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| 1 | Model predictive control and improved low-pass filtering strategies based on wind power fluctuation mitigation显示文摘The rapid development of renewable energy sources such as wind power has brought great challenges to the power grid. Wind power penetration can be improved by using hybrid energy storage(ES) to mitigate wind power fluctuation. We studied the strategy of smoothing wind power fluctuation and the strategy of hybrid ES power distribution. Firstly, an effective control strategy can be extracted by comparing constant-time low-pass filtering(CLF), variable-time low-pass filtering(VLF), wavelet packet decomposition(WPD), empirical mode decomposition(EMD) and model predictive control algorithms with fluctuation rate constraints of the identical grid-connected wind power. Moreover, the mean frequency of ES as the cutoff frequency can be acquired by the Hilbert Huang transform(HHT), and the time constant of filtering algorithm can be obtained. Then, an improved low-pass filtering algorithm(ILFA) is proposed to achieve the power allocation between lithium battery(LB) and supercapacitor(SC), which can overcome the over-charge and over-discharge of ES in the traditional low-pass filtering algorithm(TLFA). In addition, the optimized LB and SC power are further obtained based on the SC priority control strategy combined with the fuzzy control(FC) method. Finally, simulation results show that wind power fluctuation can be effectively suppressed by LB and SC based on the proposed control strategies, which is beneficial to the development of wind and storage system. | Yushu SUN Xisheng TANG Xiaozhe SUN Dongqiang JIA Zhihuang CAO Jing PAN Bin XU | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，3： | 13 |
| 2 | Roles of main pro-and anti-angiogenic factors in tumor angiogenesis显示文摘Tumor growth without size restriction depends on vascular supply.The ability of tumor to induce new blood-vessel formation has been a major focus of cancer research over the past decade.It is now known that members of the vascular endothelial growth factor and angiopoietin families,mainly secreted by tumor cells, induce tumor angiogenesis,whereas other endogenous angiogenic inhibitors, including thrombospondin-1 and angiostatin, keep tumor in dormancy.Experimental and clinical evidence has suggested that the process of tumor metastasis depends on angiogenesis or lymphangiogenesis. This article summarizes the recent research progress for some basic pro- or anti-angiogenic factors in tumor angiogenesis. | ZhiHuang Shi-DengBao | 2004 | World Journal of Gastroenterology2004，10，4： | 11 |
| 3 | NMRCloudQ: a quantum cloud experience on a nuclear magnetic resonance quantum computer显示文摘Cloud-based quantum computing is anticipated to be the most useful and reachable form for public users to experience with the power of quantum. As initial attempts, IBM Q has launched influential cloud services on a superconducting quantum processor in 2016, but no other platforms has followed up yet. Here,we report our new cloud quantum computing service – NMRCloud Q(http://gffzz93b8cbf03a7349b1hov5xcp6fouov6kk9.ffgz.tsg.suse.edu.cn/zh-hans/),where nuclear magnetic resonance, one of the pioneer platforms with mature techniques in experimental quantum computing, plays as the role of implementing computing tasks. Our service provides a comprehensive software environment preconfigured with a list of quantum information processing packages,and aims to be freely accessible to either amateurs that look forward to keeping pace with this quantum era or professionals that are interested in carrying out real quantum computing experiments in person. In our current version, four qubits are already usable with in average 99.10% single-qubit gate fidelity and 97.15% two-qubit fidelity via randomized benchmaking tests. Improved control precisions as well as a new seven-qubit processor are also in preparation and will be available later. | Tao Xin Shilin Huang Sirui Lu Keren Li Zhihuang Luo Zhangqi Yin Jun Li Dawei Lu Guilu Long Bei Zeng | 2018 | Science Bulletin2018，63，1： | 5 |
