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| 1 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 2 | Simultaneous determination of nine fluoro-quinolonesin egg white and egg yolk by liquid chromatography withfluorescence detection显示文摘 | Zhenling Zeng Aiguo Dong Guixiang Yang | 2005 | Journal of ChromatographyB2005，821，： | 1 |
| 3 | Determination of ractopamine and clenbuterol in feeds by gas chromatography–mass spectrometry显示文摘 | Limin He Yijuan Su Zhenling Zeng Yahong Liu Xianhui Huang | 2006 | Animal Feed Science and Technology2006，，3： | 1 |
| 4 | Determination of ractopamine and clenbuterol in feeds by gas chromatography-mass spectrometry显示文摘 | He Limin Su Yijuan Zeng Zhenling | 2007 | Animal Feed Science and Technology2007，132，34： | 1 |
| 5 | Effects of experimentally induced Streptococcus suis infection on pharmacokinetics of penicillin G in pigs显示文摘 | Zeng Zhenling Fung Ki-Fai | 1990 | Vet Pharmacol Ther1990，13，： | 1 |
| 6 | Novel cyromazine imprinted polymer applied to the solid-phase extraction of melamine from feed and milk samples显示文摘 | Limin He Yijuan Su Yaqiu Zheng Xianhui Huang Li Wu Yahong Liu Zhenling Zeng Zhangliu Chen | 2009 | Journal of Chromatography A2009，，34： | 1 |
| 7 | Simultaneous determination of nine fluoroquinolones in egg white and egg yolk by liquid chromatography with fluorescence detection 显示文摘 | ZENG Zhenling DONG Aiguo YANG Guixiang | 2005 | J Chromatogr B2005，821，2： | 1 |
| 8 | Determination of Sudan dye residues in eggs by liquid chromatography and gas chromatography–mass spectrometry显示文摘 | Limin He Yijuan Su Binghu fang Xiangguang Shen Zhenling Zeng Yahong Liu | 2007 | Analytica Chimica Acta2007，，1： | 1 |
| 9 | Determina- tion of Residual Clopidol in Chicken Musele by Capillary Gas Chromatography/Mass Spectrometry 显示文摘 | He LiMin Liu YaHong Zeng ZhenLing | 2005 | Journal of Interna- tional AOAC2005，88，4： | 1 |
| 10 | Metabolism of mequindox and its metabolites identification in chickens using LC–LTQ-Orbitrap mass spectrometry显示文摘 | Qi Shan Yiming Liu Limin He Huanzhong Ding Xianhui Huang Fan Yang Yafei Li Zhenling Zeng | 2011 | Journal of Chromatography B2011，，： | 1 |
| 11 | Determination of rac- topamine and clenbuterol in feeds by gas chromatography-mass spectrometry显示文摘 | Limin He Yijuan Su Zhenling Zeng | 2007 | Animal Feed Science and Technology2007，132，： | 1 |
| 12 | Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration显示文摘 | Guanghui Li Fan Yang Limin He Huanzhong Ding Na Sun Yingchun Liu Yiming Liu Qi Shan Yafei Li Zhenling Zeng | 2012 | Research in Veterinary Science2012，，3： | 1 |
| 13 | Pharmacokinetics of mequindox and one of its major metabolites in chickens after intravenous, intramuscular and oral administration显示文摘 | Huanzhong Ding Yingchun Liu Zhenling Zeng Hongbin Si Kaiyong Liu Yiming Liu Fan Yang Yafei Li Dongping Zeng | 2011 | Research in Veterinary Science2011，，1： | 1 |
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