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| 1 | Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies显示文摘Coronavirus disease 2019(COVID-19),caused by the novel human coronavirus SARS-CoV-2,is currently a major threat to public health worldwide.The viral spike protein binds the host receptor angiotensin-converting enzyme 2(ACE2)via the receptor-binding domain(RBD),and thus is believed to be a major target to block viral entry.Both SARS-CoV-2 and SARS-CoV share this mechanism.Here we functionally analyzed the key amino acid residues located within receptor binding motif of RBD that may interact with human ACE2 and available neutralizing antibodies.The in vivo experiments showed that immunization with either the SARS-CoV RBD or SARS-CoV-2 RBD was able to induce strong clade-specific neutralizing antibodies in mice;however,the cross-neutralizing activity was much weaker,indicating that there are distinct antigenic features in the RBDs of the two viruses.This finding was confirmed with the available neutralizing monoclonal antibodies against SARS-CoV or SARS-CoV-2.It is worth noting that a newly developed SARS-CoV-2 human antibody,HA001,was able to neutralize SARS-CoV-2,but failed to recognize SARS-CoV.Moreover,the potential epitope residues of HA001 were identified as A475 and F486 in the SARS-CoV-2 RBD,representing new binding sites for neutralizing antibodies.Overall,our study has revealed the presence of different key epitopes between SARS-CoV and SARSCoV-2,which indicates the necessity to develop new prophylactic vaccine and antibody drugs for specific control of the COVID-19 pandemic although the available agents obtained from the SARS-CoV study are unneglectable. | Chunyan Yi Xiaoyu Sun Jing Ye Longfei Ding Meiqin Liu Zhuo Yang Xiao Lu Yaguang Zhang Liyang Ma Wangpeng Gu Aidong Qu Jianqing Xu Zhengli Shi Zhiyang Ling Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，6： | 13 |
| 2 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 3 | Animal stem cells: the engineering development front of 2018显示文摘The Engineering Fronts reports are important guidelines for the future development directions of engineering science and technology. The Chinese Academy of Engineering (CAE) has been conducting studies relevant to Engineering Fronts for two years since 2017. | Wenye YUAN Jianxiang XU Chenying LI Lijuan SHI Aidong YANG Yan WANG Lu XING Shaozhong KANG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，1： | 1 |
| 4 | Effect of dis- solved oxygen on nitrogen purification of microbial ecosystem in sediments显示文摘 | RUAN Aidong HE Ruo XU Shengyou | 2009 | Journal of Environmental Science and Health Part A2009，44，4： | 1 |
| 5 | A nuclear localized protein ZCCHC9 is expressed in cerebral cortex and suppresses the MAPK signal pathway显示文摘The CCHC-type zinc finger motif has numerous biological activities (such as DNA binding and RNA binding) and can also mediate protein-protein interaction. This article gives a primary report about the human ZCCHC9 gene. Protein ZCCHC9 contains four CCHC motifs and is highly conserved in humans, mice, and rats. The whole cDNA sequence of the ZCCHC9 gene has been amplified by PCR and a number of plasmids have been constructed for further study. The results show that ZCCHC9 is localized in the nucleus, and especially concentrated in the nucleolus. It is highly expressed in the brain and testicles of the mouse. This has been confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR). In situ hybridization of the mouse brain indicates that ZCCHC9 is mainly expressed in the cerebral cortex. Reporter gene assay shows that ZCCHC9 suppresses the transcription activities of NF-kappa B and SRE, and may play roles in the Mitogen-Activated Protein Kinase (MAPK) signaling transduction pathway. | Aidong Zhou Jianlin Zhou Liping Yang Mingjun Liu Hong Li Su Xu Mei Han Jian Zhang | 2008 | Journal of Genetics and Genomics2008，35，8： | 1 |
| 6 | Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors显示文摘The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the efficiency.This contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs. | Lei Yang Linqing Qin Yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui Lu Aidong Peng Hui Huang | 2019 | Science China Chemistry2019，62，7： | 1 |
