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| 1 | Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial显示文摘背景 2009 流行性感冒 A (H1N1 ) 病毒感染与严重复杂并发症的高风险被联系并且比另外的报导季节的流行性感冒在整个 wodd 更快正在传播。试图评估在病人的草药的药 Lianhuaqingwen 囊( LHC )与 16-65 年的 244 个病人的一个总数由实时 RT-PCR 与流行性感冒 A ( H1N1 )病毒感染证实了的流行性感冒 A ( H1N1 ) virus.Methods 感染了的性质的功效和安全的这研究被使随机化到之一二治疗各 122 组织病人。每个组分配了收到 LHC 或 Oseltamivir 五天和观察七天。如果他们有 37.4 并且与至少一下列症状的腋的温度,病人在 36 小时病发作以内被注册:鼻音阻塞,流鼻涕的鼻子,咳嗽,酸的喉咙,疲劳,头疼,肌痛,寒冷并且出汗。主要结束点是 244 个病人,的 illness.Results 的持续时间 240 (98.36 ) 有 21 年完成了的中部的年龄的病人在 10 月 24,2009 日和 2009 年 11 月 23 日之间的学习。对待的 LHC 之间没有重要全面差别, Oseltamivir 在病(LHC 69 小时对 Oseltamivir 85 小时 P 0.05 ) 的中部的持续时间或病毒的流的中部的持续时间对待病人(LHC 103 小时对 Oseltamivir 96 小时, P 0.05 ) 。然而,注意 LHC 显著地包括发烧,咳嗽,酸的喉咙,和疲劳(P 0.05 ) 减少了病和症状的持续时间的严厉是值得的。两学习药很好被容忍。没有药联系了严肃的不利事件与 Oseltamivir 相比发生在 study.Conclusions 期间, LHC 完成了病的持续时间和病毒的流的持续时间的类似的治疗学的有效性减小。因此, LHC 可能是为流行性感冒 A (H1N1 ) 病毒感染的一项其他的治疗学的措施。(临床的试用数字:ChiCTR-TRC-00000589 ) 。 | DUAN Zhong-ping JIA Zhen-hua ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong SUN Yan ZHANG Shu-qin WANG Yong-yan WU Yi-ling | 2011 | Chinese Medical Journal2011，，18： | 55 |
| 2 | In-situ U-Pb dating of uraninite by fs-LA-ICP-MS显示文摘In this study,the Pb/U fractionation between zircon and uraninite during femtosecond Laser Ablation Inductively Coupled Plasma Mass Spectrometry(fs-LA-ICP-MS)analysis was studied in detail.The results show significant Pb/U fractionation between zircon and uraninite during fs-LA-ICP-MS analysis that when calibrated against the zircon standard M257,the obtained U-Pb age of the Chinese national uraninite standard GBW04420 is 17%older than the recommended value.Thus,the accurate in-situ U-Pb dating of uraninite by LA-ICP-MS requires matrix-matched external standards for calibration.Uraninite in thin sections of two U-mineralized leucogranite from the Gaudeanmus in Namibia was analyzed by a fs-LA-ICP-MS equipped with a Signal Smooth Device(SSD),using laser spot and frequency of 10μm and 1 Hz,respectively.When calibrated using GBW04420 as the external standard,two samples give weighted mean 206Pb/238U ages of 504±3 Ma(2σ,n=21)and503±3 Ma(2σ,n=22),and only one of two samples yields a concordia U-Pb age of 507±1 Ma(2σ,n=21).These results are consistent with ID-TIMS U-Pb ages of 509±1 and 508±12 Ma and are also indistinguishable from zircon U-Pb upper intercept ages of 506±33 Ma(2σ,n=29)and 501±51 Ma(2σ,n=29).The present study shows that in-situ U-Pb dating of uraninite can deliver more reliable formation ages of the deposit than dating coeval high-U zircon because the latter commonly suffer significant Pb loss after formation.Our results confirm that GBW04420 is an ideal matrix matching standard for in-situ U-Pb dating of uraninite. | ZONG KeQing CHEN JinYong HU ZhaoChu LIU YongSheng LI Ming FAN HongHai MENG YanNing | 2015 | Science China Earth Sciences2015，58，10： | 22 |
