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| 1 | Investigation of Solidification and Segregation Characteristics of Cast Ni-Base Superalloy K417G显示文摘Differential scanning calorimetry(DSC) analysis, isothermal solidification experiment and Thermo-Calc simulation were employed to investigate solidification characteristics of K417 G Ni-base superalloy. Electron probe microanalysis(EPMA) was employed to analyze the segregation characteristics. Liquidus,solidus and the formation temperatures of main phases were measured. In the process of solidification,the volume fraction of liquid dropped dramatically in the initial stage, while the dropping rate became very low in the final stage due to severe segregation of positive segregation elements into the residual liquid. The solidification began with the formation of primary γ. Then with solidification proceeding, Ti and Mo were enriched in the liquid interdendrite, which resulted in the precipitation of MC carbides in the interdendrite. Al accumulated into liquid at the initial stage, but gathered to solid later due to the precipitation of γ/γ’ eutectic at the intermediate stage of solidification. However, Co tended to segregate toward the solid phase. In the case of K417 G alloy, combining DSC analysis and isothermal solidification experiment is a good way to investigate the solidification characteristics. Thermo-Calc simulation can serve as reference to investigate K417 G alloy. | Li Gong Bo Chen Zhanhui Du Mengshu Zhang Ruichang Liu Kui Liu | 2018 | Journal of Materials Science & Technology2018，34，3： | 9 |
| 2 | A Resource for Inactivation of MicroRNAs Using Short Tandem Target Mimic Technology in Model and Crop Plants显示文摘microRNAs (miRNAs)are endogenous small non-coding RNAs that bind to mRNAs and target them for cleavage and/or translational repression,leading to gene silencing.We previously developed short tandem target mimic (STTM)technology to deactivate endogenous miRNAs in Arabidopsis.Here,we created hundreds of STTMs that target both conserved and species-specific miRNAs in Arabidopsis,tomato,rice,and maize,providing a resource for the functional interrogation of miRNAs.We not only revealed the functions of several miRNAs in plant development,but also demonstrated that tissue-specific inactivation of a few miRNAs in rice leads to an increase in grain size without adversely affecting overall plant growth and development.RNA-seq and small RNAseq analyses of STTM156/157 and STTM165/166 transgenic plants revealed the roles of these miRNAs in plant hormone biosynthesis and activation,secondary metabolism,and ion-channel activity-associated electrophysiology,demonstrating that STTM technology is an effective approach for studying miRNA functions.To facilitate the study and application of STTM transgenic plants and to provide a useful platform for storing and sharing of information about miRNA-regulated gene networks,we have established an online Genome Browser (http://gffzzc750bc0108fa4044snq95kbbn0npx60f9.ffgz.tsg.suse.edu.cn/designindex2.php) to display the transcriptomic and miRNAomic changes in STTMinduced miRNA knockdown plants. | Ting Peng Mengmeng Qiao Haiping Liu Sachin Teotia Zhanhui Zhang Yafan Zhao Bobo Wang Dongjie Zhao Lina Shi Cui Zhang Brandon Le Kestrel Rogers Chathura Gunasekara Haitang Duan Yiyou Gu Lei Tian Jinfu Nie Jian Qi Fanrong Meng Lan Huang Qinghui Chen Zhenlin Wang Jinshan Tang Xiaoqing Tang Ting Lan Xuemei Chen Hairong Wei Quanzhi Zhao Guiliang Tang | 2018 | Molecular Plant2018，11，11： | 7 |
| 3 | Development of a Rapid Multi-residue Assay for Detecting β-lactams Using Penicillin Binding Protein 2x显示文摘Objective To develop a rapid multi-residue assay for detecting 16 demanded by the European Union (EU). Methods A recombinant penicillin-binding protein(PBP)2x* from Streptococcus pneumoniae R6 was expressed in vitro and six β-lactams were conjugated to HRP by four methods.A rapid multi-residue assay for β-lactams was established with PBP2x* and HRP-conjugate. Results PBP2x* was expressed and purified successfully and the ideal HRP-conjugate was identified. The multi-residue assay was developed.After optimization,penicillin G,ampicillin,amoxicillin, cloxacillin,dicloxacillin,oxacillin,nafcillin,cephalexin,ceftiofur,cefaIonium,cefquinome,cefazolin, cefoperazone,cephacetrile,and cephapirin can be detected at levels below MRL in milk with simple pretreatment. Conclusion This assay developed can detect all 16 β-lactams demanded by the European Union(EU). The whole procedure takes only 45 min and can detect 42 samples and the standards with duplicate analysis. | ZENG Kum ZHANG Jing WANG Yang WANG ZhanHui ZHANG Su Xia WU Chong Ming SHEN Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，2： | 7 |
