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| 1 | Crustal and upper mantle structure and the deep seismogenic environment in the source regions of the Lushan earthquake and the Wenchuan earthquake显示文摘Following the M w 7.9 Wenchuan earthquake, the M w 6.6 Lushan earthquake is another devastating earthquake that struck the Longmenshan Fault Zone (LFZ) and caused severe damages. In this study, we collected continuous broadband ambient noise seismic data and earthquake event data from Chinese provincial digital seismic network, and then utilized ambient noise tomography method and receiver function method to obtain high resolution shear wave velocity structure, crustal thickness, and Poisson ratio in the earthquake source region and its surroundings. Based on the tomography images and the receiver function results, we further analyzed the deep seismogenic environment of the LFZ and its neighborhood. We reveal three main findings: (1) There is big contrast of the shear wave velocities across the LFZ. (2) Both the Lushan earthquake and the Wenchuan earthquake occurred in the regions where crustal shear wave velocity and crustal thickness change dramatically. The rupture faults and the aftershock zones are also concentrated in the areas where the lateral gradients of crustal seismic wave speed and crustal thickness change significantly, and the focal depths of the earthquakes are concentrated in the transitional depths where shear wave velocities change dramatically from laterally uniform to laterally non-uniform. (3) The Wenchuan earthquake and its aftershocks occurred in low Poisson ratio region, while the Lushan earthquake sequences are located in high Poisson ratio zone. We proposed that the effect of the dramatic lateral variation of shear wave velocity, and the gravity potential energy differences caused by the big contrast in the topography and the crustal thickness across the LFZ may constitute the seismogenic environment for the strong earthquakes in the LFZ, and the Poisson ratio difference between the rocks in the south and north segments of the Longmenshan Fault zone may explain the 5 years delay of the occurrence of the Lushan earthquake than the Wenchuan earthquake. | ZHENG Yong GE Can XIE ZuJun YANG YingJie XIONG Xiong HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 37 |
| 2 | Analysis of DNA methylation variation in wheat genetic background after alien chromatin introduction based on methylation-sensitive amplification polymorphism显示文摘During the process of alien germplasm introduced into wheat genome by chromosome engineering, extensive genetic variations of genome structure and gene expression in recipient could be induced. In this study, we performed GISH (genome in situ hybridization) and AFLP (amplified fragment length po-lymorphism) on wheat-rye chromosome translocation lines and their parents to detect the identity in genomic structure of different translocation lines. The results showed that the genome primary struc-ture variations were not obviously detected in different translocation lines except the same 1RS chromosome translocation. Methylation sensitive amplification polymorphism (MSAP) analyses on genomic DNA showed that the ratios of fully-methylated sites were significantly increased in translo-cation lines (CN12, 20.15%; CN17, 20.91%; CN18, 22.42%), but the ratios of hemimethylated sites were significantly lowered (CN12, 21.41%; CN17, 23.43%; CN18, 22.42%), whereas 16.37% were fully-me-thylated and 25.44% were hemimethylated in case of their wheat parent. Twenty-nine classes of me-thylation patterns were identified in a comparative assay of cytosine methylation patterns between wheat-rye translocation lines and their wheat parent, including 13 hypermethylation patterns (33.74%), 9 demethylation patterns (22.76%) and 7 uncertain patterns (4.07%). In further sequence analysis, the alterations of methylation pattern affected both repetitive DNA sequences, such as retrotransposons and tandem repetitive sequences, and low-copy DNA. | ZHANG Yong LIU ZhaoHui LIU Cheng YANG ZuJun DENG KeJun PENG JinHua ZHOU JianPing LI GuangRong TANG ZongXiang REN ZhengLong | 2008 | Chinese Science Bulletin2008，53，1： | 8 |