| 3 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 4 | Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus显示文摘瞄准:为了观察淀粉的贝它( Abeta )是否在 interleukin ( IL )导致了增加, -1beta 被 p38 的增加伴随在房间幸存小径的 激活mitogen 的蛋白质激酶( MAPK )小径和减少,并且钠 ferulate ( SF )处理是否在阻止这些 导致Abeta 的变化是有效的。方法:老鼠与 Abeta25-35 intracerebroventricularly 被注射。在注射以后的七天,免疫为神经胶质 fibrillary 的组织化学的技术酸的蛋白质(GFAP ) 被用来在海马趾的 CA1 区域决定星形细胞渗入和激活。IL-1beta,细胞外的调整信号的激酶(英皇家空军之阶级最低之兵) , p38 MAPK, Akt/protein 激酶 B (PKB ) ,船边交货 ligand 和 caspase-3 的表示被西方的弄污决定。caspase-3 活动被 caspase-3 底层(Ac-DEVD-pNA ) 的劈开测量。反向的抄写聚合酶链反应被用来在 IL-1beta mRNA 层次分析变化。结果:Abeta25-35 的 Intracerebroventricular 注射得到了星形细胞激活和渗入并且引起了增加的 IL-1beta 生产描绘并且提高了 IL-1beta mRNA 的层次的强壮的炎性反应。增加的 IL-1beta 合成被 p38 MAPK 并且在 phospho 英皇家空军之阶级最低之兵和 phospho-Akt/PKB 的规定下面的增加的激活在从对待 Abeta 的老鼠准备的海马趾的 CA 区域伴随,导致由 caspase-3 的激活估计了的细胞死亡。SF 显著地在 phospho 英皇家空军之阶级最低之兵和 phospho-Akt/PKB 表示层次在 IL-1beta 和 p38 MAPK 激活和也导致 Abeta 的变化阻止了导致 Abeta 的增加。结论:SF 通过 p38 MAPK 激活并且在 phospho 英皇家空军之阶级最低之兵和 phospho-Akt/PKB 表示的规定上面的抑制阻止导致 Abeta 的 neurotoxicity。 | Ying JIN En-zhi YAN Ying FAN Zhi-hong ZONG Zhi-min QI Zhi LI | 2005 | Acta Pharmacologica Sinica2005，26，8： | 18 |
| 5 | Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways显示文摘目的:调查钠 ferulate ( SF )是否能保护外皮的神经原免受 导致glutamate 的 neurotoxicity 和为这 protection.Methods 负责的机制的伤害:有教养的外皮的神经原与 50 亩 mol/L 被孵化充斥为 30 min 或 24 h 的使挫折,与或没有有 SF 的孵化前( 100,200 ,并且 500 亩 mol/L ,分别地) .LY294002 , wortmannin , PD98059 ,和 U0126 分别地被加到房间在 SF 处理以前的 1 h 。在孵化与以后充斥为 24 h 的使挫折,神经元 apoptosis 被与 apoptotic 获得房间的百分比确定在染色的 Hoechst 33258 以后的原子形态学。在孵化与以后充斥为 30 min 或 24 h 的使挫折,细胞的摘录为活跃 caspase-3 的西方的弄污作好准备,多形核白细胞(自动数据处理核糖)聚合酶( PARP ), mu-calpain , Bcl-2 , phospho-Akt , phosphorylated ribosomal 蛋白质 S6 蛋白质激酶( p70S6K ), phospho-mitogen-activated 蛋白质激酶激酶( MEK1/2 )和 phosphorylated 细胞外的调整信号的激酶(英皇家空军之阶级最低之兵) 1/2 .Results : SF 减少了 唤起glutamate 的 apoptotic 形态学,活跃 caspase-3 蛋白质表示,和 PARP 劈开并且禁止在 mu-calpain 蛋白质水平的规定上面 导致glutamate 。protective 对导致 glutamate 的神经元 apoptosis.SF SF 完成的 phosphatidylinositol 3-kinase (PI3K ) 和部分废除的 MEK/ERK1/2 小径的抑制在 PI3K/Akt/p70S6K 和 MEK/ERK1/2 小径的活动阻止了导致 glutamate 的减少。而且,有为 30 min 的 SF 的外皮的神经原的孵化禁止了 glutamate.Conclusion 导致的 Bcl-2 表示的减小: 结果显示表明小径的那 PI3K/Akt/p70S6K 和 MEK/ERK 在 SF 的保护的效果起重要作用对充斥在外皮的神经原的使挫折毒性。 | Ying JIN En-zhi YAN Ying FAN Xiao-li GUO Yan-jie ZHAO Zhi-hong ZONG Zhuo LIU | 2007 | Acta Pharmacologica Sinica2007，28，12： | 16 |
| 6 | Aberrant TGF-β1 signaling contributes to the development of primary biliary cirrhosis in murine model显示文摘AIM:To investigate whether transforming growth factor-β1(TGF-β1)signaling pathway is involved in the pathogenesis of primary biliary cirrhosis(PBC).METHODS:A murine model of PBC was developed by injection of polyinosinic polycytidylic acids(polyⅠ:C)in C57BL/6 mice,and the liver expressions of TGFβ1,TGF-βreceptorⅠ(TβRⅠ),TGF-βreceptorⅡ(TβRⅡ),p-Smad2/3,monoclonalα-smooth muscle actin antibody(α-SMA)andα1(Ⅰ)collagen in the mouse model and control mice were evaluated by immunohistochemistry,immunoblotting and real-time polymerase chain reaction(RT-PCR).Lymphocyte subsets in liver were analyzed using flow cytometry.RESULTS:The mouse model had several key phenotypic features of human PBC,including elevated levels of alkaline phosphatase,antimitochondrial antibodies,portal bile ducts inflammation,and progressive collagen deposition.Compared with control mice,protein and mRNA levels of TGFβ1,TβRⅠ,TβRⅡ,p-Smad2/3,α-SMA andα1(Ⅰ)collagen in liver(1.7±0.4 vs 8.9±1.8,0.8±0.2 vs 5.1±1.5,0.6±0.01 vs5.1±0.1,0.6±0.3 vs 2.0±0.3,0.9±0.4 vs 3.4±0.6,0.8±0.4 vs 1.7±0.3,1.1±1.2 vs 11.8±0.6,P<0.05),and the total number and percentage of CD4+CD25+FOXP3+and CD8+lymphocytes(0.01±0.001vs 0.004±0.00,0.12±0.04 vs 0.52±0.23,P<0.01)were higher in the mouse model.CONCLUSION:TGFβ1 might play a dual role in the development of PBC:it suppresses inflammatory response but operates to enhance fibrogenesis.The aberrant activity of TGF-β1 signaling contributes to the development of PBC. | Bin Liu Xuan Zhang Feng-Chun Zhang Jin-Bao Zong Wen Zhang Yan Zhao | 2013 | World Journal of Gastroenterology2013，19，35： | 14 |
