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| 1 | Apoptosis-inducing activity of the antimicrobial peptide cecropin of Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and the possible mechanism显示文摘我们在人的 hepatocellular 癌房间线 BEL-7402 和它的内在的机制学习了蝇属 domestica 的抗菌剂肽 cecropin 的导致 apoptosis 性质。人的 hepatocellular 癌 BEL-7402 房间和人的正常的肝房间的增长抑制被 MTT 试金决定,并且房间生存能力被 trypan 蓝色染料排除试金决定。与 cecropin 对待的 apoptotic 肿瘤房间被传播电子显微镜学和 terminal-deoxynucleotidyl transferase 检验标记的调停的刻痕结束。apoptosis 率被流动 cytometry (FCM ) 与 PI/Annexin-V 测量两倍染色。西方的污点分析和 RT-PCR 被用来决定涉及 apoptosis 的蛋白质的表示层次,例如船边交货, Fas-L, caspase-8,和 caspase-3。试验性的结果证明蝇属 domestica cecropin 在剂量依赖者和时间依赖者礼貌禁止了人的 hepatocellular 癌 BEL-7402 房间的增长,没有影响正常的肝房间的增长。FCM 证明房间 apoptosis 率是 5. | Xiaobao Jin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，4： | 23 |
| 2 | In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31显示文摘The performance of biodegradable magnesium alloy requires special attention to rapid degradation and poor biocompatibility, which can cause the implant to fail. Here, a sodium montmorillonite(MMT)/bovine serum albumin(BSA) composite coating was prepared upon magnesium alloy AZ31 via hydrothermal synthesis, followed by dip coating. We evaluated the surface characterization and corrosion behavior in vitro, and the biocompatibility in vitro and in vivo. Biodegradation progress of the MMT-BSA coated Mg pieces was examined through hydrogen evolution, immersion tests, and electrochemical measurements in Hank’s solution. In vitro biocompatibility studies were evaluated via hemolysis tests, dynamic cruor time tests, platelet adhesion, MTT testing and live-dead stain of osteoblast cells(MC3 T3-E1). It was found that the MMT-BSA coating had good corrosion resistance and a marked improvement in biocompatibility in comparison to bare Mg alloy AZ31. in vivo studies were carried out in rat model and the degradation was characterized by computed tomography scans. Results revealed that the MMT-BSA coated Mg alloy AZ31 implants maintained their structural integrity and slight degradation after 120 d of post-implantation. A100% survival rate for the rats was observed with no obvious toxic damages on the organs and tissues.Additionally, we proposed a sound coating formation mechanism. Considering the good corrosion protection and biocompatibility, the MMT-BSA coated Mg alloy AZ31 is a promising candidate material for biomedical implants. | Jian Wang Lanyue Cui Yande Ren Yuhong Zou Jinlong Ma Chengjian Wang Zhongyin Zheng Xiaobo Chen Rongchang Zeng Yufeng Zheng | 2020 | Journal of Materials Science & Technology2020，47，12： | 7 |
| 3 | Receiver Function Estimated by Wiener Filtering显示文摘Wiener filtering is used to estimate receiver function in a time_domain. With the vertical component of 3_component teleseismic P waveform as the input of a Wiener filter, receiver function as the filter response, and radial and tangential components as the expected output, receiver function is estimated by minimizing the error between expected and actual outputs. Receiver function can be obtained by solving the Toeplitz equation using the Levinson algorithm. The non_singularity of the Toeplitz equation ensures the stability of Wiener Deconvolution. Both synthetic and observational seismogram checks show that Wiener Deconvolution is an effective time_domain method to estimate receiver function from teleseismic P waveform. | Wu Qingju, Tian Xiaobo, Zhang Nailing, Li Weiping and Zeng RongshengInstitute of Geophysics, China Seismological Bureau, Beijing 100081, China | 2003 | Earthquake Research in China2003，17，4： | 4 |
| 4 | Quantitative analysis on microstructure evolution and tensile property for the isothermally forged Ti 2 AlNb based alloy during heat treatment显示文摘 | Chen Xue Weidong Zeng Wei Wang Xiaobo Liang Jianwei Zhang | 2013 | Materials Science & Engineering A2013，，： | 3 |
| 5 | Microbial diversity and functionally distinct groups in produced water from the Daqing Oilfield,China显示文摘The microbial community structure and functionally distinct groups in three kinds of produced water samples from the shallow,mesothermic and low-salinity Daqing oil reservoir were systematically evaluated using both culture-dependent and culture-independent methods.Sequence analysis of the 16S rRNA genes indicated that the bacterial library was dominated by Acinetobacter and Arcobacter and the archaeal community was dominated by Methanosaeta and Methanolinea.Two isolated methanogens were closely related with Methanothermobacter thermautotrophicus and Methanoculleus receptaculi.The fermentative bacteria were identified as Pseudomonas,Haloanaerobium,Alcalibacter,Arcobacter,and Pannonibacter.The predominant nitrate-reducing bacteria fell within the genus Pseudomonas.The dominant members of the cultured hydrocarbon-oxidizing