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| 1 | Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress显示文摘AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of cellular AMP, distinct compartmentalized pools of AMPK are activated, phosphorylating different sets of targets. Low glucose activates AMPK exclusively through the AMP-independent, AXIN-based pathway in lysosomes to phosphorylate targets such as ACC1 and SREBP1c, exerting early anti-anabolic and pro-catabolic roles. Moderate increases in AMP expand this to activate cytosolic AMPK also in an AXIN-dependent manner. In contrast, high concentrations of AMP, arising from severe nutrient stress, activate all pools of AMPK independently of AXIN. Surprisingly, mitochondrion-localized AMPK is activated to phosphorylate ACC2 and mitochondrial fission factor (MFF) only during severe nutrient stress. Our findings reveal a spatiotemporal basis for hierarchical activation of different pools of AMPK during differing degrees of stress severity. | Yue Zong Chen-Song Zhang Mengqi Li Wen Wang Zhichao Wang Simon A. Hawley Teng Ma Jin-Wei Feng Xiao Tian Qu Qi Yu-Qing Wu Cixiong Zhang Zhiyun Ye Shu-Yong Lin Hai-Long Piao D. Grahame Hardie Sheng-Cai Lin | 2019 | Cell Research2019，29，6： | 8 |
| 2 | Arbuscular mycorrhizal associations in the Gurbantunggut Desert显示文摘在位于 Xinjiang 的 Gurbantunggut 沙漠的植物,中国是改编的干旱种类并且在通常滋养穷人的土壤成长。调查在沙漠被进行决定与合适的荒芜的植物联系的 arbuscular mycorrhizal (AM ) 地位从 annuals 和 perennials 的 11 个家庭的 to23 种类。从所有植物的根为决定 mycorrhizal 殖民的地位和程度的内部、外部的 hyphae,泡和 coils/arbuscules 的存在被检验。调查的植物种类,(61%) 14 被发现形成 AMassociations,(22%) 5 是可能的 AM 开拓殖民地于种类,并且 4 是 non-my-corrhizal 植物。形成 AM 的 annuals 和灌木的 Theproportions 分别地是比 perennials 和植物的那些显著地低的。孢子密度在根地区的土壤每 20 g 从 5 ~ 21 变化了。在 3 个类的上午 14 点 fungaltaxa 被孤立并且识别了其 10 属于血管球, 3 到 Acaulospora, and1 到 Archaeospora。血管球是在识别的所有类的主导的类。G。deser-ticola 和 G.etunicatum 是最普通的税一孤立与 77.4% 和 74.8% 的出现频率,并且相对许多 14.4% 和 15.5% 分别地。 | TIAN Changyan SHI Zhaoyong CHEN Zhichao FENG Gu | 2006 | Chinese Science Bulletin2006，51，A01： | 8 |
| 3 | A New Safety Assessment Method Based on Belief Rule Base With Attribute Reliability显示文摘Safety assessment is one of important aspects in health management.In safety assessment for practical systems,three problems exist:lack of observation information,high system complexity and environment interference.Belief rule base with attribute reliability(BRB-r)is an expert system that provides a useful way for dealing with these three problems.In BRB-r,once the input information is unreliable,the reliability of belief rule is influenced,which further influences the accuracy of its output belief degree.On the other hand,when many system characteristics exist,the belief rule combination will explode in BRB-r,and the BRB-r based safety assessment model becomes too complicated to be applied.Thus,in this paper,to balance the complexity and accuracy of the safety assessment model,a new safety assessment model based on BRB-r with considering belief rule reliability is developed for the first time.In the developed model,a new calculation method of the belief rule reliability is proposed with considering both attribute reliability and global ignorance.Moreover,to reduce the influence of uncertainty of expert knowledge,an optimization model for the developed safety assessment model is constructed.A case study of safety assessment of liquefied natural gas(LNG)storage tank is conducted to illustrate the effectiveness of the new developed model. | Zhichao Feng Wei He Zhijie Zhou Xiaojun Ban Changhua Hu Xiaoxia Han | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，11： | 6 |
| 4 | A Local Cluster of Omicron Variant COVID-19 Likely Caused by Internationally Mailed Document——Beijing Municipality,China,January 2022显示文摘On January 15,2022,a 26 years old female(Case A)went to a sampling site for coronavirus disease 2019(COVID-19)testing due to excessive fatigue and fever for two days.This patient preliminarily tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using a quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR)method. | Daitao Zhang Shuangsheng Wu Zhenyong Ren Ying Sun Xiangfeng Dou Zhaomin Feng Fu Li Yi Tian Shujuan Cui Baiwei Liu Bing Lyu Xiaoli Wang Feng Liu Lina Jin Chu Jiang Lina Tian Zhenjiang Xin Zhichao Liang Lei Jia Quanyi Wang Yang Pan Peng Yang | 2022 | China CDC weekly2022，4，14： | 6 |
