|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 2 | Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2显示文摘MicroRNAs (miRNAs ) 是在 posttranscriptional 水平调整目标基因表示的 noncoding RNA 的一个类,导致进一步生物的函数。我们证明了 microvesicles (MV ) 能作为细胞间的通讯的一个新奇方法交付 miRNAs 进目标房间。在中央神经系统, glial 房间释放 MV,这被报导,它处于正常状况调制 neuronal 功能。阐明在疾病的 glial MV 的潜在的角色,我们在压力状况上评估了分泌 astrocytic MV 的效果。我们的结果证明在 Lipopolysaccharide (LPS ) 刺激以后,星形细胞释放了流提高了 dopaminergic 神经原的危险到神经毒素的泡(SV ) 。进一步的调查证明在 SV 的那增加的 astrocytic miR-34a 经由在 dopaminergic 神经原指向 anti-apoptotic 蛋白质 Bcl-2 涉及这进步。我们也发现在 LPS 刺激以后的 astrocytic miR-34a 的抑制能在神经毒素应力下面推迟 dopaminergic 神经原损失。这些数据揭示了在疾病位于星形细胞神经原相互作用下面的新奇机制。 | Susu Mao | 2015 | Protein & Cell2015，6，7： | 7 |
| 3 | MicroRNA-29a modulates axon branching by targeting doublecortin in primary neurons显示文摘MicroRNAs (miRNAs ) 内长地被表示调整蛋白质表示的小、非编码的抄本。实质的证据建议 miRNAs 在中央神经系统被充实,在他们被假设在神经开发期间起枢轴的作用的地方。在现在的学习,我们在在不同发展阶段和发现 miR-29a 的服的外皮和马头鱼尾的怪兽在出生后的阶段戏剧性地增加了的老鼠分析了 miRNAs 表示。另外,我们提供了 miR-29a 在 vitro 并且在 vivo 在成熟神经原被充实的充分证据。进一步的调查证明 glutamate 受体的激活在主要神经原导致了内长的 miR-29a 水平。而且,我们证明 miR-29a 直接调整了它的目标蛋白质 Doublecortin (DCX ) 表示,它进一步调制的轴突在主要文化分叉。一起,我们的结果建议 miR-29a 在鼠标的 neuronal 开发起一个重要作用大脑。 | Hanqin Li Susu Mao Haitao Wang Ke Zen Chenyu Zhang Liang Li | 2014 | Protein & Cell2014，5，2： | 2 |
| 4 | Crack-free single-crystalline Co-free Ni-rich LiNi_(0.95)Mn_(0.05)O_(2) layered cathode显示文摘The rapid growth in global electric vehicles(EVs)sales has promoted the development of Co-free,Ni-rich layered cathodes for state-of-the-art high energy-density,inexpensive lithium-ion batteries(LIBs).However,progress in their commercial use has been seriously hampered by exasperating performance deterioration and safety concerns.Herein,a robust single-crystalline,Co-free,Ni-rich LiNi_(0.95)Mn_(0.05)O_(2)(SC-NM95)cathode is successfully designed using a molten salt-assisted method,and it exhibits better structural stability and cycling durability than those of polycrystalline LiNi_(0.95)Mn_(0.05)O_(2) (PC-NM95).Notably,the SC-NM95 cathode achieves a high discharge capacity of 218.2 mAh g^(-1),together with a high energy density of 837.3 Wh kg^(-1) at 0.1 C,mainly due to abundant Ni^(2+)/Ni^(3+) redox.It also presents an outstanding capacity retention(84.4%)after 200 cycles at 1 C,because its integrated single-crystalline structure effectively inhibits particle microcracking and surface phase transformation.In contrast,the PC-NM95 cathode suffers from rapid capacity fading owing to the nucleation and propagation of intergranular microcracking during cycling,facilitating aggravated parasitic reactions and rocksalt phase accumulation.This work provides a fundamental strategy for designing high-performance singlecrystalline,Co-free,Ni-rich cathode materials and also represents an important breakthrough in developing high-safe,low-cost,and high-energy LIBs. | Lianshan Ni Ruiting Guo Susu Fang Jun Chen Jinqiang Gao Yu Mei Shu Zhang Wentao Deng Guoqiang Zou Hongshuai Hou Xiaobo Ji | 2022 | eScience2022，2，1： | 2 |
| 5 | Effects of high intensity pulsed electric fields on yield and chemical composition of rose essential oil显示文摘High intensity pulsed electric fields(PEF)combined with distillation was used to extract essential oil from rose.Three main parameters,namely electric field intensity,pulse number and distillation times,which can affect the efficiency of extraction,were optimized.Then,in order to demonstrate the feasibility of the method,oil obtained under optimal conditions was compared quantitatively and qualitatively with that obtained by conventional hydro distillation.Considering the extraction yield,the optimal parameters combination was obtained with electric field intensity of 20 kV/cm,pulse number of 8 and distillation time of 2 h.PEF treatment had no significant influence on the quality of essential oils.However,there was an increase in methyl eugenol percentage,which is a disadvantage from qualitative point of view. | Zhou Yajun Xue Changmei Zhang Susu Yao Guangming Zhang Ling Wang Shujie | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 1 |
