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| 1 | Effects of Ziyin Jianghuo Ningxin decoction plus dehydroepiandrosterone and femoston in treatment of patients with menopausal symptoms显示文摘OBJECTIVE: To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction(ZYJHNXD) plus dehydroepiandrosterone(DHEA) and menopausalhormone therapy(MHT) in patients suffering from menopausal symptoms identified as, in terms of Traditional Chinese Medicine, symptom pattern of Yin deficiency with hyperactive fire.METHODS: Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston, femoston with ZYJHNXD,femoston with DHEA, femoston with ZYJHNXD and DHEA therapies, respectively, for three months.Common questionnaire-based measure instruments included modified Kupperman index(MKI),Hamilton Rating Scale for Anxiety(HAMA), and Hamilton Rating Scale for Depression(HAMD). Follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), 5-hydroxyindole-3-acetic acid(5-HIAA), norepinephrine(NE), dopamine(DA),bone mineral density(BMD), and sleep quality were evaluated before and three months after the treatments.RESULTS: In all four groups, the scores of MKI, HAMA, HAMD and the levels of FSH, LH decreased significantly(P < 0.05) after the treatment, while the levels of E2, 5-HIAA, NE, and DA showed obvious elevation(P < 0.05). The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.CONCLUSION: ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms, restoring hormone levels, preventing skeletal rarefaction or osteoporosis,and improving sleep quality for postmenopausal women. | Lin Jing Zhu Jun Tian Fubo Chen Lanting Zhang Yang Wang Yan Wang Mingyan Hans-Jurgen Gober Li Da-jin Wang Ling | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 6 |
| 2 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 3 | Toward dendrite-free and anti-corrosion Zn anodes by regulating a bismuth-based energizer显示文摘Aqueous rechargeable zinc metal batteries display high theoretical capacity along with economical effectiveness,environmental benignity and high safety.However,dendritic growth and chemical corrosion at the Zn anodes limit their widespread applications.Here,we construct a Zn/Bi electrode via in-situ growth of a Bi-based energizer upon Zn metal surface using a replacement reaction.Experimental and theoretical calculations reveal that the Bi-based energizer composed of metallic Bi and ZnBi alloy contributes to Zn plating/stripping due to strong adsorption energy and fast ion transport rates.The resultant Zn/Bi electrode not only circumvents Zn dendrite growth but also improves Zn anode anti-corrosion performance.Specifically,the corrosion current of the Zn/Bi electrode is reduced by 90%compared to bare Zn.Impressively,an ultra-low overpotential of 12mV and stable cycling for 4000h are achieved in a Zn/Bi symmetric cell.A Zn–Cu/Bi asymmetric cell displays a cycle life of 1000 cycles,with an average Coulombic efficiency as high as 99.6%.In addition,an assembled Zn/Bi-activated carbon hybrid capacitor exhibits a stable life of more than 50,000 cycles,an energy density of 64Wh kg−1,and a power density of 7kWkg−1.The capacity retention rate of a Zn/Bi–MnO_(2)full cell is improved by over 150%compared to a Zn–MnO_(2)cell without the Bi-based energizer.Our findings open a new arena for the industrialization of Zn metal batteries for large-scale energy storage applications. | Mingming Wang Yahan Meng Ke Li Touqeer Ahmad Na Chen Yan Xu Jifei Sun Mingyan Chuai Xinhua Zheng Yuan Yuan Chunyue Shen Ziqi Zhang Wei Chen | 2022 | eScience2022，2，5： | 4 |
