the distinguishing clinical manifestations.Disease-free survival after radical surgery of both RCC and LCC are similar.In the treatment of RCC,the benefit gained from adjuvant FOLFIRI chemotherapy is superior,or at least similar,to LCC,but inferior to LCC if FOLFOX regimen is applied.On the other hand,metastatic LCC exhibits longer survival than that of RCC in a palliative chemotherapy setting.For KRAS wild-type cancers,LCC benefits more from cetuximab treatment than RCC.Moreover,advanced LCC shows a higher sensitivity to bevacizumab treatment in comparison with advanced RCC.Significant varieties exist at the molecular level between RCC and LCC,which may serve as the cause of all apparent differences.With respect to carcinogenesis mechanisms,RCC is associated with known gene types,such as MMR,KRAS,BRAF,and mi RNA-31,while LCC is associated with CIN,p53,NRAS,mi RNA-146 a,mi RNA-147 b,and mi RNA-1288.Regarding protein expression,RCC is related to GNAS,NQO1,telomerase activity,P-PDH,and annexin A10,while LCC is related to Topo I,TS,and EGFR.In addition,separated pathways dominate progressionto relapse in RCC and LCC.Therefore,RCC and LCC should be regarded as two heterogeneous entities,with this heterogeneity being used to stratify patients in order for them to have the optimal,current,and novel therapeutic strategies in clinical practice.Additional research is needed to uncover further differences between RCC and LCC. | Hong Shen Jiao Yang Qing Huang Meng-Jie Jiang Yi-Nuo Tan Jian-Fei Fu Li-Zhen Zhu Xue-Feng Fang Ying Yuan | 2015 | World Journal of Gastroenterology2015，21，21： | 33 |
| 12 | Polymorphism Analyses of Hepatitis B Virus X Gene in Hepatocellular Carcinoma Patients from Southern China显示文摘长期的肝炎 B 病毒( HBV )感染是主要原因 ofhepatocellular 癌( HCC )之一,并且 HBV X ( HBx )基因在HBV相关的 HCC.We 的分子的致病起一个关键作用调查了是否有特别 HBx 基因变化,从南部的中国在病人与 HCC 联系。HBx 基因被嵌套的聚合酶链反应(PCR ) 从 HBVcarrier 与 HCC 和 25 件浆液样品从病人在 51paraffin-embedded 肿瘤织物样品检验,搁浅单人赛的 conformational 多型性 andheteroduplex 分析。有从肿瘤织物样品的潜在地重要的变化的 HBx 基因被克隆,在肿瘤织物样品与出版 HBx 基因 sequence.HBV 遗传型定序并且排列被在肿瘤织物的31.3% HBx 基因碎片取样的基因多型性显示出的 HBx 的嵌套的 PCR.Analyses 分析有特殊 pattern.A 在 29 点突变伴随的 HBxgene 的 nt 382-400 的普通删除随机在四被检测有在 HBx 开的读物引起了框架移动的这个模式的选择肿瘤织物样品在 atnt 上与一条新站鳕鱼装裱 1818 ,导致 HBx 多肽链在这些情况中在 C 结束截断了。在四件随机选择的样品之中,三是 HBV 遗传型 B ,并且一个人没被我们的现在的 assay.Inanother 肿瘤织物样品检测,全身的 HBx 基因的扩大产出揭示的这碎片的 shorterfragment.Sequencing 在 1577 HBVgene.These 和 1840 结果建议的 nt 之间的 264 bp 删除那个 HBx 基因变化在 HCC 样品经常发生,并且在 HBx 基因的 nt 382-400 的删除可能在南部的中国在 HCC 的 carcinogenesis 起一个作用。 | Ping'an ZHU Deming TAN Zhongtian PENG Fei LIU Lin SONG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 29 |
| 13 | Regulation of multidrug resistance by microRNAs in anti-cancer therapy显示文摘Multidrug resistance(MDR) remains a major clinical obstacle to successful cancer treatment.Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly understood.Micro RNAs(mi RNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression.Accumulating evidence shows that mi RNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of mi RNAs in regulating MDR in cancer treatment. | Xin An Cesar Sarmiento Tao Tan Hua Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 29 |
| 14 | Development of Oryza rufipogon and O. sativa Introgression Lines and Assessment for Yield-related Quantitative Trait Loci显示文摘基因渗入线人口有效地在印射量的特点 loci (QTL ) 被使用,识别有利基因,发现隐藏的遗传变异,评估处于多重条件的 QTL 的行动或相互作用并且提供为植物繁殖和基因研究的有利试验性的材料。在这研究,先进回交和连续 selfing 策略被用来开发基因渗入线(IL ) ,它源于 Oryza rufipogon Griff 的就职。从 Yuanjiang 县镇定,中国的云南省,著名计算机生产厂商他施主,和精英 indica 栽培变种 Teqing (O。sativa L.) ,接受者。从 O 的 Introgressionsegments。rufipogon 用 179 次多态的简单顺序重复(SSR ) 被屏蔽在每 IL 的染色体的标记。基因渗入线人口带的 Introgressed 片断包含了盖住整个 O 的 120 IL。rufipogon 染色体。同型结合的 O 的吝啬的数字。rufipogonsegments 每基因渗入线是大约 3.88。introgressed 片断的平均长度是近似的 25.5 厘米,并且有的大约 20.8% 这些片断缩放不到 10 厘米。eachIL 的染色体怀有 O 的 chromosomal 碎片。rufipogon 从 0.54% ~ 23.7%,与 5.79% 的全面一般水准。在每个地点, O 的替换的比率。rufipogon 等位基因有范围 of1.67-9.33,与 5.50 的一般水准。大量改变在词法并且 yield-relatedtraits 也在基因渗入线人口被发现。用单个点的分析,为产量和产量构成因素的 37 通常认为的 QTL 的一个总数与解释 phenotypic 的 7%-20% 在二个地点被检测。十九 QTL (51.4%) 在两个地点被检测,并且从在十五 loci (40.5%) 的 O.rufipogon 的等位基因在 Teging 背景改进了收益和产量构成因素。这些 O。rufipogon-O。sativa 基因渗入线将为从普通野米饭识别并且使用有利基因用作遗传物质…… | Lubin Tan | 2007 | Journal of Integrative Plant Biology2007，49，6： | 28 |
