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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Geochronology, Geochemistry and Sr-Nd-Pb-Hf Isotopes of No. I Complex from the Shitoukengde Ni–Cu Sulfide Deposit in the Eastern Kunlun Orogen, Western China: Implications for the Magmatic Source, Geodynamic Setting and Genesis显示文摘The Shitoukengde Ni-Cu deposit, located in the Eastern Kunlun Orogen, comprises three mafic–ultramafic complexes, with the No. I complex hosting six Ni-Cu orebodies found recently. The deposit is hosted in the small ultramafic bodies intruding Proterozoic metamorphic rocks. Complexes at Shitoukengde contain all kinds of mafic-ultramafic rocks, and olivine websterite and pyroxene peridotite are the most important Ni-Cu-hosted rocks. Zircon U-Pb dating suggests that the Shitoukengde Ni-Cu deposit formed in late Silurian(426–422 Ma), and their zircons have εHf(t) values of-9.4 to 5.9 with the older T_(DM1) ages(0.80–1.42 Ga). Mafic-ultramafic rocks from the No. I complex show the similar rare earth and trace element patterns, which are enriched in light rare earth elements and large ion lithophile elements(e.g., K, Rb, Th) and depleted in heavy rare earth elements and high field strength elements(e.g., Ta, Nb, Zr, Ti). Sulfides from the deposit have the slightly higher δ^(34)S values of 1.9–4.3‰ than the mantle(0 ± 2‰). The major and trace element characteristics, and Sr-Nd-Pb and Hf, S isotopes indicate that their parental magmas originated from a metasomatised, asthenospheric mantle source which had previously been modified by subduction-related fluids, and experienced significant crustal contamination both in the magma chamber and during ascent triggering S oversaturation by addition of S and Si, that resulted in the deposition and enrichment of sulfides. Combined with the tectonic evolution, we suggest that the Shitoukengde Ni-Cu deposit formed in the post-collisional, extensional regime related to the subducted oceanic slab break-off after the Wanbaogou oceanic basalt plateau collaged northward to the Qaidam Block in late Silurian. | LI Liang SUN Fengyue LI Bile LI Shijin CHEN Guangjun WANG Wei YAN Jiaming ZHAO Tuofei DONG Jun ZHANG Dexin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 10 |
| 3 | Co-delivery of doxorubicin and quercetin via mPEG-PLGA copolymer assembly for synergistic anti-tumor efficacy and reducing cardio-toxicity显示文摘橡黄素(Que ) 是自然多功能的 bioflavonoid,并且为减少不利副作用并且提高化学疗法的药的反肿瘤功效显示出大潜力。然而,它的临床的申请在生理的系统由于很低的溶解度和结构的不稳定性被限制。此处,我们共同交付由开发 amphiphilic 聚合物包括的 biocompatible nanocarrier 的恐水病的橡黄素和吸水的 doxorubicin (纪录影片) , methoxy poly (乙烯乙二醇) 并且 poly (D, L-lactide-co-glycolide ) 分别地。反肿瘤和这个系统的预防功效被评估在细胞并且动物模型。我们说明的调查结果 Dox-Que nanoparticulate 明确的表达保护了正常脉管的 endothelial 房间免受免费的任何一个或 nanoparticulate 的伤害导致 doxorubicin 的 cytotoxicity 和增加的癌症房间死亡。与免费 doxorubicin 和它的 nanoformulation 相比,用我们的 nanosystem 的橡黄素和 doxorubicin 的合作交货 synergistically 禁止了肿瘤生长,当在浆液维持心脏的功能指示物的正常层次并且在心织物恢复组织病理学说的损坏时。这研究为提高反癌症药功效并且减少 nanoparticulate 表明有希望的策略正常纸巾上的导致化疗的毒性。 | Waseem Akhtar Qureshi Ruifang Zhao Hai Wang Tianjiao Ji Yanping Ding Ayesha Ihsan Ayeesha Mujeeb Guangjun Nie Yuliang Zhao | 2016 | Science Bulletin2016，61，21： | 9 |
| 4 | Review of Chinese atmospheric science research over the past 70 years: Climate and climate change显示文摘Climate and climate change have always been a research focus of atmospheric sciences. This paper summaries research efforts, achievements and international contributions of the Chinese scientific community on climate and climate change over the past 70 years. The review is based on papers published officially in national or international scientific journals,and is organized to cover six aspects:(1) general climate studies;(2) impact of the Qinghai-Tibetan Plateau;(3) impact of the East Asian monsoon;(4) influences of teleconnection oscillation and westerlies;(5) climate dynamics and development of climate models;and(6) climate change. It is, however, to be noted that the present review can not be considered as an exhaustive one, since there is a huge body of literature in the field. | Jianping HUANG Wen CHEN Zhiping WEN Guangjun ZHANG Zhaoxin LI Zhiyan ZUO Qingyun ZHAO | 2019 | Science China Earth Sciences2019，62，10： | 6 |
