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| 1 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 2 | Thermal studies of novel molecular perovskite energetic material(C_(6)H_(14)N_(2))[NH_(4)(ClO_(4))_(3)]显示文摘(C6H(14)N2)[NH4(ClO4)3] is a newly developed porous hybrid inorganic-organic framework material with easy access and excellent detonation performances,however,its thermal properties is still unclear and severely hampered further applications.In this study,thermal behaviors and non-isothermal decomposition reaction kinetics of(C6H(14)N2)[NH4(ClO4)3] were investigated systematically by the combination of differential scanning calorimetry(DSC) and simultaneous thermal analysis methods.In-situ FTIR spectroscopy technology was applied for investigation of the structure changes of(C6H(14)N2) NH4(ClO4)3]and some selected referents for better understanding of interactions between different components during the heating process.Experiment results indicated that the novel molecular perovskite structure renders(C6H(14)N2)[NH4(ClO4)3] better thermal stability than most of currently used energetic materials.Underhigh temperature s,the stability of the cage skeleton constructed by NH4^+and ClO4^-ions determined the decomposition process rather than organic moiety confined in the skeleton.The simple synthetic method,good detonation performances and excellent thermal properties make(C6H(14)N2)[NH4(ClO4)3] an ideal candidate for the preparation of advanced explosives and propellants. | Jing Zhou Li Ding Fengqi Zhao Bozhou Wang Junlin Zhang | 2020 | Chinese Chemical Letters2020，31，2： | 5 |
| 3 | Thermochemical properties and thermokinetic behavior of energetic triazole ionic salts显示文摘The properties of dissolution in different solvents,the specific heat capacity and thermal decomposition process under the non-isothermal conditions for energetic triazole ionic salts 1,2,4-triazolium nitrate(1a),1,2,3-triazolium nitrate(1b),3,4,5triamino-1,2,4-triazolium nitrate(2a),3,4,5-triamino-1,2,4-triazolium dinitramide(2b)were precisely measured using a Calvet Microcalorimeter.The thermochemical equation,differential enthalpies of dissolution(△difH m ),standard molar enthalpies of dissolution(△difH m ),apparent activation energy(E),pre-exponential constant(A),kinetic equation,linear relationship of specific heat capacity with temperature over the temperature range from 283 to 353 K,standard molar heat capacity(C p,m)and enthalpy,entropy and Gibbs free energy at 283–353 K,taking 298.15 K as the benchmark for 1a,1b,2a and 2b were obtained with treating experimental data and theoretical calculation method.The kinetic and thermodynamic parameters of thermal decomposition reaction,critical temperature of thermal explosion(Tb),self-accelerating decomposition temperature(TSADT)and adiabatic time-to-explosion(t)of 1a,1b,2a and 2b were calculated.Their heat-resistance abilities were evaluated.Information was obtained on the relation between molecular structures and properties of 1a,1b,2a and 2b. | ZHAO FengQi XUE Liang XING XiaoLing HU RongZu ZHOU ZhiMing GAO HongXu YI JianHua XU SiYu PEI Qing | 2011 | Science China Chemistry2011，54，3： | 4 |
| 4 | Broad area quantum cascade lasers operating in pulsed mode above 100℃ at λ ~ 4.7 μm显示文摘We demonstrate a broad area(400 μm) high power quantum cascade laser(QCL). A total peak power of 62 W operating at room temperature is achieved at λ~ 4.7 μm. The temperature dependence of the peak power characteristic is given in the experiment, and also the temperature of the active zone is simulated by a finite-elementmethod(FEM). We find that the interface roughness of the active core has a great effect on the temperature of the active zone and can be enormously improved using the solid source molecular beam epitaxy(MBE) growth system. | Yue Zhao Fangliang Yan Jinchuan Zhang Fengqi Liu Ning Zhuo Junqi Liu Lijun Wang Zhanguo Wang | 2017 | Journal of Semiconductors2017，38，7： | 3 |
| 5 | Branched chain amino acids alter fatty acid profile in colostrum of sows fed a high fat diet显示文摘Background:Branched chain amino acids(BCAAs)are important substrates for milk protein synthesis in the mammary gland,and are tightly related to lipid metabolism.No study has been performed examining the role of BCAAs with high fat diets on milk fat synthesis.This study was designed to investigate the effect of dietary BCAAs on growth performance of piglets,progeny body weight,and milk fat composition in sows fed a high fat diet.Four diets(CON=control diet;HF=high fat diet with 8%soybean oil;HF-MB=HF plus 0.39%BCAAs;HF-HB=HF plus 0.78%BCAAs)were fed to sows from late gestation to weaning.Results:Compared