| 15 | Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. | Liu Jian Wang Yuan Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，5： | 27 |
| 16 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 17 | Secondary organic carbon quantification and source apportionment of PM_(10) in Kaifeng, China显示文摘During 2005, the filter samples of ambient PM10 from five sites and the source samples of particulate matter were collected in Kaifeng, Henan Province of China. Nineteen elements, water-soluble ions, total carbon (TC) and organic carbon (OC) contained in samples were analyzed. Seven contributive source types were identified and their contributions to ambient PM10 were estimated by chemical mass balance (CMB) receptor model. Weak associations between the concentrations of organic carbon and element carbon (EC) were observed during the sampling periods, indicating that there was secondary organic aerosol pollution in the urban atmosphere. An indirect method of 'OC/EC minimum ratio' was applied to estimate the concentration of secondary organic carbon (SOC). The results showed that SOC contributed 26.2%, 32.4% and 18.0% of TC in spring, summer-fall and winter, respectively, and the annual average SOC concentration was 7.07 μg/m3, accounting for 5.73% of the total mass in ambient PM10. The carbon species concentrations in ambient PM10 were recalculated by subtracting SOC concentrations from measured concentrations of TC and OC to increase the compatibility of source and receptor measurements for CMB model. | WU Lin FENG Yinchang WU Jianhui ZHU Tan BI Xiaohui HAN Bo YANG Weihong YANG Zhiqiang | 2009 | Journal of Environmental Sciences2009，21，10： | 26 |
| 18 | Surveillance, epidemiology, and pathogen spectrum of hand, foot, and mouth disease in mainland of China from 2008 to 2017显示文摘Hand,foot and mouth disease(HFMD)was reported in May 2,2008 to be the 38th legally notifiable disease in China's National Notifiable Disease Reporting and Surveillance System.In order to solve the infection,an extensive three-level HFMD surveillance laboratory network was established.In this study,the framework of that network is assessed and the incidence of HFMD in China from 2008 to 2017 is reported using a descriptive epidemiologic method.During these 10 years,a series of techniques have been widely applied in all the network laboratories.Using information and material obtained from the network,a virus bank and database containing 18,238 viruses were established.Nationally,18,184,834 HFMD cases,including 152,436 severe cases and 3633 fatal cases,were reported in mainland of China.The average annual incidence in the population was 133.99/100,000 people,with a maximum incidence of 205.06/100,000 people in 2014.The incidence and mortality rates of HFMD were the highest in children aged 1–2 years.The numbers of reported cases fluctuated,with a high incidence observed every 2 years.An overall increase in the number of reported cases was also observed throughout the study period.Despite this,the incidence of severe cases and the mortality rate have been decreasing.High-risk regions are located in southern,eastern,and central China.Two peaks of HFMD infection cases were observed annually except for Northeast China.Different