| 6 | A dynamic simulation method of ground coupled heat pump system- based on borehole heat exchange effectiveness显示文摘 | Yang Weibo Zhang Susu Chen Yongping | 2014 | Energy and Buildings2014，77，： | 1 |
| 7 | Coolstreaming: design, theory, and practice 显示文摘 | Xie Susu Li Bo Zhang Xinyan | 2007 | IEEE Transactions on Multimedia2007，9，8： | 1 |
| 8 | A Mean-Field Linear-Quadratic Stochastic Stackelberg Differential Game with one Leader and Two Followers显示文摘This paper is concerned with a linear-quadrati stochastic Stackelberg differential game with one leader and two followers,where the game system is governed by a mean-field stochastic differential equatio.By maximum principle and verification theorem,the open-loop Stackelberg solution is expressed as a feedback form of the state and its mean with the help of three systems of Riccati equations. | WANG Guangchen ZHANG Susu | 2020 | Journal of Systems Science & Complexity2020，33，5： | 1 |
| 9 | Novel attapulgite/polyaniline/phosphomolybdic acid-based modified electrode for the electrochemical determination of iodate显示文摘 | Zhang Susu He Ping Lei Wen | 2014 | Journal of Electroanalytical Chemistry2014，724，4： | 1 |
| 10 | Mefatinib as first-line treatment of patients with advanced EGFR-mutant non-small-cell lung cancer:a phase Ib/II efficacy and biomarker study显示文摘EGFR inhibitors have revolutionized the treatment of advanced non-small-cell lung cancer(NSCLC).Mefatinib is a novel,bioavailable,second-generation,irreversible pan-EGFR inhibitor.This phase Ib/II open-label,single-arm,multi-center study investigated the efficacy,safety,biomarker,and resistance mechanisms of mefatinib in the first-line treatment of patients with advanced EGFR-mutant NSCLC.This study included 106 patients with EGFR-mutant stage IIIB-IV NSCLC who received first-line mefatinib at a daily dose of either 60 mg(n=51)or 80 mg(n=55).The primary endpoint was progression-free survival(PFS).Secondary endpoints were overall response rate(ORR),disease control rate(DCR),overall survival(OS),and safety.The cohort achieved an ORR of 84.9%and DCR of 97.2%.The median PFS was 15.4 months and the median OS was 31.6 months.Brain metastasis was detected in 29%of patients(n=31)at diagnosis and demonstrated an ORR of 87.1%,PFS of 12.8 months,and OS of 25.2 months.Adverse events primarily involved skin and gastrointestinal toxicities,which were well-tolerated and manageable.Analyses of mutation profiles were performed using targeted sequencing of plasma samples at baseline,first follow-up 6 weeks from starting mefatinib therapy(F1),and at progression.Patients with concurrent TP53 mutations had comparable PFS as wild-type TP53(14.0 vs 15.4 months;p=0.315).Furthermore,circulating tumor DNA clearance was associated with longer PFS(p=0.040)and OS(p=0.002).EGFR T790M was the predominant molecular mechanism of mefatinib resistance(42.1%,16/38).First-line mefatinib provides durable PFS and an acceptable toxicity profile in patients with advanced EGFR-mutant NSCLC. | Pingli Wang Yuping Li Dongqing Lv Lingge Yang Liren Ding Jianya Zhou Wei Hong Youfei Chen Dongqing Zhang Susu He Jianying Zhou Kai Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 11 | Probability-based analytical model for predicting the post-earthquake residual deformation of SDOF systems显示文摘A probability-based analytical model for predicting the seismic residual deformation of bilinear single-degreeof-freedom(SDOF)systems with a kinematic/Takeda hysteretic model is proposed based on a statistical analysis of the nonlinear time history response,and the proposed model explicitly incorporates the influence of record-to-record variability.In addition,the influence of primary parameters such as the natural vibration period,relative yield force coefficient,stiffness ratio and peak ground acceleration(PGA)on the seismic residual/maximum deformation ratio(dR/dm)are investigated.The results show that significant dispersion of the dR/dm ratio is observed for SDOF systems under different seismic ground motion records,and the dispersion degree is influenced by the model parameters and record-to-record variability.The statistical distribution of the dR/dm results of SDOF systems can be described by a lognormal distribution.Finally,a case study for seismic residual deformation and reparability assessment of the bridge structure designed with a single pier is carried out to illustrate the detailed analytical procedure of the probability-based analytical model proposed in this study. | Zhang Qin Gong Susu Gong Jinxin Zhang Guanhua Xi Guangheng | 2022 | Earthquake Engineering and Engineering Vibration2022，21，2： | 1 |
