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| 1 | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus显示文摘全身的豺狼座 erythematosus (SLE ) 是 B 房间 hyperreactivity 描绘的自体免疫的疾病。像使用费的受体 7 (TLR7 ) 表明小径反常地在 SLE B 房间被激活。CyclinD3 (CCND3 ) 在 B 房间增长,开发,和区别起一个重要作用。尽管以前的研究为自发的幼芽的中心的发展集中了于 TLR7 的 B 房间内在的角色,在 SLE B 房间的 CCND3 上的 TLR7 的影响仍然不是清楚的。这里,我们使用了介绍薄片的 B 房间并且发现 CCND3 与 SLE 有关并且显著地在 SLE B 房间提高了。而且,我们决定 CCND3 的表示水平更高,当 miR-15b 与正常题目相比在从 SLE 病人和 B6.MRL-Faslpr/J 豺狼座老鼠的 B 房间是显著地更低的时。而且,我们证明 TLR7 的激活戏剧性地增加了 CCND3 表示,但是显著地减少了在在 vitro 的 B 房间的 miR-15b 并且我们鉴别 CCND3 是 miR-15b 的一个直接目标。为了推进,证实我们的结果,我们由谈论地对待 C57BL/6 (B6 ) 建立了另一个豺狼座模型有为 8 个星期的 TLR-7 收缩筋 imiquimod (IMQ ) 的老鼠根据以前描述的协议。Expectedly,有 IMQ 的热门治疗显著地也增加了 CCND3 并且减少在 B6 老鼠的 B 房间的 miR-15b。一起拿,我们的结果鉴别 TLR7 的激活在 B cells; 经由 miR-15b 的 downregulation 增加了 CCND3 表示;因此,这些调查结果建议那外来的导致因素的 CCND3 表情可以在 SLE 贡献 B 房间的反常。 | Deshan Ren Fei Liu Guanjun Dong Ming You Jianjian Ji Yahong Huang Yayi Hou Hongye Fan | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 2 | Modulation of nitrate-induced phosphate response by the MYB transcription factor RLI1/HINGE1 in the nucleus显示文摘The coordinated utilization of nitrogen(N)and phosphorus(P)is vital for plants to maintain nutrient balance and achieve optimal growth.Previously,we revealed a mechanism by which nitrate induces genes for phosphate utilization;this mechanism depends on NRT1.1B-facilitated degradation of cytoplasmic SPX4,which in turn promotes cytoplasmic-nuclear shuttling of PHR2,the central transcription factor of phosphate signaling,and triggers the nitrate-induced phosphate response(NIPR)and N-P coordinated utilization in rice.In this study,we unveiled a fine-tuning mechanism of NIPR in the nucleus regulated by Highly Induced by Nitrate Gene 1(HINGE1,also known as RLI1),a MYB-transcription factor closely related to PHR2.RLI1/HINGE1,which is transcriptionally activated by PHR2 under nitrate induction,can directly activate the expression of phosphate starvation-induced genes.More importantly,RLI1/HINGE1 competes with PHR2 for binding to its repressor proteins in the nucleus(SPX proteins),and consequently releases PHR2 to further enhance phosphate response.Therefore,RLI1/HINGE1 amplifies the phosphate response in the nucleus downstream of the cytoplasmic SPX4-PHR2 cascade,thereby enabling fine-tuning of N-P balance when nitrate supply is sufficient. | Zhihua Zhang Zhao Li Wei Wang Zhimin Jiang Liping Guo Xiaohan Wang Yangwen Qian Xiahe Huang Yongqiang Liu Xiujie Liu Yahong Liu Aifu Li Yu Yan Junpeng Xie Shouyun Cao Stanislav Kopriva Legong Li Fanjiang Kong Baohui Liu Yingchun Wang Bin Hu Chengcai Chu | 2021 | Molecular Plant2021，14，3： | 4 |
| 3 | The Construction of Active Source Repeated Monitoring in the Qilian Mountain, Gansu Province显示文摘The exciting source of the active source repeated monitoring is located in the Xiliushui Reservoir in Zhangye,Gansu Province. The system began operating normally on July 9,2015,and we had completed a period of 40 days of continuous excitation experiment before November 10,2015. Our results reveal that the airgun source has good consistency and repeatability,and the detective system of active source can record signal clearly. The construction of active source repeated exploration projects has achieved some results,which can provide valuable experience for the research of active source repeated exploration. The observation data we obtained makes it possible to follow the temporal and spatial variations of the deep structure of the Qilian Mountain areas. | Zhang Yuansheng Guo Xiao Qin Manzhong Liu Xuzhou Wei Congxin Shen Xuzhang Yan Wenhua Zou Rui Yin Liang Wang Yahong Sun Dianfeng Feng Hongwu Zhang Lifeng Guo Yingxia | 2016 | Earthquake Research in China2016，30，3： | 4 |
