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| 1 | First-principles study of structure,mechanical and optical properties of La-and Sc-doped Y2O3显示文摘The electronic,mechanical and optical properties of La-and Sc-doped Y2O3 were investigated using firstprinciples calculations.Two doping sites of Sc and La in Y2O3 were modeled.The calculated values of the energy of formation show that the most energetically favorable site for a La atom in Y2O3 is a d-site Y atom,while for Sc a b-site Y atom is the more stable position.The calculated band gap shows a slight decrease with increasing La or Sc concentration.The calculated results for the mechanical and optical properties of Y(2-x)RxO3(R=Sc or La,0 | Xian Zhang Sen Gao Wenhua Gui Qingfeng Zeng | 2019 | Journal of Rare Earths2019，37，8： | 8 |
| 2 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 3 | FRUCTOKINASE-LIKE PROTEIN 1 interacts with TRXz to regulate chloroplast development in rice显示文摘Chloroplast genes are transcribed by the plastidencoded RNA polymerase(PEP) or nucleus-encoded RNA polymerase. FRUCTOKINASE-LIKE PROTEINS(FLNs) are phosphofructokinase-B(Pfk B)-type carbohydrate kinases that act as part of the PEP complex; however, the molecular mechanisms underlying FLN activity in rice remain elusive.Previously, we identified and characterized a heat-stress sensitive albino(hsa_1) mutant in rice. Map-based cloning revealed that HSA_1 encodes a putative OsFLN_2. Here, we further demonstrated that knockdown or knockout of the OsFLN_1, a close homolog of HSA_1/OsFLN_2, considerably inhibits chloroplast biogenesis and the fln_1 knockout mutants, created by clustered regularly interspaced short palindromic repeats(CRISPR) and CRISPR-associate protein_9, exhibit severe albino phenotype and seedling lethality. Moreover, OsFLN_1 localizes to the chloroplast.Yeast two-hybrid, pull-down and bimolecular fluorescencecomplementation experiments revealed that OsFLN_1 and HSA_1/OsFLN_2 interact with THIOREDOXINZ(OsTRXz) to regulate chloroplast development. In agreement with this,knockout of OsTRXz resulted in a similar albino and seedling lethality phenotype to that of the fln_1 mutants. Quantitative reverse transcription polymerase chain reaction and immunoblot analysis revealed that the transcription and translation of PEP-dependent genes were strongly inhibited in fln_1 and trxz mutants, indicating that loss of OsFLN_1, HSA_1/OsFLN_2, or OsTRXz function perturbs the stability of the transcriptionally active chromosome complex and PEP activity. These results show that OsFLN_1 and HSA_1/OsFLN_2 contribute to chloroplast biogenesis and plant growth. | Lei He Sen Zhang Zhennan Qiu Juan Zhao Wendan Nie Haiyan Lin Zhengge Zhu Dali Zeng Qian Qian Li Zhu | 2018 | Journal of Integrative Plant Biology2018，60，2： | 6 |
| 4 | Divergent Projection Patterns Revealed by Reconstruction of Individual Neurons in Orbitofrontal Cortex显示文摘The orbitofrontal cortex(OFC)is involved in diverse brain functions via its extensive projections to multiple target regions.There is a growing understanding of the overall outputs of the OFC at the population level,but reports of the projection patterns of individual OFC neurons across different cortical layers remain rare.Here,by combining neuronal sparse and bright labeling with a whole-brain florescence imaging system(fMOST),we obtained an uninterrupted three-dimensional whole-brain dataset and achieved the full morphological reconstruction of 25 OFC pyramidal neurons.We compared the wholebrain projection targets of these individual OFC neurons in different cortical layers as well as in the same cortical layer.We found cortical layer-dependent projections characterized by divergent patterns for information delivery.Our study not only provides a structural basis for understanding the principles of laminar organizations in the OFC,but also provides clues for future functional and behavioral studies on OFC pyramidal neurons. | Junjun Wang Pei Sun Xiaohua Lv Sen Jin Anan Li Jianxia Kuang Ning Li Yadong Gang Rui Guo Shaoqun Zeng Fuqiang Xu Yu-Hui Zhang | 2021 | Neuroscience Bulletin2021，37，4： | 5 |
| 5 | Molecular mechanisms of insect adaptation to plant defense: Lessons learned from a Bruchid beetle显示文摘植物能积累,组成地或在正式就职以后,在他们授与抵抗到食草的昆虫的纸巾的许多防卫混合物。自然地发生的植物抵抗基因水池能经由转基因的途径在害虫管理用作一个军火库。当昆虫植物相互作用研究很快进展,植物防卫混合物的效果不仅由他们向目标地点的毒性,而且由昆虫怎么对挑战作出回应是坚定的,逐渐地变得清楚。昆虫消化的道不是植物防卫的被动目标,但是能经常适应饮食的挑战并且成功地处理各种各样的植物毒素和抗代谢物。这适应回答形成了一个障碍到基于生物工学的害虫控制途径,它强调理解昆虫的重要性适应机制。昆虫消化上的朊酶禁止者的影响上的分子的研究显著地作出贡献到我们昆虫改编的理解种防卫。这评论将集中于暴露昆虫怎么对朊酶禁止者作出回应由质、量用豇豆 bruchid 大豆半胱氨酸朊酶禁止者 N 系统他们的消化朊酶改变。 | Keyan Zhu-Salzman Ren Sen Zeng | 2008 | Insect Science2008，15，6： | 3 |
