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| 1 | The regulation of MDM2 oncogene and its impact on human cancers显示文摘肿瘤 suppressor p53 在阻止肿瘤形成起一个中央作用。p53 的层次和活动在紧密的 regulationto 下面保证它的合适的功能。鼠科的双分钟 2 (MDM2 ) , p53 目标基因,是 E3 ubiquitin ligase。MDM2 是 p53 蛋白质的一个 keynegative 管理者,并且与 p53 形成一个自动调整的反馈环。MDM2 是有两 p53-dependentand 的 oncogene p53 独立的 oncogenic 活动,并且经常在许多人的癌症增加了表示层次。ishighly 调整的 MDM2;MDM2 的层次和功能在 transcriptional 被调整,翻译并且 post-translationallevels。这评论提供 MDM2 的规定的概述。MDM2 的 Dysregulation 在 p53functions 之上显著地影响,并且接着 tumorigenesis。就 MDM2 在人的癌症起的关键作用而言,更好的 understandingof MDM2 的规定将帮助我们得新奇、更有效的癌症在房间指向 MDM2 andactivate p53 的治疗学的策略。 | Yuhan Zhao Haiyang Yu Wenwei Hu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，3： | 18 |
| 2 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 3 | Dominant Gene cplsr1 Corresponding to Premature Leaf Senescence Resistance in Cotton (Gossypium hirsutum L.)显示文摘Cotton (Gossypium hirsutum L.) premature leaf senescence-resistant inbred XLZ33 and senescence-susceptible inbred lines XLZ13 were selected and crossed to produce F1, F1-reciprocal, F2 and BC1 generations for evaluation of leaf senescence process and inheritance. The results showed that leaf senescence processes for XLZ13 and XLZ33 were obviously different and leaf senescence traits could be distinguished between the two parents at particular periods of cotton growth. Inheritance anlysis for the cotton premature leaf senescence resistant trait further showed that the segregation in the F2 fit a 3:1 ratio inheritance pattern, with resistance being dominant. The backcross of F1 to the susceptible parent produced a 1:1 ratio, confirming that cotton premature leaf senescence resistant trait was from a single gene. The single dominant gene controlling cotton premature leaf senescence resistance in XLZ33 was named as cotton premature leaf senescence resistance 1, with the symbol cplsr1. | Jingqing Zhao Tengfei Jiang Zhi Liu Wenwei Zhang Guiliang Jian Fanfljun Qi | 2012 | Journal of Integrative Plant Biology2012，54，8： | 6 |
| 4 | Pollen-based Holocene quantitative temperature reconstruction on the eastern Tibetan Plateau using a comprehensive method framework显示文摘Quantitative climate reconstruction on long timescales can provide important insights for understanding the climate variability and providing valuable data for simulations. Unfortunately, the credibility of some attempts was hampered by incomplete reconstruction procedures. We here establish a comprehensive framework resting on high-quality Chinese modern pollen database, including modern pollen data screening, calibration set selection, major climate factor analysis, appropriate model selection, strict statistical assessment of results and ecological interpretation. The application of this framework to three high-resolution pollen records from the eastern Tibetan Plateau allows accurate quantitative inferences of Holocene temperature changes, which is the major control of regional vegetation. The results show that the mean warmest month temperature(MTwa)during the early Holocene was ca. 10.4℃ and reached the highest value at 8.5–6 ka BP(ca. 11℃). The early and mid-Holocene(11–5 ka BP) warmth was followed by 1.2℃ temperature decrease, culminating in the coolest temperatures of the Holocene during the Neoglacial cooling. Superimposing on the general cooling trend, MTwareveals a significant 500-yr periodicity with varying intensities through time, showing that warm(cold) intervals are in phase with solar maxima(minima) periods. This spectral similarity indicates a possible connection of multi-century scale climate fluctuations with solar forcing. | Chen LIANG Yan ZHAO Feng QIN Zhuo ZHENG Xiayun XIAO Chunmei MA Huan LI Wenwei ZHAO | 2020 | Science China Earth Sciences2020，63，8： | 5 |
| 5 | Ischemic postconditioning enhances glycogen synthase kinase-3β expression and alleviates cerebral ischemia/reperfusion injury显示文摘The present study established global brain ischemia using the four-vessel occlusion method.Following three rounds of reperfusion for 30 seconds,and occlusion for 10 seconds,followed by reperfusion for 48 hours,infarct area,the number of TUNEL-positive cells and Bcl-2 expression were significantly reduced.However,glycogen synthase kinase-3β activity,cortical Bax and caspase-3 expression significantly increased,similar to results following ischemic postconditioning.Our results indicated that ischemic postconditioning may enhance glycogen synthase kinase-3β activity,a downstream molecule of the phosphatase and tensin homolog deleted on chromosome 10/phosphatidylinositol 3-kinase/protein kinase B signaling pathway,which reduces caspase-3 expression to protect the brain against ischemic injury. | Bo Zhao Wenwei Gao Jiabao Hou Yang Wu Zhongyuan Xia | 2012 | Neural Regeneration Research2012，7，19： | 2 |
