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| 1 | Towards an Artificial Intelligence Framework for Data-Driven Prediction of Coronavirus Clinical Severity显示文摘The virus SARS-CoV2,which causes the Coronavirus disease COVID-19 has become a pandemic and has spread to every inhabited continent.Given the increasing caseload,there is an urgent need to augment clinical skills in order to identify from among the many mild cases the few that will progress to critical illness.We present a first step towards building an artificial intelligence(AI)framework,with predictive analytics(PA)capabilities applied to real patient data,to provide rapid clinical decision-making support.COVID-19 has presented a pressing need as a)clinicians are still developing clinical acumen given the disease’s novelty,and b)resource limitations in a rapidly expanding pandemic require difficult decisions relating to resource allocation.The objectives of this research are:(1)to algorithmically identify the combinations of clinical characteristics of COVID-19 that predict outcomes,and(2)to develop a tool with AI capabilities that will predict patients at risk for more severe illness on initial presentation.The predictive models learn from historical data to help predict specifically who will develop acute respiratory distress syndrome(ARDS),a severe outcome in COVID-19.Our experimental results based on two hospitals in Wenzhou,Zhejang,China identify features most predictive of ARDS in COVID-19 initial presentation which would not have stood out to clinicians.A mild increase in elevated alanine aminotransferase(ALT)(a liver enzyme)),a presence of myalgias(body aches),and an increase in hemoglobin,in this order,are the clinical features,on presentation,that are the most predictive.Those two centers’COVID-19 case series symptoms on initial presentation can help predict severe outcomes.Predictive models that learned from historical data of patients from two Chinese hospitals achieved 70%to 80%accuracy in predicting severe cases. | Xiangao Jiang Megan Coffee Anasse Bari Junzhang Wang Xinyue Jiang Jianping Huang Jichan Shi Jianyi Dai Jing Cai Tianxiao Zhang Zhengxing Wu Guiqing He Yitong Huang | 2020 | Computers, Materials & Continua2020，，4： | 15 |
| 2 | Novel Mobility Formula for Parallel Mechanisms Expressed with Mobility of General Link Group显示文摘The determination of virtual constraints is always one of the key and difficult problems in traditional mobility calculation.To make mobility calculation simple,considering avoiding virtual constraints,some new formulae have been presented,however these formulae can hardly intuitively reflect general link group’s restrictions on output member and its influences on independence of output parameters,which is premise to the judgment of the properties of mobility.Towards the problem to reveal the intrinsic relationship between the degree of freedom(DOF)of a mechanism,the link group,and the dimension of output parameters,also to avoid determination of virtual constraint,based on the new concepts of the'DOF of general link group'and'node parameters',a new formula in the calculation of the mobility of mechanisms is presented that is expressed with DOFs of the general link groups and rank of motion parameters of base point of the output link.It is named GOM(mobility of groups and output parameter)formula.On the basis of new concepts of'effective parameters'and'invalid parameters',a rule is put forward for solving the DOF of mechanisms with invalid parameters by GOM formula,that is,the base point parameters are the subset of effective parameters of link group.Thereafter,several examples are enumerated and the results coincide with the prototype data,which proves the validity of the proposed formula.Meanwhile,it is obtained that the necessary and sufficient condition for the judgment of output parameters independence is that each of the DOF of the link group is not less than zero.The proposed formula which is simple in calculation provides theoretical basis for the judgment of independence of output parameters and provides references for type synthesis of novel parallel mechanisms with independence requirements of their output parameters. | ZHANG Yitong LU Wenjuan MU Dejun YANG Yandong ZHANG Lijie ZENG Daxing | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 14 |
