|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Natural Variation in OsPRR37 Regulates Heading Date and Contributes to Rice Cultivation at a Wide Range of Latitudes显示文摘标题日期和光周期敏感是决定米饭改编到大量 geographicenvironments 的基本特点。由印射的量的特点地点(QTL ) 和候选人基因分析使用整个染色体重新定序,我们 foundthat Oryza sativa 伪反应 Regulator37 (OsPRR37;此后 PRR37 ) 为早 heading7-2 (EH7-2 ) 负责从迟了标题的米饭 Milyang23 (M23 ) 和早标题的米饭 H143 的一个十字被识别的 /Heading date2 (Hd2 ) QTL。在 CCT 的不变地保存的氨基酸的 H143 containsa 错误感觉变化(CONSTANS,共同喜欢,并且 TOC1 ) PRR37 protein.In 的领域世界米饭收集, nonfunctional PRR37 等位基因的不同类型在许多欧洲、亚洲的米饭栽培变种被发现。尤其是,在自然长天的条件下面极其早怀有 Ghd7/Hd4 和 PRR37/Hd2 花的 nonfunctional 等位基因的装饰用的梨树变化,并且被使适应米饭耕作的极北的区域,多达 53 ?? ? 攠潸祣瑳 ????? 楶牴 ??? 啅?? | Bon-Hyuk Koo Soo-Cheul Yoo Joon-Woo Park Choon-Tak Kwon Byoung-Doo Lee Gynheung An Zhanying Zhang linjie Li Zichao Li Nam-Chon Paek | 2013 | Molecular Plant2013，6，6： | 42 |
| 2 | GNP6,a novel allele of MOC1,regulates panicle and tiller development in rice显示文摘The yield of rice is mostly affected by three factors,namely,panicle number,grain number and grain weight.Variation in panicle and grain numbers is mainly caused by tiller and panicle branches generated from axillary meristems(AMs).MOC1 encodes a putative GRAS family nuclear protein that regulates AM formation.Although several alleles of MOC1 have been identified,its variation in germplasm resources remains unclear.In the present study we characterized a novel mocl allele named gnp6 which has a thymine insertion in the coding sequence of the SAW motif in the GRAS domain.This mutation causes arrested branch formation.The SAW motif is necessary for nuclear localization of GNP6/MOC1 where it functions as a transcription factor or co-regulator.Haplotype analysis showed that the coding region of GNP6/MOC1 was conserved without any non-synonymous mutations in 240 rice accessions.However,variation in the promoter region might affect the expression of it and its downstream genes.Joint haplotype analysis of GNP6/MOC1 and MOC3 showed that haplotype combinations H9,H10 and H11,namely MOC1-Hap1 in combination with MOC3-Hap3,MOC3-Hap4 or MOC3-Hap5 could be bred to promote branch formation.These findings will enrich the genetic resources available for rice breeders. | Zhanying Zhang Xingming Sun Xiaoqian Ma Bingxia Xu Yong Zhao Zhiqi Ma Gangling Li Najeeb Ullah Khan Yinghua Pan Yuntao Liang Hongliang Zhang Jinjie Li Zichao Li | 2021 | The Crop Journal2021，9，1： | 6 |
| 3 | Application of third-party mediation for medical disputes: an introduction of Chinese experience显示文摘 | Cao Yanlin Wang Jiangjun Zheng Xueqian Jin Qinghan Tian Yongquan Wen Xuebin Wei Zhanying Li Wu | 2014 | Chinese Medical Journal2014，，14： | 4 |
| 4 | Hydrothermal Synthesis and Visible-light Photocatalytic Activities of SnS_2 Nanoflakes显示文摘SnS2 nanoflakes were successfully synthesized via a simple hydrothermal process. The as-prepared SnS2 samples were characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM), nitrogen adsorption-desorption isotherms, and UV-vis diffuse reflectance spectroscopy(DRS). The photocatalytic activities of the as-prepared SnS2 nanoflakes under visible light irradiation(λ>420 nm) were evaluated by the degradation of rhodamine B(Rh B). The effect of hydrothermal temperatures on the photocatalytic efficiency of as-prepared SnS2 nanoflakes was investigated. The experimental result showed that SnS2 nanoflakes synthesized at the temprature of 160 o had higher photocatalytic efficiency and good photocatalytic stability. | 贾铁昆 MIN Zhiyu CAO Jianliang SUN Guang WANG Xiaodong ZHANG Zhanying LI Tingting | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，2： | 2 |