| 12 | Highly uniform Ni particles with phosphorus and phosphorus and adjacent defects catalyze 1,5-dinitronaphthalene hydrogenation with excellent catalytic performance显示文摘This work proposes a modified activated carbon support,with defects and heteroatoms(N,P-ACs)by nitrogen and phosphorus doping to load non-noble nickel to catalyze aromatic compound hydrogenation.The Ni/N,P-ACs-900(prepared at 900℃)showed promising catalytic activity in liquid-phase 1,5-dinitronaphthalene hydrogenation with a 1,5-diaminonaphthalene yield of 95.8% under the mild condition of 100℃,which is comparable to the commercial Pd/C catalyst.The nitrogen species were burned off at 900℃,causing more defects for nickel metal loading,facilitating the interaction between the supports and the nickel metal,and resulting in highly dispersed metal particles.The computational study of the nickel binding energy has been conducted using density functional theory.It exhibits that the defects formed by heteroatom doping are beneficial to nickel anchoring and deposition to form highly uniform nickel particles.The phosphorus species in combination with the defects are suitable for H_(2) adsorption and dissociation.These results reveal that the heteroatomic doping on the active carbon shows significant effects in the hydrogenation of the liquid-phase aromatic compounds.These findings could provide a promising route for the rational design of aromatic compound hydrogenation catalysts to significantly decrease the cost by instead using noble metal catalysts in the industry. | Wei Xiong Susu Zhou Zeyong Zhao Fang Hao Zhihui Cai Pingle Liu Hailiang Zhang Hean Luo | 2021 | Frontiers of Chemical Science and Engineering2021，15，4： | 1 |
| 13 | From smart testing to smartlearning : how testing technology can assist the new gener-ation of education 显示文摘 | Zhang Susu Chang Hua-Hua | 2016 | International Journal of SmartTechnology and Learning2016，1，1： | 1 |
| 14 | Advances in microwave absorbing materials with broad-bandwidth response显示文摘Microwave absorbing materials(MAMs)are playing an increasingly essential role in the development of wireless communications,high-power electronic devices,and advanced target detection technology.MAMs with a broad-bandwidth response are particularly important in the area of communication security,radiation prevention,electronic reliability,and military stealth.Although considerable progress has been made in the design and preparation of MAMs with a broad-bandwidth response,a number of challenges still remain,and the structure–function relationship of MAMs is still far from being completely understood.Herein,the advances in the design and research of MAMs with a broad-bandwidth response are outlined.The main strategies for expanding the effective absorption bandwidth of MAMs are comprehensively summarized considering three perspectives:the chemical combination strategy,morphological control strategy,and macrostructure control strategy.Several important results as well as design principles and absorption mechanisms are highlighted.A coherent explanation detailing the influence of the chemical composition and structure of various materials on the microwave absorption properties of MAMs is provided.The main challenges,new opportunities,and future perspectives in this promising field are also presented. | Susu Bao Meixi Zhang Zhiyuan Jiang Zhaoxiong Xie Lansun Zheng | 2023 | Nano Research2023，16，8： | 1 |
