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| 1 | Evolution of the CBM reservoir-forming dynamic system with mixed secondary biogenic and thermogenic gases in the Huainan Coalfield,China显示文摘The secondary biogenic gas is an important original type of the coalbed methane (CBM) in China. Based on the analyses of sedimentary and burial history of the Permian coal-bearing strata, combined with thermal history and gas generation process of coals, the CBM reservoir-forming dynamic system with mixed secondary biogenic and thermogenic gases in the Huainan Coalfield is subdivided into four evolutionary stages as follows: (i) shallowly-buried peat and early biogenic gas stage; (ii) deeply buried coal seams and thermogenic gas stage; (iii) exhumation of coal-bearing strata and adsorbed gas lost stage; and (iv) re-buried coal-bearing strata and secondary biogenic gas supplement stage. The Huainan CBM reservoir-forming model has the features of the basin-centered gas accumulation. The evolution of the reservoir-forming dynamic system proves that the thermogenic gas is not the main gas source for the Huainan CBM reservoir. Only the secondary biogenic gases as an additional source replenish into the coal bed after basin-uplift, erosional unroofing and subsequent scattering of thermogenic gases. Then this kind of mixed CBM reservoirs can be formed under suitable conditions. | ZHANG Hong CUI Yongjun TAO Mingxin PENG Gelin JIN Xianglan LI Guihong | 2005 | Chinese Science Bulletin2005，50，S1： | 10 |
| 2 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 3 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 4 | Dietary Fiber Intake Reduces Risk for Gastric Cancer: A Meta-analysis显示文摘 | Zhizhong Zhang Gelin Xu Minmin Ma Jie Yang Xinfeng Liu | 2013 | Gastroenterology2013，，1： | 1 |
| 5 | A user-space file system for on-demand legacy desktop software显示文摘Some user-level virtualization technologies have been used to convert legacy software (like the existing Windows desktop applications) into the on-demand software without any modification. To give the client a friendly and compatible method to access on-demand legacy software across the Internet, this paper presents a clientend file system for this usage case. It is a Windows user-space file system based on the cloud storage (where the on-demand software is stored), which converts the local file system accesses into remote visits. Quite a few optimizations are adopted and adjusted to suit the file-access-pattern of on-demand software, including the local cache, metadata/data/software prefetch and content-addressable storage (CAS), to decrease the number of remote visits and/or to overlap IO (input/output) operations with software execution. Detailed access-pattern analyses are also presented. This file system has been implemented and tests show that it is practical for much daily-used software-a local cache of limited size can provide up to 80% hit ratio and the corresponding overhead of running-time is about 37%. Owing to this method, on any compatible and networked computer, a user can use his/her personalized software conveniently although it does not exist on the local host. | ZHANG YouHui 1,2 , SU GeLin 1,2 & ZHENG WeiMin 1,2 1 Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China 2 Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing 100084, China | 2011 | Science China(Information Sciences)2011，54，6： | 1 |
| 6 | High performance liquid chromatographic method for simultaneous determination of baicalein and baicalein 7 glucuronide in rat plasma 显示文摘 | Li Zhang GeLin Zhong Zuo | 2004 | Journal of Phar maceutical and Biomedical Analysis2004，36，3： | 1 |
| 7 | Stereotactic Aspiration Plus Subsequent Thrombolysis for Moderate Thalamic Hemorrhage显示文摘 | Maogang Chen Qizhang Wang Wusheng Zhu Qin Yin Minmin Ma Xinying Fan Yongkun Li Guanzhong Ni Chaolai Liu Wenhua Liu Renliang Zhang Gelin Xu Xinfeng Liu | 2012 | World Neurosurgery2012，，1： | 1 |
| 8 | Double cladding seven-core photonic crystal fibers with different GVD properties and fundamental supermode output 显示文摘 | Yan Peiguang Zhang Gelin Wei Huifeng | 2013 | Journal of Lightwave Technology2013，31，23： | 1 |
| 9 | Risk factors associated with haemodynamic depression during and after carotid artery stenting显示文摘 | Xuegan Lian Min Lin Shuanggen Zhu Wenhua Liu Min Li Wen Sun Qin Yin Gelin Xu Renliang Zhang Xinfeng Liu | 2011 | Journal of Clinical Neuroscience2011，，10： | 1 |
| 10 | DSA-Based Quantitative Assessment of Cerebral Hypoperfusion in Patients with Asymmetric Carotid Stenosis显示文摘Digital subtraction angiography(DSA)is often used to evaluate the morphological and pathological changes of cerebral arteries in clinical practice.This study aims to explore the possibility of assessing cerebral hypoperfusion with DSA in patients with carotid stenosis.Thirty patients with a mild to severe stenosis on one side,and a mild stenosis on the other side of the carotid artery were recruited.Frontal,parietal,temporal and occipital lobes were chosen as regions of interest for measuring the quantitative perfusion parameters from their time-density curves(TDCs)of DSA images.The perfusion parameters were compared between the two hemispheres by using paired ttest.In