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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 3 | Cold acclimation improves photosynthesis by regulating the ascorbate–glutathione cycle in chloroplasts of Kandelia obovata显示文摘As the most northerly mangrove species in China, Kandelia obovata may undergo extreme cold event stress. Enhancing the cold tolerance of this species is crucial to its successful afforestation. This study aimed to determine the resistance of K. obovata seedlings to low temperature stress by cold acclimation and to explain the mechanisms for alleviating cold injury. To understand these mechanisms, seedlings that were acclimatized and not acclimatized were exposed to 5℃/- 2℃(day/night)for 48 h.Results showed that low temperature stress reduced leaf photosynthesis of non-acclimatized seedlings by inducing oxidative stress and structural damage to chloroplasts. These phenomena were shown by increasing levels of malondialdehyde (MDA), O2-and H2O2, as well as decreasing enzyme activities in the ascorbate–glutathione (AsA-GSH) cycle. However, cold-acclimatized seedlings had improved photosynthetic rates and efficiency of photosystem II (PSII) under low temperature stress. Compared with non-acclimatized seedlings, leaves of coldacclimatized seedlings under low temperature stress for 48 h exhibited higher anti-oxidative enzyme activities, lower levels of O2^- and H2O2, less damage to chloroplast structure, and removed 33.7% of MDA at low temperature stress for 48 h. The data indicate that cold acclimation enhances photosynthetic capacity by effectively regulating activation in the PSII electron transport and the AsA–GSH cycle to scavenge excess ROS in chloroplasts, while the latter is more important. | Weicheng Liu Chunfang Zheng Jinong Chen Jianbiao Qiu Zhixing Huang Qi Wang Yong Ye | 2019 | Journal of Forestry Research2019，30，3： | 11 |
| 4 | Mechanisms on inhibition of photosynthesis in Kandelia obovata due to extreme cold events under climate change显示文摘Introduction:Mangroves that grow at the latitudinal extremes of their distribution are susceptible to extreme cold events.Successive enhancement of low temperature stress(seLTS)is a typical characteristic of extreme cold events.Low temperature stress can inhibit mangrove photosynthesis,which often inhibits the growth and development of mangroves.However,the possible reasons for impairment to photosynthesis of mangroves due to extreme cold events remain unclear.Methods:Kandelia obovata seedlings in a growth chamber were exposed to 5℃/−2℃(day/night)for 36 h(−2℃ for 16 h)with 12 h light per day at 600μmol m^(−2) s^(−1) photosynthetic photon flux density(PPFD)(a low temperature stress,aLTS),then the plants were transferred to the control condition(15℃/10℃(day/night)and allowed to recover for 5 days(R1).The other seedlings were subjected to low temperature treatment with a day/night temperature of 5℃/−1℃ in a growth chamber for 24 h.Then these plants were transferred to 5℃/−2℃(day/night)under the same light and climate conditions for 36 h(two low temperature stresses,tLTS).Following the successive enhancement of low temperature treatment,these plants were returned to 15℃/10℃(day/night)for another 5-day recovery period(R2).Results:Results showed that aLTS treatment significantly reduced leaf net photosynthetic rate(P_(n))and stomatal conductance(G_(s)),while increased intercellular CO_(2) concentration(C_(i)).Photosynthetic activity of leaves quickly recovered after the plants were returned to control temperature for 5 days(R1).However,decreases in leaf Pn were more obvious under tLTS treatment than those under aLTS treatment.This reduced Pn might be attributed to stomatal and non-stomatal limitations.Moreover,non-stomatal limitation played a major role in reducing Pn during tLTS treatment,as proven by reduced ribulose 1,5-biphosphate carboxylase(RuBPCase)activity.This limitation also enhanced lipid peroxidation in chloroplasts,decreased sucrosemetabolizing enzymes and ratios of both chlorophyll a/chlorophyll b(Chl a/b)and chlorophyll/carotenoids(Chl/Car),and increased