| 3 | New concept and new theory of mobility calculation for multi-loop mechanisms显示文摘In 2005,Gogu,a Frenchman,analyzed 35 different existing formulas for mobility calculation and pointed that the formulas for quick mobility calculation had some limitations and were not general.Therefore,looking for a general and simple mobility formula is still a hot topic in mechanisms.At the meantime,it is also an important topic to complete the mechanism theory.Gogu proposed a new method that can avoid determining virtual constraints in 2008,but the method is still not general.To solve the problem,this paper defines the new concepts of link-group rank,general-kinematic-pair rank,virtual pair,virtual loop,and virtual-loop rank,and gives a new simple and general formula.Our method converts multi-loop mechanisms into some independent virtual loops,simplifies the problem,avoids calculating virtual constraints,and reduces the calculation difficulty.It is proved that the new formula is simple,general and effective through the mobility analysis of several different kinds of mechanisms.The application of this formula will provide great convenience for general engineers in mobility calculation. | ZHANG YiTong & MU DeJun Mechanical Engineering College of Yanshan University,Qinhuangdao 066004,China | 2010 | Science China(Technological Sciences)2010，53，6： | 12 |
| 4 | A new formula of mechanism mobility based on virtual constraint loop显示文摘Several important developing phases of the formulas for mobility calculation based on constraints are introduced. The shortcoming of the mobility formulas based on common constraints of loops of a mechanism is that virtual constraints must be calculated before determining the mobility of a mechanism with virtual constraints. In order to avoid the shortcoming, some new concepts including virtual loop, virtual-loop constraint and general-kinematic-pair constraint are used to analyze the relationship between mobility of links and constraint of kinematic pairs and a mobility formula based on common constraints of virtual loops is proposed. The formula is that the number of mobility of a mechanism is the sum of mobility of all links in the mecha-nism minus the sum of constraints of all kinematic pairs plus the sum of the common constraints of all virtual loops. The sum of over constraints of a mechanism is the sum of constraints of all virtual loops in the mechanism. This mobility formula expressed in terms of common constraints of virtual loops in a mechanism can avoid calculating virtual constraints. It is proved that the new formula is correct, simple and effective through the analysis of several different kinds of mechanisms. | ZHANG YiTong LI YanWent WANG LiYa | 2011 | Science China(Technological Sciences)2011，54，10： | 10 |
| 5 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 6 | Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway显示文摘Gallbladder carcinoma (GBC) is the most comm on and aggressive can cer of the biliary tract. Liensinine has been proved to have hypotensive effect. However, the effect of liensinine on GBC is still unknown. The aim of this study is to investigate the effect and mechanism of liensinine in human GBC cells. Cell viability assay and colony formation assay were performed to assess cell growth and proliferation. Flow cytometry analysis was used to investigate cell cycle apoptosis in vitro. Hoechst 33342 staining was also used to evaluate cell apoptosis. Western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis.The effect of liensinine treatment in vivo was experimented with xenografted tumors. We found that liensinine significantly inhibited the growth of GBC cells both in vivo and in vitro. In vitro, cell growth and proliferation were significantly suppressed by liensinine in a dose- and time-dependent manner. In vivo, liensinine inhibited tumor growth. Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins. Liensinine also affected GBC cell cycle progress!on and induced apoptosis by down-regulating phosphorylated protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), phosphatidylinositol 3-kinase (PI3K), and Zinc finger X-chromosomal protein (ZFX) proteins. Liensinine induced G2/M arrest and apoptosis in gallbladder cancer, suggest!ng that liensinine might represent a novel and effective agent against gallbladder cancer. | Yitong Shen Rui Bian Yaxiong Li Yuan Gao Yingbin Liu Yuzhen Xu Xiaoling Song Yijian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 7 | A Self-Powered Breath Analyzer Based on PANI/PVDF Piezo-Gas-Sensing Arrays for Potential Diagnostics Application显示文摘The increasing morbidity of internal diseases poses serious threats to human health and quality of life.Exhaled breath analysis is a noninvasive and convenient diagnostic method to improve the cure rate of patients. In this study, a self-powered breath analyzer based on polyaniline/polyvinylidene fluoride(PANI/PVDF) piezogas-sensing arrays has been developed for potential detection of several internal diseases. The device works by converting exhaled breath energy into piezoelectric gassensing signals without any external power sources. The five sensing units in the device have different sensitivities to various gas markers with concentrations ranging from 0 to 600 ppm. The working principle can be attributed to the coupling of the in-pipe gas-flow-induced piezoelectric effect of PVDF and gas-sensing properties of PANI electrodes. In addition, the device demonstrates its use as an ethanol analyzer to roughly mimic fatty liver diagnosis.This new approach can be applied to fabricating new exhaled breath analyzers and promoting the development of self-powered systems. | Yongming Fu Haoxuan He Tianming Zhao Yitong Dai Wuxiao Han Jie Ma Lili Xing Yan Zhang Xinyu Xue | 2018 | Nano-Micro Letters2018，10，4： | 4 |
| 8 | Changes in progenitors and differentiated epithelial cells of neonatal piglets显示文摘This study aimed to assess the changes of small intestinal morphology,progenitors,differentiated epithelial cells,and potential mechanisms in neonatal piglets.Hematoxylin and eosin staining of samples from 36 piglets suggested that dramatic changes were observed in the jejunum crypts depth and crypt fission index of neonatal piglets(P<0.001).The number of intestinal stem cells(ISC)tended to increase(P<0.10),and a decreased number of enteroendocrine cells appeared in the jejunal crypt on d 7(P<0.05).Furthermore,the mRNA expression of jejunal chromogranin A(ChgA)was down-regulated in d 7 piglets(P<0.05).There was an up-regulation of the adult ISC marker gene of SPARC related modular calcium binding 2(Smoc2),and Wnt/b-catenin target genes on d 7(P<0.05).These results were further verified in vitro enteroid culture experiments.A mass of hollow spheroids was cultured from the fetal intestine of 0-d-old piglets(P<0.001),whereas substantial organoids with budding and branching structures were cultured from the intestine of 7-d-old piglets(P<0.001).The difference was reflected by the organoid budding efficiency,crypt domains per organoid,and the surface area of the organoid.Furthermore,spheroids on d 0 had more Ki67-positive cells and enteroendocrine cells(P<0.05)and showed a decreasing trend in the ISC and goblet cells(P<0.10).Moreover,the mRNA expression of spheroids differed markedly from that of organoids,with low expression of intestinal differentiation gene(Lysozyme;P<0.05),epithelial-specific markers(Villin,E-cadherin;P<0.05),and adult ISC markers(leucine-rich repeat-containing G protein-coupled receptor 5[Lgr5],Smoc2;P<0.001),and upregulation of fetal marker(connexin 43[Cnx43];P<0.05).The mRNA expression of relevant genes was up-regulated,and involved in Wnt/b-catenin,epidermal growth factor(EGF),Notch,and bone morphogenetic protein(BMP)signaling on d 7 organoids(P<0.05).Spheroids displayed low differentiated phenotype and high proliferation,while organoids exhibited strong differentiation potential.These results indicated that the conversion from the fetal progenitors(spheroids)to adult ISC(normal organoids)might largely be responsible for the fast development of intestinal epithelial cells in neonatal piglets. | Lanmei Yin Jun Li Yitong Zhang Qing Yang Cuiyan Yang Zhenfeng Yi Yuebang Yin Qiye Wang Jianzhong Li Nengshui Ding Zhigang Zhang Huansheng Yang Yulong Yin | 2022 | Animal Nutrition2022，，1： | 3 |
