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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Correlation analysis between vegetation coverage and climate drought conditions in North China during 2001–2013显示文摘Climate change is one of the most important factors that affect vegetation distribution in North China. Among all climatic factors, drought is considered to have the most significant effect on the environment. Based on previous studies, the climate drought index can be used to assess the evolutionary trend of the ecological environment under various arid climatic conditions. It is necessary for us to further explore the relationship between vegetation coverage(index) and climate drought conditions. Therefore, in this study, based on MODIS-NDVI products and meteorological observation data, the Palmer Drought Severity Index(PDSI) and vegetation coverage in North China were first calculated. Then, the interannual variations of PDSI and vegetation coverage during 2001–2013 were analyzed using a Theil-Sen slope estimator. Finally, an ecoregion perspective of the correlation between them was discussed. The experimental results demonstrated that the PDSI index and vegetation coverage value varied over different ecoregions. During the period 2001–2013, vegetation coverage increased in the southern and northern mountains of North China, while it showed a decreasing trend in the Beijing-Tianjin-Tangshan City Circle area and suburban agricultural zone located in Hebei Province and Henan Province). Over 13 years, the climate of the northeastern part of North China became more humid, while in the southern part of North China, it tended to be dry. According to the correlation analysis results, 73.37% of North China showed a positive correlation between the vegetation coverage and climate drought index. A negative correlation was observed mainly in urban and suburban areas of Beijing, Tianjin, Hebei Province, and Henan Province. In most parts of North China, drought conditions in summer and autumn had a strong influence on vegetation coverage. | GONG Zhaoning ZHAO Shuyi GU Jinzhi | 2017 | Journal of Geographical Sciences2017，27，2： | 38 |
| 3 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 4 | Correlation between echolocation calls and morphological features among three kinds of bats显示文摘The correlation between echolocation sound and morphological features of 18 species of bats, which are subordinated to 3 families including rhinolophidae, hipposideridae and vespertilionidae is studied. Pearson's correlation and regression analysis are adopted to analyze the correlations between noseleaf width (NW) and forearm length (FAL), NW and dominant frequency (DF), FAL and DF. The results show a positive correlation between NW and FAL and a negative correlation between NW and DF in Rhinolophidae. In each family, there is a negative correlation between FAL and DF. Some species have a higher or lower frequency than predicted one according to their body size. There are significant differences of the regression equation of FAL and DF among the three families. For the bats with the same body size, the order in frequency is: hipposiderid bats> rhinolophid bats> vespertilionid bats. The mechanism of interrelationship between FAL and DF of bats, the reason why these deviations occur in correlativity of the three families and the mechanism of the interaction between morphological, physiological and ecological characteristics are discussed. | FENG Jiang , CHEN Min, LI Zhenxin, ZHANG Shuyi, ZHAO Huihua and ZHOU Jiang(1. Environmental Science Department, Northeast Normal University, Changchun 130024, China 2. Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China 3. Biology Department, Guizhou Normal University, Guiyang 550000, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 4 |
| 5 | Modeling Trusted Computing显示文摘In this paper, a formal approach based on predicate logic is proposed for representing and reasoning of trusted computing models. Predicates are defined to represent the characteristics of the objects and the relationship among these objects in a trusted system according to trusted computing specifications. Inference rules of trusted relation are given too. With the semantics proposed, some trusted computing models are formalized and verified, which shows that Predicate calculus logic provides a general and effective method for modeling and reasoning trusted computing systems. | CHEN Shuyi WEN Yingyou ZHAO Hong | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 2 |