| 4 | Comparative QTL analysis of maize seed artificial aging between an immortalized F_2 population and its corresponding RILs显示文摘Seed aging decreases the quality and vigor of crop seeds,thereby causing substantial agricultural and economic losses in crops.To identify genetic differences in seed aging between homozygotes and heterozygotes in maize,the seeds of a set of recombinant inbred lines(RILs) and an immortalized F_2(IF_2) population were subjected to artificial aging treatments for 0,2,3,and 4 days under 45℃ and 85%relative humidity and seed vigor was then evaluated in a field experiment.Seed vigor of all entries tested decreased sharply with longer aging treatment and seed vigor decreased more slowly in heterozygotes than in homozygotes.Forty-nine QTL were detected for four measured seed vigor traits in the RIL(28QTL) and IF_2(21 QTL) populations.Only one QTL,qGP5,was detected in both populations,indicating that the genes involved in anti-aging mechanisms differed between inbred lines and hybrids.Several QTL were identified to be responsible for multiple seed vigor traits simultaneously in the RIL and IF_2 populations under artificial aging conditions.These QTL may include major genes for seed vigor or seed aging.QTL qVI4 b and qGE3 a detected in the RIL population coincided with genes ZmLOX1 and ZmPLD1 in the same respective chromosomal regions.These QTL would be useful for screening for anti-aging genes in maize breeding. | Bin Wang Zhanhui Zhang Zhiyuan Fu Zonghua Liu Yanmin Hu Jihua Tang | 2016 | The Crop Journal2016，4，1： | 5 |
| 5 | Single-cell RNA sequencing of meiocytes and microspores reveals the involvement of the Rf4 gene in redox homeostasis of CMS-C maize显示文摘Normal microsporogenesis is determined by both nuclear and mitochondrial genes. In maize C-type cytoplasmic male sterility, it is unclear how the development of meiocytes and microspores is affected by the mitochondrial sterility gene and the nuclear restorer gene. In this study, we sequenced the transcriptomes of single meiocytes(tetrad stage) and early mononucleate microspores from sterile and restorer lines. The numbers of expressed genes varied in individual cells and fewer than half of the expressed genes were common to the same cell types. Four comparisons revealed 3379 differentially expressed genes(DEGs), with 277 putatively associated with mitochondria, 226 encoding transcription factors,and 467 possibly targeted by RF4. KEGG analysis indicated that the DEGs in the two lines at the tetrad stage were involved predominantly in carbon metabolism and in amino acid biosynthesis and metabolism, whereas the DEGs during the transition from the tetrad stage to the early mononucleate stage were associated mostly with regulation of protein metabolism, fatty acid metabolism, and anatomical structure morphogenesis. Thus, meiocyte and microspore development was affected by the surrounding cells and the restorer gene, and the restorer gene helped restore the redox homeostasis of microspores and the normal cellular reconstruction during the transition. | Huaisheng Zhang Huili Yang Desheng Hu Bing Li Yanan Lin Wen Yao Zhanyong Guo Haochuan Li Dong Ding Zhanhui Zhang Yanmin Hu Yadong Xue Jihua Tang | 2021 | The Crop Journal2021，9，6： | 4 |
| 6 | MiR319-targeted OsTCP21 and OsGAmyb regulate tillering and grain yield in rice显示文摘Multiple genes and microRNAs(miRNAs)improve grain yield by promoting tillering.MiR319s are known to regulate several aspects of plant development;however,whether miR319s are essential for tillering regulation remains unclear.Here,we report that miR319 is highly expressed in the basal part of rice plant at different development stages.The miR319 knockdown line Short Tandem Target Mimic 319(STTM319)showed higher tiller bud length in seedlings under low nitrogen(N)condition and higher tiller bud number under high N condition compared with the miR319a-overexpression line.Through targets prediction,we identified OsTCP21 and OsGAmyb as downstream targets of miR319.Moreover,OsTCP21 and OsGAmyb overexpression lines and STTM319 had increased tiller bud length and biomass,whereas both were decreased in OsTCP21 and OsGAmyb knockout lines and OE319a.These data suggest that miR319 regulates rice tiller bud development and tillering through targeting OsTCP21 and OsGAmyb.Notably,the tiller number and grain yield increased in STTM319 and overexpression lines of OsTCP21 and OsGAmyb but decreased in OE319a and knockout lines of OsTCP21 and OsGAmyb.Taken together,our findings indicate that miR319s negatively affect tiller number and grain yield by targeting OsTCP21 and OsGAmyb,revealing a novel function for miR319 in rice. | Rongna Wang Xiuyan Yang Shuang Guo Zhaohui Wang Zhanhui Zhang Zhongming Fang | 2021 | Journal of Integrative Plant Biology2021，63，7： | 4 |