| 5 | Variations in OsSPL10 confer drought tolerance by directly regulating OsNAC2 expression and ROS production in rice显示文摘Drought is a major factor restricting the production of rice(Oryza sativa L.).The identification of natural variants for drought stress-related genes is an important step toward developing genetically improved rice varieties.Here,we characterized a member of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)family,OsSPL10,as a transcription factor involved in the regulation of drought tolerance in rice.OsSPL10 appears to play a vital role in drought tolerance by controlling reactive oxygen species(ROS)production and stomatal movements.Haplotype and allele frequency analyses of OsSPL10 indicated that most upland rice and improved lowland rice varieties harbor the OsSPL10Hap1allele,whereas the OsSPL10Hap2allele was mainly present in lowland and landrace rice varieties.Importantly,we demonstrated that the varieties with the OsSPL10Hap1allele showed low expression levels of OsSPL10 and its downstream gene,OsNAC2,which decreases the expression of OsAP37 and increases the expression of OsCOX11,thus preventing ROS accumulation and programmed cell death(PCD).Furthermore,the knockdown or knockout of OsSPL10 induced fast stomatal closure and prevented water loss,thereby improving drought tolerance in rice.Based on these observations,we propose that OsSPL10 confers drought tolerance by regulating OsNAC2 expression and that OsSPL10Hap1could be a valuable haplotype for the genetic improvement of drought tolerance in rice. | Yingxiu Li Shichen Han Xingming Sun Najeeb Ullah Khan Qun Zhong Zhanying Zhang Hongliang Zhang Feng Ming Zichao Li Jinjie Li | 2023 | Journal of Integrative Plant Biology2023，65，4： | 2 |
| 6 | Toll-like receptor 9 defciency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation显示文摘Toll-like receptors(TLRs)play pivotal roles in inflammation and provide important links between the immune and skeletal systems.Although the activation of TLRs may affect osteoclast differentiation and bone metabolism,whether and how TLRs are required for normal bone remodeling remains to be fully explored.In the current study,we show for the first time that TLR9^(-/-)mice exhibit a low bone mass and low-grade systemic chronic inflammation,which is characterized by the expansion of CD4^(+)T cells and increased levels of inflammatory cytokines,including TNFα,RANKL,and IL1β.The increased levels of these cytokines significantly promote osteoclastogenesis and induce bone loss.Importantly,TLR9 deletion alters the gut microbiota,and this dysbiosis is the basis of the systemic inflammation and bone loss observed in TLR9^(-/-)mice.Furthermore,through single-cell RNA sequencing,we identified myeloid-biased hematopoiesis in the bone marrow of TLR9^(-/-)mice and determined that the increase in myelopoiesis,likely caused by the adaptation of hematopoietic stem cells to systemic inflammation,also contributes to inflammation-induced osteoclastogenesis and subsequent bone loss in TLR9^(-/-)mice.Thus,our study provides novel evidence that TLR9 signaling connects the gut microbiota,immune system,and bone and is critical in maintaining the homeostasis of inflammation,hematopoiesis,and bone metabolism under normal conditions. | Peng Ding Qiyuan Tan Zhanying Wei Qiyu Chen Chun Wang Luyue Qi Li Wen Changqing Zhang Chen Yao | 2022 | Bone Research2022，10，3： | 2 |
| 7 | Genetic control of panicle architecture in rice显示文摘Rice panicle architecture affects grain number per panicle and thereby grain yield.Many genes involved in control of panicle architecture have been identified in the past decades.According to their effect on phenotype,these genes are divided into three categories:panicle branch and lateral spikelets,multifloret spikelets,and panicle type.We review these genes,describe their genetic regulatory network,and propose a strategy for using them in rice breeding.These findings on rice panicle architecture may facilitate related studies in other crops. | Gangling Li Hongliang Zhang Jinjie Li Zhanying Zhang Zichao Li | 2021 | The Crop Journal2021，9，3： | 2 |