bacteria were phylogenetically associated with Micrococcus,Pseudomonas,and Bacillus.Enrichments of biosurfactants and biopolymer producing groups mainly yielded Pseudomonas,Bacillus,and Acenitobacter-related members.The functional groups related to polymer degradation were also affiliated with Pseudomonas and Bacillus.Results from this study provide the fresh insight into the diversity of microbial communities in Daqing petroleum reservoirs.The vast pool of functional strains retrieved in this study was presumed to include the promising strains that could be applied in microbial-enhanced oil recovery in future. | Li Hui Ai Mingqiang Han Siqin Guo Yanling Li Nana Shi Rongjiu Zeng Xiangling Leng Shengbing Zhao Jinyi Liu Xiaobo Zhang Ying | 2012 | Petroleum Science2012，9，4： | 3 |
| 6 | A Phytophthora sojae gene of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induced in host infection and its anti-oxidative function in yeast显示文摘Glyceraldehyde-3-phosphate dehydro- genase (GAPDH) is a multifunctional protein well defined in eukaryotes, especially in mammalian and Saccharomyces cerevisiae. Using the method of suppression subtractive hybridization (SSH), we identified a Phytophthora sojae cDNA coding GAPDH, which was up-regulated during the early stage of soybean infection. The termed PsGapdh gene pos- sessed three copies in the P. sojae genome. Its amino acid sequence harbored overall conserved domain of GADPH, homologous closest to GapC1 of Achlya bisexualis (oomycete) and adjoined to GapC2s of Odontella sinensis and Phaeodactylum tricornutum (diatom), on the C-Ⅱ branch of subfamily GapC in phylogeny tree of GAPDH. The transcrip- tional level of PsGapdh was up-regulated throughout early infection. Heterogenous expression of PsGapdh in the yeast tdh1-deleted mutant could rescue growth arrest under continuous exposure to H2O2. These results indicated active roles of PsGapdh in patho- gen-host interaction and anti-oxidation. | ZENG Juan WANG Yuanchao SHEN Gu ZHENG Xiaobo | 2006 | Chinese Science Bulletin2006，51，11： | 2 |
| 7 | Extraction optimization of insecticidal compounds from Lysurus mokusin by response surface methodology显示文摘We optimized the extraction process of Lysurus mokusin(L.)Fr.insecticidal compound(LMIC)using response surface methodology with ultrasonic extraction(UE).The surface morphologies of maceration extract(ME)and UE residues were compared by scanning electron microscopy,and then the activity of LMIC on Lymantria dispar(Asian gypsy moths)larvae was determined.Results showed that the optimal condition of UE was followed by 80 min of extraction time,60%of ethanol concentration and 80 mL g^-1 of liquid–solid ratio.The surface morphologies of UE residue were looser and rougher than ME residue.The corrected mortalities of LMIC on L.dispar larvae was 59.77%.This result indicated that L.mokusin was a good candidate as pesticide for pest management. | Liannan Lin Jing Yang Guocai Zhang Xiaobo Zhang Chuanshan Zou Tingyu Wang Jianyong Zeng | 2020 | Journal of Forestry Research2020，31，5： | 2 |
| 8 | Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics. | Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 2 |
| 9 | A hybrid approach for processing parameters optimization of Ti-22Al-25Nb alloy during hot deformation using artificial neural network and genetic algorithm显示文摘 | Yu Sun Weidong Zeng Xiong Ma Bin Xu Xiaobo Liang Jianwei Zhang | 2011 | Intermetallics2011，，7： | 1 |
| 10 | Bone morphogenic protein-2 regulates the myogenic differentiation of PMVECs in CBDL rat serum-induced pulmonary microvascular remodeling显示文摘 | Chang Liu Lin Chen Jing Zeng Jian Cui Jiao-nin Ning Guan-song Wang Karine Belguise Xiaobo Wang Gui-sheng Qian Kai-zhi Lu Bin Yi | 2015 | Experimental Cell Research2015，，1： | 1 |
| 11 | Quantitative analysis on microstructure evolution and tensile property for the isothermally forged Ti 2 AlNb based alloy during heat treatment显示文摘 | Chen Xue Weidong Zeng Wei Wang Xiaobo Liang Jianwei Zhang | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 12 | Multi-class cancer classification through gene expression profiles: microRNA versus mRNA显示文摘Both microRNA (miRNA) and mRNA expression profiles are important methods for cancer type classification. A comparative study of their classification performance will be helpful in choosing the means of classification. Here we evaluated the classification performance of miRNA and mRNA profiles using a new data mining approach based on a novel SVM (Support Vector Machines) based recursive feature elimination (nRFE) algorithm. Computational experiments showed that information encoded in miRNAs is not sufficient to classify cancers; gut-derived samples cluster more accurately when using mRNA expression profiles compared with using miRNA profiles; and poorly differentiated tumors (PDT) could be classified by mRNA expression profiles at the accuracy of 100% versus 93.8% when using miRNA profiles. Furthermore, we showed that mRNA expression profiles have higher capacity in normal tissue classifications than miRNA. We concluded that classification performance using mRNA profiles is superior to that of miRNA profiles in multiple-class cancer classifications. | Sihua Peng Xiaomin Zeng Xiaobo Li Xiaoning Peng Liangbiao Chen | 2009 | Journal of Genetics and Genomics2009，36，7： | 1 |
