|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma显示文摘Mantle cell lymphoma(MCL)is a B-cell malignancy with poor clinical outcome and undefined pathogenesis.Development of clinically relevant cellular models for MCL research is an urgent need.Our preliminary observations lead the development of two novel hypotheses that we tested in this study:1.multicellular spheroid might be a unique growth mode of earlystage cells in MCL;2.MCL might be a polyclonal tumor.We made the following original observations that have not been reported:First,we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples.Second,we have established a clinically relevant cellular model of MCL,the JeKo-1-spheroid cell line,that was highly enriched in early-stage sub-clones.JeKo-1-spheroid cells and the spheroid growing cells enriched from MCL patients exhibited comparably enhanced tumorigenic abilities and similar biological features.Third,Immunophenotypic analysis has revealed that MCL may be derived from precursor-B(pre-B),immature-B and mature-B cells,not only the mature-B cells as WHO classified in 2016.Fourth,MCL may be a polyclonal disease composed of CD19e/IgMe,CD19 e/IgMt,CD19t/IgMt three sub-clones,of which the CD19e/IgMt sub-clone might be the dominant sub-clone with the strongest tumorigenic ability.Fifth,CD19t/IgMe that differentiates MCL and normal B cells may represent a new marker for MCL early detection,minor residual disease monitoring after therapies and prognosis. | Junling Tang Li Zhang Tiejun Zhou Zhiwei Sun Liangsheng Kong Li Jing Hongyun Xing Hongyan Wu Yongli Liu Shixia Zhou Jingyuan Li Mei Chen Fang Xu Jirui Tang Tao Ma Min Hu Dan Liu Jing Guo Xiaofeng Zhu Yan Chen Ting Ye Jianyu Wang Xiaoming Li H.Rosie Xing | 2019 | Genes & Diseases2019，6，4： | 2 |
| 2 | FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors显示文摘 | Aamir Ahmad Zhiwei Wang Dejuan Kong Shadan Ali Yiwei Li Sanjeev Banerjee Raza Ali Fazlul H. Sarkar | 2010 | Breast Cancer Research and Treatment2010，，2： | 2 |
| 3 | Tailoring thermal conductivity of bulk graphene oxide by tuning the oxidation degree显示文摘Bulk graphene oxide(GO) shows great potential in a variety of applications, such as sensors,photodetectors, supercapacitors, lithium ion batteries and catalysts. However, its thermal conductivity,one of the most important and fundamental physical properties, is still less known. Herein, we have systematically investigated the thermal conductivity of bulk GOs and find that it can be tailored by tuning their oxidation degree during preparation process. Notably, the cross-plane thermal conductivity of bulk GO, in comparison with its precursor graphite, exhibits more than 100 times decrease at room temperature. The dependence of thermal conductivity of GO on oxidation degree is attributed to the chemical and structural changes by introducing oxygen atoms and oxygen-containing functional groups,which can lead to a significant enhancement in atomic-and nano-scale phonon scattering. Furthermore,we reveal that the thermal conductivity of bulk GOs exhibits evident anisotropic behavior. These results provide fundamental understanding and valuable information on thermal transport properties of bulk GOs for various practical applications. | Qing-Long Meng Hengchang Liu Zhiwei Huang Shuang Kong Peng Jiang Xinhe Bao | 2018 | Chinese Chemical Letters2018，29，5： | 2 |
| 4 | The complexities of obesity and diabetes with the development and progression of pancreatic cancer显示文摘 | Bin Bao Zhiwei Wang Yiwei Li Dejuan Kong Shadan Ali Sanjeev Banerjee Aamir Ahmad Fazlul H. Sarkar | 2010 | BBA - Reviews on Cancer2010，，2： | 2 |
| 5 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 6 | Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance显示文摘 | Zhiwei Wang Yiwei Li Aamir Ahmad Asfar S. Azmi Dejuan Kong Sanjeev Banerjee Fazlul H. Sarkar | 2010 | Drug Resistance Updates2010，，4： | 2 |
| 7 | Over‐expression of FoxM1 leads to epithelial–mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells显示文摘 | Bin Bao Zhiwei Wang Shadan Ali Dejuan Kong Sanjeev Banerjee Aamir Ahmad Yiwei Li Asfar S. Azmi Lucio Miele Fazlul H. Sarkar | 2011 | J Cell Biochem2011，，9： | 2 |