| 3 | Zanthoxylum-specific whole genome duplication and recent activity of transposable elements in the highly repetitive paleotetraploid Z.bungeanum genome显示文摘Zanthoxylum bungeanum is an important spice and medicinal plant that is unique for its accumulation of abundant secondary metabolites,which create a characteristic aroma and tingling sensation in the mouth.Owing to the high proportion of repetitive sequences,high heterozygosity,and increased chromosome number of Z.bungeanum,the assembly of its chromosomal pseudomolecules is extremely challenging.Here,we present a genome sequence for Z.bungeanum,with a dramatically expanded size of 4.23 Gb,assembled into 68 chromosomes.This genome is approximately tenfold larger than that of its close relative Citrus sinensis.After the divergence of Zanthoxylum and Citrus,the lineage-specific whole-genome duplication event q-WGD approximately 26.8 million years ago(MYA)and the recent transposable element(TE)burst~6.41 MYA account for the substantial genome expansion in Z.bungeanum.The independent Zanthoxylum-specific WGD event was followed by numerous fusion/fission events that shaped the genomic architecture.Integrative genomic and transcriptomic analyses suggested that prominent speciesspecific gene family expansions and changes in gene expression have shaped the biosynthesis of sanshools,terpenoids,and anthocyanins,which contribute to the special flavor and appearance of Z.bungeanum.In summary,the reference genome provides a valuable model for studying the impact of WGDs with recent TE activity on gene gain and loss and genome reconstruction and provides resources to accelerate Zanthoxylum improvement. | Shijing Feng Zhenshan Liu Jian Cheng Zihe Li Lu Tian Min Liu Tuxi Yang Yulin Liu Yonghong Liu He Dai Zujun Yang Qing Zhang Gang Wang Jisen Zhang Huifeng Jiang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 5 |
| 4 | Development of powdery mildew resistant derivatives of wheat variety Fielder for use in genetic transformation显示文摘Genetic transformation is widely used to improve target traits and to study gene function in wheat.However,transformation efficiency depends on the physiological status of the recipient genotype and that is affected by several factors including powdery mildew(PM)infection.The widely used recipient variety Fielder is very susceptible to PM.Therefore,it would be beneficial to develop PM resistant derivatives with high regeneration ability for use in genetic transformation.In the present study PM resistant lines CB037 and Pm97033 carrying genes Pm21 and PmV,respectively,were backcrossed to Fielder with selection for PM resistance.Five lines,NT89,NT90,NT154,and WT48 with Pm21 and line FL347 with PmV were developed,identified by molecular markers and genomic in situ hybridization(GISH)or fluorescent in situ hybridization(FISH),and further subjected to detailed assessment of agronomic traits and regeneration ability following genetic transformation capacity.Lines FL347,WT48,NT89 and NT154 assessed as being equal to,or superior,to Fielder in regeneration and transformation ability are recommended as suitable materials for the replacement of Fielder for wheat gene transfer and genome editing study. | Xiaona Liang Xiaomin Bie Yuliang Qiu Ke Wang Zujun Yang Yuqi Jia Zhiying Xu Mei Yu Lipu Du Zhishan Lin Xingguo Ye | 2023 | The Crop Journal2023，11，2： | 2 |
| 5 | Comparative FISH and molecular identification of new stripe rust resistant wheat-Thinopyrum intermedium ssp. trichophorum introgression lines显示文摘Thinopyrum intermedium(2 n = 6 x = 42, JJJ^sJ^sStSt) has been hybridized extensively with common wheat and has proven to be a valuable germplasm source for improving disease resistance, quality attributes, and yield potential in wheat. We characterized new disease resistant wheat-Th. intermedium derivatives A1082 and A5-5 using sequential multi-color fluorescence in situ hybridization(mc-FISH), genomic in situ hybridization(GISH), PCRbased landmark unique gene(PLUG) and intron targeting(IT) markers. A1082 was identified as a wheat-Th. intermedium 3J disomic addition line, and A5-5 was a T4BS·5J^sL homozygous Robertsonian translocation line. Seventy-one and 106 pairs of primers amplified Th.intermedium-specific bands allowing chromosomes 3J and 5J^s to be tracked, respectively. A new oligonucleotide probe, Oligo-6 H-2-100, was developed for FISH labeling of the subterminal region of the long arm of chromosome 5J^s. Both lines were highly resistant to stripe rust pathogen races prevalent in Chinese field screening nurseries. A5-5 also displayed a significant increase in tiller number compared to its wheat parent. The new lines can be exploited as useful germplasms for wheat improvement. | Jianbo Li Qiheng Chen Peng Zhang Tao Lang Sami Hoxha Guangrong Li Zujun Yang | 2019 | The Crop Journal2019，7，6： | 2 |
| 6 | Adaptive microclimatic evolution of the dehydrin 6 gene in wild barley at “Evolution Canyon”, Israel显示文摘 | Zujun Yang Tao Zhang Guangrong Li Eviatar Nevo | 2011 | Genetica2011，，11： | 1 |
| 7 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 8 | Development and characterization of a new 1BL-1RS translocation line with resistance to stripe rust and powdery mildew of wheat 显示文摘 | Tianheng Ren Zujun Yang Benju Yan | 2009 | Euphytica2009，169，2： | 1 |