| 13 | Memory access integrity:detecting fine-grained memory access errors in binary code显示文摘As one of the most notorious programming errors,memory access errors still hurt modern software security.Particularly,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access errors.However,all existing works lack the ability to handle two challenges.First,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data structure.These errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program crash.Second,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary code.However,searching memory access errors in binary code is a very common scenario in software vulnerability detection and exploitation.In order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary executables.The core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the policy.The key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing policy.Based on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is violated.We evaluate our tool on popular CTF datasets and real world softwares.Compared with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and efficiently.As the practical impact,our tool has detected three 0-day memory access errors in an audio decoder. | Wenjie Li Dongpeng Xu WeiWu Xiaorui Gong Xiaobo Xiang Yan Wang Fangming gu Qianxiang Zeng | 2019 | Cybersecurity2019，2，1： | 1 |
| 14 | A hybrid approach for processing parameters optimization of Ti-22Al-25Nb alloy during hot deformation using artificial neural network and genetic algorithm显示文摘 | Yu Sun Weidong Zeng Xiong Ma Bin Xu Xiaobo Liang Jianwei Zhang | 2011 | Intermetallics2011，，7： | 1 |
| 15 | Super-resolution Reconstruction for License Plate Images of Moving Vehicles 显示文摘 | Lu Xiaobo Zeng Weili | 2010 | Journal of Southeast University2010，26，3： | 1 |
| 16 | B2 grain growth and particle pinning effect of Ti-22Al-25Nb orthorhombic intermetallic alloy during heating process显示文摘 | Chen Xue Weidong Zeng Bin Xu Xiaobo Liang Jianwei Zhang Shiqiong Li | 2012 | Intermetallics2012，，： | 1 |
| 17 | Mixotrophic cultivation of Chlorella pyrenoidosa with diluted primary piggery wastewater to produce lipids显示文摘 | Haiying Wang Hairong Xiong Zhenglong Hui Xiaobo Zeng | 2011 | Bioresource Technology2011，，： | 1 |
| 18 | Magnetic responsive hydroxyapatite composite scaffolds construction for bone defect reparation显示文摘 | Xiaobo Zeng Wu Lan Xie Hu Xiaobo Zeng Zhongwei Gu Jiang | 2012 | International Journal of Nanomedicine . 2012 (defa)2012，，： | 1 |
| 19 | More than just a GPCRligand: structure-based discovery of thioridazine derivativesas pim-1 kinase inhibitors显示文摘 | Li Wei Wan Xiaobo Zeng Fanqi | 2014 | Med Chem Comm2014，5，4： | 1 |
| 20 | The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway显示文摘Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently,there are no molecular targeted drugs approved for osteosarcoma treatment,particularly effective drugs for osteosarcoma with pulmonary metastases.It has been reported that fibroblast activation protein alpha(FAPa)is upregulated in osteosarcoma and critically associated with osteosarcoma progression and metastasis,demonstrating that FAPa-targeted agents might be a promising therapeutic strategy for osteosarcoma.In the present study,we reported that the FAPa-activated vinblastine prodrug Z-GP-DAVLBH exhibited potent antitumor activities against FAPa-positive osteosarcoma cells in vitro and in vivo.Z-GP-DAVLBH inhibited the growth and induced the apoptosis of osteosarcoma cells.Importantly,it also decreased the migration and invasion capacities and reversed epithelial-mesenchymal transition(EMT)of osteosarcoma cells in vitro and suppressed pulmonary metastasis of osteosarcoma xenografts in vivo.Mechanistically,Z-GP-DAVLBH suppressed the AXL/AKT/GSK-3β/β-catenin pathway,leading to inhibition of the growth and metastatic spread of osteosarcoma cells.These findings demonstrate that Z-GP-DAVLBH is a promising agent for the treatment of FAPa-positive osteosarcoma,particularly osteosarcoma with pulmonary metastases. | Geni Ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Wen Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin Wencai Ye Dongmei Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
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