| 5 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 6 | Towards intelligent design optimization: Progress and challenge of design optimization theories and technologies for plastic forming显示文摘Plastic forming is one of enabling and fundamental technologies in advanced manufacturing chains. Design optimization is a critical way to improve the performance of the forming system, exploit the advantages of high productivity, high product quality, low production cost and short time to market and develop precise, accurate, green, and intelligent(smart) plastic forming technology. However, plastic forming is quite complicated, relating to multi-physics field coupling,multi-factor influence, multi-defect constraint, and triple nonlinear, etc., and the design optimization for plastic forming involves multi-objective, multi-parameter, multi-constraint, nonlinear,high-dimensionality, non-continuity, time-varying, and uncertainty, etc. Therefore, how to achieve accurate and efficient design optimization of products, equipment, tools/dies, and processing as well as materials characterization has always been the research frontier and focus in the field of engineering and manufacturing. In recent years, with the rapid development of computing science, data science and internet of things(Io T), the theories and technologies of design optimization have attracted more and more attention, and developed rapidly in forming process. Accordingly, this paper first introduced the framework of design optimization for plastic forming. Then, focusing on the key problems of design optimization, such as numerical model and optimization algorithm,this paper summarized the research progress on the development and application of the theories and technologies about design optimization in forming process, including deterministic and uncertain optimization. Moreover, the applicability of various modeling methods and optimization algorithms was elaborated in solving the design optimization problems of plastic forming. Finally, considering the development trends of forming technology, this paper discusses some challenges of design optimization that may need to be solved and faced in forming process. | Heng LI Jingchao YANG Guangyao CHEN Xin LIU Zhao ZHANG Guangjun LI Wenhui LIU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 4 |
| 7 | sEMG based quantitative assessment of acupuncture on Bell's palsy:an experimental study显示文摘Acupuncture is a traditional Chinese therapeutic method, recognized by western medicine as an important complementary therapy. However, the efficacy assessment of this traditional intervention has been mainly empirical rather than scientific. In this paper, we propose a surface electromyography(s EMG) based approach for quantitative assessment of acupuncture on Bell's palsy. The assessment is made by comparing the muscle activities of healthy with diseased ones. A feature-vector of four individual s EMG features is introduced for more comprehensive representation of muscle activity. A clustering technique is then proposed to calculate quantitative differences between the muscle activities of the healthy and diseased sides. A regressive model is also proposed to predict the recovery trend of a patient based on the quantitative assessments during his/her clinical acupuncture history. As reported in the paper, a total of 20 selected Bell's palsy patients have participated in the extensive experiments that were conducted to verify the performance of the proposed method. | HAN JianDa XIONG AnBin ZHAO XinGang DING QiChuan CHEN YiGuo LIU GuangJun | 2015 | Science China(Information Sciences)2015，58，8： | 3 |
| 8 | Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells显示文摘Nanocarriers with intrinsic immune adjuvant properties can activate the innate immune system while delivering tumor antigen,thus efficiently facilitating antitumor adaptive immunity.Bacteria-derived outer membrane vesicles(OMVs)are an excellent candidate due to their abundance of pathogen associated molecular patterns.However,during the uptake of OMVs by dendritic cells(DCs),the interaction between lipopolysaccharide and toll-like receptor 4 induces rapid DC maturation and uptake blockage,a phenomenon we refer to as“maturation-induced uptake obstruction'(MUO).Herein we decorated OMV with the DC-targeting aDEC205 antibody(OMV-DEC),which endowed the nanovaccine with an uptake mechanism termed as 4 | Jie Liang Keman Cheng Yao Li Jiaqi Xu Yiwei Chen Nana Ma Qingqing Feng Fei Zhu Xiaotu Ma Tianjiao Zhang Yale Yue Guangna Liu Xinjing Guo Zhiqiang Chen Xinwei Wang Ruifang Zhao Ying Zhao Jian Shi Xiao Zhao Guangjun Nie | 2022 | Fundamental Research2022，2，1： | 2 |