| 8 | Rice SPL10 positively regulates trichome development through expression of HL6 and auxin-related genes显示文摘Trichomes function in plant defenses against biotic and abiotic stresses;examination of glabrous lines,which lack trichomes,has revealed key aspects of trichome development and function.Tests of allelism in 51 glabrous rice(Oryza sativa)accessions collected worldwide identified OsSPL10 and OsWOX3B as regulators of trichome development in rice.Here,we report that OsSPL10 acts as a transcriptional regulator controlling trichome development.Haplotype and transient expression analyses revealed that variation in the approximately 700-bp OsSPL10 promoter region is the primary cause of the glabrous phenotype in the indica cultivar WD-17993.Disruption of OsSPL10 by genome editing decreased leaf trichome density and length in the NIL-HL6 background.Plants with genotype OsSPL10^(WD-17993)/HL6 generated by crossing WD-17993 with NIL-HL6 also had fewer trichomes in the glumes.HAIRY LEAF6(HL6)encodes another transcription factor that regulates trichome initiation and elongation,and OsSPL10 directly binds to the HL6 promoter to regulate its expression.Moreover,the transcript levels of auxin-related genes,such as OsYUCCA5 and OsPIN-FORMED1b,were altered in OsSPL10 overexpression and RNAi transgenic lines.Feeding tests using locusts(Locusta migratoria)demonstrated that non-glandular trichomes affect feeding by this herbivore.Our findings provide a molecular framework for trichome development and an ecological perspective on trichome functions. | Jinjie Li Bo Tang Yingxiu Li Chenguang Li Minjie Guo Haiyang Chen Shichen Han Jin Li Qijin Lou Wenqiang Sun Peng Wang Haifeng Guo Wei Ye Zhanying Zhang Hongliang Zhang Sibin Yu Long Zhang Zichao Li | 2021 | Journal of Integrative Plant Biology2021，63，8： | 2 |
| 9 | Microfluidic adhesion analysis of single glioma cells for evaluating the effect of drugs显示文摘Cancer metastasis is one of the most serious problems for tumor therapy,which is closely related to cell adhesion and deadhesion process.Better comprehension of cell adhesion ability will benefit drug research.Here,a biomimetic microfluidic enzyme digestion method was proposed to gently measure the influence of drugs on cell-matrix adhesion ability at the single cell level.The method can selectively digest the extracellular matrix(ECM)that linked to a single cell,and the trypsin concentration around the cell is relatively uniform and constant,thus the measured cell adhesion strength should be precise.Commercially available anti-cancer agents including 5-fluorouracil(5-FU),actinomycin D(Act D),temozolomide(TMZ)and allicin were evaluated,and the data showed only TMZ and allicin can inhibit cell adhesion significantly under our experiment conditions.The influence of TMZ became more and more obvious as the increase of duration and the effect became prominent only after 6 h adhesion process,which could provide a quick evaluation of whether the drugs are effective to cancer cell(compared with Calcein-AM/PI cell viability test).The adhesion strength of U87 cells decreased when the concentration of TMZ increased,and the effect of TMZ can be effectively inhibited by adding lactic acid to culture medium,which indicated acidic tumor microenvironment could promote drug resistance of tumor cells.Different from conventional evaluation methods which focus on the drugs’influence on cellular viability or metabolism,this work provides a new perspective to study the effect of drugs,which is helpful to enrich the drug evaluation system. | Qiang Zhang Sifeng Mao Weiwei Li Qiushi Huang Shuo Feng Zhanying Hong Jin-Ming Lin | 2020 | Science China Chemistry2020，63，6： | 1 |
| 10 | GABA ergic projections from the lateral lemniscuses to the inferior collculus of the rat 显示文摘 | Zhany D X Li L Kelly J B | 1998 | Hearing Res1998，117，： | 1 |