| 4 | Clinical characteristics and post-discharge follow-up analyses of 10 infants with congenital tuberculosis:A retrospective observational study显示文摘Importance Congenital tuberculosis(TB)is a rare,potentially fatal disease.There is currently a lack of detailed clinical information available regarding this disease.Objective This retrospective study investigated the clinical manifestations,treatment,and long-term prognosis of congenital TB.Methods Patients were treated in Beijing Children’s Hospital,Capital Medical University(Beijing,China)between 2009 and 2018.Their demographic data,maternal and family histories,symptoms and signs,treatment information,and follow-up data were retrospectively collected using the hospital’s electronic information system.Results Ten infants with congenital TB were enrolled.The mean gestational age was 36.6±2.2 weeks and mean birth weight was 2517±487 g.All 10 patients exhibited fever,nine patients(90%)had anemia,and six patients(60%)had extrauterine growth retardation.On chest computed tomography scans,all 10 patients presented multiple pulmonary nodules and four patients(40%)had mediastinal adenopathy.Nine out of ten(90%)completed the T-spot test,and eight of them(8/9,89%)were positive.Anti-TB treatment was initiated upon diagnostic confirmation.All patients(100%)received combined treatment with isoniazid(INH)and rifampicin(RIF).Eight of 10 patients(80%)received combined treatment with INH,RIF,and pyrazinamide.The survival rate was 100%.One patient was lost to follow-up and four patients are currently continuing treatment.Three of nine patients(33%)achieved normal developmental milestones at 6 months of age.Interpretation Early diagnosis based on maternal history,typical imaging results,and timely treatment can improve outcomes in infants with congenital TB. | Juan Du Shixiao Dong Shengnan Jia Qiaoru Zhang Mingyan Hei | 2021 | Pediatric Investigation2021，5，2： | 4 |
| 5 | The synthesis of benzoxaboroles and their applications in medicinal chemistry显示文摘Benzoxaborole,as a versatile scaffold,plays important roles in organic synthesis,molecular recognition and supramolecular chemistry.It is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like properties.Recently,benzoxaboroles were widely applied as antifungal,antibacterial,antiviral,anti-parasite,and anti-inflammatory agents.This review covers the properties,synthetic methods and applications of benzoxaboroles in medicinal chemistry. | ZHANG Jiong ZHU MingYan LIN YiNan ZHOU HuChen | 2013 | Science China Chemistry2013，56，10： | 3 |
| 6 | Metal porphyrin intercalated reduced graphene oxide nanocomposite utilized for electrocatalytic oxygen reduction显示文摘In this paper, we report a simple and facile self-assembly method to successfully fabricate cationic metal porphyrin-MtTMPyP(Mt= Cobalt(Ⅱ), Manganese(Ⅲ), or Iron(Ⅲ); TMPyP = 5, 10, 15, 20-tetrakis(N-methylpyridinium-4-yl) porphyrin) intercalated into the layer of graphene oxide(GO) by the cooperative effects of electrostatic and π-π stacking interaction between positively charged metal porphyrin and negatively charged GO sheets. Followed by reduction with hydrazine vapor, a series of novel 2 D MtTMPyP/rGO_n were fabricated. The as-prepared 2 D hybrids were fully characterized and tested as non-noble metal catalysts for oxygen reduction reaction(ORR) in an alkaline medium. The MtTMPyP/rGO_n hybrids, especially CoTMPyP/rGO_5, demonstrated an improved electrocatalytic activity for ORR and a number of exchanged electrons close to 4-electron reaction, increased stability and excellent tolerance to methanol, showing a potential alternative catalyst for ORR in fuel cells and air batteries. | Mingyan Wang Qing Wang Wei Zhu Ying Yang Huixian Zhou Fan Zhang Lihua Zhou Joselito M.Razal Gordon G.Wallace Jun Chen | 2017 | Green Energy & Environment2017，2，3： | 3 |
| 7 | Parallel discrete lion swarm optimization algorithm for solving traveling salesman problem显示文摘As a typical representative of the NP-complete problem, the traveling salesman problem(TSP) is widely utilized in computer networks, logistics distribution, and other fields. In this paper, a discrete lion swarm optimization(DLSO) algorithm is proposed to solve the TSP. Firstly, we introduce discrete coding and order crossover operators in DLSO. Secondly, we use the complete 2-opt(C2-opt) algorithm to enhance the local search ability.Then in order to enhance the efficiency of the algorithm, a parallel discrete lion swarm optimization(PDLSO) algorithm is proposed.The PDLSO has multiple populations, and each sub-population independently runs the DLSO algorithm in parallel. We use the ring topology to transfer information between sub-populations. Experiments on some benchmarks TSP problems show that the DLSO algorithm has a better accuracy than other algorithms, and the PDLSO algorithm can effectively shorten the running time. | ZHANG Daoqing JIANG Mingyan | 2020 | Journal of Systems Engineering and Electronics2020，31，4： | 2 |