| 15 | Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation显示文摘Acrylic acid(AA)is an important and widely used industrial chemical,but its high toxicity renders its use incompatible with the concept of green development.By leveraging its terminal carboxyl group and unsaturated bond,we designed and explored a new strategy to increase the greenness of AA via its eutectic melting using a quaternary ammonium salt(choline chloride)to form a deep eutectic solvent(DES),followed by polymerisation of the DES to form a polymer(poly(DES)).The greenness of AA,DES,and poly(DES)was evaluated via an in vitro test using MGC80-3 cells and an in vivo test using Kunming mice.The toxicity improved from Grade 2(moderately toxic)for AA to Grade 1(slightly toxic)for DESs and Grade 0(non-toxic)for poly(DES)in the in vitro test.Moreover,the poly(DES)s showed a lower toxicity in mice than the DESs in the in vivo test.Thus,greenness enhancement was successfully achieved,with the greenness following the order AA | Liteng Li Xiaofang Li Susu Zhang Hongyuan Yan Xiaoqiang Qiao Hongyan He Tao Zhu Baokun Tang | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 16 | Efficient synthesis of cyclic carbonates under atmospheric CO_(2) by DMAP-based ionic liquids: the difference of inert hydrogen atom and active hydrogen atom in cation显示文摘The coupling reaction of carbon dioxide(CO_(2)) and epoxides is one of the most efficient pathways to achieve the carbon balance.However,to accomplish it under the mild conditions,especially under the atmospheric pressure,is still a perplexing problem.Three novel ionic liquids(ILs),[DMAPBrPC][TMGH],[DMAPBrPC][DBUH],and[DMAPBrPC][BTMA],are designed and synthesized.All of them display the excellent catalytic activity for the title reaction achieving the yield over 96.6% under the atmospheric CO_(2) pressure at 60℃.Interestingly,[DMAPBrPC][BTMA]with the inert hydrogen atom in cation exhibits the superior catalytic activity as compared to other two ILs with the protic hydrogen atom in cation along with the same anion.The active hydrogen atom in[DMAPBrPC][TMGH]and[DMAPBrPC][DBUH]would impede the–COO^(-)group to absorb CO 2,which is an unfavorable item for the reaction.Moreover,the strong hydrogen bond in[DMAPBrPC][TMGH]and[DMAPBrPC][DBUH]would lessen the nucleophilic ability of Br^(-) anion resulting in the inferior catalytic performance,which is further confirmed by the density functional theory(DFT)calculations.The cation without the active hydrogen atom could also be employed to design the ILs with the excellent catalytic feature when it is combined with the suitable anion. | Zhengkun Zhang Jinya Li Guanyao Yu Chao Zeng Menglong Wang Susu Huang Li Wang Jinglai Zhang | 2023 | Green Chemical Engineering2023，4，3： | 0 |
| 17 | Corrigendum to “Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation” [Green Energy & Environ 7 (4) (August 2022) 840–853]显示文摘The authors regret that the name of the ethic committee that approved the study and the reference number was omitted from the published paper.In this research,all animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals(US National Institutes of Healh)and were approved by the Animal Welfare and Ethical Committee of Hebei University(No.IACUC-2020XG021,Baoding,China). | Liteng Li Xiaofang Li Susu Zhang Hongyuan Yan Xiaoqiang Qiao Hongyan He Tao Zhu Baokun Tang | 2024 | Green Energy & Environment2024，9，3： | 0 |
| 18 | Determination of Sodium Pentachlorophenoxide Residues in Animal-derived Foods by Ultra-performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS)显示文摘[Objectives]This study was conducted to establish an ultra-high performance liquid chromatography-tandem mass spectrometry for the rapid extraction of sodium pentachlorophenoxide from animal-derived food.[Methods]The samples were extracted with an acetonitrile water solution(8∶2),0.1 mol/L hydrochloric acid and a purification extraction bag with shaking.Centrifugation was performed to obtain supernatants,which were added to purification tubes containing PSA and C_(18) for purification,and then filtered with membranes for determination.Each test solution was separated by a ZORBAX Eclipse plus C_(18) column with acetonitrile and 5 mmol/L ammonium acetate as mobile phases,and determined with electrospray ionization and multiple reaction monitoring.