| 7 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 8 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 9 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 10 | Oxidative Stress and Apoptotic Changes of Rat Cerebral Cortical Neurons Exposed to Cadmium in Vitro显示文摘Objective To investigate the cytotoxic mechanism of cadmium(Cd) on cerebral cortical neurons.Methods The primary cultures of rat cerebral cortical neurons were treated with different concentrations of cadmium acetate(0,5,10,and 20 μmol/L),and then the cell viability,apoptosis,ultrastructure,intracellular [Ca2+]i and reactive oxygen species(ROS) levels,mitochondrial membrane potential(ΔΨ),activities of catalase(CAT) and superoxide dismutase(SOD) were measured.Results A progressive loss in cell viability and an increased number of apoptotic cells were observed.In addition,Cd-induced apoptotic morphological changes in cerebral cortical neurons were also demonstrated by Hoechst 33258 staining.Meanwhile,ultrastructural changes were distortion of mitochondrial cristae and an unusual arrangement.Simultaneously,elevation of intracellular [Ca2+]i and ROS levels,depletion of ΔΨ were revealed in a dose-dependent manner during the exposure.Moreover,CAT and SOD activities in the living cells increased significantly.Conclusion Exposure of cortical neurons to different doses of Cd led to cellular death,mediated by an apoptotic mechanism,and the apoptotic death induced by oxidative stress may be a potential reason.And the disorder of intracellular homeostasis caused by oxidative stress and mitochondrial dysfunction may be a trigger for apoptosis in cortical neurons. | YUAN Yan BIAN Jian Chun LIU Xue Zhong ZHANG Ying SUN Ya LIU Zong Ping | 2012 | Biomedical and Environmental Sciences2012，25，2： | 10 |
| 11 | Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus显示文摘瞄准:在淀粉的贝它(Abeta ) 上观察钠 ferulate (SF ) 的效果 1-40-induced p38 激活 mitogen 的蛋白质激酶(MAPK ) 信号转导变异小径和 SF 的 neuroprotective 效果。方法:老鼠与 Abeta1-40 intracerebroventricularly 被注射。在注射以后的六个小时,西方的弄污被用来决定 phosphorylated 的表情 激活mitogen 的蛋白质激酶激酶( MKK ) 3/MKK6 , phospho-p38 MAPK , interleukin ( IL )-1beta, phospho-MAPK 激活蛋白质激酶 2 ( MAPKAPK-2 ), 27 kDa 热吃惊蛋白质( Hsp27 ), procaspase-9 ,-3,和 -7 劈开,和多形核白细胞(自动数据处理核糖)聚合酶( PARP )劈开。在注射以后的七天,染色的 Nissl 被用来在海马趾的 CA1 区域观察词法变化。结果:Abeta1-40 的 Intracerebroventricular 注射在海马趾的织物在 phosphorylated MKK3/MKK6 和 p38 MAPK 表情导致了增加。这些增加,在有提高的 interleukin (IL ) 的联合 -1beta 蛋白质表示和 phospho-Hsp27 表示,调停由 procaspase-9, -3, 和 -7 的劈开和 caspase-3 底层 PARP 劈开估计了的细胞死亡事件的导致 Abeta 的激活。有 SF 的预告的处理(100 mg/kg 和 200 mg/kg 日报, 3 个星期) 显著地阻止的 Abeta1-40-induced 在 phosphorylated MKK3/MKK6 和 p38 MAPK 增加表示。IL-1beta 蛋白质水平的 Abeta1-40-induced 增加被预告的处理与 SF 稀释。另外,在 phosphorylated MAPKAPK2 和 Hsp27 表示的 Abeta1-40-induced 减少被 SF 的管理废除。与这些调查结果同时,在 caspase-9, caspase-7,和 caspase-3 的激活的 Abeta1-40-induced 变化被预告的处理与 SF 禁止。结论:SF 通过 MKK3/MKK6-p38 MAPK 活动和 IL-1beta 表示并且在 phospho-Hsp27 表示的规定上面的抑制阻止 Abeta1-40-induced neurotoxicity。 | Ying JIN Ying FAN En-zhi YAN Zhuo LIU Zhi-hong ZONG Zhi-min QI | 2006 | Acta Pharmacologica Sinica2006，27，10： | 10 |