| 4 | Sensitivity of simulated short-range high-temperature weather to land surface schemes by WRF显示文摘The simulations of a heat wave occurring in southern Yangtze-Huaihe valley and southern China during late July,2003 were conducted to examine the sensitivity of simulated surface air temperature(SAT) to different land surface schemes(LSSs) using the Weather Research and Forecasting Model(WRF) Version 2.2 in the short-range mode for 24-h integrations.Initial and boundary conditions employed a National Centers for Environmental Prediction(NCEP) analysis.The results showed that,overall,simulated high-temperature weather is sensitive to different LSSs.Large differences in simulated SAT intensity,threat score,and simulated error under different schemes are identified clearly.In addition,some systematic differences are also in-duced by the LSSs.In terms of threat score from the three LSSs,SLAB is the best,and RUC is better than NOAH.SLAB gives the lowest absolute error for area-averaged SAT,and tends to depict the western Pacific subtropical high with the east-ernmost position at low levels.The LSSs modify the simulated SAT,primarily via the transfer of sensible heat from the land surface to the atmosphere.The physical mechanism of the positive feedback between atmospheric circulation and the SAT is unimportant,with'negative'feedback over most of the simulated areas.This study emphasizes the importance of improving LSSs in SAT forecasting by numerical models. | ZENG XinMin WU ZhiHuang XIONG ShiYan SONG Shuai ZHENG YiQun LIU HuaQiang | 2011 | Science China Earth Sciences2011，54，4： | 5 |
| 5 | Thrombin is a therapeutic target for non-small-cell lung cancer to inhibit vasculogenic mimicry formation显示文摘Tumor cells transform into endothelial cells by epithelial-to-mesenchymal transition,which is characterized by vasculogenic mimicry(VM).VM not only accelerates tumor progression but also increases drug-induced resistance.However,very little is currently known about the molecular determinants that enable VM.Targeting VM might bring a new breakthrough in cancer treatment.Thrombin is the key enzyme of the blood coagulation system and could contribute to tumor progression.Nevertheless,the association between thrombin and VM formation remains largely unknown.We found that VM was associated with the overall survival of non-small-cell lung cancer(NSCLC)patients,and that thrombin expression was closely related to VM formation.This research revealed that thrombin induced VM formation via PAR-1-mediated NF-κB signaling cascades.The novel thrombin inhibitors r-hirudin and DTIP inhibited VM formation and spontaneous metastases in subcutaneous tumors.Clinical pathological analysis confirmed that NSCLC patients with thrombin-positive/PAR-1-high expression had the poorest prognosis and were the most likely to form VM.The promotional activity of thrombin in VM formation and tumor metastasis was abolished in PAR-1-deficient NSCLC cells.The EGFR inhibitor gefitinib had no effect on VM and increased VEGF expression in tumors.The combination therapy of DTIP and gefitinib achieved a better therapeutic effect than either agent alone.This study is the first to illustrate that thrombin substantially contributes,together with PAR-1,to VM formation and to illustrate that VM might be a target of r-hirudin and DTIP to suppress tumor progression.The anticoagulants r-hirudin and DTIP could be employed for antitumor therapy.Combination therapy with DTIP with an EGFR inhibitor might achieve superior therapeutic effects. | Bing Zhao Mengfang Wu Zhihuang Hu Yixin Ma Wang Qi Yanling Zhang Yaran Li Min Yu Huijie Wang Wei Mo | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 6 | Algorithm Based on Taboo Search and Shifting Bottleneck for Job Shop Scheduling显示文摘In this paper, a computational effective heuristic method for solving the minimum makespan problem of job shop scheduling is presented. It is based on taboo search procedure and on the shifting bottleneck procedure used to jump out of the trap of the taboo search procedure. A key point of the algorithm is that in the taboo search procedure two taboo lists are used to forbid two kinds of reversals of arcs, which is a new and effective way in taboo search methods for job shop scheduling. Computational experiments on a set of benchmark problem instances show that, in several cases, the approach, in reasonable time, yields better solutions than the other heuristic procedures discussed in the literature. | Wen-QiHuang ZhiHuang | 2004 | Journal of Computer Science & Technology2004，19，6： | 2 |
