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| 1 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 2 | Genome-and transcriptome-wide association studies provide insights into the genetic basis of natural variation of seed oil content in Brassica napus显示文摘Seed oil content(SOC)is a highly important and complex trait in oil crops.Here,we decipher the genetic basis of natural variation in SOC of Brassica napus by genome-and transcriptome-wide association studies using 505 inbred lines.We mapped reliable quantitative trait loci(QTLs)that control SOC in eight environments,evaluated the effect of each QTL on SOC,and analyzed selection in QTL regions during breeding.Six-hundred and ninety-two genes and four gene modules significantly associated with SOC were identified by analyzing population transcriptomes from seeds.A gene prioritization framework,POCKET(prioritizing the candidate genes by incorporating information on knowledge-based gene sets,effects of variants,genome-wide association studies,and transcriptome-wide association studies),was implemented to determine the causal genes in the QTL regions based on multi-omic datasets.A pair of homologous genes,BnPMT6s,in two QTLs were identified and experimentally demonstrated to negatively regulate SOC.This study provides rich genetic resources for improving SOC and valuable insights toward understanding the complex machinery that directs oil accumulation in the seeds of B.napus and other oil crops. | Shan Tang Hu Zhao Shaoping Lu Liangqian Yu Guofang Zhang Yuting Zhang Qing-Yong Yang Yongming Zhou Xuemin Wang Wei Ma Weibo Xie Liang Guo | 2021 | Molecular Plant2021，14，3： | 6 |
| 3 | Rice Information GateWay: A Comprehensive Bioinformatics Platform for Indica Rice Genomes显示文摘 | Jia-Ming,Song Yang,Lei Cheng-Cheng,Shu Yuduan,Ding Feng,Xing Hao,Liu Jia,Wang Weibo,Xie Jianwei,Zhang Ling-Ling,Chen | 2018 | Molecular Plant2018，11，3： | 5 |
| 4 | Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome显示文摘To unravel the genetic mechanisms of disease and physiological traits,it requires comprehensive sequencing analysis of large sample size in Chinese populations.Here,we report the primary results of the Chinese Academy of Sciences Precision Medicine Initiative(CASPMI)project launched by the Chinese Academy of Sciences,including the de novo assembly of a northern Han reference genome(NH1.0)and whole genome analyses of 597 healthy people coming from most areas in China.Given the two existing reference genomes for Han Chinese(YH and HX1)were both from the south,we constructed NH1.0,a new reference genome from a northern individual,by combining the sequencing strategies of PacBio,10×Genomics,and Bionano mapping.Using this integrated approach,we obtained an N50 scaffold size of 46.63 Mb for the NH1.0 genome and performed a comparative genome analysis of NH1.0 with YH and HX1.In order to generate a genomic variation map of Chinese populations,we performed the whole-genome sequencing of 597 participants and identified 24.85 million(M)single nucleotide variants(SNVs),3.85 M small indels,and 106,382 structural variations.In the association analysis with collected phenotypes,we found that the T allele of rs1549293 in KAT8 significantly correlated with the waist circumference in northern Han males.Moreover,significant genetic diversity in MTHFR,TCN2,FADS1,and FADS2,which associate with circulating folate,vitamin B12,or lipid metabolism,was observed between northerners and southerners.Especially,for the homocysteine-increasing allele of rs1801133(MTHFR 677T),we hypothesize that there exists a “comfort”zone for a high frequency of 677T between latitudes of 35–45 degree North.Taken together,our results provide a high-quality northern Han reference genome and novel population-specific data sets of genetic variants for use in the personalized and precision medicine. | Zhenglin Du Liang Ma Hongzhu Qu Wei Chen Bing Zhang Xi Lu Weibo Zhai Xin Sheng Yongqiao Sun Wenjie Li Meng Lei Qiuhui Qi Na Yuan Shuo Shi Jingyao Zeng Jinyue Wang Yadong Yang Qi Liu Yaqiang Hong Lili Dong Zhewen Zhang Dong Zou Yanqing Wang Shuhui Song Fan Liu Xiangdong Fang Hua Chen Xin Liu Jingfa Xiao Changqing Zeng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，3： | 4 |
| 5 | An improved fireworks algorithm for the capacitated vehicle routing problem显示文摘The capacitated vehicle routing problem (CVRP), which aims at minimizing travel costs, is a wellknown NP-hard combinatorial optimization. Owing to its hardness, many heuristic search algorithms have been proposed to tackle this problem. This paper explores a recently proposed heuristic algorithm named the fireworks algorithm (FWA), which is a swarm intelligence algorithm. We adopt FWA for the combinatorial CVRP problem with several modifications of the original FWA: it employs a new method to generate 'sparks' according to the selection rule, and it uses a new method to determine the explosion amplitude for each firework. The proposed algorithm is compared with several heuristic search methods on some classical benchmark CVRP instances. The experimental results show a promising performance of the proposed method. We also discuss the strengths and weaknesses of our algorithm in contrast to traditional algorithms. | Weibo YANG Liangjun KE | 2019 | Frontiers of Computer Science2019，13，3： | 4 |