| 6 | High-throughput 16S rDNA sequencing of the pulmonary microbiome of rats with allergic asthma显示文摘A decrease in microbial infection in adolescents is implicated with an increase in the incidence of asthma and allergic diseases in adulthood,indicating that the microbiome plays a critical role in asthma.However,the microbial composition of the lower respiratory tract remains unclear,hindering the further exploration of the pathogenesis of asthma.This study aims to explore the microbial distribution and composition in the lungs of normal rats and rats with allergic asthma via 16S rDNA sequencing.The DNA of the pulmonary microbiome was extracted from the left lungs collected from normal control group(NC),saline control group(SC),and allergic asthma group(AA)under aseptic conditions.After the 16s rDNA V4eV5 region was amplified,the products were sequenced using Illumina high-throughput technology and subjected to operational taxonomic unit(OTU)cluster and taxonomy analysis.The OTU values of AA increased significantly compared with those of NC and SC.Microbiome structure analysis showed that the dominant phylum of the pulmonary microbiome changed from Proteobacteria in NC to Firmicutes in AA.Linear discriminant analysis indicated that the key microbiomes involved in the three groups varied. | Yang Xiong Sen Hu Hongyao Zhou Hui Zeng Xuan He Dongni Huang Xiaoyu Li | 2020 | Genes & Diseases2020，7，2： | 2 |
| 7 | Field controlled experiments on the physiological responses of maize ( Zea mays L.) leaves to low-level air and soil mercury exposures显示文摘 | Zhenchuan Niu Xiaoshan Zhang Sen Wang Ming Zeng Zhangwei Wang Yi Zhang Zhijia Ci | 2014 | Environmental Science and Pollution Research2014，，2： | 1 |
| 8 | Aflatoxin B1: Toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni显示文摘Trichoplusia ni 毛虫是杂食的 foliage-feeders 并且很少可能遇到黄麴毒素 B1 (AFB1 ) , mycotoxin 由曲霉属菌 flavus 和 A 生产了。parasiticus,在他们的主人植物。决定怎么 T。ni 应付 AFB1,我们评估了 AFB1 的毒性到 T。在不同发展阶段的 ni 毛虫并且发现忍耐显著地与幼虫的开发增加的那 AFB1。在 1 g/g 的 AFB1 的食谱加入完全禁止了最新孵的幼虫,而是 3 g/g 的幼虫的生长和 AFB1 没有的化蛹首先消费这的毛虫的幼虫的生长和化蛹上的明显的有毒的效果在孵化以后加重 10 天。Piperonyl butoxide,细胞色素 P450 monooxygenases (P450s ) 的一个一般禁止者,减少了 AFB1 的毒性,建议那 AFB1 是在 T 的 bioactivated。ni 和这 bioactivation 被 P450s 调停。某植物 allelochemicals 包括象黄酮,象 xanthotoxin 和 imperatorin 那样的 furanocoumarins,和象 visnagin 那样的 furanochromones 那样的 flavonoids,在另外的鳞翅类的幼虫导致 P450s 改善 AFB1 毒性,建议那 P450s 也在 T 涉及 AFB1 detoxification。ni。 | Ren Sen Zeng Zhimou Wen Guodong Niu R. Berenbaum | 2013 | Insect Science2013，20，3： | 1 |
| 9 | An Investigation on the Molecular Characteristics and Intracellular Growth Ability among Environmental and Clinical Isolates of Legionella pneumophila in Sichuan Province, China显示文摘Objective To investigate the molecular characteristics and intracellular growth ability of Legionella pneumophila(L. pneumophila) strains from 1989 to 2016 in Sichuan Province, China. Methods Seventy-nine isolates of L. pneumophila were collected from environmental and clinical sources, including cooling towers, hot springs, bath water, fountains, and patients, and identified with 16 S rRNA gene analysis and serum agglutination assay. The isolates were then typed by Sequence-Based Typing(SBT), and Genotyping of forty-two LP1 strains were analyzed by means of multiple-locus VNTR analysis with 8 loci(MLVA-8). All strains were further analyzed for two virulence genes: Legionella vir homologue(lvh) and repeats in structural toxin(rtx A). The intracellular growth ability of 33 selected isolates was determined by examining their interaction with J774 cells. Results All isolates were identified to L. pneumophila including 11 serogroups, among which the main serogroup were LP1, accounting for 54.43%. Thirty-three different sequence types(STs) from five main clonal groups and five singletons were identified, along with 8 different MLVA patterns. Both the lvh and rtx A loci were found in all 79 strains. Thirty isolates showed high intracellular growth ability in J774 cells. Conclusion L. pneumophila is a potential threat to public health, and effective control and prevention strategies are urgently needed. | ZENG Lin Zi LIAO Hong Yu LUO Long Ze HE Shu Sen QIN Tian ZHOU Hai Jian LI Hong Xia CHEN Da Li CHEN Jian Ping | 2019 | Biomedical and Environmental Sciences2019，32，7： | 1 |