| 4 | A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors显示文摘The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2(SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screening protocol that combined the fluorescence-based enzyme assay and the conformation-dependent thermal shift assay for the discovery of SHP2 inhibitors. The established method can effectively exclude the false positive SHP2 inhibitors with fluorescence interference and was also successfully employed to identify new protein tyrosine phosphatase domain of SHP2(SHP2-PTP) and allosteric inhibitors. Of note, this protocol showed potential for identifying SHP2 inhibitors against cancer-associated SHP2 mutation SHP2-E76 A. After initial screening of our in-house compound library(w2300 compounds), we identified 4 new SHP2-PTP inhibitors(0.17%hit rate) and 28 novel allosteric SHP2 inhibitors(1.22% hit rate), of which SYK-85 and WS-635 effectively inhibited SHP2-PTP(SYK-85: IC_(50) Z 0.32 mmol/L;WS-635: IC_(50) Z 4.13 mmol/L) and thus represent novel scaffolds for designing new SHP2-PTP inhibitors. TK-147, an allosteric inhibitor, inhibited SHP2 potently(IC_(50) Z 0.25 mmol/L). In structure, TK-147 could be regarded as a bioisostere of the well characterized SHP2 inhibitor SHP-099, highlighting the essential structural elements for allosteric inhibition of SHP2. The principle underlying the cross-validation protocol is potentially feasible to identify allosteric inhibitors or those inactivating mutants of other proteins. | Yihui Song Min Zhao Yahong Wu Bin Yu Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 2 |
| 5 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 6 | Robust far-field imaging by spatial coherence engineering显示文摘The degree of coherence(DOC)function that characterizes the second-order correlations at any two points in a light field is shown to provide a new degree of freedom for carrying information.As a rule,the DOC varies along the beam propagation path,preventing from the efficient information recovery.In this paper,we report that when a partially coher-ent beam carrying a cross phase propagates in free space,in a paraxial optical system or in a turbulent medium,the modulus of the far-field(focal plane)DOC acquires the same value as it has in the source plane.This unique propaga-tion feature is employed in a novel protocol for far-field imaging via the DOC,applicable to transmission in both free-space and turbulence.The advantages of the proposed approach are the confidentiality and resistance to turbulence,as well as the weaker requirement for the beam alignment accuracy.We demonstrate the feasibility and the robustness of the far-field imaging via the DOC in the turbulent media through both the experiment and the numerical simulations.Our findings have potential applications in optical imaging and remote sensing in natural environments,in the presence of op-tical turbulence. | Yonglei Liu Yahong Chen Fei Wang Yangjian Cai Chunhao Liang Olga Korotkova | 2021 | Opto-Electronic Advances2021，4，12： | 2 |
| 7 | Determination of ractopamine and clenbuterol in feeds by gas chromatography–mass spectrometry显示文摘 | Limin He Yijuan Su Zhenling Zeng Yahong Liu Xianhui Huang | 2006 | Animal Feed Science and Technology2006，，3： | 1 |
| 8 | Arc discharge regulation of a megawatt hot cathode bucket ion source for the experimental advanced superconducting Tokamak neutral beam injector显示文摘 | Xie Yahong Hu Chundong Liu Sheng | 2012 | Review of Scientific Instruments2012，83，01： | 1 |
| 9 | Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer显示文摘 | Wei Liu Mingxia Zhai Zongyin Wu Yuanming Qi Yahong Wu Chao Dai Meng Sun Lu Li Yanfeng Gao | 2012 | Amino Acids2012，，： | 1 |
| 10 | Two Loop-free Alternate Interface Selection Criterions in Shortest-path-first Network显示文摘 | LIU Jinhua WANG Yahong | 2006 | China Communications2006，，： | 1 |
| 11 | Scintillation index of a multi-Gaussian Schell-model beam in turbulent atmosphere显示文摘 | Yangsheng Yuan Xianlong Liu Fei Wang Yahong Chen Yangjian Cai Jun Qu Halil T. Eyyubo?lu | 2013 | Optics Communications2013，，： | 1 |
| 12 | Novel cyromazine imprinted polymer applied to the solid-phase extraction of melamine from feed and milk samples显示文摘 | Limin He Yijuan Su Yaqiu Zheng Xianhui Huang Li Wu Yahong Liu Zhenling Zeng Zhangliu Chen | 2009 | Journal of Chromatography A2009，，34： | 1 |