| 7 | Growth arrest and apoptosis of human hepatocellular carcinoma cells induced by hexamethylene bisacetamide显示文摘AIM: To investigate the cellular effects of hybrid polar compound hexamethylene bisacetamide (HMBA) on the growth and apoptosis of human hepatocellular carcinoma cells and to provide the molecular mechanism for potential application of HMBA in the treatment of liver cancer. METHODS: Effects of HMBA on the growth of human hepatocellular carcinoma SMMC-7721 cells were assayed by MTT chronometry. Apoptosis induced by HMBA was detected by phase-contrast microscopy, flow cytometry, propidium iodide staining and immunocytochemical analysis. RESULTS: The growth of SMMC-7721 cells was significantly inhibited by HMBA, and the growth inhibitory rate was 51.1%, 62.6%, 68.7% and 73.9% respectively after treatment with 5.0, 7.5, 10.0 and 12.5 mmol/L of HMBA. In the cells treated with 10 mmol/L of HMBA for 72 h, the population of cells at sub-G1 phase significantly increased, and the apoptotic bodies and condensed nuclei were detected. Moreover, treatment of SMMC-7721 cells with 10 mmol/L of HMBA down-regulated the expression of Bcl2 anti-apoptotic protein, while slightly up-regulated the level of pro-apoptotic protein Bax. CONCLUSION: Treatment with 10.0 mmol/L of HMBA can significantly inhibit the growth and induce apoptosis of human hepatocellular carcinoma SMMC-7721 cells by decreasing the ratio of Bcl-2 to Bax. | Gao-LiangOuyang Qiu-FengCai MinLiu Rui-ChuanChen ZhiHuang Rui-ShengJiang FuChen Shui-GenHong Shi-DengBao | 2004 | World Journal of Gastroenterology2004，10，7： | 2 |
| 8 | Biomimeticpropertiesofaninjectablechitosan/nano-hydroxyapatite/collagencomposite显示文摘 | ZhiHuang Feng Qingling Bo Yu etal | 2011 | MaterialsScienceandEngineeringC2011，31，1： | 1 |
| 9 | National survey of the medical treatment status for non-small cell lung cancer (NSCLC) in China显示文摘 | Cong Xue Zhihuang Hu Wei Jiang Yuanyuan Zhao Fei Xu Yan Huang Hongyun Zhao Jingxun Wu Yang Zhang Liping Zhao Jing Zhang Likun Chen Li Zhang | 2012 | Lung Cancer2012，，2： | 1 |
| 10 | Efficacy and safety of Sancai powder in patients with type 2 diabetes mellitus: a randomized controlled trial显示文摘OBJECTIVE: To assess the efficacy and safety of Sancai powder in patients with type 2 diabetes mellitus(T2DM) inadequately controlled with single oral metformin in a randomized controlled trial(RCT).METHODS: A total of 132 patients with T2 DM were enrolled in the study, who only took metformin(500-1000 mg/day) for at least three months and with inadequate glycemic control(7.0% ≤ hemoglobin A1 c ≤ 9.0%) in the past three months.The patients stopped taking metformin with lifestyle interventions for three weeks, and 105 patients qualified for the program. They were randomly divided into the Sancai powder group and the metformin group(1500 mg/day). The follow-up period was for 12 weeks. Comparisons of several variables were analyzed.RESULTS: No significant differences were found between the two groups in hemoglobin A1c(Hb A1c),fasting plasma glucose(FPG) and 2 h post-meal glucose(2h PG), although they had decreased significantly(P < 0.01). Homeostasis model assessment of beta cell function index was significantly improved in Sancai powder group(P < 0.01), and there were significant differences in the changes of homeostasis model assessment of insulin resistance and insulin sensitivity index in the two groups(P < 0.05). Sancai powder significantly reduced triglyceride level(P < 0.05), although there was no significant difference in the body weight and body mass index in the two groups.CONCLUSION: In this 12-week study, Sancai powder could significantly reduce hemoglobin A1 c,FPG and 2h PG levels, improved beta-cell function and insulin resistance of the T2 DM inadequately controlled with metformin. | Guo Qiang Zhang Hengyao Li Mindian Zhao Ziyi Luo Yunlin Luo Yulei Cao Wenzhai Zhao Huan Zhu Ranran Lei Xingxing Chen Huizhen Gan Huakui Zuo Zhihuang Chen Qi Shi Cuimei Zhang Xinli Guo Jian Zhong Sen Chen Qiu | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 1 |
