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| 1 | SPIRIT 2013声明:定义临床研究方案的标准条目显示文摘临床研究方案是临床研究设计、实行、报告和评价的基础。然而,临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》(Standard Protocol Items:Recommendations for Interventional Trials 2013 ),简称SPIRIT2013声明,一个临床研究方案必须报告的条目指引的系统建立和范围。 | An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis Peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William S.M.Summerskill Trish Groves Kenneth F.Schulz Harold C.Sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹 郑颂华 吴泰相 李幼平 商洪才 张伯礼 唐旭东 吕爱平 卞兆祥 | 2013 | 中国循证医学杂志2013，13，12： | 23 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish显示文摘Besides obvious benefits,the Three Gorges Dam's construction resulted in new pollution scenarios with the potentials to threaten the Three Gorges Reservoir(TGR) ecosystem.In order to record organic contamination,to find links to ecotoxicological impacts and to serve as reference for ensuing monitoring,several sites in the TGR area were screened applying the triad approach with additional lines-of-evidence as a holistic assessment method.Sediments and the benthic fish species Pelteobagrus vachellii were sampled in 2011 and 2012 to determine organic pollution levels,mutagenic potentials and genotoxic impacts.Two regional hot-spots near the cities of Chongqing and Kaixian were identified and further investigated in 2013.Only polycyclic aromatic hydrocarbons(PAHs) could be detected in sediments in 2011(165–1653 ng/g),emphasizing their roles as key pollutants of the area.Their ubiquity was confirmed at Chongqing(150–433 ng/g) and Kaixian(127–590 ng/g) in2013.Concentrations were comparable to other major Chinese and German rivers.However,the immense sediment influx suggested a deposition of 216–636 kg PAH/day(0.2–0.6 mg PAH/(m2·day)),indicating an ecotoxicological risk.PAH source analysis highlighted primary impacts of combustion sources on the more industrialized upper TGR section,whereas petrogenic sources dominated the mid-low section.Furthermore,sediment extracts from several sites exhibited significant activities of frameshift promutagens in the Ames fluctuation assay.Additionally,significant genotoxic impairments in erythrocytes of P.vachellii were detected(Chongqing/Kaixian),demonstrating the relevance of genotoxicity as animportant mode of action in the TGR's fish.PAHs,their derivatives and non-target compounds are considered as main causative agents. | Tilman Floehr Bj?rn Scholz-Starke Hongxia Xiao Josef Koch Lingling Wu Junli Hou Anja Wolf Axel Bergmann Kerstin Bluhm Xingzhong Yuan Martina Ro?-Nickoll Andreas Sch?ffer Henner Hollert | 2015 | Journal of Environmental Sciences2015，27，12： | 9 |
| 4 | CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis显示文摘 | Simon Greulich Claudia Christina Deluigi Steffen Gloekler Andreas Wahl Christine Zürn Ulrich Kramer Detlev Nothnagel Helmut Bültel Julia Schumm Stefan Grün Peter Ong Anja Wagner Steffen Schneider Kai Nassenstein Meinrad Gawaz Udo Sechtem Oliver Bruder Hei | 2013 | JACC: Cardiovascular Imaging2013，，： | 2 |
