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| 1 | Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique显示文摘AIM: To identify the hepatic vascular architecture of patients with hepatitis C virus(HCV) using superb microvascular imaging(SMI) and investigate the use of SMI in the evaluation of liver fibrosis.METHODS: SMI was performed in 100 HCV patients. SMI images were classified into five types according to the vascular pattern, and these patterns were compared with the fibrosis stage. Moreover, the images were analyzed to examine vascularity by integrating the number of SMI signals in the region of interest ROI [number of vascular trees(VT)]. The number of VT, fibrosis stage, serum parameters of liver function, and CD34 expression were investigated.RESULTS: There was a significant difference between SMI distribution pattern and fibrosis stage(P < 0.001). The mean VT values in each of the fibrosis stages were as follows: 26.69 ± 7.08 in F0, 27.72 ± 9.32 in F1, 36.74 ± 9.23 in F2, 37.36 ± 5.32 in F3, and 58.14 ± 14.08 in F4. The VT showed excellent diagnostic ability for F4 [area under the receiver operator characteristic(AUROC): 0.911]. The VT was significantly correlated with the CD34 labeling index(r = 0.617, P < 0.0001).CONCLUSION: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients. | Hidekatsu Kuroda Tamami Abe Keisuke Kakisaka Yudai Fujiwara Yuichi Yoshida Akio Miyasaka Kazuyuki Ishida Hideaki Ishida Tamotsu Sugai Yasuhiro Takikawa | 2016 | World Journal of Gastroenterology2016，22，26： | 12 |
| 2 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 3 | 在早 colorectal 癌症的内视镜的切除术的组织学的评估的重要性显示文摘 The diagnostic criteria for colonic intraepithelial tumors vary from country to country.While intramucosal adenocarcinoma is recognized in Japan,in Western countries adenocarcinoma is diagnosed only if the tumor invades to the submucosa and accesses the muscularis mucosae.However,endoscopic therapy,including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),is used worldwide to treat adenoma and early colorectal cancer.Precise histopathological evaluation is important for the curativeness of these therapies as inappropriate endoscopic therapy causes local recurrence of the tumor that may develop into fatal metastasis.Therefore,colorectal ESD and EMR are not indicated for cancers with massive submucosal invasion.However,diagnosis of cancer with massive submucosal invasion by endoscopy is limited,even when magnifying endoscopy for pit pattern and narrow band imaging and flexible spectral imaging color of enhancement are performed.Therefore,occasional cancers with massive submucosal invasion will be treated by ESD and EMR.Precise histopathological evaluation of these lesions should be performed in order to determine the necessity of additional therapy,including surgical resection. | Naohisa Yoshida Yuji Naito Nobuaki Yagi Akio Yanagisawa | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，2： | 5 |
| 4 | Efficient hemostatic method for endoscopic submucosal dissection of colorectal tumors显示文摘AIM:To evaluate a new hemostatic method using hemostatic forceps to prevent perforation and perioperative hemorrhage during colonic endoscopic submucosal dissection(ESD).METHODS:We studied 250 cases,in which ESD for colorectal tumors was performed at the Kyoto Prefectural University of Medicine or Nara City Hospital between 2005 and 2010.We developed a new hemostatic method using hemostatic forceps in December 2008 for the efficient treatment of submucosal thick vessels.ESD was performed on 126 cases after adoption of the new method(the adopted group)and the new method was performed on 102 of these cases.ESD was performed on 124 cases before the adoption of the new method (the unadopted group).The details of the new method are as follows:firstly,a vessel was coagulated using the hemostatic forceps in the soft coagulation mode according to the standard procedure,and the coagulated vessel was removed using the forceps in the'endocut' mode without perioperative hemorrhage.Secondly,the partial surrounding submucosa was dissected using the forceps in the endocut mode.In the current study,we evaluated the efficacy of this method.RESULTS:Coagulated vessels were successfully removed using the hemostatic forceps in all 102 cases without severe perioperative hemorrhage.Moderate perioperative hemorrhage occurred in five cases(4.9%);however,it was stopped by immediately reuse of the hemostatic forceps.The partial surrounding submucosa was dissected using the forceps in all 102 cases.In the adopted group,the median operation time was 105 min.The proportion of endoscopic en bloc resection was 92.8%(P<0.01)compared to 80.6%in the unadopted group.The postoperative hemorrhage and perforation rates were 2.3%and 2.3%.The rate of perforation was significantly lower than that in the unadopted group (9.6%,P<0.01).We evaluated the ease of use of this method by allowing our three trainees to performed ESD on 46 cases,which were accomplished without any severe hemorrhage.CONCLUSION:The new method effectively treated submucosal thick vessels and shows promise for the prevention of perforation and perioperative hemorrhage in colonic ESD. | Naohisa Yoshida Yuji Naito Munehiro Kugai Ken Inoue Naoki Wakabayashi Nobuaki Yagi Akio Yanagisawa Toshikazu Yoshikawa | 2010 | World Journal of Gastroenterology2010，16，33： | 4 |