| 12 | Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing显示文摘Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine(TMP), one of the most widely used medicinal compound isolated from traditional Chinese herb, is usually employed for anti-oxidation, anti-inflammation, anti-platelet aggregation, antilipid, anti-fibrosis, as well as activating blood, removing stasis, dilating small arteries, improving microcirculation and antagonizing calcium. In the present paper, the anti-adhesion effect of TMP were reviewed. TMP was found to play a multi-target and muti-link role in anti-adhesion by inhibiting hyperplasia of collagen and overexpression of adhesion-related factors and reducing the concentration of white blood cells and fibrin in plasma. Because previous studies mostly focused on in vitro experiments and animal experiments, there is an urgent need for clinical research with abundant indicators to further prove its anti-adhesion potency. Future basic research should concentrate on the development of TMP as a biological material. | YAN Shuai YUE Yin-zi ZONG Yang ZENG Li | 2019 | Chinese Journal of Integrative Medicine2019，25，7： | 9 |
| 13 | Biogeographic distribution patterns of algal community in different urban lakes in China: Insights into the dynamics and co-existence显示文摘Urban lake ecosystems are significant for social development,but currently we know little about the geographical distribution of algal community in urban lakes at a large-scale.In this study,we investigated the algal community structure in different areas of urban lakes in China and evaluated the influence of water quality parameters and geographical location on the algal community.The results showed that obvious differences in water quality and algal communities were observed among urban lakes in different geographical areas.Chlorophyta was the dominant phylum,followed by cyanobacteria in all areas.The network analysis indicated that algal community composition in urban lakes of the western and southern area showed more variations than the eastern and northern areas,respectively.Redundancy analysis and structural equation model revealed that nutrients and p H were dominant environmental factors that affected the algal community,and they showed higher influence than that of iron,manganese and COD Mn concentration.Importantly,algal community and density exhibited longitude and latitude relationship.In general,these results provided an ecological insight into large-scale geographical distributions of algal community in urban lakes,thereby having potential applications for management of the lakes. | Haihan Zhang Rongrong Zong Huiyan He Kaiwen Liu Miaomiao Yan Yutian Miao Ben Ma Xin Huang | 2021 | Journal of Environmental Sciences2021，33，2： | 9 |