| 5 | A hidden fault prediction model based on the belief rule base with power set and considering attribute reliability显示文摘Hidden faults are important characteristics of complex systems that cannot be observed directly.The hidden behavior of a system, such as the health state and safety level, has a direct correlation with these hidden faults. After the predicted hidden behavior reaches a fault boundary, certain measures must be taken to avoid fault occurrences. Thus, hidden faults can be predicted by the hidden behavior of a system.The belief rule base(BRB) has been used to predict hidden behaviors. However, two problems remain to be solved in engineering practice. First, when the observed information is absent, ignorance may exist in the output. If only global ignorance is considered, it may be unreasonable in certain cases, which can influence the prediction model. Second, the effects of disturbance factors such as noise and sensor quality may cause the reliability of the gathered information to decline, which indirectly leads to unreliability of the hidden behavior. Thus, to address the global ignorance and unreliable hidden behavior, a new hidden BRB model with a power set and considering attribute reliability(PHBRB-r) is proposed for hidden fault prediction. In the PHBRB-r model, the effects of disturbance factors on hidden behavior are considered using attribute reliability, and the discernment frame is a power set. A case study of hidden fault prediction is conducted to demonstrate the effectiveness of the PHBRB-r model. | Zhijie ZHOU Zhichao FENG Changhua HU Xiaoxia HAN Zhiguo ZHOU Gailing LI | 2019 | Science China(Information Sciences)2019，62，10： | 6 |
| 6 | Improving uniform scattering device for straw-smashing,back-throwing,no-tillage planter under complete straw mulching condition显示文摘With the objective of obtaining a completely straw-mulched field,when no-tillage mechanical sowing is implemented with straw smashing,delivering,and back-throwing approaches,it may be difficult to scatter the smashed straw uniformly during a succeeding wheat sowing step.This is because the previous rice straw is substantial in quantity and has a high humidity and toughness,which may easily result in non-uniform straw mulching and thus sparse and weak seedlings of wheat.Therefore a force-dispersing and uniform-scattering device was designed.With the number of scattering impellers,impeller angle,and impeller rotation speed as the main factors and the percentage of pass for the scattering width and non-uniformity of the straw mulching as the assessment indices,single-factor experiments and orthogonal regressive tests were performed,and a dual-index(percentage of pass for the scattering width and non-uniformity of the straw mulching)fitted regression equation was established.The test results suggested that the main factors(from primary to secondary)that influence the indices were the impeller rotation speed,number of scattering impellers,and impeller angle.The optimal parameter combination for the uniform scattering device was four rows of impellers with an angle of 15°,rotation speed of 1015 r/min,percentage of pass of 72.65%for the scattering width,and a non-uniformity of 13.8%in the straw mulching.This combination can be used to realize a uniform scattering of the smashed straw along the seedling rows on the after-sowing ground.According to the field investigation of the wheat growth,the wheat emergence rate was 90.7%.The research results can provide a reference for improving the uniform scattering device for a straw-smashing,back-throwing,no-tillage planter for obtaining a completely straw-mulched field,enhancing the quality of the machinery operation,and ensuring good and strong seedlings after sowing. | Fengwei Gu Xuemei Gao Feng Wu Zhichao Hu Youqing Chen Chong Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 5 |
| 7 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 8 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 9 | CeO_(2)with diverse morphologies-supported IrOx nanocatalysts for efficient oxygen evolution reaction—Commemorating the 100th anniversary of the birth of Academician Guangxian Xu显示文摘IrOx-based catalysts are considered the most promising candidates for oxygen evolution reaction(OER)due to their high efficiency.However,improving their intrinsic catalytic activity is essential for practical application.In this work,CeO_(2)with three different morphologies(rod,cube,octahedron)and supported IrOx nanoparticles were fabricated,and they display morphology-dependent OER activity.The IrOx/CeO_(2)-rod shows the highest activity;the catalysts have a catalytic activity sequence of rod>cube>octahedron.A plausible mechanism was proposed:the CeO_(2)support with different morphologies modulates the electronic structure of IrOx by the synergistic interaction promoted by oxygen vacancies between the active component and the support,thereby altering the catalytic activity of the IrOx/CeO_(2)catalyst. | Qingqing Li Zhichao Zeng Xiaolei Sun Feng Luo Yaping Du | 2021 | Journal of Rare Earths2021，39，4： | 3 |