| 5 | Image-enhanced endoscopy for diagnosis of colorectal tumors in view of endoscopic treatment显示文摘Recently,image-enhanced endoscopy(IEE) has been used to diagnose gastrointestinal tumors.This method is a change from conventional white-light(WL) endoscopy without dyeing solution,requiring only the push of a button.In IEE,there are many advantages in diagnosis of neoplastic tumors,evaluation of invasion depth for cancerous lesions,and detection of neoplastic lesions.In narrow band imaging(NBI) systems(Olympus Medical Co.,Tokyo,Japan),optical filters that allow narrow-band light to pass at wavelengths of 415 and 540 nm are used.Mucosal surface blood vessels are seen most clearly at 415 nm,which is the wavelength that corresponds to the hemoglobin absorption band,while vessels in the deep layer of the mucosa can be detected at 540 nm.Thus,NBI also can detect pit-like structures named surface pattern.The flexible spectral imaging color enhancement(FICE) system(Fujifilm Medical Co.,Tokyo,Japan) is also an IEE but different to NBI.FICE depends on the use of spectral-estimation technology to reconstruct images at different wavelengths based on WL images.FICE can enhance vascular and surface patterns.The autofluorescence imaging(AFI) video endoscope system(Olympus Medical Co.,Tokyo,Japan) is a new illumination method that uses the difference in intensity of autofluorescence between the normal area and neoplastic lesions.AFI light comprises a blue light for emitting and a green light for hemoglobin absorption.The aim of this review is to highlight the efficacy of IEE for diagnosis of colorectal tumors for endoscopic treatment. | Naohisa Yoshida Nobuaki Yagi Akio Yanagisawa Yuji Naito | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，12： | 3 |
| 6 | Influence of pore volume on laser performance of Nd:YAG ceramics显示文摘 | Ikesue Akio Yoshida Kunio | 1999 | J Mater Sci1999，34，6： | 1 |
| 7 | Influence of pore volume on laser performance of Nd : YAG ceramics 显示文摘 | Akio Ikesue Kunio Yoshida | 1999 | J Mater Sci1999，34，： | 1 |
| 8 | Influence of pore volume on laser performance of Nd : YAG ceramics显示文摘 | Akio Ikesue Kunio Yoshida | 1999 | Journal of Materials Science1999，，6： | 1 |
| 9 | Identification of a novel splice variant of the human anti-apoptopsis gene survivin显示文摘 | Adel Badran Akira Yoshida Keiko Ishikawa Takanori Goi Akio Yamaguchi Takanori Ueda Manabu Inuzuka | 2003 | Biochemical and Biophysical Research Communications2003，，3： | 1 |
| 10 | Production of pyrroloquinoline quinone by using methanol-utilizing bacteria 显示文摘 | Teizi Urakami Yashima Hisao Kobay Ashi Akio Yoshida | 1992 | Applied and Environmental Microbiology1992，58，12： | 1 |
| 11 | The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes显示文摘 | Reiko Kuno Yusuke Yoshida Atsumi Nitta Toshitaka Nabeshima Jinyan Wang Yoshifumi Sonobe Jun Kawanokuchi Hideyuki Takeuchi Tetsuya Mizuno Akio Suzumura | 2006 | Brain Research2006，，： | 1 |
| 12 | Structure-activity relationship in piericidins inhibitors on the electron transport system in mitochondria显示文摘 | Shigeo Yoshida Yuichiro Nagao Akio watanabe | 1980 | Agric Biol Chem1980，44，12： | 1 |
| 13 | Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injection显示文摘 | Akio Sakamoto Shuichi Matsuda Tatsuya Yoshida Yukihide Iwamoto | 2010 | Journal of Orthopaedic Science2010，，： | 1 |
| 14 | Molecular breeding for transgenic rice with low-phytic-acid phenotype through manipulating myo-inositol 3-phosphate synthase gene显示文摘 | Mio Kuwano Akio Ohyama Yusuke Tanaka Tetsuro Mimura Fumio Takaiwa Kaoru T. Yoshida | 2006 | Molecular Breeding2006，，3： | 1 |
| 15 | Plasma ghrelin isoforms and gastric ghrelin O -acyltransferase expression are influenced by Helicobacter pylori status显示文摘 | Takashi Ando Shigeto Mizuno Tsukasa Ishida Yasuyuki Kondo Ikuya Miki Masaru Yoshida Takeshi Azuma Takeshi Ishikawa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa Akihiro Asakawa Akio Inui | 2012 | Nutrition2012，，10： | 1 |
| 16 | Influence of pore volume on laser performance of Nd?:?YAG ceramics显示文摘 | Akio Ikesue Kunio Yoshida | 1999 | Journal of Materials Science1999，，6： | 1 |
| 17 | Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts显示文摘 | Hiroshi Takayanagi Sunhwa Kim Takako Koga Hiroshi Nishina Masashi Isshiki Hiroki Yoshida Akio Saiura Miho Isobe Taeko Yokochi Jun-ichiro Inoue Erwin F. Wagner Tak W. Mak Tatsuhiko Kodama Tadatsugu Taniguchi | 2002 | Developmental Cell2002，，6： | 1 |
| 18 | Influence of pore volume on laser performance of Nd: YAG ceramics显示文摘 | Kunio Yoshida | 1999 | J Mat Sci1999，34，： | 1 |
| 19 | Highly selective methoxycarbonylation of aliphatic diamines with methyl phenyl carbonate to the corresponding methyl N -alkyl dicarbamates显示文摘 | Tsutomu Yoshida Masaaki Sasaki Fumiaki Hirata Yukio Kawamani Koji Inazu Akio Ishikawa Kazuhito Murai Tsuneo Echizen Toshihide Baba | 2005 | Applied Catalysis A, General2005，，2： | 1 |
| 20 | Simultaneous determination of eight β-lactam antibiotics in human serum by liquid chromatography–tandem mass spectrometry显示文摘 | Tomofumi Ohmori Akio Suzuki Takashi Niwa Hiroaki Ushikoshi Kunihiro Shirai Shozo Yoshida Shinji Ogura Yoshinori Itoh | 2011 | Journal of Chromatography B2011，，： | 1 |
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