[Results]The method had good linearity in the concentration range of 1.0-50 ng/ml,and the correlation coefficient was 0.9997.The limit of detection was 0.25μg/kg and the limit of quantification was 0.75μg/kg.The recovery was between 87.4%and 112.5%,and the RSD%was between 0.5%and 10.0%.[Conclusions]The method has simple operation and high sensitivity,and is suitable for trace detection of sodium pentachlorophenoxide in large quantities of animal-derived food. | Chengmei WANG Chunxia CHENG Guixia YANG Susu ZHANG Xuan QIAN | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 19 | Enhanced H_(2) permeation and CO_(2) tolerance of self-assembled ceramic-metal-ceramic BZCYYb-Ni-CeO_(2) hybrid membrane for hydrogen separation显示文摘Perovskite-type mixed protonic-electronic conducting membranes have attracted attention because of their ability to separate and purify hydrogen from a mixture of gases generated by industrial-scale steam reforming based on an ion diffusion mechanism.Exploring cost-effective membrane materials that can achieve both high H_(2) permeability and strong CO_(2)-tolerant chemical stability has been a major challenge for industrial applications.Herein,we constructed a triple phase(ceramic-metal-ceramic)membrane composed of a perovskite ceramic phase BaZr_(0.1)Ce_(0.7)Y_(0.1)Yb_(0.1)O_(3-δ)(BZCYYb),Ni metal phase and a fluorite ceramic phase CeO_(2).Under H_(2) atmosphere,Ni metal in-situ exsolved from the oxide grains,and decorated the grain surface and boundary,thus the electronic conductivity and hydrogen separation performance can be promoted.The BZCYYbNi-CeO_(2)hybrid membrane achieved an exceptional hydrogen separation performance of 0.53 mL min^(-1)cm^(-2) at 800℃ under a 10 vol% H_(2) atmosphere,surpassing all other perovskite membranes reported to date.Furthermore,the CeO_(2) phase incorporated into the BZCYYb-Ni effectively improved the CO_(2)-tolerant chemical stability.The BZCYYbNi-CeO_(2) membrane exhibited outstanding long-term stability for at least 80 h at 700℃ under 10 vol%CO_(2)-10 vol%H_(2).The success of hybrid membrane construction creates a new direction for simultaneously improving their hydrogen separation performance and CO_(2) resistance stability. | Jianqiu Zhu Jingzeng Cui Yuxuan Zhang Ze Liu Chuan Zhou Susu Bi Jingyuan Ma Jing Zhou Zhiwei Hu Tao Liu Zhi Li Xiangyong Zhao Jian-Qiang Wang Linjuan Zhang | 2023 | Journal of Energy Chemistry2023，，7： | 0 |
| 20 | Effect of N_(2) partial pressure on comprehensive properties of antibacterial TiN/Cu nanocomposite coating显示文摘Foreign body reactions to the wear debris and corrosion products from the implants,and bacterial infections are the main factors leading to the implant failures.In order to resolve these problems,the antibacterial TiN/Cu nanocomposite coatings with various N_(2) partial pressures were deposited on 304 stainless steels(SS)using an arc ion plating(AIP)system,named TiN/Cu-x(x=0.5,1.0,1.5 Pa).The results of X-ray diffraction analysis,energy-dispersive X-ray spectroscopy,and scanning electron microscopy showed that the N_(2) partial pressures determined the Cu contents,surface defects,and crystallite sizes of TiN/Cu nanocomposite coatings,which further influenced the comprehensive abilities.And the hardness and wear resistances of TiN/Cu coatings were enhanced with increase of the crystallite sizes.Under the co-actions of surface defects,crystallite sizes,and Cu content,TiN/Cu-1.0 and TiN/Cu-1.5 coatings possessed excellent corrosion resistance.Besides,the biological tests proved that all the TiN/Cu coatings showed no cytotoxicity with strong antibacterial ability.Among them,TiN/Cu-1.5 coating significantly promoted the cell proliferation,which is expected to be a novel antibacterial,corrosion-resistant,and wear-resistant coating on the surfaces of medical implants. | Hui Liu Yanhui Zhao Chuanshi Sui Yi Li Muhammad Ali Siddiqui Susu Li Tong Li Shuyuan Zhang Hai Wang Tao Jin Ling Ren Ke Yang Ning Zhang | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员