| 13 | Infection Prevention Strategy in Operating Room during Coronavirus Disease 2019(COVID-19)Outbreak显示文摘A novel coronavirus that emerged in late 2019 rapidly spread around the world.Most severe cases need endotracheal intubation and mechanical ventilation,and some mild cases may need emergent surgery under general anesthesia.The novel coronavirus was reported to transmit via droplets,contact and natural aerosols from human to human.Therefore,aerosol-producing procedures such as endotracheal intubation and airway suction may put the healthcare providers at high risk of nosocomial infection.Based on recently published articles,this review provides detailed feasible recommendations for primary anesthesiologists on infection prevention in operating room during COVID-19 outbreak. | Yi Tian Yahong Gong Peiyu Liu Sheng Wang Xiaohan Xu Xiaoyue Wang Yuguang Huang | 2020 | Chinese Medical Sciences Journal2020，35，2： | 1 |
| 14 | Arc discharge regulation of a megawatt hot cath- ode bucket ion source for the experimental ad- vanced superconducting Tokamak neutral beam injector显示文摘 | XIE Yahong HU Chundong LIU Sheng | 2012 | Review of Scientific Instruments2012，83，1： | 1 |
| 15 | Urotensin Ⅱ receptor in the rat airway smooth muscle and its effect on the airway smooth muscle cells proliferation显示文摘 | Chen Yahong Zhao Mingwu Liu Xiuhua | 2001 | Chin Med Sci J2001，16，4： | 1 |
| 16 | Determination of Sudan dye residues in eggs by liquid chromatography and gas chromatography–mass spectrometry显示文摘 | Limin He Yijuan Su Binghu fang Xiangguang Shen Zhenling Zeng Yahong Liu | 2007 | Analytica Chimica Acta2007，，1： | 1 |
| 17 | Two‐Way Nanopore Sensing of Sequence‐Specific Oligonucleotides and Small‐Molecule Targets in Complex Matrices Using Integrated DNA Supersandwich Structures显示文摘 | Nannan Liu Yanan Jiang Yahong Zhou Fan Xia Wei Guo Lei Jiang | 2013 | Angew Chem Int Ed2013，，7： | 1 |
| 18 | Determina- tion of Residual Clopidol in Chicken Musele by Capillary Gas Chromatography/Mass Spectrometry 显示文摘 | He LiMin Liu YaHong Zeng ZhenLing | 2005 | Journal of Interna- tional AOAC2005，88，4： | 1 |
| 19 | Evaluating the expression and diagnostic value of human epididymis protein 4 (HE4) in small cell lung cancer显示文摘 | Ximing Wang Yahong Fan Jinliang Wang Huaming Wang Wenchao Liu | 2014 | Tumor Biology2014，，7： | 1 |
| 20 | Fibroblast exosomal TFAP2C induced by chitosan oligosaccharides promotes peripheral axon regeneration via the miR-132-5p/CAMKK1 axis显示文摘Chitosan and its degradation product,oligosaccharides,have been shown to facilitate peripheral nerve regeneration.However,the underlying mechanisms are not well understood.In this study,we analyzed the protein expression profiles in sciatic nerves after injury using proteomics.A group of proteins related to exosome packaging and transport is up-regulated by chitosan oligosaccharides(COS),implying that exosomes are involved in COS-induced peripheral nerve regeneration.In fact,exosomes derived from fibroblasts(f-EXOs)treated with COS significantly promoted axon extension and regeneration.Exosomal protein identification and functional studies,revealed that TFAP2C is a key factor in neurite outgrowth induced by COS-f-EXOs.Furthermore,we showed that TFAP2C targets the pri-miRNA-132 gene and represses miR-132-5p expression in dorsal root ganglion neurons.Camkk1 is a downstream substrate of miR-132-5p that positively affects axon extension.In rats,miR-132-5p antagomir stimulates CAMKK1 expression and improves axon regeneration and functional recovery in sciatic nerves after injury.Our data reveal the mechanism for COS in axon regeneration,that is COS induce fibroblasts to produce TFAP2C-enriched EXOs,which are then transferred into axons to promote axon regeneration via miR-132-5p/CAMKK1.Moreover,these results show a new facet of fibroblasts in axon regeneration in peripheral nerves. | Yahong Zhao Jina Liu Sha Liu Panpan Yang Yunyun Liang Jinyu Ma Susu Mao Cheng Sun Yumin Yang | 2023 | Bioactive Materials2023，，8： | 1 |
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