| 9 | Molecular cytogenetic characterization of a new wheat Secale africanum 2R a (2D) substitution line for resistance to stripe rust显示文摘 | MENGPING LEI GUANGRONG LI SUFEN ZHANG CHENG LIU ZUJUN YANG | 2011 | Journal of Genetics2011，，2： | 1 |
| 10 | Inheritance and mapping of powdery mildew resistance gene Pm43 introgressed from Thinopyrum intermedium into wheat显示文摘 | Runli He Zhijian Chang Zujun Yang Zongying Yuan Haixian Zhan Xiaojun Zhang Jianxia Liu | 2009 | Theoretical and Applied Genetics2009，，： | 1 |
| 11 | Investigation on the electronically excited state properties of multiwalled carbon nanotube (MDDA) in solution显示文摘Sub-microsecond time-resolved absorption spectroscopy has been used to study the electronically excited state behavior of soluble multiwalled carbon nanotube (MWNTsCON((CH2)9- CH3)2, denoted as MDDA) in chloroform, toluene and cyclohexane. Following pulsed photo-excitation of MDDA at 355 nm, three major spectral components are clearly identified with the help of global analysis carried out over 7 representative kinetics curves from 450 to 700 nm. The solvent depend-ence of decay associated difference spectra (DADS) and the corresponding lifetimes help to assign these transient species to singlet state (S1), triplet state (T1) and charge-separated state (CS), re-spectively. Preliminary discussion had been made to explore the involved photophysical and electron transfer processes. | FENG Juan YANG Zujun REN Zhenglong | 2006 | Science China Chemistry2006，49，2： | 1 |
| 12 | Outage Performance of Cognitive AF Relay Networks with Imperfect CSI Based on Geometrical Analysis显示文摘This paper studies the outage performance of a cognitive Amplify-and-forward(AF) relay network subject to Rayleigh fading.Under the condition of imperfect Channel state information(CSI) estimations of the links from the secondary system to the Primary user(PU),the closed-form upper and lower bounds of the outage probability are derived through a geometrical analysis method.An asymptotic analysis of the outage probability is also derived in the high Signal-to-noise ratio(SNR)regime to gain additional insights on the system.The simulation results corroborate our theoretical analysis,and the effectiveness of the geometrical analysis method is verified with the conventional approach as a benchmark.The asymptotic results are very tight with the analytical lower bound in the high SNR regime.It also can be observed from the simulation results that the impact of the number of relays as well as the imperfect CSI on the outage probability and the diversity order. | LIU Shuai SUN Dechun LIU Zujun YI Kechu YANG Hong WANG Kan | 2017 | Chinese Journal of Electronics2017，26，5： | 0 |
| 13 | On the Performance of Wireless-Powered Cooperative DF Relaying Networks with Imperfect CSI显示文摘This paper studies several performance metrics of a wireless-powered decode-and-forward(DF) relay network with imperfect channel state information(CSI). In particular, based on the time switching(TS) protocol, the energy-constrained relay harvesting energy from a power beacon(PB), and uses that harvested energy to forward the source information to destination. The closedform expression of the outage probability is firstly derived over Rayleigh fading channels. Then, the asymptotic analysis, throughput as well as the symbol error probability(SEP) are derived based on the expression of the outage probability. Next, both transmission power of the source and the power beacon are optimized through the throughput optimization. Finally, simulations are conducted to corroborate our theoretical analysis, and to reveal the impact of the transmission power of the source and PB as well as the imperfect CSI on the system performance. | Shuai Liu Zujun Liu Dechun Sun Hong Yang Kechu Yi Kan Wang | 2018 | China Communications2018，15，11： | 0 |
| 14 | China's Economic Growth:The“Two-Dimensional Driving Effect”of Data Factors显示文摘Data factors have become one of the five essential production factors,but their role in economic growth has always been ambiguous.Starting from AI technologies,this paper establishes an endogenous growth model of data factors affecting economic growth,constructs the generation path and value path of data factors,and estimates the value of new data factors at the provincial level in China from 1999 to 2018 accordingly.Based on theoretical analyses and empirical tests,it clarifes that data factors have a“two-dimensional driving effect”on China's economic growth,that is,data factors can drive growth both directly through its own economic growth effect and indirectly by promoting technological progress.Furthermore,this paper makes three extended discussions,aiming to make a trial study on the impacts of local government big data transaction platforms on data factors and their growth effects,discuss whether it is possible to reduce the uncertainties of local economic policy based on the nature of data factors,and make a preliminary survey of the output elasticity of data factors between 1999 and 2018. | Yan Yang Li Wang Yujia Li Zujun Liao | 2023 | China Finance and Economic Review2023，12，4： | 0 |