| 6 | Plasma Levels of Interleukin 18, Interleukin 10, and Matrix Metalloproteinase-9 and -137G/C Polymorphism of Interleukin 18 Are Associated with Incidence of In-stent Restenosis After Percutaneous Coronary Intervention显示文摘 | Wenwei Liu Yongsheng Liu Hua Jiang Xiangwu Ding Rui Zhu Bin Li Yuqin Zhao | 2013 | Inflammation2013，，： | 2 |
| 7 | An Impedance-based Parameter Design Method for Active Damping of Load Converter Station in MTDC Distribution System显示文摘To achieve the efficient application of impedance analysis in the stability assessment and enhancement of multiterminal DC distribution systems, this paper proposes the DCside reduced-order impedance models with power control and AC voltage control, respectively, by taking the load converter station as the object. By using the DC-side current as the feedforward state, the active compensator applied to the load converter station with two control modes is also derived as well as the corresponding reduced-order impedance models. Combined with the reduced-order impedance models, a method based on damping factor sensitivity is further proposed to design the parameters of the derived active compensators. The verification results in the frequency domain and time domain demonstrate the accuracy of the reduced-order impedance and the effectiveness of the proposed compensator parameter design method. | Pengwei Chen Wenmeng Zhao Xin Chen Wenwei Jiang | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 2 |
| 8 | nvasive Spartina and reduced sediments: Shanghai’s dangerous silver bullet显示文摘Aims This synthesis paper is developed to provide a summary of ecological,socioeconomic challenges facing the estuarine wetlands within the Yangtze River delta.Methods We combined literature review of the estuarine wetlands and ground measurements of sedimentation,vegetation,and carbon fluxes to illustrate the foreseeable crises in managing these wetlands that play a critical role in Shanghai’s urban development.Where the Yangtze River meets the Pacific Ocean,4.153108 mg/year of suspended sediments are deposited along mainland and island shorelines of the 40000 km2 delta-resulting in an average growth rate of land outwards 64 m/year since 1951.However,completion of the Three Gorges Dam in 2003,and earlier dam projects,reduced the rates of sedimentation and growth of the islands.To meet the increasing demands for lands and agriculture,policymakers have attempted to enlarge the islands by diking coastal areas and introducing Spartina alterniflora-a grass native to tidal salt marshes of the southeastern USA but exotic to China.Spartina is one of the 16 greatest invasive species listed by the State Environmental Protection Administration of China.Successful plantations and rapid spread of this species have increased the production and fertility of the coast,but at the cost of native ecosystems.We outline the social,economic,and ecological controversies related to this land management strategy in the context of global warming.Important findings Combinations of these changes,including sea level rise,and alterations to storm patterns and long-shore currents,with the continued spread of Spartina,human population growth,and river flow and sediment reduction will make current management untenable. | Jiquan Chen Bin Zhao Wenwei Ren Sari C.Saunders Zhijun Ma Bo Li Yiqi Luo Jiakuan Chen | 2008 | Journal of Plant Ecology2008，1，2： | 2 |
| 9 | Density Functional Theory Study on (Cl2GaN3)n (n=1 4) Clusters显示文摘 | Xia, Qiying Ma, Dengxue Zhao, Wenwei Xiao, Heming | 2011 | Chinese Journal of Chemistry2011，29，9： | 1 |
| 10 | 酵母的 CryoEM 结构细胞质的 exosome 建筑群显示文摘真核细胞的多子单元 RNA exosome 建筑群在 3 ′ 起关键作用; -to-5′RNA 处理和腐烂。Rrp6 和 Ski7 分别地是为原子、细胞质的 exosomes 的主要余因子。在细胞质, Ski7 帮助 exosome 经由一条通过核心小径为降级和周转指向 mRNAs。然而,在 Ski7 之间的相互作用和 exosome 建筑群仍然保持不清楚。在 exosome 以内的 RNA 底层的办理也是逃犯的。在这个工作,我们使用了单个粒子的 cryo 电子显微镜学在 4.2 Å 的决定在 RNA 免费、 RNA 固定的形式解决 Ski7-exosome 建筑群的结构;并且 5.8 Å分别地。这些结构表明 Ski7 的 N 终端领域采用结构的安排并且以一种类似的方式与 exosome 交往到原子 Rrp6 的 C 终端领域。与怀有 3 ′ 的 RNA 底层推进 exosomes 的结构的分析;不同长度悬于在 RNA 处理的通过核心小径建议导致 RNA 的 exosome 激活的开关机制。 | Jun-Jie Liu Chu-Ya Niu Yao Wu Dan Tan Yang Wang Ming-Da Ye Yang Liu Wenwei Zhao Ke Zhou Quan-Sheng Liu Junbiao Dai Xuerui Yang Meng-Qiu Dong Niu Huang Hong-Wei Wang | 2016 | Cell Research2016，26，7： | 1 |