| 14 | Cadmium Activates Reactive Oxygen Species-dependent AKT/mT OR and Mitochondrial Apoptotic Pathways in Neuronal Cells显示文摘Objective To examine the role of Cd-induced reactive oxygen species(ROS)generation in the apoptosis of neuronal cells.Methods Neuronal cells(primary rat cerebral cortical neurons and PC12 cells)were incubated with or without Cd post-pretreatment with rapamycin(Rap)or N-acetyl-L-cysteine(NAC).Cell viability was determined by MTT assay,apoptosis was examined using flow cytometry and fluorescence microscopy,and the activation of phosphoinositide 3'-kinase/protein kinase B(Akt)/mammalian target of rapamycin(m TOR)and mitochondrial apoptotic pathways were measured by western blotting or immunofluorescence assays.Results Cd-induced activation of Akt/m TOR signaling,including Akt,m TOR,p70 S6 kinase(p70 S6K),and eukaryotic initiation factor 4E binding protein 1(4E-BP1).Rap,an m TOR inhibitor and NAC,a ROS scavenger,blocked Cd-induced activation of Akt/m TOR signaling and apoptosis of neuronal cells.Furthermore,NAC blocked the decrease of B-cell lymphoma 2/Bcl-2 associated X protein(Bcl-2/Bax)ratio,release of cytochrome c,cleavage of caspase-3 and poly(ADP-ribose)polymerase(PARP),and nuclear translocation of apoptosis-inducing factor(AIF)and endonuclease G(Endo G).Conclusion Cd-induced ROS generation activates Akt/m TOR and mitochondrial pathways,leading to apoptosis of neuronal cells.Our findings suggest that m TOR inhibitors or antioxidants have potential for preventing Cd-induced neurodegenerative diseases. | YUAN Yan WANG Yi HU Fei Fei JIANG Chen Yang ZHANG Ya Jing YANG Jin Long ZHAO Shi Wen GU Jian Hong LIU Xue Zhong BIAN Jian Chun LIU Zong Ping | 2016 | Biomedical and Environmental Sciences2016，29，2： | 8 |
| 15 | Evaluation of Vaporized Hydrogen Peroxide Fumigation as a Method for the Bio-decontamination of the High Efficiency Particulate Air Filter Unit显示文摘Objective To evaluate the performance of vaporized hydrogen peroxide (VHP) for the bio-decontamination of the high efficiency particulate air (HEPA) filter unit. Methods Self-made or commercially available bioindicators were placed at designated locations in the HEPA filter unit under VHP fumigation. The spores on coupons were then extracted by 0.5 h submergence in eluent followed by 200-time violent knocks. Results Due to the presence of HEPA filter in the box, spore recovery from coupons placed at the bottom of the filter downstream was significantly higher than that from coupons placed at the other locations. The gap of decontamination efficiency between the top and the bottom of the filter downstream became narrower with the exposure time extended. The decontamination efficiency of the bottom of the filter downstream only improved gently with the injection rate of H2O2 increased and the decontamination efficiency decreased instead when the injection rate exceeded 2.5 g/min. The commercially available bioindicators were competent to indicate the disinfection efficiency of VHP for the HEPA filter unit. Conclusion The HEPA filter unit is more difficult than common enclosure to decontaminate using VHP fumigation. Complete decontamination can be achieved by extending fumigation time. VHP fumigation can be applied for in-situ biodecontamination of the HEPA filter unit as an alternative method to formaldehyde fumigation. | JIA Hai Quan LI Yan Ju SUN Bei ZHAO Si Qing YI Ying ZHAO Ming ZHANG Zong Xing PAN Xin QI Jian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，2： | 8 |