| 9 | Morphology and magnetic properties of Sm_(2)Co_(7)/α-Fe nanocomposite magnets produced by high energy ball milling and spark plasma sintering显示文摘In this article,the Sm_(2)Co_(7)/α-Fe nanocomposite magnets were prepared by high energy ball milling and spark plasma sintering method.The effect of soft phase content on the magnetic properties was studied.Up to 30 wt% α-Fe was added into Sm_(2)Co_(7) matrix without the decrease of remanence.Optimal energy product(BH)max of 9.2 MGOe was obtained with 20 wt% α-Fe.TEM observation shows that the grain size of α-Fe is 20-50 nm which ensures a good coupling effect between soft and hard phase.One more thing needs to be mentioned is that there exists inter-diffusion between Sm-Co phase and α-Fe phase.Moreover,our results can also illustrate that the Sm_(2)Co_(7)/α-Fe nanocomposite magnets are able to acquire better magnetic properties than the SmCo_(5)/α-Fe magnets prepared by the same process due to the large domain width of Sm_(2)Co_(7) phase. | Yitong Zhuge Yuqing Li Xiaochang Xu Dongtao Zhang Hongguo Zhang Weiqiang Liu Ming Yue | 2021 | Journal of Rare Earths2021，39，3： | 3 |
| 10 | ON THE ORIENTATION OF BUCKLING DIRECTION OF ANISOTROPIC ELASTIC PLATE UNDER UNIAXIAL COMPRESSION显示文摘The theory of small deformation superimposed on a large deformation of an elastic solid is used to investigate the buckling of anisotropic elastic plate under uniaxial compression. The buckling direction (the direction of buckling wave) is generally not aligned with the compression direction. The equation for determining the buckling direction is obtained. It is found that the out-of-plane buckling of anisotropic elastic plate is possible and both buckling conditions for flexural and extensional modes are presented.As a specific case of buckling of anisotropic elastic plate, the buckling of an orthotropic elastic plate subjected to a compression in a direction that forms an arbitrary angle with an elastic principal axis of the materials is analyzed. It is found that the buckling direction depends on the angle between the compression direction and the principal axis of the materials, the critical compressive force and plate-thickness parameters.In the case that the compression direction is aligned with the principal axis of the materials, the buckling direction will be aligned with the compression one irrespective of critical compressive force and plate-thickness. | Zhang Yitong (Department of Mechanics, Tianjin University, Tianjin 300072, China) | 2001 | Acta Mechanica Solida Sinica2001，14，2： | 3 |
| 11 | Preparation and characterization of poly(vinylidene fluoride) composite membranes blended with nano-crystalline cellulose | Haolong Bai Xuan Wang Yitong Zhou Liping Zhang | 2012 | Progress in Natural Science:Materials International2012，22，3： | 2 |
| 12 | The KES Shear Test for Fabrics 显示文摘 | Hu Jinlian Zhang Yitong | 1997 | Textile Research Journal1997，67，9： | 1 |
| 13 | Preparation of CH_3NH_3PbI_3 thin films for solar cells via Vapor Transfer Method显示文摘Organometal halide perovskite based solar cells have emerged as one of the most promising candidates for low-cost and high-efficiency solar cell technologies.Here a Vapor Transfer Method(VTM)is used to fabricate high quality perovskite thin films in a balanced vacuum capsule.By adjusting the reaction temperature,CH_3NH_3I saturated vapor which then reacts with PbI_2films can be controlled and the formation process of CH_3NH_3PbI_3perovskite films can be further influenced.Prepared perovskite films which exhibit pure phase,smooth surface and high crystallinity are assembled into planar heterojunction inverted solar cells.The whole fabrication process of solar cell devices is organic solution free.Finally,the champion cell achieved power conversion efficiency(PCE)of 13.08%with negligible current–voltage hysteresis under fully open-air conditions.The photovoltaic performance could be further enhanced by optimizing perovskite composition and the device structure. | Kejie Feng Yitong Liu Yuancheng Zhang Yujie Liu Xiaoliang Mo | 2018 | Journal of Energy Chemistry2018，27，5： | 1 |