| 15 | Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway显示文摘Lung cancer is the leading cause of cancer-related death in China and worldwide[1].Although the popularization and application of PET-CT have improved the detection rate of patients with early lung cancer,there is still a lack of effective drugs to prevent and treat lung cancer metastasis and prolong the survival of patients[2,3].Circulating tumor cells(CTCs),as seeds of tumor metastasis,play an important role in the metastasis of lung cancer. | Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 16 | Genome sequencing of Sitopsis species provides insights into their contribution to the B subgenome of bread wheat显示文摘Wheat(Triticum aestivum,BBAADD)is an allohexaploid species that originated from two polyploidization events.The progenitors of the A and D subgenomes have been identified as Triticum urartu and Aegilops tauschii,respectively.Current research suggests that Aegilops speltoides is the closest but not the direct ancestor of the B subgenome.However,whether Ae.speltoides has contributed genomically to the wheat B subgenome and which chromosome regions are conserved between Ae.speltoides and the B subgenome remain unclear.Here,we assembled a high-quality reference genome for Ae.speltoides,resequenced 53 accessions from seven species(Aegilops bicornis,Aegilops longissima,Aegilops searsii,Aegilops sharonensis,Ae.speltoides,Aegilops mutica[syn.Amblyopyrum muticum],and Triticumdicoccoides)and revealed their genomic contributions to the wheat B subgenome.Our results showed that centromeric regions were particularly conserved between Aegilops and Triticum and revealed 0.17 Gb of conserved blocks between Ae.speltoides and the B subgenome.We classified five groups of conserved and non-conserved genes between Aegilops and Triticum,revealing their biological characteristics,differentiation in gene expression patterns,and collinear relationships between Ae.speltoides and the wheat B subgenome.We also identified gene families that expanded in Ae.speltoides during its evolution and 789 genes specific to Ae.speltoides.These genes can serve as genetic resources for improvement of adaptability to biotic and abiotic stress.The newly constructed reference genome and large-scale resequencing data for Sitopsis species will provide a valuable genomic resource for wheat genetic improvement and genomic studies. | Yuxin Yang Licao Cui Zefu Lu Guangrong Li Zujun Yang Guangyao Zhao Chuizheng Kong Danping Li Yaoyu Chen Zhencheng Xie Zhongxu Chen Lichao Zhang Chuan Xia Xu Liu Jizeng Jia Xiuying Kong | 2023 | Plant Communications2023，4，4： | 0 |
| 17 | Outage performance of cognitive multisource multidestination relay networks with imperfect channel state information and interference from primary transmitter显示文摘Given imperfect channel state information(CSI)and considering the interference from the primary transmitter,an underlay cognitive multisource multidestination relay network is proposed.A closed-form exact outage probability and asymptotic outage probability are derived for the secondary system of the network.The results show that the outage probability is influenced by the source and destination number,the CSI imperfection as well as the interference from the primary transmitter,while the diversity order is independent of the CSI imperfection and the interference from the primary transmitter,yet it is equal to the minimum of the source and destination number.Moreover,extensive simulations are conducted with different system parameters to verify the theoretical analysis. | 刘帅 Sun Dechun Liu Zujun Yi Kechu Yang Hong Wang Kan | 2019 | High Technology Letters2019，25，4： | 0 |