| 8 | A fluorometric and mitochondrion-targetable probe for rapid,naked-eye test of hypochlorite in real samples显示文摘Hypochlorite anion is a ubiquitous reactive molecule in the terminal disinfection systems, inflammatory stress and immune systems. Thus, rapid and visual monitoring ClO^- in water and biological samples is very meaningful for water quality safety and toxicity assessment of contaminants. Herein, a colorimetric and fluorometric probe(Rh-ClO) based on rhodamine B fluorophore and thiophene-2-carbohydrazide has been unveiled and successfully utilized for ClO^- detection in water samples and HeLa cells. Upon addition of ClO^-, color changes of solution from colorless to pink were immediately visible to the nakedeyes, meanwhile, brilliant red fluorescence was observed under excited at UV light(365 nm). Rh-ClO displayed high selectivity and sensitivity for ClO^- , and the detection limit was 7 mmol/L calculated from the fluorescence titration. With the aid of its merits including rapid response to ClO^- within 10 s, Rh-ClO and its test paper could successfully detect ClO^- in water. Additionally, HeLa cells image co-stained with Rh-ClO and Rh123 demonstrated that Rh-ClO possessed excellent and fast cell-membrane permeability and mitochondrion-targetability. It was clearly confirmed that Rh-ClO would be a promising probe for rapid tracking of ClO^- in water samples and in mitochondria of living cells. | Ying Xia Xiaoyu Liu Dan Wang Zechen Wang Qiang Liu Haibo Yu Mingyan Zhang Youtao Song | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 9 | Wireless/wired integrated transmission for industrial cyber-physical systems:risk-sensitive co-design of 5G and TSN protocols显示文摘The growing popularity of intelligent manufacturing is driven by deterministic transmission demands of applications in industrial cyber-physical systems(ICPS).However,the ossified shortages of industrial wireless communication such as diverse quality of service(Qo S)and complex signaling processes incur a severe long tail of transmission delay distribution.As a solution,the 5th generation(5 G)wireless communication technology provides ultra-reliable and low-latency communication(URLLC)for industry scenarios.Moreover,the newly proposed time-sensitive networking(TSN)standards guarantee the transmission determinacy by gate mechanism.In this paper,we propose a heterogeneous time-sensitive network(HTSN)co-designed by 5 G and TSN.We first develop a predictive multi-priority wireless scheduling mechanism based on semi-persistent scheduling(SPS)to reduce signaling delay by reserving resources in advance.Then we propose an adaptive data injection mechanism for TSN based on per-stream filtering and policing(PSFP),which dynamically adjusts the priority of data for queue injection in TSN.To further reduce the long tail of delay,we employ a risk-sensitive learning method to improve the worst-case delay.Simulations on a hot rolling production scenario demonstrate that the proposed mechanisms under HTSN achieve great performance in terms of integrated delay and resource utilization. | Yajing ZHANG Qimin XU Xinping GUAN Cailian CHEN Mingyan LI | 2022 | Science China(Information Sciences)2022，65，1： | 1 |
| 10 | The effect of the mixing characters of primary and secondary air on NOx formation in a swirling pulverized coal flame显示文摘 | Gu Mingyan Zhang Mingchuan Fan Weidong | 2005 | Fuel2005，84，8： | 1 |