| 7 | Simulation of growing GaN in vertical HVPE reactor显示文摘The paper reports the setting up of a model of fluid dynamic for GaN HVPE system and the simulation. It is found that when the direction of gravity is opposite to the direction of GaCl flow inlet,there exits a distance at which the uniformity of the deposition is optimal. Here the good uniformity of the deposition is obtained when the distance between the substrate and GaCl inlet is 5 cm. The parameters of gas flow used in growing GaN are also optimized. In addition, the influence of gravity and buoyancy on the deposition of GaN is discussed, too. It is found that the angle between the direction of gravity and the direction of GaCl flow inlet has a major effect on the deposition rate and the uniformity of the growth. Compared with the situation when the direction of gravity is the same with the direction of GaCl flow inlet, although the deposition rate of GaN has decreased obviously, the uniformity of the deposition has improved largely when the direction of gravity is opposite to the direction of GaCl flow inlet. | ZHAO ChuanZhen, XIU XiangQian , ZHANG Rong , XIE ZiLi, LIU Bin, LIU ZhanHui, YAN HuaiYue & ZHENG YouDou Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials, Department of Physics, Nanjing University, Nanjing 210093, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，1： | 3 |
| 8 | Composition and Distribution of Planktonic Ciliates in the Southern South China Sea During Late Summer: Comparison Between Surface and 75 m Deep Layer显示文摘Ciliates are very important components in most marine ecosystem.They are trophic link between the microbial food web and grazing food chain.In this study,ciliates were collected from 11 sites in the southern South China Sea(SCS) during August 25 to September 28,2011.Their composition and distribution at the surface and 75 m deep depth of the ocean were studied.A total of 30 species belonging to 22 genera were identified,and 22 species of 15 genera were Tintinnids.Eutintinnus fraknoii and E.stramentus were the most common species.The other dominants were strombidiids ciliates including Strombidium conicum and S.globosaneum,which were followed by the tide form,Mesodinium pulex.Ciliates abundance ranged from 46 ind L^(-1) to 368 ind L^(-1) in the open sites,46–368 ind L^(-1) at surface and 73–198 ind L^(-1) at 75 m deep layer.In the Yongshu reef,ciliates abundance ranged from 167 ind L^(-1) to 365 ind L^(-1) in the water column,similar to that in Sanya coral reef waters.Ciliates composition showed obvious difference between surface and 75 m deep layer at station S2(P < 0.05),while no similar result was observed at other sites.At 75 m deep layer,salinity was negatively related to mixed layer depth(P < 0.05),but positively to chlorophyll a concentration(P < 0.05),indicating that the change of vertical mixing in water column influenced vertical distribution of ciliates in the southern SCS. | LIU Huaxue SHEN Pingping LI Chunhou CHEN Zuozhi QI Zhanhui HUANG Honghui | 2016 | Journal of Ocean University of China2016，15，1： | 3 |
| 9 | Biodegradable intestinal stents: A review显示文摘Biodegradable stents are an attractive alternative to self-expanding metal stents in the treatment of intestinal strictures. Biodegradable stent can be made of biodegradable polymers and biodegradable metals(magnesium alloys). An overview on current biodegradable intestinal stents is presented. The future trends and perspectives in the development of biodegradable intestinal stents are proposed. For the biodegradable polymer intestinal stents, the clinical trials have shown promising results, although improved design of stents and reduced migration rate are expected. For the biodegradable magnesium intestinal stents, results of preliminary studies indicate magnesium alloys to have good biocompatibility. With many of the key fundamental and practical issues resolved and better methods for adjusting corrosion resistance and progressing biocompatibilities of magnesium alloys, it is possible to use biodegradable intestinal stents made of magnesium alloys in hospital in the not too distant future. | Zhanhui Wang Nan Li Rui Li Yawei Li Liqun Ruan | 2014 | Progress in Natural Science:Materials International2014，24，5： | 2 |