| 11 | Improved triethylamine sensing properties of fish-scale-like porous SnO_(2) nanosheets by decorating with Ag nanoparticles显示文摘Three dimensional(3D)porous nanostructures assembled by low-dimensional nanomaterials are widely applied in gas sensor according to porous structure which can facilitate the transport of gas molecules.In this work,fish-scale-like porous SnO 2 nanomaterials assembled from ultrathin nanosheets with thick-ness of 16.8 nm were synthesized by a facile hydrothermal route.Then Ag nanoparticles were decorated on the surface of SnO_(2) nanosheets via one-step method to improve their gas-sensing performances.The sensing properties of pristine SnO_(2) and Ag/SnO_(2) nanosheets were investigated intensively.After deco-rating with Ag nanoparticles,the characteristics of SnO_(2) based sensor for triethylamine detection were significantly improved.Especially,the Ag/SnO_(2) based sensor with Ag content of 2 at%exhibited the highest triethylamine sensing sensitivity at optimum work temperature of 170?C.The improved sensing properties of Ag/SnO_(2) sensors were attributed to the sensitizing actions of Ag nanoparticles as well as the unique hierarchical porous architecture. | Jingyi Zhang Bowen Zhang Shujuan Yao Hongyuan Li Can Chen Hari Bala Zhanying Zhang | 2022 | Journal of Materiomics2022，8，2： | 1 |
| 12 | Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies显示文摘 | Sheng Ge Xiaohui Feng Li Shen Zhanying Wei Qiankun Zhu Juan Sun Jin-Lian Chen | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 13 | In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography显示文摘Cell membrane affinity chromatography has been widely applied in membrane protein(MP)-targeted drug screening and interaction analysis.However,in current methods,the MP sources are derived from cell lines or recombinant protein expression,which are time-consuming for cell culture or purification,and also difficult to ensure the purity and consistent orientation of MPs in the chromatographic stationary phase.In this study,a novel in situ synthesis membrane protein affinity chromatography(iSMAC)method was developed utilizing cell-free protein expression(CFE)and covalent immobilized affinity chromatography,which achieved efficient in situ synthesis and unidirectional insertion of MPs into liposomes in the stationary phase.The advantages of iSMAC are:1)There is no need to culture cells or prepare recombinant proteins;2)Specific and purified MPs with stable and controllable content can be obtained within 2 h;3)MPs maintain the transmembrane structure and a consistent orientation in the chromatographic stationary phase;4)The flexible and personalized construction of cDNAs makes it possible to analyze drug binding sites.iSMAC was successfully applied to screen PDGFRβinhibitors from Salvia miltiorrhiza and Schisandra chinensis.Micro columns prepared by in-situ synthesis maintain satisfactory analysis activity within 72 h.Two new PDGFRβinhibitors,salvianolic acid B and gomisin D,were screened out with KD values of 13.44 and 7.39μmol/L,respectively.In vitro experiments confirmed that the two compounds decreasedα-SMA and collagen Ⅰ mRNA levels raised by TGF-βin HSC-T6 cells through regulating the phosphorylation of p38,AKT and ERK.In vivo,Sal B could also attenuate CCl_(4)-induced liver fibrosis by downregulating PDGFRβdownstream related protein levels.The iSMAC method can be applied to other general MPs,and provides a practical approach for the rapid preparation of MP-immobilized or other biological solid-phase materials. | Yanqiu Gu Rong Wang Panpan Chen Shengnan Li Xinyi Chai Chun Chen Yue Liu Yan Cao Diya Lv Zhanying Hong Zhenyu Zhu Yifeng Chai Yongfang Yuan Xiaofei Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 14 | Genome-wide association study of 23 f lowering phenology traits and 4 f loral agronomic traits in tree peony (Paeonia section Moutan DC.) reveals five genes known to regulate f lowering time显示文摘Tree peony is a unique traditional f lower in China,with