| 11 | Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents显示文摘 | HU Hao JIANG Mingyan XIE Lijun HU Gang ZHANG Cuirong ZHANG Lixia ZHOU Shunguang ZHANG Meihui GONG Ping | 2015 | Chemical Research in Chinese Universities2015，31，5： | 1 |
| 12 | Ultra Low-Voltage Low-Power CMOS 4-2 and 5-2 Compressors for Fast Arithmetic Circuits显示文摘 | Chang Chip-Hong Gu Jiangmin Zhang Mingyan | 2004 | IEEE Transactions On Circuits And Systems2004，51，10： | 1 |
| 13 | Effectiveness and safety of Suxiao Jiuxin pill in treating acute coronary syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE:To evaluate the effectiveness and safety of Suxiao Jiuxin pill(SX)in acute coronary syndrome(ACS)treatment.METHODS:An extensive search of four English databases(Medline/PubMed,Cochrane Library,Embase,and World Health Organization International Clinical Trials Registration Platform)and four Chinese databases(Chinese National Knowledge Infrastructure,Wanfang,China Science and Technology Journal,and Chinese Biomedical Literature Service System)was performed.Randomized,controlled trials(RCTs)involving SX combined with conventional therapy versus conventional therapy were included.The extracted data included populations,interventions,outcomes,and risk of bias.The cardiovascular events served as the primary outcome.Review Manager 5.3 software was used for data analysis.Relative risks(RRs)with 95%confidence intervals(CIs)were the effect measure.RESULTS:A total of eight RCTs with 979 patients were included.There were 559 patients with unstable angina(UA)in six RCTs and 420 patients with acute myocardial infarction(AMI)in two RCTs.Our review showed that SX plus conventional therapy might reduce the incidence of the total endpoint(RR:0.34,95%CI:0.17,0.68,P=0.002),with no obvious adverse events(RR:1.29,95%CI:0.60,2.77,P=0.52)compared with conventional therapy for patients with UA.Additionally,SX plus conventional therapy also reduced the incidence of the total endpoint(RR:0.35,95%CI:0.18,0.68,P=0.002)compared with conventional therapy in patients with AMI.SX plus conventional therapy also reduced the incidence of ventricular fibrillation(RR:0.23,95%CI:0.10,0.57,P=0.001)compared with conventional therapy in patients with AMI.CONCLUSION:Our results suggest that SX is beneficial for treating patients with UA or AMI.However,our findings should be treated with caution because of the poor methodological quality of the included trials.Therefore,more multicenter,large-sample,high-quality RCTs are required to provide high-quality evidence. | Liu Chao Duan Lian Huang Mingyan Li Jun Xiong Xingjiang Chen Guang He Haoqiang Zhang Zhenpeng Wang Jie | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 1 |
| 14 | Fuzzy-ART Based Adaptive Digital Watermarking Scheme显示文摘 | Chang C H Ye Zhi Zhang Mingyan | 2005 | IEEE Trans on Circuits and Systems for Video Technology2005，15，1： | 1 |
| 15 | Ultra low-voltage low-power CMOS 4-2 and 5-2 compressors for fast arithmetic circuits显示文摘 | Chip-Hong Chang Jiangmin Gu Mingyan Zhang | 2004 | IEEE Transactions on Circuits and Systems2004，51，10： | 1 |
| 16 | Synthesis and characterization of silica-alumina co-doped polyimide film 显示文摘 | ZHONG Jinghe ZHANG Mingyan JIANG Qibin | 2006 | Materials Letters2006，60，： | 1 |
| 17 | Activity study of a hydroxynaphthoquinone fraction from Arnebia euchroma in experimental arthritis显示文摘 | Huaying Fan Mingyan Yang Xin Che Ziliang Zhang Hui Xu Ke Liu Qinggang Meng | 2012 | Fitoterapia2012，，7： | 1 |
| 18 | The Effect of the Mixing Characters of Primary and Secondary Air on NOx Formation in a Swirling Pulverized Coal Flame 显示文摘 | Gu Mingyan Zhang Mingchuan Fan Weidong | 2005 | Fuel2005，，84： | 1 |
| 19 | Fuzzy-ART Based Adaptive Digital Watermarking Scheme显示文摘 | Chang Chip-Hong Ye Zhi Zhang Mingyan | 2005 | IEEE Transactions on Circuits and Systems for Video Technology2005，15，1： | 1 |
| 20 | Ultra low-voltage low-power CMOS 4-2 and 5-2 compressors for fast arithmetic circuits显示文摘 | Chang Chip-Hong Gu Jiangmin Zhang Mingyan | 2004 | IEEE Transactions on Circuits and Systems2004，51，10： | 1 |
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