protease senescence.Damages of tLTS treatment to photosynthesis were insufficiently alleviated even after the plants were returned to control temperature for 5 days(R2).Conclusions:Successive enhancement of low temperature depressed successful recovery of leaf photosynthesis of K.obovata seedlings mainly by impairing pigment synthesis,antioxidant metabolism,and sucrose translocation,as well as accelerating senescence of endopeptidase.Furthermore,our results suggest that decreases in sucrose content in leaves might also account for increases in reactive oxygen species(ROS)in chloroplasts. | Chunfang Zheng Jianwu Tang Jinong Chen Weicheng Liu Jianbiao Qiu Xin Peng Yong Ye | 2016 | Ecological Processes2016，5，1： | 6 |
| 5 | Recovery of photosynthesis,sucrose metabolism,and proteolytic enzymes in Kandelia obovata from rare cold events in the northernmost mangrove,China显示文摘Introduction:Understanding how mangroves respond to rare cold events has implications for both restoration and conservation under climate change scenarios.This study investigated the responses of photosynthesis and activities of key enzymes involving carbon and nitrogen metabolism at different ages of Kandelia obovata to a rare cold event in the winter of 2010.Methods:This study took place on Ximen Island,Zhejiang Province,China.We measured the physiological recovery of 2-3-,5-6-,9-10-and 54-55-year-old K.obovata trees after freezing injury in February and March in 2011 and 2012,respectively.Results:Chilling injury index and electrolyte leakage of K.obovata increased with increasing tree age in the winter of 2010,and electrolyte leakage in K.obovata at different ages in the winter of 2010 was far higher than that in the winter of 2011.The rare cold events significantly changed the recoveries of the leaf net photosynthetic rate(Pn)and stomatal conductance(Gs);ratios of chlorophyll a/chlorophyll b(Chl a/Chl b);contents of total soluble sugar(TSS),sucrose,free amino acid(FAA),and soluble protein;and activities of sucrose phosphate synthase(SPS),endopeptidase,and carboxypeptidase in K.obovata at different ages.These effects were mainly due to changes in the physiological mechanism in the 2-year-old trees.A clear decrease in Pn of the 2-year-old trees was observed in February 2011,as exemplified by reductions in ratios of Chl a/Chl b and chlorophyll/carotenoid(Chl/Car),as well as inhibition of the levels of TSS and FAA(osmotic substances).During recovery in 2011 and 2012,the activities of SPS and sucrose synthase(SS)were responsible for sucrose synthesis after the rare cold events in 2011,but only SPS activity was one of the main factors contributing to the metabolism of stachyose to sucrose without cold damage in 2012.Carboxypeptidase played a more important role than endopeptidase during protein hydrolysis after the rare cold events.Conclusions:The results suggest that the recovery of photosynthetic capacity in K.obovata was changed after a rare cold event,which is associated with pigment components and activities of SS,SPS,and carboxypeptidase,especially the seedlings. | Chunfang Zheng Yong Ye Weicheng Liu Jianwu Tang Chengnian Zhang Jianbiao Qiu Jinong Chen | 2016 | Ecological Processes2016，5，1： | 4 |
| 6 | Exogenous nitric oxide improves seed germination in wheat against mitochondrial oxidative damage induced by high salinity显示文摘 | Chunfang Zheng Dong Jiang Fulai Liu Tingbo Dai Weicheng Liu Qi Jing Weixing Cao | 2009 | Environmental and Experimental Botany2009，，1： | 2 |
| 7 | Self-assembled natural rubber/multi-walled carbon nanotube composites using latex compounding techniques显示文摘 | Peng Zheng Feng Chunfang Luo Yongyue | 2010 | Carbon2010，48，15： | 1 |
| 8 | Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma显示文摘 | Tao Zhang Jingcun Zheng Ning Jiang Guozeng Wang Quan Shi Chunfang Liu Yuan Lu | 2009 | Cancer Letters2009，，1： | 1 |
| 9 | Self-assembled natural rubber/multi-walled carbon nanotube composites using la- tex compounding techniques 显示文摘 | Peng Zheng Feng Chunfang Luo Yongyue | 2010 | Carbon2010，15，48： | 1 |