| 10 | Foraging areas of Rousettus leschenaulti on the Hainan Island of China显示文摘We investigated the foraging area of three individuals (1 female and 2 males) of Rousettus leschenaulti (Chiroptera,Pteropodidae) in suburban Haikou City, Hainan Province, South China from November 2005 to January 2006 using radio telemetry.These animals left the daytime roosting sites about 90 min after sunset with no significant difference in departure time betweenthe male and female bats. The average active times were 391.8 min for males and 533.7 min for the female, respectively.By reconstructing 93 radio-telemetry recording positions, we found that the long axis of foraging area of the bats ranged from7.45 to 11.70 km. The foraging area of the female (3867 ha) was larger than that of the males (1138 ha), and there was overlapbetween the foraging areas of different individuals. These bats usually kept the same flight routes across a few successive daysfrom the daytime roosting site to the foraging areas. Our findings suggested that female R. leschenaulti may explore a larger foragingarea than males. No obvious territorial behaviors were observed in our studied area. | Zhanhui TANG Zhong CHEN Jie MA Guangjian ZHU Xunfeng MA Lianxi SHENG Yuchun LI | 2010 | Current Zoology2010，56，4： | 2 |
| 11 | Safety and efficacy of anti-EGFR monoclonal antibody (SCT200) as second-line therapy in advanced esophageal squamous cell carcinoma显示文摘Objective:The mainstay treatment of esophageal squamous cell carcinoma(ESCC)involves chemotherapy and immunotherapy.However,alternative therapies are required for patients who are refractory or intolerant to existing therapies.Methods:In this single-arm,multicenter,open-label phase Ib study,30 patients received an intravenous infusion of SCT200,an antiepidermal growth factor receptor(EGFR)monoclonal antibody,6.0 mg/kg once a week for 6 weeks,followed by 8.0 mg/kg once every 2 weeks until disease progression or intolerable toxicity.The primary endpoint was the objective response rate(ORR).The secondary endpoints were progression-free survival(PFS),overall survival(OS),and safety.Results:Thirty patients were enrolled between July 2018 and May 2019.The ORR was 16.7%(95%CI:5.6%–34.7%).The median PFS and OS were 3.1 months(95%CI:1.5–4.3)and 6.8 months(95%CI:4.7–10.1),respectively.A numerical difference without any statistical significance in ORR was observed in patients with different EGFR expressions(≥50%:25.0%vs.<50%:0%,P=0.140)or TP53 mutation abundance(<10%:23.8%vs.≥10%:0%,P=0.286).Improved median PFS(3.4 vs.1.4 months,P=0.006)and OS(8.0 vs.4.2 months,P=0.027)were associated with TP53 mutation abundance of<10%.The most common treatment-related adverse events of grade 3 or 4(occurring in≥2 patients)were hypomagnesemia[7(23.3%)]and rash[2(6.7%)].No treatmentrelated death occurred.Conclusions:SCT200 monotherapy as the second-or further-line treatment for advanced ESCC showed favorable efficacy,with an acceptable safety profile.TP53 mutation abundance might serve as a potential predictive biomarker. | Ming Bai Meng Wang Ting Deng Yuxian Bai Kai Zang Zhanhui Miao Wenlin Gai Liangzhi Xie Yi Ba | 2022 | Cancer Biology & Medicine2022，19，3： | 2 |
| 12 | Synthesis of a Novel Co-B/CTAB Catalyst via Solid-state-reaction at Room Temperature for Hydrolysis of Ammonia-borane显示文摘Cobalt-boride(Co-B)is emerging as one of the promising materials in the base-hydrolytic dehydrogena-tion of ammonia-borane(AB).In order to avoid the low specific area and poor catalytic capacity of Co-B catalyst caused by aggregation arising from the strong reducing property and rapid reaction condensation of sodium borohy-dride(NaBHa),novel cobalt boride/cetyltrimethylammonium bromide(Co-B/CTAB)catalyst was obtained via solid-state grinding at room temperature,and the catalyst was further characterized by XRD,SEM,XPS and BET.The hydrogen generation rate(HGR)was then determined by the hydrolysis reaction of AB.The SEM images indicate that a lot of irregular folds and curled edges are formed on the sample with a maximum surface area of 145.57 m2/g,thus possibly resulting in the high hydrogen production(HGR was 10.68 L.minlg),which may be attributed to CTAB that provide favorable large specific surface area and abundant porous structure.Additionally,catalyst will not be affected by solvants during solid-state reaction.As a diluent,the surfactant CTAB hindered the reaction rate of sodium borohydride reduction to cobalt boride and obtained the novel catalyst with a large specific surface area. | HU Haibin LONG Bo JIANG Yifan SUN Shichang Ibrahim LAWAN ZHOU Weiming- ZHANG Mingxin WANG Liwei ZHANG Fan YUAN Zhanhui | 2020 | Chemical Research in Chinese Universities2020，36，6： | 2 |