| 6 | A Nonresonant Hybridized Electromagnetic-Triboelectric Nanogenerator for Irregular and Ultralow Frequency Blue Energy Harvesting显示文摘As a promising renewable energy source,it is a challenging task to obtain blue energy,which is irregular and has an ultralow frequency,due to the limitation of technology.Herein,a nonresonant hybridized electromagnetic-triboelectric nanogenerator was presented to efficiently obtain the ultralow frequency energy.The instrument adopted the flexible pendulum structure with a precise design and combined the working principle of electromagnetism and triboelectricity to realize the all-directional vibration energy acquisition successfully.The results confirmed that the triboelectric nanogenerator(TENG)had the potential to deliver the maximum power point of about 470μW while the electromagnetic nanogenerator(EMG)can provide 523 mW at most.The conversion efficiency of energy of the system reached 48.48%,which exhibited a remarkable improvement by about 2.96 times,due to the elastic buffering effect of the TENG with the double helix structure.Furthermore,its ability to collect low frequency wave energy was successfully proven by a buoy in Jialing River.This woke provides an effective candidate to harvest irregular and ultralow frequency blue energy on a large scale. | Weibo Xie Lingxiao Gao Lingke Wu Xin Chen Fayang Wang Daqiao Tong Jian Zhang Jianyu Lan Xiaobin He Xiaojing Mu Ya Yang | 2021 | Research2021，，1： | 4 |
| 7 | Control of T H 17/T reg Balance by Hypoxia-Inducible Factor 1显示文摘 | Eric V. Dang Joseph Barbi Huang-Yu Yang Dilini Jinasena Hong Yu Ying Zheng Zachary Bordman Juan Fu Young Kim Hung-Rong Yen Weibo Luo Karen Zeller Larissa Shimoda Suzanne L. Topalian Gregg L. Semenza Chi V. Dang Drew M. Pardoll Fan Pan | 2011 | Cell2011，，5： | 3 |
| 8 | Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol显示文摘End stage renal disease (ESRD), an advanced stage of chronic kidney disease, has received increasing attention as a leading public health problem (Webster et al., 2017). Chronic kidney disease (CKD) and ESRD are invariably accompanied by chronic systemic inflammation which plays central roles in CKD progression (Cachofeiro et al., 2008) and the increased mortality due to cardiovascular disease (Landray et al., 2004). | Xifan Wang Yanling Hao Xiaoxue Liu Shoujuan Yu Weibo Zhang Songtao Yang Zhengquan Yu Fazheng Ren | 2019 | Journal of Genetics and Genomics2019，46，8： | 3 |
| 9 | An inferred functional impact map of genetic variants in rice显示文摘Interpreting the functional impacts of genetic variants(GVs)is an important challenge for functional genomic studies in crops and next-generation breeding.Previous studies in rice(Oryza sativa)have focused mainly on the identification of GVs,whereas systematic functional annotation of GVs has not yet been performed.Here,we present a functional impact map of GVs in rice.We curated haplotype information for 17397026 GVs from sequencing data of 4726 rice accessions.We quantitatively evaluated the effects of missense mutations in coding regions in each haplotype based on the conservation of amino acid residues and obtained the effects of 918848 non-redundant missense GVs.Furthermore,we generated high-quality chromatin accessibility(CA)data from six representative rice tissues and used these data to train deep convolutional neural network models to predict the impacts of 5067405 GVs for CA in regulatory regions.We characterized the functional properties and tissue specificity of the GV effects and found that large-effect GVs in coding and regulatory regions may be subject to selection in different directions.Finally,we demonstrated how the functional impact map could be used to prioritize causal variants in mapping populations.This impact map will be a useful resource for accelerating gene cloning and functional studies in rice,and can be freely queried in RiceVarMap V2.0(http://gffzz90f9113514c343b0hpxxoq0kwvfwn6xn5.ffgz.tsg.suse.edu.cn). | Hu Zhao Jiacheng Li Ling Yang Gang Qin Chunjiao Xia Xingbing Xu Yangmeng Su Yinmeng Liu Luchang Ming Ling-Ung Chen Lizhong Xiong Weibo Xie | 2021 | Molecular Plant2021，14，9： | 3 |
| 10 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 11 | Photoelectrical performance of nanocrystalline TiO_2 film electrode sensitized by Ru(Ⅱ)-bipyridine complexes显示文摘Two kinds of Ru(Ⅱ)-bipyridine complexes, cis-di(thiocyanate)bis(2,2′-bipyridyl-4,4′-dicarboxylate) ruthenium(Ⅱ) and cis-di(thiocyanate)bis(2,2′-bipyridyl-3,3′-dicarboxylate) ruthenium(Ⅱ), were utilized as the sensitizers to the nanocrystalline TiO-2 film electrodes. Study shows that the two dyes have quite different sensitization properties due to the strong steric effect of carboxyl groups. In addition, the pretreatment to nanocrystalline TiO-2 film electrodes with TiCl-4 was investigated, which is an effective way to improve the photoelectric conversion performances of sensitized TiO-2 electrodes. | YANG Rong, WANG Weibo, XIAO Xurui *, HOU Yuanjun, ZHANG Baowen and GAO Yi Institute of Photographic Chemistry, Chinese Academy of Sciences, Beijing 100101, China. * Corresponding author | 1998 | Chinese Science Bulletin1998，43，6： | 2 |