| 10 | Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate - induced diarrhoea model显示文摘 | Chunfang Liu Yangfang Zheng Wen Xu | 2014 | Biomed Res Int2014，18，8： | 1 |
| 11 | Exogenous nitricoxide improves seed germination in wheat against mitochondrialoxidative damage induced by high salinity显示文摘 | ZHENG Chunfang JIANG Dong LIU Fulai | 2009 | Environmental andExperimental Botany2009，67，： | 1 |
| 12 | Triggering dynamics of acetylene topochemical polymerization显示文摘Topochemical reactions are a promising method to obtain crystalline polymeric materials with distance-determined regio-or stereoselectivity.It has been concluded on an empirical basis that the closest intermolecular C⋅⋅⋅C distance in crystals of alkynes,d(C⋅⋅⋅C)min,should reach a threshold of∼3Åfor bonding to occur at room temperature.To understand this empirical threshold,we study here the polymerization of acetylene in the crystalline state under high pressure by calculating the structural geometry,vibrational modes,and reaction profile.We find d(C⋅⋅⋅C)min to be the sum of an intrinsic threshold of 2.3Åand a thermal displacement of 0.8Å(at room temperature).Molecules at the empirical threshold move via several phonon modes to reach the intrinsic threshold,at which the intermolecular electronic interaction is sharply enhanced and bonding commences.A distance–vibration-based reaction picture is thus demonstrated,which provides a basis for the prediction and design of topochemical reactions,as well as an enhanced understanding of the bonding process in solids. | Xingyu Tang Xiao Dong Chunfang Zhang Kuo Li Haiyan Zheng Ho-kwang Mao | 2023 | Matter and Radiation at Extremes2023，8，5： | 1 |
| 13 | Effects of salt and waterlogging stresses and their combination on leaf photosynthesis, chloroplast ATP synthesis, and antioxidant capacity in wheat显示文摘 | Zheng Chunfang Jiang Dong Liu Fulai | 2009 | Plant Science2009，176，： | 1 |
| 14 | Effects of different types of nutrient effluent from shrimp ponds on the seedling growth of Kandelia obovata显示文摘Extensive shrimp ponds are located next to the landward edges of most of mangrove forests in China. A shrimp pond may influence mangroves by(1) routine effluent between pond and tide, and(2) dredging effluent from pond-dredging at least once a year. Our study consisted of two experiments to study the effects of these two effluents on the seedling growth of Kandelia obovata. One experiment simulated the effects of routine effluents.The other simulated four sedimentation thicknesses(0 cm, 2 cm, 4 cm, 8 cm) over mangrove soils by dredging effluent from pond-dredging, and revealed the cumulative effects of dredging effluents on K. obovata. At each of the three fixed salinities, i.e., 5, 15 and 25, routine effluent did not result in significant differences in each of the measured growth parameters of K. obovata seedlings. However, effects of dredging effluent on seedling growth of K. obovata were related with sedimentation thickness. Most growth parameters showed maximum values at sedimentation thickness 4 cm. The data indicated that K. obovata accelerated its growth under moderate sedimentation thicknesses and it was tolerant and adaptable to shrimp pond-cleaning effluent sediments up to about 8 cm in our experiment. | TIAN Yuan CHEN Guangcheng TANG Feilong ZHENG Chunfang YE Yong | 2018 | Acta Oceanologica Sinica2018，37，6： | 1 |
| 15 | Genome sequence and evolution of Betula platyphylla显示文摘Betula L.(birch)is a pioneer hardwood tree species with ecological,economic,and evolutionary importance in the Northern Hemisphere.We sequenced the Betula platyphylla genome and assembled the sequences into 14 chromosomes.The Betula genome lacks evidence of recent whole-genome duplication and has the same paleoploidy level as Vitis vinifera and Prunus mume.Phylogenetic analysis of lignin pathway genes coupled with tissue-specific expression patterns provided clues for understanding the formation of higher ratios of syringyl to guaiacyl lignin observed in Betula species.Our transcriptome analysis of leaf tissues under a time-series cold stress experiment revealed the presence of the MEKK1–MKK2–MPK4 cascade and