| 11 | Holocene vegetation and climate histories in the eastern Tibetan Plateau: controls by insolation-driven temperature or monsoon-derived precipita- tion changes? 显示文摘 | Zhao Yan Yu Zicheng Zhao Wenwei | 2011 | Quaternary Science Reviews2011，30，： | 1 |
| 12 | The Study on the Wet Air Oxidation of Highly Concentrated Emulsified Wastewater and Its Kinetic显示文摘 | Tang Wenwei Zeng Xinping ZHAO Jianfu | 2003 | Separation and Purification Technology2003，4，： | 1 |
| 13 | Heating Lithium-Ion Batteries at Low Temperatures for Onboard Applications:Recent Progress,Challenges and Prospects显示文摘Lithium-ion batteries(LIBs)are commonly used in electric vehicles(EVs)due to their good performance,long lifecycle,and environmentally friendly merits.Heating LIBs at low temperatures before operation is vitally important to protect the battery from serious capacity degradation and safety hazards.This paper reviews recent progress on heating methods that can be used onboard.The existing methods are divided into two categories,namely external heating methods and internal heating methods,mechanisms,advantages and limitations of each method are systematically reviewed.Then,the rates of temperature rise,energy consumptions,and maximum temperature gradient of different methods are quantitatively summa-rized to compare the heating performances of each method.In addition,features related to the onboard application of each method are qualitatively compared,which is essential for the rapid cold start of EVs in frigid weather.Finally,prospects of external and internal heating methods are given.This paper aims to provide researchers and engineers with guidelines about how to select a method based on their requirements and application environments. | Cheng Lin Weifeng Kong Yu Tian Wenwei Wang Mingjie Zhao | 2022 | Automotive Innovation2022，5，1： | 1 |
| 14 | Holocene vegetation and climate histories in the eastern Tibetan Plateau: controls by insolation-driven temperature or monsoon-derived precipitation changes?显示文摘 | Yan Zhao Zicheng Yu Wenwei Zhao | 2011 | Quaternary Science Reviews2011，，9： | 1 |
| 15 | Dynamic single-cell mapping unveils Epstein-Barr virusimprinted T-cell exhaustion and on-treatment response显示文摘Epstein-Barr virus(EBV)-associated gastric cancer(GC)manifests an intriguing immunotherapy response.However,the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined.This study aimed to finely characterize the dynamic tumour immune contexture of human EBV(+)GC treated with immunochemotherapy by longitudinal scRNA-seg and paired scTCR/BCR-seq.EBV(+)GC exhibits an inflamed-immune phenotype with increased T-cell and B-cell infiltration. | Miao-Zhen Qiu Chaye Wang Zhiying Wu Qi Zhao Zhibin Zhao Chun-Yu Huang Wenwei Wu Li-Qiong Yang Zhi-Wei Zhou Yu Zheng Hong-Ming Pan Zexian Liu Zhao-Lei Zeng Hui-Yan Luo Feng Wang Feng-Hua Wang Si-Yu Yang Meng-Xing Huang Zhexiaon Lian Haiyan Zhang Rui-Hua Xu | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 16 | Cloning and Analysis of Chitinase Gene in Bacillus subtilis HAS显示文摘[Objective] The paper was to study the possible mechanism of chitinase gene. [Method] The chitinase gene with inhibitory effect against a variety of pathogenic fungi was cloned and analyzed in this study. [Result] The genome of HAS strain contained an ORF of 834 bp. The homology of coding protein corresponding to ORF with chitosanase [Bacillus subtilis subsp. subtilis str. 168](ref|NP_390566.1) was the highest of 98%(272/277).[Conclusion]Through the analysis of amino acid sequence and secondary structure of the protease, tertiary structure prediction and analysis, HAS strain may play a pivotal role in controlling Sporisorium scitaminea Syd. | Xiong Guoru Zhao Gengfeng Cai Wenwei Wang Jungang Yang Benpeng Zhang Shuzhen | 2019 | Plant Diseases and Pests2019，10，2： | 0 |
| 17 | Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry显示文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience. | Bin Liu Xuedong Zhou Lin Yue Benxiang Hou Qing Yu Bing Fan Xi Wei Lihong Qiu Zhengwei Huang Wenwei Xia Zhe Sun Hanguo Wang Liuyan Meng Bin Peng Chen Zhang Shuli Deng Zhaojie Lu Deqin Yang Tiezhou Hou Qianzhou Jiang Xiaoli Xie Xuejun Liu Jiyao Li Zuhua Wang Haipeng Lyu Ming Xue Jiuyu Ge Yi Du Jin Zhao Jingping Liang | 2023 | International Journal of Oral Science2023，15，3： | 0 |