| 8 | Role of the carrier gas flow rate in monolayer MoS2 growth by modified chemical vapor deposition显示文摘单层铝二硫化物(因为潜在的应用的变化,瞬间 2) 吸引了许多注意。然而,它的控制生长仍然是大挑战。这里,我们报导一个修改化学蒸汽免职方法种单层瞬间 2 。我们观察到瞬间 2 晶体的质量能被在加热阶段期间调节搬运人气体流动率极大地改进。这微妙的修正阻止在先锋之间的控制不了的反应,为高质量的单层瞬间 2 的生长的一个关键因素。基于优化煤气的流动率,瞬间 2 范围和薄片尺寸能被调整生长时间控制。 | Hengchang Liu Yuanhu Zhu Qinglong Meng Xiaowei Lu Shuang Kong Zhiwei Huang Peng Jiang Xinhe Bao | 2017 | Nano Research2017，10，2： | 1 |
| 9 | Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells显示文摘 | Bin Bao Zhiwei Wang Shadan Ali Dejuan Kong Yiwei Li Aamir Ahmad Sanjeev Banerjee Asfar S. Azmi Lucio Miele Fazlul H. Sarkar | 2011 | Cancer Letters2011，，1： | 1 |
| 10 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang<.--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，： | 1 |
| 11 | Forkhead box M1 transcription factor: A novel target for cancer therapy显示文摘 | Zhiwei Wang Aamir Ahmad Yiwei Li Sanjeev Banerjee Dejuan Kong Fazlul H. Sarkar | 2009 | Cancer Treatment Reviews2009，，2： | 1 |
| 12 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 13 | Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research显示文摘 | Yiwei Li Dejuan Kong Zhiwei Wang Fazlul H. Sarkar | 2010 | Pharmaceutical Research2010，，6： | 1 |
| 14 | Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells显示文摘 | Kong Dejuan Wang Zhiwei Sarkar SH | 2008 | Stem Cells2008，26，6： | 1 |
| 15 | Down-regulation of platelet derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and Nuclear Factor-KB Signaling显示文摘 | Wang Zhiwei Kong Dejuan Banerjee S | 2007 | Cancer Res2007，67，11： | 1 |
| 16 | The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer显示文摘 | Fazlul H. Sarkar Yiwei Li Zhiwei Wang Dejuan Kong | 2010 | Cancer and Metastasis Reviews2010，，3： | 1 |
| 17 | FoxM1 is a Novel Target of a Natural Agent in Pancreatic Cancer显示文摘 | Zhiwei Wang Aamir Ahmad Sanjeev Banerjee Asfar Azmi Dejuan Kong Yiwei Li Fazlul H. Sarkar | 2010 | Pharmaceutical Research2010，，6： | 1 |
| 18 | Selective laser melted high Ni content TiNi alloy with superior superelasticity and hardwearing显示文摘TiNi alloys with high content Ni(52-55 at.%)are perfectly suitable for preparing wear-and corrosionresistant parts that service on the space station,spacecraft,and submarine,because of their superior superelasticity,high strength,and hardwearing.However,the fabrication of complicated Ni-rich TiNi parts by the traditional machining method often faces problems of poor precision,low efficiency,and high cost.In this work,we succeed in preparing an excellent Ti_(47)Ni_(53) alloy by selective laser melting(SLM),and thus,open a new way for the efficient and precise formation of complicated Ni-rich TiNi parts with superelasticity and hardwearing.An optimized processing window for compact parts without defects is reported.The elaborately fabricated Ti_(47)Ni_(53) alloy exhibited a breaking strain of 11%,a breaking stress of 2.0 GPa,a superelastic strain of 9%,and a better hardwearing than that of casting and quenched Ti_(47)Ni_(53) alloy.Besides,the microstructure,phase transformation,and deformation,as well as their influence mechanisms are investigated by in situ transmission electron microscope(TEM)and high-energy X-ray diffraction(HE-XRD).The results obtained are of significance for both fundamental research and technological applications of SLM-fabricated high Ni content TiNi alloys. | Hui Shen Qingquan Zhang Ying Yang Yang Ren Yanbao Guo Yafeng Yang Zhonghan Li Zhiwei Xiong Xiangguang Kong Zhihui Zhang Fangmin Guo Lishan Cui Shijie Hao | 2022 | Journal of Materials Science & Technology2022，，21： | 1 |
| 19 | MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma显示文摘 | Yanqiong Zhang< !--Q1: Please confirm that given names and surnames have been identified correctly.--> Xiaodong Guo Lu Xiong Xiangying Kong Ying Xu Chunfang Liu Lin Zou Zhiwei Li Jingmin Zhao Na Lin | 2012 | FEBS Letters2012，，24： | 1 |
| 20 | Over‐expression of FoxM1 leads to epithelial–mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells显示文摘 | Bin Bao Zhiwei Wang Shadan Ali Dejuan Kong Sanjeev Banerjee Aamir Ahmad Yiwei Li Asfar S. Azmi Lucio Miele Fazlul H. Sarkar | 2011 | Biochem2011，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员