| 13 | Influential Intensity of Urban Agglomeration on Evolution of Ecoenvironmental Pressure:A Case Study of Changchun,China显示文摘In this paper,we study the interactive relationship between the agglomeration of urban elements and the evolution of eco-environmental pressure.We build an index system for evaluating the agglomeration of urban elements and eco-environmental pressure.Using the entropy method and response intensity model,we analyze how urban elements agglomeration influenced eco-environmental pressure in Changchun from 1990 to 2012,eliciting the changing features and influential factors.Ultimately,we conclude there is a significant interactive relationship between the agglomeration of urban elements and the evolution of eco-environmental pressure in Changchun.This is inferred from the degree of this agglomeration in Changchun having increased since 1990,with the degree of eco-environmental pressure first decreasing and then increasing.Alongside this,the impact of urban elements agglomeration on eco-environmental pressure has changed from negative to positive.The main reasons behind this shift are arguably the rapid growth of urban investment and ongoing urbanization. | LIU Yanjun ZHANG Jing LI Chenggu ZHOU Guolei FU Zhanhui LIU Degang | 2017 | Chinese Geographical Science2017，27，4： | 2 |
| 14 | Photoluminescence of Zn2SiO4: Mn^2+ prepared by combustion technique 显示文摘 | Hao Yan Wang Yuhua Zhang Zhanhui | 2003 | Journal of Rare Earths2003，21，： | 1 |
| 15 | Penicillin-binding protein 3 of Streptococcus pneumoniae and its application in screening of β-lactams in milk显示文摘 | Jing Zhang Zhanhui Wang Kai Wen Xiao Liang Jianzhong Shen | 2013 | Analytical Biochemistry2013，，2： | 1 |
| 16 | Effects of biodegradable Mg–6Zn alloy extracts on apoptosis of intestinal epithelial cells显示文摘 | Zhanhui Wang Jun Yan Jianan Li Qi Zheng Zhigang Wang Xiaonong Zhang Shaoxiang Zhang | 2012 | Materials Science & Engineering B2012，，4： | 1 |
| 17 | Development of an im- munochromatography strip for the rapid detection of 12 fluoro- quinolones in chicken muscle and liver显示文摘 | Zhu Yan Li Lin Wang Zhanhui | 2008 | Journal of agricultural and food chemistry2008，56，14： | 1 |
| 18 | Hepatitis B virus geno- types and subgenotypes in China显示文摘 | Zhanhui Wang Yuehua Shujuan | 2007 | Hepatology Research2007，37，1： | 1 |
| 19 | Biodegradable magnesium alloy with eddy thermal effect for effective and accurate magnetic hyperthermia ablation of tumors显示文摘Magnetic hyperthermia therapy(MHT)is able to ablate tumors using an alternating magnetic field(AMF)to heat up magnetocaloric agents(e.g.magnetic nanoparticles)administered into the tumors.For clinical applications,there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility.As a kind of biocompatible and biodegradable material,magnesium(Mg)and its alloys have been extensively used in the clinic as an implant metal.Herein,we discovered that the eddy thermal effect of the magnesium alloy(MgA)could be employed for MHT to effectively ablate tumors.Under low-field-intensity AMFs,Mg A rods could be rapidly heated,resulting in a temperature increase in nearby tissues.Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro,but also be employed for effective and accurate ablation of tumors in vivo.In addition to killing tumors in mice,we further demonstrated that VX2 tumors of much larger sizes growing in rabbits after implantation of Mg A rods could also be eliminated after exposure to an AMF,illustrating the ability of MgA-based MHT to kill large-sized tumors.Moreover,the implanted MgA rods showed excellent biocompatibility and~20%of their mass was degraded within three months.Our work thus discovered for the first time that non-magnetic biodegradable Mg A,an extensively used implant metal in clinic,could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF.Such a strategy could be readily translated into clinical use. | Nailin Yang Fei Gong Liang Cheng Huali Lei Wei Li Zongbin Sun Caifang Ni Zhanhui Wang Zhuang Liu | 2021 | National Science Review2021，8，1： | 1 |
| 20 | Research on ge- ometry relationship of pinrack gearing显示文摘 | Feng Zhanhui Gou Mingkang Wu Shao | 2011 | Applied Me- chanics and Materials2011，，86： | 1 |
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