| 10 | Dual-wavelength single-longitudinal-mode fiber laser with switchable wavelength spacing based on a graphene saturable absorber显示文摘We propose and demonstrate a dual-wavelength single-longitudinal-mode(SLM) fiber laser with switchable wavelength spacing based on a graphene saturable absorber(GSA) and a Wave Shaper. By virtue of the excellent saturable absorption ability of graphene, the linewidths of the lasing wavelengths can be effectively reduced and eventually SLM operation can be obtained. The linewidths of both wavelengths are measured to be narrower than 7.3 kHz. The obtained results suggest that the graphene would be a good candidate nonlinear optical material for applications in related photonic fields, such as SLM oscillation generation for microwave generation and optical sensing. | Jingjuan Zhou Aiping Luo Zhichao Luo Xudong Wang Xinhuan Feng Bai-ou Guan | 2015 | Photonics Research2015，3，2： | 2 |
| 11 | Progress in octahedral spherical hohlraum study显示文摘In this paper,we give a review of our theoretical and experimental progress in octahedral spherical hohlraum study.From our theoretical study,the octahedral spherical hohlraums with 6 Laser Entrance Holes(LEHs)of octahedral symmetry have robust high symmetry during the capsule implosion at hohlraum-to-capsule radius ratio larger than 3.7.In addition,the octahedral spherical hohlraums also have potential superiority on low backscattering without supplementary technology.We studied the laser arrangement and constraints of the octahedral spherical hohlraums,and gave a design on the laser arrangement for ignition octahedral hohlraums.As a result,the injection angle of laser beams of 50°-60°was proposed as the optimum candidate range for the octahedral spherical hohlraums.We proposed a novel octahedral spherical hohlraum with cylindrical LEHs and LEH shields,in order to increase the laser coupling efficiency and improve the capsule symmetry and to mitigate the influence of the wall blowoff on laser transport.We studied on the sensitivity of the octahedral spherical hohlraums to random errors and compared the sensitivity among the octahedral spherical hohlraums,the rugby hohlraums and the cylindrical hohlraums,and the results show that the octahedral spherical hohlraums are robust to these random errors while the cylindrical hohlraums are the most sensitive.Up till to now,we have carried out three experiments on the spherical hohlraum with 2 LEHs on Shenguang(SG)laser facilities,including demonstration of improving laser transport by using the cylindrical LEHs in the spherical hohlraums,spherical hohlraum energetics on the SGIII prototype laser facility,and comparisons of laser plasma instabilities between the spherical hohlraums and the cylindrical hohlraums on the SGIII laser facility. | Ke Lan Jie Liu Zhichao Li Xufei Xie Wenyi Huo Yaohua Chen Guoli Ren Chunyang Zheng Dong Yang Sanwei Li Zhiwen Yang Liang Guo Shu Li Mingyu Zhang Xiaoying Han Chuanlei Zhai Lifei Hou Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Feng Wang Guanghui Yuan Haijun Zhang Bobin Jiang Lizhen Huang Wei Zhang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Xuewei Deng Dongxia Hu Wei Zhou Huaiting Jia Yongkun Ding Wanguo Zheng Xiantu He | 2016 | Matter and Radiation at Extremes2016，1，1： | 2 |
| 12 | Arg462Gln and Asp541Glu polymorphisms in ribonuclease L and prostate cancer risk:a meta-analysis显示文摘Objective:The association between ribonuclease L(RNASEL)gene polymorphisms and prostate cancer risk has been widely reported,but the results of these studies remained controversial and underpowered.We performed a meta-analysis of 28 studies to evaluate the association between Arg462Gln and Asp541Glu polymorphisms in the RNASEL gene and prostate cancer risk.Methods:Odds ratios(ORs)with 95%confidence intervals(CIs) were estimated to assess the association between RNASEL polymorphisms and prostate cancer risk.Results:A significantly increased prostate cancer risk was found for the Arg462Gln polymorphism in Africans(Gln/Gln vs Arg/Arg:OR=2.50,95%CI=1.28-4.87;Gln/Gln vs Gln/Arg+Arg/Arg:OR=2.54,95%CI=1.30-4.95),but not in Europeans and Asians.Additionally,the Asp541Glu polymorphism was associated with increased total prostate cancer risk(Glu-allele vs Asp-allele:OR=1.04,95%CI=1.01-1.07;Glu/Glu vs Asp/Asp:OR=1.22,95%CI= 1.03-1.46;Glu/Glu vs Glu/Asp+Asp/Asp:OR=1.09,95%CI=1.02-1.16).In the stratified analysis for the Asp541Glu polymorphism,there was a significantly increased prostate cancer risk in Africans and Europeans,and in hospital-based prostate cancer cases.Conclusion:The meta-analysis results showed evidence that RNASEL Arg462Gln and Asp541Glu polymorphisms are associated with prostate cancer risk and could be low-penetrance prostate cancer susceptibility biomarkers. | Yuanyuan Mi Qianqian Yu Zhichao Min Bin Xu Lifeng Zhang Wei Zhang Ninghan Feng L ixin Hua | 2010 | The Journal of Biomedical Research2010，24，5： | 2 |