six additional mitogen-activated protein kinases that can be linked to a gene regulatory network involving many transcription factors and cold tolerance genes.Our genomic and transcriptome analyses provide insight into the structures,features,and evolution of the B.platyphylla genome.The chromosome-level genome and gene resources of B.platyphylla obtained in this study will facilitate the identification of important and essential genes governing important traits of trees and genetic improvement of B.platyphylla. | Su Chen Yucheng Wang Lili Yu Tao Zheng Sui Wang Zhen Yue Jing Jiang Sapna Kumari Chunfang Zheng Haibao Tang Jun Li Yuqi Li Jiongjiong Chen Wenbo Zhang Hanhui Kuang Jon SRobertson Patrick XZhao Huiyu Li Shengqiang Shu Yordan SYordanov Haijiao Huang David MGoodstein Ying Gai Qi Qi JiuMeng Min ChunYan Xu SongBo Wang Guan-Zheng Qu Andrew HPaterson David Sankoff Hairong Wei Guifeng Liu Chuanping Yang | 2021 | Horticulture Research2021，8，1： | 1 |
| 16 | Erratum to: Mechanisms on inhibition of photosynthesis in Kandelia obovata due to extreme cold events under climate change显示文摘Erratum Following publication of the original article(Zheng et al.2016)it was brought to our attention that there was a typographical mistake in figure 6c,whereby the ordinate title had an“e”between the words“Endopeptidase”and“activity”.Please see below for the corrected figure:This has now been updated on the BioMed central website. | Chunfang Zheng Jianwu Tang Jinong Chen Weicheng Liu Jianbiao Qiu Xin Peng Yong Ye | 2017 | Ecological Processes2017，6，1： | 0 |
| 17 | Ultra-fast and high-efficient synthesis of caffeic acid phenethyl ester by microwave assistant ionic liquids catalysis显示文摘Caffeic acid phenethyl ester (CAPE), a natural and rare ingredient with several biological activities, was successfully synthesized from caffeic acid (CA) and phenylethanol (PE) by microwave assistant coupled with ionic liquids (ILs) catalysis. Four ILs, acted as both solvent and catalyst in this chemical synthesis, were optimized. Among them, [Bmim] [PF6] was the best with the highest CA conversion. 95% conversion was achieved under substrate molar ratio 4:1 (PE/CA, n/n), IL content 7:1 (IL/CA, w/w), microwave power 200 W, at 135 oC for 7 min. This study might be attributed to developing new chemical reaction system to produce caffeic acid derived esters. | Zhe Dong Shi Wang Mingming Zheng Chunfang Xu Fenghong Huang | 2017 | Oil Crop Science2017，2，4： | 0 |
| 18 | Investigation and Analysis of Artificial Rearing Snake Diseases in Yongzhou Area of Hunan Province显示文摘In recent years,artificial rearing snake diseases are increasingly rising,and some farms have suffered huge losses due to outbreak of snake diseases.Disease has become a big bottleneck restricting artificial breeding industry of snakes,and effective prevention and control of snake diseases has become the top priority.To control snake diseases purposely,questionnaires of artificial rearing snake diseases were released to 21 snake households in Yongzhou area of Hunan Province from February to May in 2014,and on-the-spot investigation was conducted as well.The types,etiology,epidemic characteristics,clinical symptoms and control effects of snake diseases in Yongzhou area were preliminarily understood,and their causes were analyzed.Survey showed that dermatitis,pneumonia,stomatitis,parasitosis,enteritis and powdery mildew were the six major diseases of artificial rearing snakes in Yongzhou area.The incidence of dermatitis was the highest of 61.9%,followed by pneumonia (42.8%). | Zheng Chunfang Tan Qunying Guo Dezhi Hu Minghang Yu Guiyang | 2016 | Animal Husbandry and Feed Science2016，8，5： | 0 |
| 19 | Evolution of the Nanhua-Sinian Rifts in the Tarim Block显示文摘The Tarim block,located in northwestern China,is one of the largest blocks in China.Precambrian rifts in the Tarim block control the evolution of Paleozoic rifts.On the basis of previous research by other authors,and | ZHENG Chunfang HOU Guiting GUAN Shuwei | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 0 |
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