| 9 | Ozonation of o-phenylenediamine in the presence of hydrogen peroxide by high-gravity technology显示文摘The study herein investigated the effectiveness of simultaneous use of ozone and hydrogen peroxide(O_3/H_2O_2 process) to degrade o-phenylenediamine(o-PDA) in a simulated wastewater. A rotor–stator reactor(RSR) was employed to create a high-gravity environment in order to enhance ozone-liquid mass transfer rate and possibly improve the degradation rate of o-PDA. The degradation efficiency of o-PDA(η) as well as the overall gas-phase volumetric mass transfer coefficient(KGa) were determined under different operating conditions of H_2O_2 concentration, initial o-PDA concentration, temperature of reaction, initial p H and rotation speed of RSR in attempt to establish the optimal conditions. Chemical oxygen demand reduction rate(rCOD) of wastewater treated at a particular set of conditions was also analyzed. Additionally, the intermediate products of degradation were identified using a gas chromatography-mass spectrometer(GC/MS) to further evaluate the extent of o-PDA degradation as well as establish its possible degradation pathway. Results were validated by comparison with those of sole use of ozone(O_3 process), and it was noted that η, KGa and rCODachieved by O_3/H_2O_2 process was 24.4%,31.6% and 25.2% respectively higher than those of O_3 process, indicating that H_2O_2 can greatly enhance ozonation of o-PDA. This work further demonstrates that an RSR can significantly intensify ozone-liquid mass transfer rate and thus provides a feasible intensification means for the ozonation of o-PDA as well as other recalcitrant organics. | Moses Arowo Zemeng Zhao Guangjun Li Guangwen Chu Baochang Sun Lei Shao | 2018 | Chinese Journal of Chemical Engineering2018，26，3： | 2 |
| 10 | Comparison of cerium-doped Lu2Si2O7 and Lu2SiO5 scintillators显示文摘 | YAN Chengfeng ZHAO Guangjun HANG Yin | 2005 | J Cryst Growth2005，281，： | 1 |
| 11 | Color Cenler of YAIO3 with Cation Vacancies 显示文摘 | Chen Jianyu Zhao Guangjun Cao Dunhua | 2010 | Current Applied Physics2010，10，2： | 1 |
| 12 | Numeri- cal simulation on gas-liquid two-phase flow in fluid couplings during braking 显示文摘 | SONG Bin LV Jiangang ZHAO Guangjun | 2010 | IEEE ICCSIT2010，，5： | 1 |
| 13 | Three-dimen- sional finite element analysis of thermal stress in single-pass multi- layer weld-based rapid prototyping显示文摘 | Huihui Zhao Guangjun Zhang Ziqiang Yin | 2012 | Journal of Materials Process- ingTechnology2012，212，： | 1 |
| 14 | Preparation of gadolinium gallium garnet polycrystalline material by co precipitation method显示文摘 | LI Tao HE Xiaoming | 2002 | Mater Lett2002，56，： | 1 |
| 15 | Utilization of novel ester-containing quaternary ammonium surfactant as cationic collector for iron ore flotation显示文摘 | WENG Xiaoqing MEI Guangjun ZHAO Taotao | 2013 | Separation and Purification Technology2013，103，： | 1 |
| 16 | Growth of Large-sized Yb:YAG Single Crystah by Temperature Gradimt Technique 显示文摘 | zhao Guangjun | 2003 | J Crystal Growth2003，252，13： | 1 |
| 17 | Characteristics of Large Sized Ce:YAG Scintillation Crystal Grown by Temperature Gradient Technique显示文摘 | Zhao Guangjun | 2003 | J Crystal Growth2003，253，14： | 1 |
| 18 | Characteristics of Large-sized Ce:YAG Scintillation Crystal Grown by Temperature Gradient Technique显示文摘 | Guangjun Zhao | 2003 | Journal of Crystal Growth2003，253，： | 1 |
| 19 | Colon hydrotherapy plus Traditional Chinese Medicine to treat non-alcoholic fatty liver disease:a pilot study显示文摘OBJECTIVE: To demonstrate the potential to treat non-alcoholic fatty liver disease(NAFLD) with colon hydrotherapy(CHT) plus Traditional Chinese Medicine(TCM).METHODS: A total of 20 patients were enrolled into the study and received CHT with TCM for 2 weeks.Body mass index(BMI) and levels of serum triglycerides(TG) and total cholesterol(TC) were compared between pre-treatment and post-treatment.RESULTS: Two-week treatment with CHT plus TCM significantly lowered BMI and reduced blood lipids.BMI decreased from 29.5 ± 4.3 to 25.4 ± 1.0, while mean TG levels decreased by 0.70 mmol/L on average from baseline and mean TC levels decreased by0.37 mmol/L. Forty-five percent of patients exhibited TC decreasing by more than 10% from baseline and25%ofpatientsexhibited TCdecreasingbymore than 20%. Sixty percent of patients exhibited TG decreasing by more than 20% and 20% of patients exhibited TG decreasing by more than 40%. However,high-density and low-density lipoprotein cholester-ol levels did not change significantly after intervention. No serious adverse events were reported.CONCLUSION: Our findings suggest that CHT plus TCM to treat NAFLD is promising and it might be a new treatment strategy for management of NAFLD. | Xiao Huanming Jiang Junmin Xie Yubao Shi Meijie Tian Guangjun Zhao Pengtao Zhang Chaozhen Chen Huijun Xu Chanyuan Chi Xiaoling | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 1 |
| 20 | Three-dimensional finite element analysis of thermal stress in single-pass multi-layer weld-based rapid prototyping显示文摘 | ZHAO Huihu ZHANG Guangjun YIN Ziqiang et a1 | 2012 | Journal of Materials Processing Technology2012，212，1： | 1 |
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