| 14 | A High Spatiotemporal Iontronic Single-Cell Viscometer显示文摘Ideal single-cell viscometer has remained unachieved,leaving a gap in current palette of single-cell nanotools.Information of single-cell viscosity could contribute to our knowledge of fundamental biological processes,e.g.,mass diffusion,biochemical interaction,and cellular responses to many diseases and pathologies.Although advances have been made to this end,existing methods generally suffer from limitations,e.g.,low spatiotemporal resolution.Here,we describe a high spatiotemporal iontronic single-cell viscometer that operates upon a patch clamp integrated with double-barreled nanopores separated by a septum of ca.32 nm.The system enables reversible electroosmotic manipulation of the adjacent small fluid bridging two nanopores,the viscous alternation of which could be sensitively monitored by the ionic responses.In practical cellular studies,significantly,our findings reveal not only the less deviated medium viscosities than those of lysosomes and mitochondria but also the highest viscosities in the near-nuclear region than those of mitochondrion-dense and lysosome-dense regions.This work has provided an accessible single-cell viscometer and enriched the armory of single-cell nanotools. | Tianyang Zhang Siyuan Yu Bing Wang Yitong Xu Xiaomei Shi Weiwei Zhao Dechen Jiang Hongyuan Chen Jingjuan Xu | 2022 | Research2022，，4： | 1 |
| 15 | NONLINEAR MICRO-MECHANICAL MODEL FOR PLAIN WOVEN FABRIC显示文摘The warp yarns and weft yarns of plain woven fabric which, being the principal axes of material of fabric, are orthogonal in the original configuration, but are obliquely crossed in the deformed configuration in general. The orthotropic constitutive model is unsuitable for fabric. In the oblique principal axes system the relations between loaded stress vectors and stress tensor are investigated, the stress fields of micro-weaving structures of fabric due to pure shear are carefully studied and, finally, a nonlinear micro-mechanical model for plain woven fabric is proposed. This model can accurately describe the nonlinear mechanical behavior of fabric observed in experiments. Under the assumption of small deformation and linearity of mechanical properties of fabric the model will degenerate into the existing linear model. | Zhang Yitong Xie Yuxin (Department of Mechanics,Tianjin University,Tianjin 300072,China) | 2003 | Acta Mechanica Solida Sinica2003，16，2： | 1 |
| 16 | A new method of objective speech quality assessment in communication system 显示文摘 | Zhang Weiwei Chang Yongyu Liu Yitong | 2013 | Journal of Multimedia2013，8，3： | 1 |
| 17 | Nanoparticle accumulation in liver may induce resistance to immune checkpoint blockade therapy显示文摘Despite immune checkpoint blockade(ICB)therapy has transformed cancer treatment,only 20.2%of these patients achieved a response.Understanding resistance mechanisms to ICB is important for the treatment of a wider population.In this work,we occasionally found that the silica nanoparticles(SiO_(2)NPs)accumulated in the liver can induce resistance to following ICB therapy to a subcutaneous tumor in mice.By analysis of T cells frequency,we uncovered that SiO_(2)NPs in the liver resulted in a siphoning of T cells from circulation to the liver by produced chemokines.In addition,liver immunosuppressive cells further inhibit the function and induce apoptosis of recruited T cells,leading to a systemic loss and reduced tumor infiltration of T cells,which contributes to poor responses to ICB therapy.However,such effect is not observed in poly(lactic-co-glycolic acid)(PLGA)NPs treated mice under the same conditions,likely due to their much lower immunogenicity in perturbing the liver immune microenvironment,indicating that cancer is not a local disease but an ecosystem that is linked to the distal environment.We further provide a new mechanism insight into ICB resistance induced by liver accumulation of nanoparticles. | Huaxing Dai Qianyu Yang Rong Sun Yue Zhang Qingle Ma Yifan Shen Beilei Wang Yitong Chen Jialu Xu Bo Tian Fang Xu Chao Wang | 2023 | Nano Research2023，16，4： | 1 |
| 18 | Biomimetic synthesis of hydroxyapatite on cellulose nanofibrils and its application 显示文摘 | Qu Ping Zhang Xiaoli Zhou Yitong | 2012 | Sci Adv Mater2012，4，2： | 1 |
| 19 | Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive Chitosan hydrogel显示文摘 | Haibin Wang Xuelian Zhang Yanmin Li Yitong Ma Ye Zhang Zhiqiang Liu Jin Zhou Qiuxia Lin Yanmeng Wang Cuimi Duan Changyong Wang | 2010 | Journal of Heart and Lung Transplantation2010，，8： | 1 |
| 20 | Surface modification of cellulose nanofibrils for poly(lactic acid) composite application 显示文摘 | Qu Ping Zhou Yitong Zhang Xiaoli | 2012 | J Appl Polym Sci2012，125，： | 1 |
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