| 13 | Recent diagnostic developments at the 100 kJ-level laser facility in China显示文摘A 100 kJ-level laser facility has been designed to study inertial confinement fusion physics in China.This facility incorporates various diagnostic techniques,including optical,x-ray imaging,x-ray spectrum,and fusion product diagnostics,as well as general diagnostics assistance systems and central control and data acquisition systems.This paper describes recent developments in diagnostics at the facility. | Feng Wang Shaoen Jiang Yongkun Ding Shenye Liu Jiamin Yang Sanwei Li Tianxuan Huang Zhurong Cao Zhenghua Yang Xin Hu Wenyong Miao Jiyan Zhang Zhebin Wang Guohong Yang Rongqing Yi Qi Tang Longyu Kuang Zhichao Li Dong Yang Yulong Li Xiaoshi Peng Kuan Ren Baohan Zhang | 2020 | Matter and Radiation at Extremes2020，5，3： | 2 |
| 14 | Experimental and Numerical Study on Co-combustion Behaviors and NO_(x) Emission Characteristics of Semi-coke and Coal in a Tangentially Fired Utility Boiler显示文摘The utilization of powdery semi-coke as a power fuel in pulverized coal-fired power plants has become a new and potential technique to consume the excess powdery semi-coke.The characteristic of low volatile results in poor combustion performance and high NO_(x) emission,and to co-fire with bituminous coal is a practical strategy to address this problem.However,the co-combustion characteristics and the inherent interaction between semi-coke and coal remain insufficiently understood.In addition,the influences of secondary air arrangement,the boiler operation load,and the fuel type on co-combustion process are still unclear,which is urgent to be further explored.In the present study,experiments and numerical simulations were jointly utilized to inquire into the co-combustion behaviors and NO_(x) emission features of semi-coke and coal.The results demonstrated that the'out-furnace method'was a suitable choice for small-capacity boiler when the proportion of semi-coke was 33%,due to the limited combinations of the semi-coke injection position.It was recommended that semi-coke was preferred to be injected from the middle layers of the furnace under the'in-furnace method'to improve the overall co-combustion performance.The critical value of the separated over fire air ratio in this study was 27.5%,over which a slight drop of carbon content in fly ash could come about.Moreover,the elevation in the proportion of separated over fire air gave rise to the significant decline of NO_(x) concentration.The constricted secondary air arrangement was preferred to be employed due to the high boiler efficiency.The separated over fire air and the surrounding air needed to maintain a wide-open degree to prevent the increase of NO_(x) emissions and the coking of nozzles.For the load reduction regulation method adopted in this study,the NO_(x) concentration first rose and then dropped,while the burnout ratio decreased obviously as the operation load was reduced.Different combinations of coal and semi-coke generated significant influences on co-combustion behaviors within the furnace.The NO_(x )generated by high-volatile fuel (bituminous coal) combustion was mainly affected by volatile-N,while the NO_(x )generated by low-volatile fuel (semi-coke) was mainly impacted by char-N.This study is of guiding significance for the efficient and clean utilization and beneficial to the large-scale application of powder semi-coke in power plants. | WANG Chang’an FENG Qinqin JIN Liyan WANG Zhichao YAO Wei WANGPengqian DU Yongbo ZHANG Xilai YANG Zhongcan CHE Defu | 2021 | Journal of Thermal Science2021，30，4： | 2 |