to HF,BCAAs(HF-MB and HF-HB)increased the litter weight(P<0.05)and overall litter weight gain(P<0.05)at weaning and increased colostrum fat content by 27.3–35.8%(P<0.01).Fatty acid profiles between the two doses of BCAAs were similar.Compared with HF,HF-MB tended to decrease the percentage of C18:3n3(P=0.063)and increased the percentage of C18:1n9c(P=0.03).In addition,BCAAs in HF-MB increased the concentration of total fatty acid by 22.1%in colostrum(P=0.03)but decreased that in serum at parturition by 53.2%(P=0.027).The fatty acids in colostrum that increased with BCAAs were C15:0,C17:0,C20:3n6,C20:4n6,C20:5n3 and C22:6n3(P=0.00~0.04).Colostrum fatty acids of C20:0,C21:0,C22:0,C16:1,C20:1,C18:1n9c also tended to be increased(0.05 | Chang Ma Yajng Liu Shaoshuai Liu Crystal L.Lévesque Fengqi Zhao Jindong Yin Bing Dong | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 3 |
| 6 | Synthesis and Thermal Behavior of 1,8-Dihydroxy- 4,5-dinitroanthraquinone Manganese Salt显示文摘 | WANG Yinglei ZHAO Fengqi JI Yueping YI Jianhua WANG Wei XU Siyu AN Ting PEI Qing | 2014 | Chemical Research in Chinese Universities2014，30，3： | 2 |
| 7 | Functional characterization of oligopeptide transporter 1 of dairy cows显示文摘Background: It is wel known that peptides play a vital role in the nutrition and health of dairy cows. Bovine oligopeptide transporter 1(bP epT 1) is involved in the peptide transport process in the gastrointestinal tracts of dairy cows. However,little information is known in the characteristics of bP epT 1. Therefore, the purpose of this study was to characterize bP epT 1 functional y using a mammalian cel expression system. The uptake of radiolabeled dipeptide glycyl-sarcosine([3 H]-Gly-Sar)into the bP epT 1-transfected Chinese hamster ovary cel s was measured at various pH and substrate concentrations and with or without 15 other smal peptides that contained Met or Lys.Results: Western blot results showed that the abundance of bP epT 1 protein in the jejunum and ileum are the highest in the gastrointestinal tract of dairy cows. The uptake of [3 H]-Gly-Sar by b Pep T1-Chinese hamster ovary cells was dependent on time, p H, and substrate concentration, with a low Kmvalue of 0.94 ± 0.06 mmol/L and a maximum velocity of 20.80 ± 1.74 nmol/(mg protein · 5 min). Most of the di-and tripeptides were the substrates of b Pep T1,based on substrate-competitive studies. However, bP epT 1 has a higher affinity to the peptides with shorter chains, greater hydrophobicity, and negative or neutral charges.Conclusions: These results demonstrated for the first time the functional characteristics of bP epT 1, and they provide a new insight and better understanding into its vital role in absorbing a wide range of peptides from the digestive tract of dairy cows. | Qingbiao Xu Zhixuan Liu Hongyun Liu Fengqi Zhao Xinbei Huang Yueming Wu Jianxin Liu | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 2 |
| 8 | Characteristics,origin and controlling effects on hydrocarbon accumulation of overpressure in foreland thrust belt of southern margin of Junggar Basin,NW China显示文摘Aiming at the differential distribution of overpressure in vertical and lateral directions in the foreland thrust belt in the southern margin of Junggar Basin,the study on overpressure origin identification and overpressure evolution simulation is carried out.Based on the measured formation pressure,drilling fluid density and well logging data,overpressure origin identification and overpressure evolution simulation techniques are used to analyze the vertical and lateral distribution patterns of overpressure,genetic mechanisms of overpressure in different structural belts and causes of the differential distribution of overpressure,and the controlling effects of overpressure development and evolution on the formation and distribution of oil and gas reservoirs.The research shows that overpressure occurs in multiple formations vertically in the southern Junggar foreland thrust belt,the deeper the formation,the bigger the scale of the overpressure is.Laterally,overpressure is least developed in the mountain front belt,most developed in the fold anticline belt,and relatively developed in the slope belt.The differential distribution of overpressure is mainly controlled by the differences in disequilibrium compaction and tectonic compression strengths of different belts.The vertical overpressure transmission caused by faults connecting the deep overpressured system has an important contribution to the further increase of the overpressure strength in this area.The controlling effect of overpressure development and evolution on hydrocarbon accumulation and