| 6 | The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells显示文摘Pancreatic adenocarcinoma(PAAD) is one of the most lethal malignancies. Although gemcitabine(GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C(Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not been investigated since it was isolated. Our research is the first to indicate that Sec C is a broad-spectrum anticancer agent and could exhibit potently similar anticancer activity both in GEM-resistant and GEM-sensitive PAAD cells. Interestingly, Sec C exerted a rapid growth-inhibiting effect(80% death at 6 h), which might be beneficial for patients who need rapid tumor shrinkage before surgery. Liquid chromatography/mass spectrometry and N-acetyl-L-cysteine(NAC) reverse assays show that Sec C sulfates cysteines to disrupt disulfide-bonds formation in endoplasmic reticulum(ER) proteins to cause protein misfolding, leading to ER stress and disorder of lipid biosynthesis. Microarray data and subsequent assays show that ER stress-mediated ER-associated degradation(ERAD) ubiquitinates anddownregulates YAP to enhance ER stress via destruction complex(YAP-Axin-GSK-βTr CP), which also elucidates a unique degrading style for YAP. Potent anticancer activity in GEM-resistant cells and low toxicity make Sec C a promising anti-PAAD candidate. | Junxia Wang Minghua Chen Mengyan Wang Wenxia Zhao Conghui Zhang Xiujun Liu Meilian Cai Yuhan Qiu Tianshu Zhang Huimin Zhou Wuli Zhao Shuyi Si Rongguang Shao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 7 | Echolocation calls of Myotis frater (Chiroptera: Hipposi- deridae) during search flight显示文摘Echolocation calls of Myotis frater emitted during the search phase consist of brief frequency-modulated pulses. The sound signals are comprised of three harmonics of which the first one is of the highest intensity and occurs in all echolocation calls. The frequency of this fundamental harmonic ranges from 110.8 to 50.2 kHz, and its duration is about 3.5 ms. The second and the third harmonics are relatively weak, occurring in 50.0% and 25.0% of echolocation calls respectively, with frequencies ranging from 138.4 to 116.6 kHz for the second harmonic and from 193.6 to 170.8 kHz for the third harmonic. We presume that, according to the echolocation call features, Myotis frater probably forages the insects on the ground of complex environments. | ZHANG Shuyi ZHAO Huihua FENG Jiang SHENG Lianxi LI Zhenxin WANG Lixin | 2000 | Chinese Science Bulletin2000，45，18： | 2 |
| 8 | Photographic composite detection using circles显示文摘在这个工作,我们为用圆检测摄影 composites 建议几个新方法。特别地,我们集中于三种场面:(1 ) 有一样的半径的二个共面的圆;(2 ) 有它的可分别的中心的一个单个圆;(3 ) 有为照相机刻度的几何限制的一个单个圆。为二种圆状况,我们首先基于二个共面的圆的尺寸的平等估计焦距,然后估计世界圆飞机的正常向量。在在正常向量之中的角度的矛盾(每个圆决定正常向量) 被用作捣弄的证据。为单个圆盒子,在另一方面,我们弄歪圆做公制的测量。表明途径的有效性,我们合成、视觉上嘴巧的合成图象的现在的结果。 | Shuyi ZHU Xiaochun CAO Handong ZHAO | 2012 | Frontiers of Computer Science2012，6，6： | 2 |
| 9 | Relationship between echolocation frequency and body size in two species of hipposiderid bats显示文摘Frequencies of echolocation calls with maximum power of Himalayan leaf-nosed bats and Horsfield’s leaf-nosed bats during searching phase were 74.1 and 92.1 kHz, respectively. Head-body length, forearm length and body mass of Himalayan leaf-nosed bats were 82.9 mm, 89.7 mm and 59.1 g, respectively; and the corresponding values of Horsfield’s leaf-nosed bats were 68.4 mm, 61.3 mm and 19.7 g, respectively. Echolocation frequency and the three parameters of body size, head-body length, forearm length and body mass, were all negatively correlated, and the correlation coefficients were -0.86, -1.58 and -2.19, respectively. This study thereby proved that echolocation frequency and body size were negatively correlated in the two species of hipposiderid bats. | ZHANG Shuyi ZHAO Huihua FENG Jiang SHENG Lianxi WANG Hui WANG Lixin | 2000 | Chinese Science Bulletin2000，45，17： | 1 |