large,fragrant,and colorful f lowers.However,a relatively short and concentrated f lowering period limits the applications and production of tree peony.A genome-wide association study(GWAS)was conducted to accelerate molecular breeding for the improvement of f lowering phenology traits and ornamental phenotypes in tree peony.A diverse panel of 451 tree peony accessions was phenotyped for 23 f lowering phenology traits and 4 f loral agronomic traits over 3 years.Genotyping by sequencing(GBS)was used to obtain a large number of genome-wide single-nucleotide polymorphisms(SNPs)(107050)for the panel genotypes,and 1047 candidate genes were identified by association mapping.Eighty-two related genes were observed during at least 2 years for f lowering,and seven SNPs repeatedly identified for multiple f lowering phenology traits over multiple years were highly significantly associated with five genes known to regulate f lowering time.We validated the temporal expression profiles of these candidate genes and highlighted their possible roles in the regulation of f lower bud differentiation and f lowering time in tree peony.This study shows that GWAS based on GBS can be used to identify the genetic determinants of complex traits in tree peony.The results expand our understanding of f lowering time control in perennial woody plants.Identification of markers closely related to these f lowering phenology traits can be used in tree peony breeding programs for important agronomic traits. | Yuying Li Lili Guo Zhanying Wang Dehui Zhao Dalong Guo John E.Carlson Weilun Yin Xiaogai Hou | 2023 | Horticulture Research2023，10，2： | 1 |
| 15 | Prediction of Ship Roll Based on Second Diagonal Recurrent Neural Network显示文摘 | Liang Xu Zhanying Li Yuzhi Song Yanping Wang | 2013 | 控制工程期刊(中英文版)2013，3，3： | 1 |
| 16 | Synthesis and Characterization of Hierarchical Porous α -FeOOH for the Adsorption and Photodegradation of Rhodamine B显示文摘 | Jianliang Cao Gaojie Li Yan Wang Guang Sun Hari Bala Xiaodong Wang Zhanying Zhang Tian-Yi Ma | 2014 | International Journal of Photoenergy2014，，： | 1 |
| 17 | Framework and development of data-driven physics based model with application in dimensional accuracy prediction in pocket milling显示文摘In the manufacturing of thin wall components for aerospace industry,apart from the side wall contour error,the Remaining Bottom Thickness Error(RBTE)for the thin-wall pocket component(e.g.rocket shell)is of the same importance but overlooked in current research.If the RBTE reduces by 30%,the weight reduction of the entire component will reach up to tens of kilograms while improving the dynamic balance performance of the large component.Current RBTE control requires the off-process measurement of limited discrete points on the component bottom to provide the reference value for compensation.This leads to incompleteness in the remaining bottom thickness control and redundant measurement in manufacturing.In this paper,the framework of data-driven physics based model is proposed and developed for the real-time prediction of critical quality for large components,which enables accurate prediction and compensation of RBTE value for the thin wall components.The physics based model considers the primary root cause,in terms of tool deflection and clamping stiffness induced Axial Material Removal Thickness(AMRT)variation,for the RBTE formation.And to incorporate the dynamic and inherent coupling of the complicated manufacturing system,the multi-feature fusion and machine learning algorithm,i.e.kernel Principal Component Analysis(kPCA)and kernel Support Vector Regression(kSVR),are incorporated with the physics based model.Therefore,the proposed data-driven physics based model combines both process mechanism and the system disturbance to achieve better prediction accuracy.The final verification experiment is implemented to validate the effectiveness of the proposed method for dimensional accuracy prediction in pocket milling,and the prediction accuracy of AMRT achieves 0.014 mm and 0.019 mm for straight and corner milling,respectively. | Zhanying CHEN Liping WANG Jiabo ZHANG Guoqiang GUO Shuailei FU Chao WANG Xuekun LI | 2021 | Chinese Journal of Aeronautics2021，34，6： | 1 |