| 18 | Therapeutic safety evaluation of sodium glycididazole combined with ^(131)I radiotherapy for differentiated thyroid carcinoma显示文摘To evaluate safety and therapeutic efficacy of sodium glycididazole (CMNa) combined with 131I radiotherapy for differentiated thyroid carcinoma (DTC),the 60 patients of DTC therapeutic protocols were selected and divided into 3 groups of the DTC 4.44 GBq 131I,DTC 3.70 GBq 131I,and combination of DTC 3.70 GBq 131I with CMNa,and the 20 patients of Graves' Disease were selected as the control group.Peripheral blood was sampled at 131I pre-treatment of 1 day,and 131I post-treatment of 7,91,and 182 days,thus analyzing lymphocyte micronucleus scores and karyotyping profiles.Compared with the control group,the lymphocyte micronucleus and chromosome mutation rates in 131I treated DTC increased after post-treatment of 7 days,recovered after post-treatment of 91 days,and did not bounce after post-treatment of 182 days.The micronucleus and chromosome mutation rates in the combination of DTC 3.70 GBq 131I with CMNa showed less significant variation than other treated DTC groups.Our results demonstrate that micronucleus assay and karyotyping analysis are favorable to evaluate 131I radiotherapy for DTC.The combination of the CMNa with 131I radiotherapy was safe for DTC patients without affecting the long-term therapeutic outcomes. | SUN Wenwei GU Xinquan GAO Shi BAI Lin CUI Qu MA Qingjie Wang Qing Zhao Guoqing | 2011 | Nuclear Science and Techniques2011，22，4： | 0 |
| 19 | Optimal operating strategy of short turning lines for the battery electric bus system显示文摘Operating short turning line is an efficient strategy to satisfy the unevenly distributed demand during peak periods while reducing operational cost.However,for the battery electric bus(BEB)system,the application of the strategy is challenging due to the disadvantages of BEBs,such as limited driving mileage and long charging time.Improper vehicle configuration and charging scheduling may dramatically increase the operational cost and cut the benefits of these strategies.In this work,we propose a general framework to design an effective short turning strategy for the BEB system at a tactical planning level.First,the trade-off relationship between the battery capacity and the average trip time is identified by modeling the BEBs operations.Second,a microeconomic model is formulated to jointly optimize the frequencies and charging schedules of the whole bus line and the short turning line,to effectively minimize passengers’waiting time and operational cost.Finally,numerical experiments have been carried out for an illustrative linear line to demonstrate the potential benefits of the sub-line operating strategy compared with the normal operation. | Wenwei Zhang Hui Zhao Min Xu | 2021 | Communications in Transportation Research2021，1，1： | 0 |
| 20 | Expression of Invertase Genes in Virus-free Sugarcane显示文摘Virus-free sugarcane seedlings have improved biomass and sucrose content compared with ordinary seedlings,and sucrose invertases are key enzymes regulating sugarcane growth and sucrose accumulation.In this study,the differences in the expression levels of 3 invertase genes,CWI,SAI and NI,between virusfree and ordinary sugarcane seedlings were analyzed.Compared with ordinary sugarcane plants,the expression of CWI was mainly up-regulated in immature leaves and stems at elongation stage and leaves and immature internodes at maturation stage,and especially,greatly up-regulated in immature internodes at maturation stage of virus-free plants.The expression of SAI and NI were mainly up-regulated in leaves and immature internodes of virus-free plants at maturation stage,which might be beneficial to sugar accumulation and rapid utilization of monosaccharide in the stalks of virus-free plants.It is further indicated that virus-free treatment could significantly improve the expression of sucrose invertases at late growth period,and might facilitate the increase of plant biomass. | Jungang WANG Tingting ZHAO Benpeng YANG Wenwei CAI Cuilian FENG Jun ZENG Guoru XIONG Shuzhen ZHANG | 2017 | Agricultural Biotechnology2017，6，4： | 0 |
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