| 15 | A novel ocean bathymetry technology based on an unmanned surface vehicle显示文摘In ocean bathymetry, the instantaneous depth measured by survey ships or by unmanned surface vehicles(USVs)cannot be directly taken as the chart depth because of the effect of waves and the tide. A novel ocean bathymetry technology is proposed based on the USV, the aim is to evaluate the potential of the USV using a real-time kinematic(RTK) and a single beam echo sounder for ocean bathymetry. First, using the RTK height of the USV with centimeter-level precision, the height of the sea level is obtained by excluding wave information using a low pass filter. Second, the datum distance between the reference ellipsoid and the chart depth is obtained by a novel method using tide tables and the height of the sea level from the USV. Previous work has usually achieved this using long-term tidal observation from traditional investigations. Finally, the chart depth is calculated using the transformation between the instantaneous depth of the USV measurement and the datum of the chart depth.Experiments were performed around the Wuzhizhou Island in Hainan Province using the unmanned surface bathymetry vehicle to validate the proposed technology. The successful results indicate the potential of the bathymetry technology based on the USV. | JIN Jiucai ZHANG Jie SHAO Feng LYU Zhichao WANG Dong | 2018 | Acta Oceanologica Sinica2018，37，9： | 2 |
| 16 | Investigation of influence of micro-structure on magnetic properties of amorphous powder core显示文摘The influence of micro-structure on magnetic properties of amorphous powder core was investigated. The results show that the amorphous powders of the powder core become crystallized with the increase of annealing temperature, and the permeability decreases from 60 to 12, the core loss increases from 0.2 to 0.3 W·cm-3, DC-bias characteristic was improved with further increase of annealing temperature, and the magnetic properties become deteriorated due to decrease of permeability and enhancement of coercive force resulting from the crystallization of amorphous powder. | GUO Feng BA Shan LI Deren LU Zhichao LU Caowei WANG Jun | 2006 | Rare Metals2006，25，z1： | 2 |
| 17 | Importation of SARS-CoV-2 Omicron variant in Beijing,China显示文摘Omicron(B.1.1.529),the fifth variant of concern(VOC)of severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),was firstly identified in November 2021 in South Africa.Omicron contains far more genome mutations than any other VOCs ever found,raising significant concerns about its increased transmissibility and immune evasion.Here,we report the importation of the Omicron variant into Beijing,China,in December 2021.Full‐length genome sequences of five imported strains were obtained,with their genetic features characterized.Each strain contained 57 to 61 nucleotide substitutions,39 deletions,and 9 insertions in the genome.Thirty to thirty‐two amino acid changes were found in the spike proteins of the five strains.The phylogenetic tree constructed by the maximum likelihood method showed that all five imported genomes belonged to Omicron(BA.1)(alias of B.1.1.529.1),which is leading to the current surge of coronavirus disease 2019(COVID‐19)cases worldwide.The globally increased COVID‐19 cases driven by the Omicron variant pose a significant challenge to disease prevention and control in China.Continuous viral genetic surveillance and increased testing among international travellers are required to contain this highly contagious variant. | Fu Li Zhichao Liang Shujuan Cui Bing Lv Zhaomin Feng Hui Xu Lei Jia Peng Yang Quanyi Wang Yang Pan Daitao Zhang | 2022 | Biosafety and Health2022，4，3： | 2 |
| 18 | Distributed Retrieval System for Large Scale Text Collection显示文摘 | Li Zhichao Xiong Feng Fu Yupeng | 2007 | Journal of Guangxi Normal University: Natural Science Edition2007，25，2： | 1 |
| 19 | pH- and H_(2)O_(2)-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group显示文摘Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response performance and efficient drug release.Nevertheless,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced simultaneously.Xanthate,one functional group with pH and H2O2 stimulus responsiveness,has significant potential applications for building dual-responsive drug delivery system.Herein,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic interaction.The amphiphile QAP5⊃SXD could self-assemble into vesicles to efficiently load the anti-cancer drug DOX.The experimental results showed that QAP5⊃SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor microenvironment.Cytotoxicity experiments proved that DOX@QAP5⊃SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer cells.The present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release. | Ziyan Shen Ning Ma Feng Wang Jiaming Ren Chenxi Hou Shuang Chao Yuxin Pei Zhichao Pei | 2022 | Chinese Chemical Letters2022，33，10： | 1 |
| 20 | Calculations of Unsteady Flow and Flutter by an Euler and Integral Boundary-Layer Method on Carte sianGrids显示文摘 | Zhichao Zhang and Feng Liu | 2004 | AIAA2004，，： | 1 |
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