| 18 | Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice显示文摘Botulinum neurotoxins serotype A(BoNT/A)is the deadliest toxins known to humans and the'Category A'agent for bioterrorism.Over the past 20 years,significant efforts have been put forth to develop effective inhibitors of BoNT/A.Unfortunately,few identified inhibitors possess noteworthy efficacy against BoNT/A in vivo.Here,we performed a high-throughput virtual screening based on the structure-based docking simulations and found a novel potent scaffold 2-thionicotinate that inhibits the BoNT/A light chain(LC).We then synthesized and optimized a novel series of 2-thionicotinate derivatives and comprehensively evaluated their activity against BoNT/A in vitro and in vivo.An optimized compound ZM299 effectively exhibits anti-BoNT/A activity in primary neurons and displayed remarkably therapeutic efficacy against BoNT/A in vivo,which could raise the survival rate of intoxicated mice to 100%(12/12)after lethal doses of BoNT/A exposures.These findings demonstrate that 2-thionicotinates is a promising scaffold for producing more effective anti-BoNT/A analogs,and compound ZM299 is worthy of further preclinical evaluation as a drug candidate for the treatment of botulism. | Jianxin Wang Yuelin Wu Deyan Luo Chunlin Zhuang Nianzhi Ning Yanming Zhang Zhili He Jie Gao Zhanying Hong Xiguo Xv Wannian Zhang Tao Li Zhenyuan Miao Hui Wang | 2022 | Chinese Journal of Chemistry2022，40，3： | 0 |
| 19 | Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices显示文摘Kirsten rat sarcoma viral oncogene homolog(KRAS)-phosphodiesterase-delta(PDEδ)is a promising target for antitumor drug discovery.Herein,highly efficient and environmentally sensitive fluorescent probes of PDEδ(DS-Probes)were rationally designed.As compared with the reported PDEδprobes,DS-Probes showed higher binding affinity and selectivity,which were able to conveniently and efficiently label PDEδin live cells as well as tumor tissues.Therefore,these fluorescent probes are expected to facilitate PDEδ-based mechanism elucidation,drug discovery and pathologic diagnosis. | Keliang Li Shanchao Wu Gaopan Dong Yu Li Wei Wang Guoqiang Dong Zhanying Hong Minyong Li Chunquan Sheng | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 20 | Rotating Surfaces Promote the Shedding of Droplets显示文摘Achieving rapid shedding of droplets from solid surfaces has received substantial attention because of its diverse applications.Previous studies have focused on minimizing contact times of liquid droplets interacting with stationary surfaces,yet little consideration has been given to that of moving surfaces.Here,we report a different scenario:A water droplet rapidly detaches from micro/nanotextured rotating surfaces in an intriguing doughnut shape,contributing to about 40%contact time reduction compared with that on stationary surfaces.The doughnut-shaped bouncing droplet fragments into satellites and spontaneously scatters,thus avoiding further collision with the substrate.In particular,the contact time is highly dependent on impact velocities of droplets,beyond previous descriptions of classical inertialcapillary scaling law.Our results not only deepen the fundamental understanding of droplet dynamics on moving surfaces but also suggest a synergistic mechanism to actively regulate the contact time by coupling the kinematics of droplet impingement and surface rotation. | Ran Tao Wei Fang Jun Wu Binhong Dou Wanghuai Xu Zhanying Zheng Bing Li Zuankai Wang Xiqiao Feng Chonglei Hao | 2023 | Research2023，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员