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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 3 | Suppressing eperythrozoon infection in swine显示文摘 | Anthony H D Kelley D C Nelson D L | 1962 | Vet Med Small Anim Clic1962，57，： | 1 |
| 4 | The pointing calibration of the Haystack antenna显示文摘 | Meeks M L John A B Anthony B H | 1968 | IEEE Transcations on Antenna and Propagation1968，16，6： | 1 |
| 5 | Gastrointestinal Symptoms are More Intense in Morbidly Obese Patients and are Improved with Laparoscopic Roux-en-Y Gastric Bypass显示文摘 | Ronald H Clements MD Quintin H Gonzalez MD Allen Foster MD William O Richards MD James McDowell MD Anthony Bondora MPH Henry L Laws MD | 2003 | Obesity Surgery2003，，4： | 1 |
| 6 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 7 | Ni-Cr-Mo alloy resists corrosive chemicals显示文摘 | HARNER L ANTHONY C H SVERDLIN A | 1999 | Advanced Materials and Processes1999，155，1： | 1 |
| 8 | Epimerization of aldoes by molybdate involving a novel rearrangement of the carbon skeleton显示文摘 | Nicholas J P Anthony S S | 1982 | J Am Chem Soc1982，104，： | 1 |
| 9 | Gadolinium delayed enhancement cardiovascular magnetic resonance correlates with clinical measures of myocardial infarction显示文摘 | W.Patricia Ingkanisorn Kenneth L Rhoads Anthony H Aletras Peter Kellman Andrew E Arai | 2004 | Journal of the American College of Cardiology2004，，12： | 1 |
| 10 | Nanoporosity andExceptional Negative Thermal Expansion in Single-Network Cadmi-um Cyanide 显示文摘 | Anthony E P Andrew L G Gregory J H | 2008 | Angewandte Ckemie2008，120，： | 1 |
| 11 | Hormonal regulation of androgen-binding protein in the rat显示文摘 | Danzo B J Pavlou S N Anthony H L | 1990 | Endocrinology1990，127，6： | 1 |
| 12 | Why Are We Doing This: Clinician Helplessness in the Face of Suf- fering 显示文摘 | Back Anthony L Rushton Cynda H Kaszniak Alfred W Halifax Joan S | 2015 | Journal of Palliative Medicine2015，15，1： | 1 |
| 13 | Activities of enzymes involved in lignification during the postharvest storage of etiolated asparagus spears显示文摘 | Stephane H C H Anthony L Claude H | 1992 | Physiologia Plantarum1992，86，： | 1 |
| 14 | Immune response to secondary immunization with live or inactivated VZV vaccine in elderly adults 显示文摘 | Anthony R H Kim B Myron J L | 1994 | Vir Immun1994，7，： | 1 |
| 15 | Effect of exercise mode on heart rate varialility during steady state exercise显示文摘 | ANTHONY S LEICHT W H SINCLAIR W L | 2008 | Europe journal of applied physiological2008，，102： | 1 |
| 16 | Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity显示文摘 | Jennifer L Dotson Jeffrey S Hyams James Markowitz Neal S LeLeiko David R Mack Jonathan S Evans Marian D Pfefferkorn Anne M Griffiths Anthony R Otley Athos Bousvaros Subra Kugathasan Joel R Rosh David Keljo Ryan S Carvalho Gitit Tomer Petar Mamula Marsha H | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，2： | 1 |
| 17 | Steam hydration of CFBC ash and the effect of hydration conditions on reactivation显示文摘 | Wu Y H Anthony E J Jia L F | 2004 | Fuel2004，83，10： | 1 |
| 18 | The management of post-herpetic neuralgia: If early treatment fails, patients should be referred to pain clinics 显示文摘 | Anthony L C Robert H D | 2000 | BMJ2000，321，7264： | 1 |
| 19 | Contact erosion in automotive DC relays显示文摘 | LEUNG C H ANTHONY L | 1991 | IEEE Transactions on Components Hybrids and Manufacturing Technology1991，14，1： | 1 |
| 20 | Requirements forDuctile-mold Machining Based on Deformation A-nalysis of Mono-crystalline Silicon by MolecularDynamic Simulation显示文摘 | Tanata H Shimada S Anthony L | 2007 | Annals of the CIRP2007，，： | 1 |
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