| 16 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 17 | Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7721 cells显示文摘N-acetylglucosaminyltransferase V (GnT-V ) 是重要 tumorigenesis 和联系转移的酶。为了学习它的简历,工作, GnT-V 稳定地压制了房间线(GnT-V-AS/7,721 ) 在以前的学习从 7,721 个 hepatocarcinoma 房间被构造。在这研究, cDNA 数组基因表示侧面在 GnT-V-AS/7,721 之间被比较并且父母 7,721 个房间。数据显示 GnT-V-AS/7,721 显示出与 ER 压力一致的一个典型表达式模式。ER 压力的分子的机制被分析在二展开的蛋白质回答(UPR ) 在关键分子上在 GnT-V-AS/7,721 探索小径。为 ATF6 和 Ire1/XBP-1 小径,它被 BIP 的起来规定在 mRNA 和蛋白质证实 XBP-1 的拼接的形式的水平,和外观。至于 PERK/eIF2alpha 小径,激活嗯 eIF2alpha kinase 津贴被观察。从 GnT-V-AS/7,721 房间证实结果,在 UPR 的关键分子在 7,721 个房间再被检验由特定的 RNAi 处理防碍 GnT-V。结果与从 GnT-V-AS/7721 的那些是类似的,显示那块 GnT-V 能明确地激活嗯在 7,721 个房间的应力。率(3 )H 人加入与率改正了(3 ) 在 GnT-V-AS/7,721 的 H 列伊加入与控制相比极大地是下面调整的,它表明了综合的酶的缺乏的功能在堵住的 GnT-V 以后的 N-glycans。而且,与 underglycosylation 联系的女伴 GRP94 的更快的移居形式,和细胞内部的 glycoproteins 的广泛地改变的 N-glycans 结构是也在 GnT-V-AS/7,721 检测了。这些结果支持了机制损害的那块 GnT-V 表达式女伴和 N-glycan-synthesizing 酶工作,它在 vivo 引起了 UPR。 | Huan Fang Wei Huang Ying Ying Xu Zong Hou Shen Chao Qun Wu Shou Yi Qiao Yan Xu Long Yu Hui Li Chen | 2006 | Cell Research2006，16，1： | 7 |
| 18 | Highly efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by heteropoly acids in water显示文摘Heteropoly,酸高效地在周围的温度在水里与醛催化 anthranilamide 的 cyclocondensation 反应并且负担得起 -quinazolinones 加重在的相应 2,3-dihydro-4 (1H ) 对优秀收益好。这个方法提供温和反应条件和干净反应侧面,用催化剂和一个简单 workup 过程的小数量。 | YingXiao Zong Yan Zhao WenCai Luo Xing Hai Yu Jun Ke Wang Yi Pan | 2010 | Chinese Chemical Letters2010，21，7： | 6 |
| 19 | Early Biomarkers in 1H Nuclear Magnetic Resonance Spectroscopy of Striatal Pathological Mechanisms after Acute Carbon Monoxide Poisoning in Rats显示文摘Objective In vivo Proton Magnetic Resonance Spectroscopy(1H-MRS) can be used to evaluate the levels of specific neurochemical biomarkers of pathological mechanisms in the brain. Methods We conducted T2-Weighted Magnetic Resonance Imaging(MRI) and 1H-MRS with a 3.0-Tesla animal MRI system to investigate the early microstructural and metabolic profiles in vivo in the striatum of rats following carbon monoxide(CO) poisoning. Results Compared to baseline, we found significant cortical surface deformation, cerebral edema changes, which were indicated by the unclear gray/white matter border, and lateral ventricular volume changes in the brain. A significant reduction in the metabolite to total creatine(Cr) ratios of N-acetylaspartate(NAA) was observed as early as 1 h after the last CO administration, while the lactate(Lac) levels increased marginally. Both the Lac/Cr and NAA/Cr ratios leveled off at 6 h and showed no subsequent significant changes. In addition, compared to the control, the choline(Cho)/Cr ratio was slightly reduced in the early stages and significantly increased after 6 h. In addition, a pathological examination revealed mild cerebral edema on cessation of the insult and more severe cerebral injury after additional CO poisoning. Conclusion The present study demonstrated that 1H-MRS of the brain identified early metabolic changes after CO poisoning. Notably, the relationship between the increased Cho/Cr ratio in the striatum and delayed neuropsychologic sequelae requires further research. | GUAN Li LI Zong Yang ZHANG Yan Lin CONG Cui Cui ZHAO Jin Yuan | 2015 | Biomedical and Environmental Sciences2015，28，10： | 6 |
| 20 | Ordered mesoporous tungsten oxide and titanium oxide composites and their photocatalytic degradation behavior | Xiaoxia Yan Xu Zong Gao Qing Lu Lianzhou Wang | 2012 | Progress in Natural Science:Materials International2012，22，6： | 6 |
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