| 18 | New PCR based markers allowed to identify Secale chromatin in wheat-Secale africanum introgression lines显示文摘The genus of Secale has many agronomically important characters.In order to use the best of this species,markers tracking the rye chromatin incorporated into wheat must be developed.In this study,one rye genome-specific random amplified polymorphic DNA(RAPD)marker was isolated from Secale africanum(Ra genome).Two cloned markers,named OPP13_(1165) and OPP13_(662),were 1165 bp and 662 bp,respectively.Sequence analysis revealed that OPP13_(1165) was highly homologous to a part of a new class of transposon-like gene called the Revolver family,and OPP13_(662) was partially similar to LTR gypsy-like retrotransposon.Fluorescence in situ hybridization(FISH)showed only OPP13_(1165) localized within the whole arms of rye except their terminal regions and no signal was detected on wheat chromosomes,while OPP13_(662) had no hybridization signal detected on wheat and rye genomes.Based on these sequences,two pairs of sequence-characterized amplified region(SCAR)primers were designed,and the resulted SCAR markers were able to target both cultivated and wild Secale species.The FISH patterns and the two SCAR markers should be able to identify and track all wheat-rye translocation lines,especially the S.africanum chromatin. | Juqing JIA Guangrong LI Cheng LIU Jianping ZHOU Zujun YANG | 2010 | Frontiers in Biology2010，5，2： | 0 |
| 19 | Novel expressed sequence tags of an alpine-cold plant species,Gymnadenia conopsea (Orchidaceae)显示文摘Gymnadenia conopsea,an alpine Orchidaceae plant,was one of the widely used Tibetan traditional medicines.In this study,we sequenced total 105 expressed sequence tags (ESTs) from a full-length cDNA expression library constructed by the Oligo-capping technique.The further bioinformatic analyses suggested that the 65 represented unique sequences showed high homology to previously identified genes in other plants:30 sequences matched to other uncharacterized expressed sequence tags (ESTs),and 10 sequences showed no good matches to available sequences in DNA databases.Gene ontology annotation by InterProScan indicated that many of these cDNAs (7 percent) have no known molecular functions and may be unique to G.conopsea.Fifty-five ESTs with matched proteins were involved in a series of diverse functions,in which molecular function such as 'binding' (42.9 percent) and 'catalytic activity' (25.0 percent) were the most frequent functions of the cDNAs.This cDNA library provided a critical basis for further investigation of functional genes expression under cold stress in this alpine species.In addition,13 ESTs-based polymerase chain reaction (PCR) primers were designed and can also be used for genotypic identification and for the genetic diversity analysis of G.conopsea and its closely related species. | JuQing Jia JianPing Zhou Tao Zhang ZhengNan Wen GuangRong Li ZuJun Yang | 2010 | Research in Cold and Arid Regions2010，2，2： | 0 |
| 20 | Haploidentical transplantation has a superior graft-versus-leukemia effect than HLA-matched sibling transplantation for Ph- high-risk B-cell acute lymphoblastic leukemia显示文摘Background: Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) effect for Philadelphia-negative (Ph-) high-risk B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to compare the GVL effect between HID and MSD transplantation for Ph- high-risk B-ALL.Methods: This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Immunosuppressant withdrawal and prophylactic or pre-emptive donor lymphocyte infusion (DLI) were administered in patients without active graft-versus-host disease (GVHD) to prevent relapse. All patients with measurable residual disease (MRD) positivity posttransplantation (post-MRD+) or non-remission (NR) pre-transplantation received prophylactic/pre-emptive interventions. The primary endpoint was the incidence of post-MRD+.Results: A total of 335 patients with Ph- high-risk B-ALL were enrolled, including 145 and 190, respectively, in the HID and MSD groups. The 3-year cumulative incidence of post-MRD+ was 27.2% (95% confidence interval [CI]: 20.2%-34.7%) and 42.6% (35.5%-49.6%) in the HID and MSD groups(P = 0.003), respectively. A total of 156 patients received DLI, including 60 (41.4%) and 96 (50.5%), respectively, in the HID and MSD groups (P= 0.096). The 3-year cumulative incidence of relapse was 18.6% (95% CI: 12.7%-25.4%) and 25.9% (19.9%-32.3%;P = 0.116) in the two groups, respectively. The 3-year overall survival (OS) was 67.4% (95% CI: 59.1%-74.4%) and 61.6% (54.2%-68.1%;P = 0.382), leukemia-free survival (LFS) was 63.4% (95% CI: 55.0%-70.7%) and 58.2% (50.8%-64.9%;P= 0.429), and GVHD-free/relapse-free survival (GRFS) was 51.7% (95% CI: 43.3%-59.5%) and 37.8% (30.9%-44.6%;P= 0.041), respectively, in the HID and MSD groups.Conclusion: HID transplantation has a lower incidence of post-MRD+ than MSD transplantation, suggesting that HID transplantation might have a superior GVL effect than MSD transplantation for Ph- high-risk B-ALL patients.Trial registration: ClinicalTrials.gov: NCT01883180, NCT02673008. | Fan Menglin Wang Yu Lin Ren Lin Tong Huang Fen Fan Zhiping Xu Yajing Yang Ting Xu Na Shi Pengcheng Nie Danian Lin Dongjun Jiang Zujun Wang Shunqing Sun Jing Huang Xiaojun Liu Qifa Xuan Li | 2022 | Chinese Medical Journal2022，，8： | 0 |
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