| 10 | Contribution of MDR1 gene polymorphisms on IBD predisposition and response to glucocorticoids in IBD in a C hinese population显示文摘 | Qing Fan Yang Bai Li Chen Qing Sen Zhang Zhen Hua Zhu Bin Hu Yao He Xiang Gao Yi Ming Wang Pin Jin Hu Min Hu Chen Zhi Rong Zeng | 2015 | Journal of Digestive Diseases2015，，1： | 1 |
| 11 | EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma显示文摘 | Mengyan Wu Yingxia Liu Xiaoqing Di Haixian Kang Hua Zeng Yi Zhao Kangrong Cai Tianyun Pang Sen Wang Yunhong Yao Xinrong Hu | 2013 | Medical Oncology2013，，1： | 1 |
| 12 | One-pot synthesis of 2,5-bis(hydroxymethyl)furan from biomass derived 5-(chloromethyl)furfural in high yield显示文摘5-(Chloromethyl)furfural(CMF),as a new platform molecular,has become a hot topic in the field of biorefinery.Herein,the one-pot conversion of CMF to 2,5-bis(hydroxymethyl)furan(BHMF)in the water phase was demonstrated for the first time.A 91%BHMF yield was obtained over Ru/Cu Oxcatalyst,and BHMF was mainly produced by the consecutive hydrolysis and hydrogenation of CMF with 5-hydroxymethylfurfural(HMF)as an intermediate.Kinetic studies revealed that the conversion of HMF to BHMF was the rate-determining step.Remarkably,the characterizations and density functional theory(DFT)calculations further revealed the lower electron density of Ru NPs in Ru/Cu Oxcatalyst,resulting in a larger adsorption energy and a smaller free energy difference for the formation of alcohols.The present findings offered a new pathway for biomass-derived diol production through CMF as a potential source. | Binglin Chen Yunchao Feng Sen Ma Weizhen Xie Guihua Yan Zheng Li Jonathan Sperry Shuliang Yang Xing Tang Yong Sun Lu Lin Xianhai Zeng | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 13 | Optimizing Winding Angles of Reinforced Thermoplastic Pipes Based on Progressive Failure Criterion显示文摘This paper examines a scheme to optimize the multiple winding angles of reinforced thermoplastic pipes(RTPs)under internal and external pressures.To consider the nonlinear mechanical behavior of the material under changes of winding angle due to deformation,we use three-dimensional(3D)thick-walled cylinder theory with the 3D Hashin failure criterion and theory of the evolution of damage to composite materials,to formulate a model that analyzes the progressive failure of RTPs.The accuracy of the model was verified by experiments.A model to optimize the multiple winding angles of the RTPs was then established using the model for progressive failure analysis and a multi-island genetic algorithm.The optimal scheme for winding angles of RTPs capable of withstanding the maximum internal/external pressure was obtained.The simulation results showed that the ply number of the reinforced layer has a prominent nonlinear effect on the internal and external pressure capacity of the RTPs.Compared with RTPs with a single angle of±55°,the multiple winding angle overlay scheme based on the multi-angle optimization model improved the internal and external pressure capacity of the RTPs,and the improvement in the external pressure capacity was significantly better than the internal pressure carrying capacity. | WANG Yangyang LOU Min ZENG Xin DONG Wenyi WANG Sen | 2021 | Journal of Ocean University of China2021，20，5： | 1 |
| 14 | Dynamic bifunctional THz metasurface via dual-mode decoupling显示文摘Metasurfaces have powerful light field manipulation capabilities and have been researched and developed extensively in various fields.With an increasing demand for diverse functionalities,terahertz(THz)metasurfaces are also expanding their domain.In particular,integrating different functionalities into a single device is a compelling domain in metasurfaces.In this work,we demonstrate a functionally decoupled THz metasurface that can incorporate any two functions into one metasurface and switch dynamically through external excitation.This proposed metasurface is formed by the combination of split-ring resonators and phase change material vanadium dioxide(VO_(2)).It operates in the single-ring resonant mode and double-ring resonant mode with varying VO_(2)in insulating and metallic states,respectively.More importantly,the phase modulation is independent in two operating modes,and both cover a 360°cross-polarized phase with efficient polarization conversion.This characteristic makes it obtain arbitrary independent phase information on the metasurface with different modes to switch dual functions dynamically.Here,we experimentally demonstrate the functions of a tunable focal length and large-angle focus deflection of a THz off-axis parabolic mirror to verify the dual-function switching characteristics of the functionally decoupled metasurface.The functionally decoupled metasurface developed in this work broadens the way for the research and application of multifunctional modulation devices in the THz band. | XUAN CONG HONGXIN ZENG SHIQI WANG QIWU SHI SHIXIONG LIANG JIANDONG SUN SEN GONG FENG LAN ZIQIANG YANG YAXIN ZHANG | 2022 | Photonics Research2022，10，9： | 1 |