| 11 | A wide dynamic range detection of biopolymer medicines with resonance light scattering and absorption ratiometry显示文摘 | LONG Yijuan LI Yuanfang CHENG Zhihuang | 2005 | Anal Chim Acta2005，552，： | 1 |
| 12 | Hilbert-Huang transform based signal analysis for the characterization of gas-liquid two-phase flow显示文摘 | DING Hao HUANG Zhiyao SONG Zhihuang | | 0，，： | 1 |
| 13 | Process monitoring based on independent component analysis-principal component analysis (ICA-PCA) and similarity factors显示文摘 | Ge Zhiqiang Song Zhihuang | 2007 | Industrial and Engineering Chemistry Research2007，46，7： | 1 |
| 14 | 一种基于禁忌搜索和转换瓶颈的作业车间调度算法显示文摘作业车间调度问题(Job Shop Scheduling Problem)是一种调度问题,同时也可以视为排序问题。一般说来,有不同的任务在只能使用有限资源的条件下要完成,都可以归为排序问题,比如,不同的零件要在机器上加工,几艘货船要进港,多条程序要在计算机上运行等。当然,调度不只是排序,它还根据所得到的排序确定各个任务的开始时间和结束时间。 | Wen-QiHuang ZhiHuang | 2004 | Journal of Computer Science & Technology2004，19，C00： | 0 |
| 15 | Hyperbaric oxygen protects against PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of cell apoptosis and autophagy显示文摘In this study,we investigated the protective effect of hyperbaric oxygen(HBO)on PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion and its possible mechanism.PC12 and H9C2 cell oxygen-glucose deprivation/reperfusion model were established.Cells were divided into a control group,model group,hyperbaric air(HBA)group and HBO group.The cell viability was detected by the CCK8 assay.Hoechst 33342 and PI staining assays and mitochondrial membrane potential(MMP)assays were used to detect cell apoptosis.The ultrastructure of cells,including autophagosomes,lysosomes,and apoptosis,were examined using a transmission electron microscope.The expression of autophagy-related proteins was detected by cellular immunofluorescence and immunocytochemistry.Our results showed that HBO can significantly improve the vitality of damaged PC12 and H9C2 cells caused by oxygen–glucose deprivation/reperfusion.HBO can significantly inhibit apoptosis of PC12 and H9C2 cells caused by oxygenglucose deprivation/reperfusion.Importantly,we found that the protective mechanism of PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion may be related to the inhibition of the autophagy pathway.In this study,the results of cellular immunofluorescence and immunocytochemistry experiments showed that the 4E-BP1,p-AKt and mTOR levels of PC12 and H9C2 cells in the model group decreased,while the levels of LC3B,Atg5 and p53 increased.However,after HBO treatment,these autophagy-related indexes were reversed.In addition,observation of the cell ultrastructure with transmission electron microscopy found that in the model group,a significant increase in the number of autophagic vesicles was observed.In the HBO group,a decrease in autophagic vesicles was observed.The study demonstrated that hyperbaric oxygen protects against PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of cell apoptosis and autophagy. | JIANRONG YANG WAN CHEN XING ZHOU YAOXUAN LI ZHIHUANG NONG LIYUAN ZHOU XUAN WEI XIAORONG PAN CHUNXIA CHEN WENSHENG LU | 2022 | BIOCELL2022，46，1： | 0 |
| 16 | Experimental preparation of topologically ordered states via adiabatic evolution显示文摘Topological orders are a class of exotic states of matter characterized by patterns of long-range entanglement. Certain topologically ordered systems are proposed as potential realization of fault-tolerant quantum computation. Topological orders can arise in two-dimensional spin-lattice models. In this paper, we engineer a time-dependent Hamiltonian to prepare a topologically ordered state through adiabatic evolution. The other sectors in the degenerate ground-state space of the model are obtained by applying nontrivial operations corresponding to closed string operators. Each sector is highly entangled, as shown from the completely reconstructed density matrices. This paves the way towards exploring the properties of topological orders and the application of topological orders in topological quantum memory. | ZhiHuang Luo Jun Li ZhaoKai Li Ling-Yan Hung Yi Dun Wan XinHua Peng JiangFeng Du | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，8： | 0 |