| 12 | Probing thermally-induced structural evolution during the synthesis of layered Li-, Na-, or K-containing 3d transition-metal oxides显示文摘Layered alkali-containing 3d transition-metal oxides are of the utmost importance in the use of electrode materials for advanced energy storage applications such as Li-,Na-,or K-ion batteries.A significant challenge in the field of materials chemistry is understanding the dynamics of the chemical reactions between alkali-free precursors and alkali species during the synthesis of these compounds.In this study,in situ high-resolution synchrotron-based X-ray diffraction was applied to reveal the Li/Na/K-ion insertion-induced structural transformation mechanism during high-temperature solid-state reaction.The in situ diffraction results demonstrate that the chemical reaction pathway strongly depends on the alkali-free precursor type,which is a structural matrix enabling phase transi-tions.Quantitative phase analysis identifies for the first time the decomposition of lithium sources as the most critical factor for the formation of metastable intermediates or impurities during the entire process of Li-rich layered Li[Li_(0.2)Ni_(0.2)Mn_(0.6)]O_(2) formation.Since the alkali ions have different ionic radii,Na/K ions tend to be located on prismatic sites in the defective layered structure(Na_(2/3-x)[Ni_(0.25)Mn_(0.75)]O_(2) or K_(2/3-x)[Ni_(0.25)Mn_(0.75)]O_(2))during calcination,whereas the Li ions prefer to be localized on the tetrahedral and/or octahedral sites,forming O-type structures. | Weibo Hua Xiaoxia Yang Nicola PMCasati Laijun Liu Suning Wang Volodymyr Baran Michael Knapp Helmut Ehrenberg Sylvio Indris | 2022 | eScience2022，2，2： | 2 |
| 13 | A dynamic simulation method of ground coupled heat pump system- based on borehole heat exchange effectiveness显示文摘 | Yang Weibo Zhang Susu Chen Yongping | 2014 | Energy and Buildings2014，77，： | 1 |
| 14 | Numerical simulation of the performance of a solar-earth source heat pump system显示文摘 | Yang Weibo Shi Mingheng Dong Hua | 2006 | Applied Thermal Engineering2006，26，18： | 1 |
| 15 | Postharvest BTH treatment induces resistance of peach ( Prunus persica L. cv. Jiubao) fruit to infection by Penicillium expansum and enhances activity of fruit defense mechanisms显示文摘 | Hongxia Liu Weibo Jiang Yang Bi Yunbo Luo | 2004 | Postharvest Biology and Technology2004，，3： | 1 |
| 16 | New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology显示文摘 | Zhi-Yi Chen Yi-Xiang Wang Feng Yang Yan Lin Qiu-Lan Zhou Yang-Ying Liao Weibo Cai | 2014 | BioMed Research International2014，，： | 1 |
| 17 | Nu- merical investigation on the underground thermal im- balance of ground-coupled heat pump operated in cool- ing-dominated district 显示文摘 | Weibo Yang Yongping Chen Mingheng Shi | 2013 | Applied Thermal Engineer- ing2013，58，： | 1 |
| 18 | Acoustic Emission Recognition Based on a Two-Streams Convolutional Neural Network显示文摘The Convolutional Neural Network(CNN)is a widely used deep neural network.Compared with the shallow neural network,the CNN network has better performance and faster computing in some image recognition tasks.It can effectively avoid the problem that network training falls into local extremes.At present,CNN has been applied in many different fields,including fault diagnosis,and it has improved the level and efficiency of fault diagnosis.In this paper,a two-streams convolutional neural network(TCNN)model is proposed.Based on the short-time Fourier transform(STFT)spectral and Mel Frequency Cepstrum Coefficient(MFCC)input characteristics of two-streams acoustic emission(AE)signals,an AE signal processing and classification system is constructed and compared with the traditional recognition methods of AE signals and traditional CNN networks.The experimental results illustrate the effectiveness of the proposed model.Compared with single-stream convolutional neural network and a simple Long Short-Term Memory(LSTM)network,the performance of TCNN which combines spatial and temporal features is greatly improved,and the accuracy rate can reach 100%on the current database,which is 12%higher than that of single-stream neural network. | Weibo Yang Weidong Liu Jinming Liu Mingyang Zhang | 2020 | Computers, Materials & Continua2020，，7： | 1 |
| 19 | Numerical investigation on the underground thermal imbalance of ground-coupled heat pump operated in cooling-dominated district 显示文摘 | Weibo Yang Yongping Chen Mingheng Shi | 2013 | Applied Thermal En- gineering2013，58，： | 1 |
| 20 | Numerical Simulation of the Performance of a Solar-earth Source Heat Pump System 显示文摘 | Yang Weibo Shi Mingheng Dong Hua | 2006 | Applied Thermal Engineering2006，26，18： | 1 |
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