proportions of enterovirus serotypes were observed during the studied years.The predominant enterovirus varies from year to year,but the disease severity is always closely related to the specific serotype.EV-A71 is the dominant serotype associated with severe and fatal cases,with constituent ratios of 70.03%and 92.23%,respectively.The studied highly sensitive and efficient surveillance network provides information that is critical for prevention and control of the disease.It is extremely necessary and important to continuously conduct extensive virological surveillance for HFMD. | Tianjiao Ji Taoli Han Xiaojuan Tan Shuangli Zhu Dongmei Yan Qian Yang Yang Song Aili Cui Yan Zhang Naiying Mao Songtao Xu Zhen Zhu Dandan Niu Yong Zhang Wenbo Xu | 2019 | Biosafety and Health2019，1，1： | 26 |
| 19 | LHD1,an Allele of DTH8/Ghd8,Controls Late Heading Date in Common Wild Rice (Oryza rufipogon)显示文摘Flowering at suitable time is very important for plants to adapt to complicated environments and produce their seeds successfully for reproduction.In rice (Oryza rufipogon Griff.) photoperiod regulation is one of the important factors for controlling heading date.Common wild rice,the ancestor of cultivated rice,exhibits a late heading date and a more sensitive photoperiodic response than cultivated rice.Here,through map-based cloning,we identified a major quantitative trait loci (QTL) LHD1 (Late Heading Date 1),an allele of DTH8/Ghd8,which controls the late heading date of wild rice and encodes a putative HAP3/NF-YB/CBF-A subunit of the CCAAT-box-binding transcription factor.Sequence analysis revealed that several variants in the coding region of LHD1 were correlated with a late heading date,and a further complementary study successfully rescued the phenotype.These results suggest that a functional site for LHD1 could be among those variants present in the coding region.We also found that LHD1 could down-regulate the expression of several floral transition activators such as Ehd1,Hd3a and RFT1 under long-day conditions,but not under short-day conditions.This indicates that LHD1 may delay flowering by repressing the expression of Ehd1,Hd3a and RFT1 under long-day conditions. | Xiaodong Dai Younian Ding Lubin Tan Yongcai Fu Fengxia Liu Zuofeng Zhu Xianyou Sun Xuewen Sun Ping Gu Hongwei Cai Chuanqing Sun | 2012 | Journal of Integrative Plant Biology2012，54，10： | 23 |
| 20 | Optimal allocation of multi-type FACTS devices in power systems based on power flow entropy显示文摘Flexible AC transmission systems(FACTS)devices can effectively optimize the distribution of power flow.Power flow entropy can be applied as a measure of load distribution.In this paper,a method is proposed to optimize the distribution of power flow with the coordination of multi-type FACTS devices and establishes the corresponding mathematical models.The modified group searcher optimization(GSO)algorithm is proposed,in which the angle search is combined with chaotic search model to avoid jumping into local optimization.Compared with the different optimal allocation of multi-FACTS devices,the optimal allocation of multi-FACTS devices is achieved under the economic constraints.The locations obtained by this method can achieve the purpose of balancing power flow and enhancing the system performances.The simulations are demonstrated in an IEEE 118-bus power system with two classical types of FACTS,namely static var compensator(SVC)and thyristor controlled series Compensator(TCSC).The simulation results show that the proposed method is feasible and effective. | Canbing LI Liwu XIAO Yijia CAO Qianlong ZHU Baling FANG Yi TAN Long ZENG | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 23 |
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