| 17 | Optical colorimetric LiTaO_(3)wafers for highprecision lithography on frequency control of SAW devices显示文摘Surface acoustic wave(SAW)resonators based on lithium tantalate(LT,LiTaO_(3))wafers are crucial elements of mobile communication filters.The use of intrinsic LT wafers typically brings about low fabrication accuracy of SAW resonators due to strong UV reflection in the lithography process.This hinders their resonance frequency control seriously in industrial manufacture.LT doping and chemical reduction could be applied to decrease the UV reflection of LT wafers for high lithographic precision.However,conventional methods fail to provide a fast and nondestructive approach to identify the UV performance of standard single-side polished LT wafers for highprecision frequency control.Here,we propose a convenient on-line sensing scheme based on the colorimetry of reduced Fe-doped LT wafers and build up an automatic testing system for industrial applications.The levels of Fe doping and chemical reduction are evaluated by the lightness and color difference of LT-based wafers.The correlation between the wafer visible colorimetry and UV reflection is established to refine the lithography process and specifically manipulate the frequency performance of SAW resonators.Our study provides a powerful tool for the fabrication control of SAW resonators and will inspire more applications on sophisticated devices of mobile communication. | MING HUI FANG YINONG XIE FANGQI XUE ZHILIN WU JUN SHI SHENG YU YANG YILIN LIU ZHIHUANG LIU HSIN CHI WANG FAJUN LI QING HUO LIU JINFENG ZHU | 2024 | Photonics Research2024，12，2： | 0 |
| 18 | Synthesis and Properties of Thermoplastic Polyisocyanurates:Polyisocyanuratoamide,Polyisocyanurato(Ester-Amide)and Polyisocyanurato(Urea-Ester)显示文摘It has been proved that introducing isocyanurate into polymer chains could improve the flame retardancy of polymers.We describe in this work the synthesis and the thermal property study of three thermoplastic polyisocyanurates,which are polyisocyanuratoamide(PICA-6),polyisocyanurato(ester amide)(PICEA-6)and polyisocyanurato(urea ester)(PICUE-6).These polymers show similar and improved thermal stability with the existence of isocyanurate rings.PICA-6 is more crystalizable than the rest two and the melting temperature is found to be around 240℃ but it still crystalizes slowly.For PICEA-6 and PICUE-6,only glass transition can be observed on the DSC traces.The glass transition temperature follows the order of PICA-6>PICEA-6>PICUE-6(101.9,77.9 and 28.7℃,respectively). | Rui Hou Zhihuang Zhang Guangzhao Zhang Donglin Tang | 2020 | Journal of Renewable Materials2020，8，4： | 0 |
| 19 | Stereoselective Synthesis of Piperamide Alkaloids by Modified Ramberg-Bcklund Reaction显示文摘A convenient and rapid approach for the synthesis ofpiperamide alkaloids la ~ h by the recently developed one-flask Ramberg-Baecklund reaction was described. The synthesis of le was reported for the first time. | YangLI YuZHANG XiaoLongWANG ZhiHUANG XiaoPingCAO | 2004 | Chinese Chemical Letters2004，15，6： | 0 |
| 20 | Fast adiabatic method for measuring topological Chern number显示文摘Topological phases play an increasingly central role in condensed matter physics[1,2]and fault-tolerant quantum computation[3].The global nature can be characterized by certain topological invariants,many among them can be defined as the integrals of some geometric quantities.A well-known example is the Chern number[4].It is the integral of Berry curvature over a surface without boundary and is thus closely related to Berry phase[5].The integer Chern number can | ZhiHuang Luo Bei Zeng | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，5： | 0 |
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