| 7 | Clinical characteristics of 78 patients with pulmonary tubercu- losis complicated by chronic pulmonary heart disease and analysis of the clinical character- istics of 显示文摘 | Wang Ting Xu Aidong | 2014 | for Chinese modern pharmaceutical applications2014，13，： | 1 |
| 8 | Cepharanthine, an Alkaloid from Stephania cepharantha Hayata, Inhibits the Inflammatory Response in the RAW264.7 Cell and Mouse Models显示文摘 | Hailong Huang Guixue Hu Chunfeng Wang Hao Xu Xiaoqing Chen Aidong Qian | 2014 | Inflammation2014，，1： | 1 |
| 9 | Haploidentical hematopoietic stem cell transplantation may improve long-term survival for children with high-risk T-cell acute lymphoblastic leukemia in first complete remission显示文摘Background: The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with high-risk (HR) T-cell acute lymphoblastic leukemia (T-ALL) in first complete remission (CR1) is still under evaluation. Moreover, relapse is the main factor affecting survival. This study aimed to explore the effect of allo-HSCT (especially haploidentical HSCT [haplo-HSCT]) on improving survival and reducing relapse for HR childhood T-ALL in CR1 and the prognostic factors of childhood T-ALL in order to identify who could benefit from HSCT.Methods: A total of 74 newly diagnosed pediatric T-ALL patients between January 1, 2012 and June 30, 2018 were enrolled in this retrospective study. Patients were stratified into the low-risk chemotherapy cohort (n = 16), HR chemotherapy cohort (n = 31), and HR transplant cohort (n = 27). Characteristics, survival outcomes, and prognostic factors of all patients were then analyzed.Results: Patient prognosis in the HR chemotherapy cohort was significantly worse than that in the low-risk chemotherapy cohort (5-year overall survival [OS]: 58.5%vs. 100%,P = 0.003;5-year event-free survival [EFS]: 54.1%vs. 83.4%,P = 0.010;5-year cumulative incidence of relapse [CIR]: 45.2%vs. 6.3%,P = 0.011). In HR patients, allo-HSCT improved the 5-year EFS and CIR compared to that of chemotherapy (5-year EFS: 80.1%vs. 54.1%,P = 0.041;5-year CIR: 11.6%vs. 45.2%,P = 0.006). The 5-year OS was higher in the HR transplant cohort than that in the HR chemotherapy cohort (81.0%vs. 58.5%,P = 0.084). Minimal residual disease re-emergence was an independent risk factor for 5-year OS, EFS, and CIR;age ≥10 years was an independent risk factor for OS and EFS;and high white blood cell count was an independent risk factor for EFS and CIR.Conclusion: Allo-HSCT, especially haplo-HSCT, could effectively reduce relapse of children with HR T-ALL in CR1. | Zhang Yongzhan Bai Lu Cheng Yifei Lu Aidong Wang Yu Wu Jun Zhang Xiaohui Zuo Yingxi Xu Lanping Jia Yueping Huang Xiaojun Zhang Leping | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 10 | A hybrid PSO-GDBased Intelligent Method for Machine Diagnosis显示文摘 | Guo Qianjin Yu Haibin Xu Aidong | 2006 | Digital Signal Processing2006，16，4： | 1 |
| 11 | Resistive Switching Properties and Failure Behaviors of(Pt, Cu)/Amorphous ZrO_(2)/Pt Sandwich Structures显示文摘The effect of Pt and Cu electrodes on the resistive switching properties and failure behaviors of amorphous ZrO_2 ?lms were investigated. Compared with Cu/ZrO_2/Pt structures, the Pt/ZrO_2/Pt structures exhibit better resistive switching properties such as the higher resistance ratio of OFF/ON states, the longer switching cycles and narrow distribution of OFF state resistance(Roff). The switching mechanism in the Pt/ZrO_2/Pt structure can be attributed to the formation and rupture of oxygen vacancy ?laments; while in the Cu/Zr O2/Pt structure, there exist both oxygen vacancy ?laments and Cu ?laments. The formation of Cu?laments is related to the redox reaction of Cu electrode under the applied voltage. The inhomogeneous dispersive injection of Cu ions results in the dispersive Roff and signi?cant decrease of operate voltage.Schematic diagrams of the formation of conductive ?laments and the failure mechanism in the Cu/ZrO_2/Pt structures are also proposed. | Haifa Zhai Jizhou Kong Jien Yang Jing Xu Qingran Xu Hongchen Sun Aidong Li Di Wu | 2016 | Journal of Materials Science & Technology2016，32，7： | 0 |