| 10 | ESCRT-Ⅲ component OsSNF7.2 modulates leaf rolling by trafficking and endosomal degradation of auxin biosynthetic enzyme OsYUC8 in rice显示文摘The endosomal sorting complex required for transport(ESCRT)is highly conserved in eukaryotic cells and plays an essential role in the biogenesis of multivesicular bodies and cargo degradation to the plant vacuole or lysosomes.Although ESCRT components affect a variety of plant growth and development processes,their impact on leaf development is rarely reported.Here,we found that OsSNF7.2,an ESCRT-Ⅲ component,controls leaf rolling in rice(Oryza sativa).The Ossnf7.2 mutant rolled leaf 17(rl17)has adaxially rolled leaves due to the decreased number and size of the bulliform cells.OsSNF7.2is expressed ubiquitously in all tissues,and its protein is localized in the endosomal compartments.OsSNF7.2 homologs,including OsSNF7,OsSNF7.3,and OsSNF7.4,can physically interact with OsSNF7.2,but their single mutation did not result in leaf rolling.Other ESCRT complex subunits,namely OsVPS20,OsVPS24,and OsBRO1,also interact with OsSNF7.2.Further assays revealed that OsSNF7.2 interacts with OsYUC8 and aids its vacuolar degradation.Both Osyuc8and rl17 Osyuc8 showed rolled leaves,indicating that OsYUC8 and OsSNF7.2 function in the same pathway,conferring leaf development.This study reveals a new biological function for the ESCRT-Ⅲcomponents,and provides new insights into the molecular mechanisms underlying leaf rolling. | Liang Zhou Saihua Chen Maohong Cai Song Cui Yulong Ren Xinyue Zhang Tianzhen Liu Chunlei Zhou Xin Jin Limin Zhang Minxi Wu Shuyi Zhang Zhijun Cheng Xin Zhang Cailin Lei Qibing Lin Xiuping Guo Jie Wang Zhichao Zhao Ling Jiang Shanshan Zhu Jianmin Wan | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
| 11 | A photographic approach to the possible mechanism of retrogradation of sweet potato starch显示文摘 | Lian Xijun Zhao Shuyi Liu Qinsheng Zhang Xu | 2011 | International Journal of Biological Macromolecules2011，48，： | 1 |
| 12 | The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells显示文摘 | Xianwei Wang Jianfeng Zhao Jianhua Huang Huihuan Tang Shuyi Yu Yuxiang Chen | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 1 |
| 13 | A photographic approach to the possible mechanism of retrogradeation of sweet potato starch显示文摘 | Lian Xijun Zhao Shuyi Liu Qinsheng | 2011 | International Journal of Biological Macromolecules2011，48，1： | 1 |
| 14 | Timing and Magnitude of the Second Wave of the COVID-19 Omicron Variant—189 Countries and Territories,November 2021 to February 2023显示文摘Summary What is already known about this topic?The first nationwide wave of coronavirus disease 2019(COVID-19),driven by the Omicron variant,has largely subsided.However,subsequent epidemic waves are inevitable due to waning immunity and the ongoing evolution of the severe acute respiratory syndrome coronavirus 2.What is added by this report?Insights gleaned from other nations offer guidance regarding the timing and scale of potential subsequent waves of COVID-19 in China.What are the implications for public health practice?Understanding the timing and magnitude of subsequent waves of COVID-19 in China is crucial for forecasting and mitigating the spread of the infection. | Beidi Niu Shuyi Ji Shi Zhao Hao Lei | 2023 | China CDC weekly2023，5，18： | 1 |
| 15 | Thermal diffisivity of composites determined by photoacoustic piezoelectric technique显示文摘 | SUN Li ZHANG Shuyi ZHAO Yanzhu | 2003 | Review of Scientific Instruments2003，74，1： | 1 |
| 16 | A photographic approach to the possible mechanism of retrogradation of sweet potato starch 显示文摘 | Lian Xijun Zhao Shuyi Liu Qinsheng et d | 2011 | International Journal of Biological Macromolecules2011，48，1： | 1 |
| 17 | A photographic approach to the possible mechanism of retrogradation of sweet potato starch 显示文摘 | Lian Xijun Zhao Shuyi Liu Qinsheng | 2011 | International Journal of Biological Macromolecules2011，48，1： | 1 |
| 18 | HPV16 E6/E7 Negatively Affect Radiosensitivity of Lung Cancer Cells显示文摘 | Lu Lu Qinghui Meng Ming Cui Xiaofei Chu Shuyi Zhao Huiwen Xiao Jiali Dong Eliot Marty Rosen Saijun Fan | 2016 | 国际放射医学核医学杂志2016，40，2： | 1 |
| 19 | Inhibition of cell growth and induction of G1-phase cell cycle arrest in hepatoma cells by steroid extract from Meretrix meretrix显示文摘 | Ting-He Wu Ruo-Lin Yang Li-Ping Xie Hong-Zhong Wang Lei Chen Shuyi Zhang Yong Zhao Rong-Qing Zhang | 2005 | Cancer Letters2005，，2： | 1 |
| 20 | Inhibition of cell growth and induction of G1-phase cell cycle arrest in hepatoma cells by steroid extract from Meretrix meretrix显示文摘 | Ting-He Wu Ruo-Lin Yang Li-Ping Xie Hong-Zhong Wang Lei Chen Shuyi Zhang Yong Zhao Rong-Qing Zhang | 2005 | Cancer Letters2005，，2： | 1 |
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