| 5 | Lack of Association Between the MEF2A Gene and Myocardial Infarction显示文摘 | Wolfgang Lieb Bj?rn Mayer Inke R. K?nig Iris Borwitzky Anika G?tz Silke Kain Christian Hengstenberg Patrick Linsel-Nitschke Marcus Fischer Angela D?ring H -Erich Wichmann Thomas Meitinger Reinhold Kreutz Andreas Ziegler Heribert Schunkert Jeanette Erdmann | 2008 | Circulation2008，，2： | 1 |
| 6 | An Efficient Algorithm for Parametric WCET Calculation显示文摘 | Stefan B Andreas E Bjrn L | 2011 | Journal of Systems Architecture2011，57，6： | 1 |
| 7 | Local Recurrence After Laparoscopic Radiofrequency Thermal Ablation of Hepatic Tumors显示文摘 | Allan Siperstein MD Adella Garland MD Kristen Engle MD Stanley Rogers MD Eren Berber MD Arash Foroutani MD Andreas String MD Tamara Ryan RN Philip Ituarte PhD MPH | 2000 | Annals of Surgical Oncology2000，，2： | 1 |
| 8 | 下肢截肢术后持续周围神经阻滞的作用:对幻肢综合征症状的影响显示文摘背景达90%的截肢者在肢体截肢术后会产生幻肢综合征(phantom limb syndroms,PLS)。尽管现在有很多不同的治疗方法,但没有一种是显著有效的。因此,我们评估了高浓度的局麻药在外周神经的持续输注对预防PLS的效果。方法在术前或术中给71例行下肢截肢术的患者放置一周围神经导管,通过弹力输注泵(非电子)在术中开始以5ml/h的速率持续输注0.5%罗哌卡因,并且持续到术后的第4—83天。在术后的第1天,第1、2、3、4周和第3、6、9、12月评估PLS。为了评估患者在接受罗哌卡因输注时PLS是否存在及其严重程度,在每次评估前中断6—12小时的给药(即直至肢体感觉的恢复)。幻肢痛和残肢痛的程度由5分级的VRS评分系统来评分,其中0分代表无疼痛,4分代表不能忍受的疼痛,而幻肢的感觉被记录为存在或者不存在。如果VRS评分大干1分或者有显著的幻肢感觉出现,罗哌卡因立即以5ml/h的速率重新开始输注。如果患者的VRS评分持续为0或1分并且无幻肢感觉达48小时,则输注完全停止并移除导管。结果局麻药的持续输注时间的中位数是30天(95%的可信区间,25-30天)。在术后第1天,73%的患者主诉有严重的或者不能忍受的疼痛(VRS评分大于2分)。但是,在12个月的评估期的最后患者“严重到不能忍受”的幻肢痛的发生率仅为3%。在第12个月末,患者VRS疼痛评分的百分比:84%的患者为0分,10%的患者为1分,3%的患者为2分,3%的患者为3分,没有患者为4分。但是,在12个月的评估期的最后仍有39%的患者有幻肢感觉。所有患者都能在家中应用这种弹力输注系统。结论术后予以0.5%的罗哌卡因于神经周的持续输注可能是下肢截肢术后治疗幻肢痛和幻肢感觉的有效方法。 | Battista Borghi, MD Marco D'Addabbo, MD Paul F. White, MD, PhD Pina Gallerani,RN Letizia Toccaceli, ND William Raffaeli, MD Andrea Tognu, MD Nicola Fabbri, MD and Mario Mercuri, MD 毛祖旻(译) 李士通(校) | 2012 | 麻醉与镇痛2012，8，3： | 1 |
| 9 | Endovascular reconstruction of the aortic bifurcation in patients with Leriche syndrome显示文摘 | Hans Krankenberg Michael Schlüter Carsten Schwencke Dirk Walter Andrea Pascotto J?rn Sandstede Thilo Tübler | 2009 | Clinical Research in Cardiology2009，，10： | 1 |
| 10 | Sentinel Lymph Node Biopsy in Colon Cancer: A Prospective Multicenter Trial显示文摘 | Andreas E. Bembenek Robert Rosenberg Elke Wagler Stephan Gretschel Andreas Sendler Joerg-Ruediger Siewert J?rg N?hrig Helmut Witzigmann Johann Hauss Christian Knorr Arno Dimmler J?rn Gr?ne Heinz-Johannes Buhr J?rg Haier Hermann Herbst Juergen Tepel Bence | 2007 | Annals of Surgery2007，，6： | 1 |
| 11 | Cytokine response after percutaneous coronary intervention in stable angina: Effect of selective glycoprotein IIb/IIIa receptor antagonism显示文摘 | Andreas W. Bonz Bj?rn Lengenfelder Martina Jacobs J?rg Strotmann Stefanie Held Georg Ertl Wolfram Voelker | 2003 | American Heart Journal2003，，4： | 1 |
| 12 | Designand run-time re- liability at the electronic system level显示文摘 | Rn S B Andreas B Wolfgang R | 2010 | IPSJ Transac- tions on System LSI Design Methodology2010，3，： | 1 |
| 13 | Downregulation of organic cation transporter 1 (SLC22A1) is associatedwith tumor progression and reduced patient survival in human cholangiocellularcarcinoma显示文摘 | Anja Lautem Michael Heise Andreas Gr?sel Maria Hoppe?Lotichius Nina Weiler Daniel Foltys Johanna Knapstein J?rn Schattenberg Arno Schad Anca Zimmermann Gerd Otto Hauke Lang Peter Galle Marcus Schuchmann Tim Zimmermann | 2013 | International Journal of Oncology2013，，4： | 1 |