| 12 | To Construct High Level Secure Communication System: CTMI Is Not Enough显示文摘Public key cryptographic(PKC) algorithms, such as the RSA, elliptic curve digital signature algorithm(ECDSA) etc., are widely used in the secure communication systems, such as OpenSSL, and a variety of information security systems. If designer do not securely implement them, the secret key will be easily extracted by side-channel attacks(SCAs) or combinational SCA thus mitigating the security of the entire communication system. Previous countermeasures of PKC implementations focused on the core part of the algorithms and ignored the modular inversion which is widely used in various PKC schemes. Many researchers believe that instead of straightforward implementation, constant time modular inversion(CTMI) is enough to resist the attack of simple power analysis combined with lattice analysis. However, we find that the CTMI security can be reduced to a hidden t-bit multiplier problem. Based on this feature, we firstly obtain Hamming weight of intermediate data through side-channel leakage. Then, we propose a heuristic algorithm to solve the problem by revealing the secret(partial and full) base of CTMI. Comparing previous nec-essary input message for masking filtering, our procedure need not any information about the secret base of the inversion. To our knowledge, this is the first time for evaluating the practical security of CTMI and experimental results show the fact that CTMI is not enough for high-level secure communication systems. | Sen Xu Xiangjun Lu Aidong Chen Haifeng Zhang Haihua Gu Dawu Gu Kaiyu Zhang Zheng Guo Junrong Liu | 2018 | China Communications2018，15，11： | 0 |
| 13 | Preparation and photodetection performance of high crystalline quality and large size β-Ga_(2)O_(3)microwires显示文摘Ultrawide band gap semiconductors are promising solar-blind ultraviolet(UV)photodetector materials due to their suitable bandgap,strong absorption and high sensitivity.Here,β-Ga_(2)O_(3)microwires with high crystal quality and large size were grown by the chemical vapor deposition(CVD)method.The microwires reach up to 1 cm in length and were single crystalline with low defect density.Owing to its high crystal quality,a metal–semiconductor–metal photodetector fabricated from a Ga_(2)O_(3)microwire showed a responsivity of 1.2 A/W at 240 nm with an ultrahigh UV/visible rejection ratio(R_(peak)/R_(400 nm))of 5.8×10^(5),indicating that the device has excellent spectral selectivity.In addition,no obvious persistent photoconductivity was observed in the test.The rise and decay time constants of the device were 0.13 and 0.14 s,respectively.This work not only provides a growth method for high-quality Ga_(2)O_(3)microwires,but also demonstrates the excellent performance of Ga_(2)O_(3)microwires in solar-blind ultraviolet detection. | Yuefei Wang Yurui Han Chong Gao Bingsheng Li Jiangang Ma Haiyang Xu Aidong Shen Yichun Liu | 2023 | Journal of Semiconductors2023，44，6： | 0 |
| 14 | Crystal Structure and Geometry-Optimization Study of N-(2-hydroxy-1-naphthaldene)-4-aminoantipyrine显示文摘N-(2-hydroxy-1-naphthaldene)-4-aminoantipyrine has been synthesized. The structure is determined by X-ray diffraction method and elemental analysis. The crystal system belongs to orthorhombic space group P(2)2(1)2(1). The geometry has been ob- tained from the density functional theory (DFT) method and the B3LYP method employing the 6-31G* basis sets. The calculated results propose that the latter is close to the experimental data. The structural parameters from the theory are close to those of the crystal and the calculated total energy of coordination is ?31677.172 eV. The energy of HOMO and LUMO and the energy gap are 5.179 eV, ?1.603 eV and 3.577 eV, respectively. | GUO Feng BI Caifeng FAN Yuhua WANG Aidong XU Jiakun ZHANG Xia | 2008 | Journal of Ocean University of China2008，7，2： | 0 |
| 15 | On Different Categories of Cybercrime in China显示文摘 | Xu Aidong Gong Yan Wang Yongquan Ai Nayan | 2010 | China Communications2010，7，6： | 0 |
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