| 15 | Analysis of clinical manifestations,mutant gene and encodedprotein in two Chinese MYH9-related disease families显示文摘 | Yi Y Sen Zhang G Xu M San Ling Z Ru Shao X Zeng Li J | 2006 | ClinChim Acta2006，373，12： | 1 |
| 16 | First-principles study of electronic structure and optical properties of Er:Lu_(2)O_(3)显示文摘In the present computational study,we found that Er:Lu_(2)O_(3)materials have promise for application in laser applications.The crystal structure and the electronic and optical properties of Er:Lu_(2)O_(3)materials were studied using first-principle calculations under the framework of density functional theory.Based on the experimental and calculated results,the structure of Lu_(2)O_(3)was established.The calculated results show that doping by Er^(3+)can effectively improve its absorption coefficient in the ultraviolet region and improve the static dielectric constant of Lu_(2)O_(3).As the doping concentration of Er^(3+)increases,the energy of the valence band electrons excited to the conduction band decreases,and the transition is more likely to occur.The absorption coefficient,reflectance,and electron energy loss spectroscopy are bathochromic shifted.The Lu_(2-x)Er_(x)O_(3)(0 | Xian Zhang Honglei Zhao Sen Gao Qingfeng Zeng | 2021 | Journal of Rare Earths2021，39，4： | 1 |
| 17 | Divergent responses of soil carbon and nitrogen pools to short-term nitrogen addition between two plantations in Northeast China显示文摘Nitrogen(N)deposition has a profound influence on forest soil carbon(C)and N pools,but there was no consensus on the responses of different C and N components in different forest types.In this study,a two-year simulated N deposition experiment with four levels of N(NH4NO3)-addition treatments(0,50,100,and 150 kg N/hm^(2)·a)were conducted in Larix gmelinii(LG)and Quercus mongolica(QM)plantation in Northeast China,in order to investigate the C and N pool dynamics under continuously enhanced N deposition.Soil organic carbon(SOC),soil total N(STN)and their active components(readily oxidizable C,ROC;dissolved organic C,DOC;microbial biomass C,MBC,dissolved organic N,DON;microbial biomass N,MBN)of the forest soil were measured monthly from May to October 2017.C and N contents in LG were observed higher than in QM.N addition had no effect on SOC and STN of LG,but significantly increased SOC and STN of QM at low N addition level.Low N addition generally raised active C components(ROC,DOC,and MBC)in both plantations,whereas high N addition did not significantly affect these components,or even decreased ROC in LG soil.Low N addition also increased STN and MBN of QM,while no significant change in STN and MBN of LG was observed.DON was directly affected by N addition and increased significantly with elevated N addition levels.The results indicated that N addition,especially of low rate,might enhance the C sequestration capacity of the forest soils and mitigate climate change. | Yedong Li Bo Wang Sen Dou Haoyue Shen Liyong Mei Yang Zhang Ximing Zeng Yaya Zhang Yameng Pei Haoye Ren Shimin Wu | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 1 |
| 18 | Op- timal Service Selection and Composition for Service--oriented Manufacturing Network显示文摘 | Huang Shuangxi Zeng Sen Fan Yushun | 2011 | In- ternational Journal of Advanced Manufacturing Technology2011，24，5： | 1 |
| 19 | Control of Panama Disease of Banana by Rotating and Intercropping with Chinese Chive ( Allium Tuberosum Rottler): Role of Plant Volatiles显示文摘 | Hui Zhang Azim Mallik Ren Sen Zeng | 2013 | Journal of Chemical Ecology2013，，2： | 1 |
| 20 | Posterior Versus Anterior Circulation Infarction: How Different Are the Neurological Deficits?显示文摘 | Wen-Dan Tao Ming Liu Marc Fisher De-Ren Wang Jie Li Karen L Furie Zi-Long Hao Sen Lin Can-Fei Zhang Quan-Tao Zeng Bo Wu | 2012 | Stroke2012，，8： | 1 |
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