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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 5 |
| 3 | Comparison of Rate Versus Rhythm Control for Atrial Fibrillation in Patients With Left Ventricular Dysfunction (from the AFFIRM Study)显示文摘 | Ronald S. Freudenberger Alan C. Wilson John B. Kostis | 2007 | The American Journal of Cardiology2007，，2： | 2 |
| 4 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 5 | Model Predictive Control of Multilevel Cascaded H-Bridge Inverters显示文摘 | Patricio Cortés Alan Wilson Samir Kouro | | 0，，08： | 1 |
| 6 | Evaluating the reliability of automated collision notification systems显示文摘 | Mohan R Akella Chaewon Bang Rob Beutner Eric M Delmelle Rajan Batta Alan Blatt Peter A Rogerson Glenn Wilson | 2002 | Accident Analysis and Prevention2002，，3： | 1 |
| 7 | Aquaporin-1 in blood vessels of rat circumventricular organs显示文摘 | Alan J Wilson CJ Carati BJ | 2010 | Cell Tissue Res2010，340，1： | 1 |
| 8 | Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry显示文摘 | Daniel M. Shindler John B. Kostis Salim Yusuf Miguel A. Quinones Bertram Pitt Dawn Stewart Tamara Pinkett Jalal K. Ghali Alan C. Wilson The SOLVD Investigators | 1996 | The American Journal of Cardiology1996，，11： | 1 |
| 9 | National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure显示文摘 | W H. Wilson Tang Gary S. Francis David A. Morrow L Kristin Newby Christopher P. Cannon Robert L. Jesse Alan B. Storrow Robert H. Christenson Robert H. Christenson Fred S. Apple Christopher P. Cannon Gary S. Francis Robert L. Jesse David A. Morrow L Kristi | 2007 | Circulation2007，，5： | 1 |
| 10 | Application of Filter Sharpening to Cascaded Integrator-comb Decimation Filters显示文摘 | Alan Y Kwentus Zhongnong Jiang Alan N Wilson | 1997 | IEEE Transactions on Signal Processing1997，45，2： | 1 |
| 11 | Regional Differences in Quinine Absorption from the Undisturbed Human Colon Assessed Using a Timed Release Delivery System显示文摘 | John M. Hebden Clive G. Wilson Robin C. Spiller Peter J. Gilchrist Elaine Blackshaw Malcolm E. Frier Alan C. Perkins | 1999 | Pharmaceutical Research1999，，7： | 1 |
| 12 | Making sense of the schistosome surface显示文摘 | Skelly PJ Alan Wilson R | 2006 | Adv Parasitol2006，63，： | 1 |
| 13 | Human herpesvirus 8 seroconversion in a population‐based cohort of men in Tobago显示文摘 | Alicia C. McDonald Frank J. Jenkins Clareann H. Bunker John W. Wilson Alan L. Patrick Joel L. Weissfeld | 2015 | J. Med. Virol2015，，： | 1 |
| 14 | Research records andthe resolution of misconduct allegations at research uni-versities显示文摘 | Kenneth Wilson Alan Schreier | 2007 | Accountability in Research2007，，1： | 1 |
| 15 | Point-of-care ultrasound versus radiology department pelvic ultrasound on emergency department length of stay显示文摘BACKGROUND: The study aimed to compare the time to overall length of stay(LOS) for patients who underwent point-of-care ultrasound(POCUS) versus radiology department ultrasound(RDUS).METHODS: This was a prospective study on a convenience sample of patients who required pelvic ultrasound imaging as part of their emergency department(ED) assessment.RESULTS: We enrolled a total of 194 patients who were on average 32 years-old. Ninety-eight(51%) patients were pregnant(<20 weeks). Time to completion of RDUS was 66 minutes longer than POCUS(95%CI 60–73, P<0.01). Patients randomized to the RDUS arm experienced a 120 minute longer ED length of stay(LOS)(95%CI 66–173, P<0.01)CONCLUSION: In patients who require pelvic ultrasound as part of their diagnostic evaluation, POCUS resulted in a signifi cant decrease in time to ultrasound and ED LOS. | Scan P. Wilson Kiah Connolly Shadi Lahham Mohammad Subeh Chanel Fischetti Alan Chiem Ariel Aspen Craig Anderson John C. Fox | 2016 | World Journal of Emergency Medicine2016，7，3： | 1 |
| 16 | Adult and child malaria mortality in India: a nationally representative mortality survey显示文摘 | Neeraj Dhingra Prabhat Jha Vinod P Sharma Alan A Cohen Raju M Jotkar Peter S Rodriguez Diego G Bassani Wilson Suraweera Ramanan Laxminarayan Richard Peto | 2010 | 2010 (9754)2010，，9754： | 1 |
| 17 | Predictive Value of the Index of Microcirculatory Resistance in Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | William F. Fearon Maulik Shah Martin Ng Todd Brinton Andrew Wilson Jennifer A. Tremmel Ingela Schnittger David P. Lee Randall H. Vagelos Peter J. Fitzgerald Paul G. Yock Alan C. Yeung | 2008 | Journal of the American College of Cardiology2008，，5： | 1 |
| 18 | U-Pb and ReOs Geochronologic Evidence for Two Alkalic Porphyry Ore-Forming Events in the Cadia District, New South Wales, Australia显示文摘 | Alan J Wilson David R Cooke HollyJ Stein | 2007 | Economic Geology2007，102，： | 1 |
| 19 | Corporate reputation: seeking a definition显示文摘 | Manto Gotsi Alan M. Wilson | 2001 | Corporate Communications: An International Journal2001，，1： | 1 |
| 20 | The clinical phenotype of two patients with a complete deletion of the iduronate-2-sulphatase gene (mucopolysaccharidosis II — Hunter syndrome)显示文摘 | James E. Wraith Alan Cooper Margaret Thornley Peter J. Wilson Paul V. Nelson C. Phillip Morris John J. Hopwood | 1991 | Human Genetics1991，，2： | 1 |
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