addition,the bilateral asymmetry of these parameters was calculated and its correlation with the bilateral asymmetry in stenosis was analyzed.The parameters included mean transit time(MTT),time of contrast uptake(TU),time taken to the half peak value(1/2TMAX),area under the curve(AUC)were significantly prolonged at the severe stenosis side than those at the mild stenosis side in frontal lobe(P=0.013;P=0.041;P=0.009;P=0.027)and parietal lobe(P=0.008;P=0.041;P=0.002;P=0.012).The asymmetric ratios of MTT and AUC showed statistically significant correlations with stenosis asymmetry in all four lobes.MTT,TU,1/2TMAX and AUC could reflect the bilateral asymmetry of the cerebral perfusion.These DSA parameters,therefore,may be used for the evaluation of cerebral hypoperfusion caused by carotid stenosis. | Xu Zhang Jie Gao Xinke Yao Zhengze Dai Gelin Xu Yan Cai Zhiyong Li | 2019 | Molecular & Cellular Biomechanics2019，16，1： | 0 |
| 11 | Genotype analysis of rotaviruses isolated from children during a phase III clinical trial with the hexavalent rotavirus vaccine in China显示文摘The oral hexavalent live human-bovine reassortant rotavirus vaccine(RV6)developed by Wuhan Institute of Biological Products Co.,Ltd(WIBP)has finished a randomized,placebo-controlled phase III clinical trial in four provinces of China in 2021.The trail demonstrated that RV6 has a high vaccine efficacy against the prevalent strains and is safe for use in infants.During the phase III clinical trial(2019–2021),200 rotavirus-positive fecal samples from children with RV gastroenteritis(RVGE)were further studied.Using reverse transcription-polymerase chain reaction and high-throughput sequencing,VP7 and VP4 sequences were obtained and their genetic characteristics,as well as the differences in antigenic epitopes of VP7,were analyzed in detail.Seven rotavirus genotypes were identified.The predominant rotavirus genotype was G9P[8](77.0%),followed by prevalent strains G8P[8](8.0%),G3P[8](3.5%),G3P[9](1.5%),G1P[8](1.0%),G2P[4](1.0%),and G4P[6](1.0%).The amino acid sequence identities of G1,G2,G3,G4,G8,and G9 genotypes of isolates compared to the vaccine strains were 98.8%,98.2%–99.7%,88.4%–99.4%,98.2%,94.2%–100%,and 93.9%–100%,respectively.Notably,the vaccine strains exhibited high similarity in amino acid sequence,with only minor differences in antigenic epitopes compared to the Chinese endemic strains.This supports the potential application of the vaccine in preventing diseases caused by rotaviruses. | Wenqi Zou Qingchuan Yu Yan Liu Qingliang Li Hong Chen Jiamei Gao Chen Shi Ying Wang Wei Chen Xuan Bai Biao Yang Jiuwei Zhang Ben Dong Bo Ruan Liuyifan Zhou Gelin Xu Zhongyu Hu Xiaoming Yang | 2023 | Virologica Sinica2023，38，6： | 0 |
| 12 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase(NAMPT)and their preclinical neuroprotective activity显示文摘The decline of nicotinamide adenine dinucleotide(NAD)occurs in a variety of human pathologies including neurodegeneration.NAD-boosting agents can provide neuroprotective benefits.Here,we report the discovery and development of a class of potent activators(NATs)of nicotinamide phosphoribosyltransferase(NAMPT),the rate-limiting enzyme in the NAD salvage pathway.We obtained the crystal structure of NAMPT in complex with the NAT,which defined the allosteric action of NAT near the enzyme active site.The optimization of NAT further revealed the critical role of K189 residue in boosting NAMPT activity.NATs effectively increased intracellular levels of NAD and induced subsequent metabolic and transcriptional reprogramming.Importantly,NATs exhibited strong neuroprotective efficacy in a mouse model of chemotherapy-induced peripheral neuropathy(CIPN)without any overt toxicity.These findings demonstrate the potential of NATs in the treatment of neurodegenerative diseases or conditions associated with NAD level decline. | Hong Yao Minghui Liu Leibo Wang Yumeng Zu Chou Wu Chenyu Li Ruoxi Zhang Haigen Lu Feifei Li Shuang Xi Shuangquan Chen Xuanyu Gu Tianya Liu Jie Cai Shirong Wang Maojun Yang Guo-Gang Xing Wei Xiong Lan Hua Yefeng Tang Gelin Wang | 2022 | Cell Research2022，32，6： | 0 |
| 13 | Resurrection of the genus Botrydium Spach(Chenopodiaceae),with a description of four new species from China,Peru and Burundi显示文摘Based on specimens from twenty-one herbaria from China and USA,as well as observations using SEM,the genus Botrydium is resurrected as Neobotrydium.It has a number of distinctive characters:the plants are covered with granular hairs and granulated globular gland-grains,strong smell,and dichasia.Neobotrydium is removed from Chenopodium.The differences between Neobotrydium and Chenopodium,as well as circumscriptions of five glandular genera,Neobotrydium,Cycloloma,Roubieva,Ambrina,and Dysphania are discussed.Neobotrydium comprises twenty species which occur in Asia,Europe,North Africa,North America to Northwest of South America and Australia.Four new species are described:Neobotrydium corniculatum and Neobotrydium ornithopodum from China,Neobotrydium peruensis from South America,and Neobotrydium burundiensis from Africa.A diagnostic key is presented. | Mingli Zhang Gelin Zhu | 2016 | Plant Diversity2016，38，6： | 0 |
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