| 14 | Sea‐level and ocean‐current control on carbonate‐platform growth, M aldives, I ndian O cean显示文摘 | Christian Betzler J?rn Fürstenau Thomas Lüdmann Christian Hübscher Sebastian Lindhorst Andreas Paul John J. G. Reijmer André W. Droxler | 2012 | Basin Res2012，，： | 1 |
| 15 | Comparison of strictureplasty and endoscopic balloon dilatation for stricturing Crohn’s disease—review of the literature显示文摘 | Andreas G. Wibmer Anton J. Kroesen J?rn Gr?ne Heinz-Johannes Buhr Joerg-Peter Ritz | 2010 | International Journal of Colorectal Disease2010，，10： | 1 |
| 16 | Circadian Blood Pressure Variation in Transgenic Hypertensive Rats显示文摘 | Bj?rn Lemmer Andreas Mattes Manfred B?hm Detlev Ganten | 1993 | Hypertension1993，，1： | 1 |
| 17 | Sentinel Lymph Node Biopsy in Colon Cancer: A Prospective Multicenter Trial显示文摘 | Andreas E. Bembenek Robert Rosenberg Elke Wagler Stephan Gretschel Andreas Sendler Joerg-Ruediger Siewert J?rg N?hrig Helmut Witzigmann Johann Hauss Christian Knorr Arno Dimmler J?rn Gr?ne Heinz-Johannes Buhr J?rg Haier Hermann Herbst Juergen Tepel Bence | 2007 | Annals of Surgery2007，，6： | 1 |
| 18 | Comparison of strictureplasty and endoscopic balloon dilatation for stricturing Crohn’s disease—review of the literature显示文摘 | Andreas G. Wibmer Anton J. Kroesen J?rn Gr?ne Heinz-Johannes Buhr Joerg-Peter Ritz | 2010 | International Journal of Colorectal Disease2010，，10： | 1 |
| 19 | Cue reactivity and its inhibition in pathological computer game players显示文摘 | Robert C. Lorenz Jenny‐Kathinka Krüger Britta Neumann Bj?rn H. Schott Christian Kaufmann Andreas Heinz Torsten Wüstenberg | 2012 | Addiction Biology2012，，： | 1 |
| 20 | Phylogenetic biogeography and taxonomy of disjunctly distributed bryophytes显示文摘More than 200 research papers on the molecular phylogeny and phylogenetic biogeography of bryophytes have been published since the beginning of this millenium.These papers corroborated assumptions of a complex genetic structure of morphologically circumscribed bryophytes,and raised reservations against many morphologically justified species concepts,especially within the mosses.However,many molecular studies allowed for corrections and modifications of morphological classification schemes.Several studies reported that the phylogenetic structure of disjunctly distributed bryophyte species reflects their geographical ranges rather than morphological disparities.Molecular data led to new appraisals of distribution ranges and allowed for the reconstruction of refugia and migration routes.Intercontinental ranges of bryophytes are often caused by dispersal rather than geographical vicariance.Many distribution patterns of disjunct bryophytes are likely formed by processes such as short distance dispersal,rare long distance dispersal events,extinction,recolonization and diversification. | Jochen HEINRICHS Jrn HENTSCHEL Kathrin FELDBERG Andrea BOMBOSCH Harald SCHNEIDER | 2009 | Journal of Systematics and Evolution2009，47，5： | 1 |
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