distribution shows in the following aspects:When the strong overpressure was formed before reservoir becoming tight overpressure maintains the physical properties of deep reservoirs to some extent,expanding the exploration depth of deep reservoirs;reservoirs below the overpressured mudstone cap rocks of the Paleogene Anjihaihe Formation and Lower Cretaceous Tugulu Group are main sites for oil and gas accumulation;under the background of overall overpressure,both overpressure strength too high or too low are not conducive to hydrocarbon enrichment and preservation,and the pressure coefficient between 1.6 and 2.1 is the best. | LU Xuesong ZHAO Mengjun ZHANG Fengqi GUI Lili LIU Gang ZHUO Qingong CHEN Zhuxin | 2022 | Petroleum Exploration and Development2022，49，5： | 2 |
| 9 | Room temperature continuous wave operation of quantum cascade laser atλ~9.4μm显示文摘Continuous wave(CW) operation of long wave infrared(LWIR) quantum cascade lasers(QCLs) is achieved up to a temperature of 303 K. For room temperature CW operation, the wafer with 35 stages was processed into buried heterostructure lasers. For a 2-mm-long and 10-μm-wide laser with high-reflectivity(HR) coating on the rear facet, CW output power of 45 m W at 283 K and 9 m W at 303 K is obtained. The lasing wavelength is around 9.4 μm locating in the LWIR spectrum range. | Chuncai Hou Yue Zhao Jinchuan Zhang Shenqiang Zhai Ning Zhuo Junqi Liu Lijun Wang Shuman Liu Fengqi Liu Zhanguo Wang | 2018 | Journal of Semiconductors2018，39，3： | 1 |
| 10 | Kinetics and mechanism of the exothermic first-stage decomposition reaction dinitroglycoluril显示文摘 | ZHAO Fengqi HU Rongzu CHEN Pei | 2004 | Chinese Journal of Chemistry2004，，22： | 1 |
| 11 | Polarons with spatially dependent mass in a finite parabolic quantum well显示文摘 | Zhao Fengqi Liang Xixia | 2002 | Chin Phys Lett2002，19，7： | 1 |
| 12 | Energy lerels of a polaron in a parabolic quantumn well显示文摘 | LIANG X X BAN S L | 2001 | International Journal of Modern Physics B2001，15，5： | 1 |
| 13 | A new high-nitrogen compound ·2H2O : Synthesis and characterization 显示文摘 | Baojuan Jiao Sanping Chen Fengqi Zhao | 2007 | Journal of Hazardous Materials2007，142，： | 1 |
| 14 | PRL和O_(2)对HC11细胞氧化应激状态下乳蛋白合成的影响显示文摘为探明催乳素(PRL)和氧气(O_(2))对大鼠乳腺上皮(HC11)细胞氧化应激的影响及作用机制,试验以大鼠HC11细胞为载体,研究了在有氧和缺氧条件下催乳素对由过氧化氢(H_(2)O_(2))诱发的HC11细胞氧化应激的影响。结果表明:催乳素有利于改善氧化应激对乳腺乳蛋白基因表达的影响,其作用是通过增加抗氧化基因的表达、激活炎症因子的表达和维持葡萄糖转运因子的正常运转而实现的。 | 田青 Alexander Jonathan Spitzer ZHAO Fengqi | 2022 | 中国饲料2022，，11： | 1 |
| 15 | Non-isother- mal decomposition kinetics specific heat capacity and adia- batic time-to-explosion of 1-amino-l-hydrazino-2,2-dinitro-ethylene(AHDNE)显示文摘 | Xu Kangzhen Zhao Fengqi Song Jirong | 2009 | 中国化学(英文版)2009，27，： | 1 |
| 16 | Researchon the combustion properties of propellants withlow content of nano metal powders显示文摘 | Jiang Zhi Li Shufen Zhao Fengqi | 2006 | Propellants Explosives Pyrotechnics2006，31，2： | 1 |
| 17 | Monoclinic mesoporous BiVO 4 : Synthesis and visible-light-driven photocatalytic property显示文摘 | Mingming Yao Mingxian Liu Lihua Gan Fengqi Zhao Xuezhong Fan Dazhang Zhu Zijie Xu Zhixian Hao Longwu Chen | 2013 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2013，，： | 1 |
| 18 | Ti–Cu–N hard nanocomposite films prepared by pulse biased arc ion plating显示文摘 | Yanhui Zhao Xueqi Wang Jinquan Xiao Baohai Yu Fengqi Li | 2011 | Applied Surface Science2011，，1： | 1 |
| 19 | Coupled-ridge waveguide quantum cascade laser array lasing at λ~5μm显示文摘In this work,we demonstrated high-power quantum cascade laser(QCL)arrays lasing at λ~5μm by employing an optimized coupled-ridge waveguide(CRW)structure.Five-element QCL arrays were simulated and fabricated through a two-step etching method to extend the CRW structure to a mid-wave infrared regime.A lateral far-field with the main peak near a diffraction-limited intensity curve of about 10°was observed by properly designing a geometric shape of the ridges and interspaces.By introducing a buried 2nd-order distributed feedback(DFB)grating,substrate emission with a radiation power above 1 W at 25℃ is achieved.Single longitudinal mode operation is obtained by changing the temperature of the heatsink with a good linear wavelength tuning coefficient of -0.2 cm^(-1)/K. | Pengchang Yang Jinchuan Zhang Zenghui Gu Chuanwei Liu Yue Zhao Fengmin Cheng Shenqiang Zhai Ning Zhuo Junqi Liu Lijun Wang Shuman Liu Fengqi Liu | 2021 | Journal of Semiconductors2021，42，9： | 1 |
| 20 | Synthesisand thermal behaviors of 4-amino-3, 5-dinitro-lH-pyrazole显示文摘 | Wang Yinglei Zhao Fengqi Ji Yueping | 2012 | Journal of Analytical and Applied Pyroly-sis2012，，98： | 1 |
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