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| 1 | Incidence and mortality of cervical cancer in China,2013显示文摘Objective: Estimating the incidence and mortality rate of cervical cancer became necessary to establish prevention measures and healthy policies.The aim of this study was to estimate the updated incidence and mortality rate of cervical cancer in 2013 in China.Methods: According to the evaluation criteria developed by the National Central Cancer Registry of China,the data submitted from 255 cancer registries met the required standards in 2013.Cervical cancer cases were retrieved from the national database and combined with the 2013 national population data.The age-standardized incidence and mortality rates were based on the demographic structure of the national census 2000 and Segi's world population.Results: In 2013,the estimated number of new cases and deaths from cervical cancer were 100,700 and 26,400,respectively.The crude incidence of cervical cancer was 15.17/100,000.The age-standardized incidence rates based on the Chinese standard population(ASIRC) and the world standard population(ASIRW) were 11.30/100,000 and10.30/100,000,respectively.The incidence of cervical cancer in urban areas was 15.62/100,000 and the ASIRC was11.12/100,000.The incidence of cervical cancer in rural areas was 14.65/100,000 and the ASIRC was11.47/100,000.The mortality rate of cervical cancer was 3.98/100,000.The age-standardized mortality rates based on the Chinese(ASMRC) and world standard populations(ASMRW) were 2.76/100,000 and 2.62/100,000,respectively.The mortality rate of cervical cancer in urban areas was 3.85/100,000 and in rural areas was4.14/100,000.Cervical cancer incidence and mortality increased with age.Urban areas had a higher incidence of cervical cancer and lower mortality rates when compared with rural areas.Conclusions: Dynamic monitoring of cervical cancer incidence and mortality is the fundamental work of cervical cancer prevention and control.Cervical cancer is a serious issue in women's health,and prevention strategies need to be enhanced,such as human papilloma virus(HPV) vaccination and screening programs. | Bingbing Song Chao Ding Wangyang Chen Huixin Sun Maoxiang Zhang Wanqing Chen | 2017 | Chinese Journal of Cancer Research2017，29，6： | 35 |
| 2 | Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Microbial Metabolite 2-Hydroxybutyric Acid in Obese Mice显示文摘Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic disorders.However,the underlying mechanisms are not well under-stood.Functional metabolomics is increasingly used to investigate systemic effects on the host by iden-tifying metabolites with particular functions.This study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides(APS)by adopting a functional metabolomics strategy.The effects of APS were determined in eight-week high-fat diet(HFD)-fed obese mice.Then,gas chromatography–time-of-flight mass spectrometry(GC–TOFMS)-based untargeted metabolomics was performed for an analysis of serum and liver tissues,and liquid chromatography–tandem mass spectrom-etry(LC–MS/MS)-based targeted metabolomics was performed.The potential functions of the metabo-lites were tested with in vitro and in vivo models of metabolic disorders.Our results first confirmed the metabolic benefits of APS in obese mice.Then,metabolomics analysis revealed that APS supplemen-tation reversed the HFD-induced metabolic changes,and identified 2-hydroxybutyric acid(2-HB)as a potential functional metabolite for APS activity that was significantly decreased by a HFD and reversed by APS.Further study indicated that 2-HB inhibited oleic acid(OA)-induced triglyceride(TG)accumula-tion.It was also found to stimulate the expression of proteins in lipid degradation in hepatocytes and TG lipolysis in 3T3-L1 cells.Moreover,it was found to reduce serum TG and regulate the proteins involved in lipid degradation in high-fat and high-sucrose(HFHS)-fed mice.In conclusion,our study demonstrates that the metabolic benefits of APS are at least partially due to 2-HB generation,which modulated lipid metabolism both in vitro and in vivo.Our results also highlight that functional metabolomics is practical for investigating the mechanism underlying the systemic benefits of plant polysaccharides. | Bingbing Li Ying Hong Yu Gu Shengjie Ye Kaili Hu Jian Yao Kan Ding Aihua Zhao Wei Jia Houkai Li | 2022 | Engineering2022，8，2： | 6 |
| 3 | Drought tolerance evaluation of tobacco plants transformed with different set of genes under laboratory and field conditions显示文摘尽管广泛的研究证明了许多干旱应答的基因授与干旱忍耐到植物,能力在各种各样的自然条件下面由不同基因授与的干旱忍耐的比较很少有报导。我们评估了并且比较 transgenes,干旱应答的基因(AtDREB1B 和 AtCBL1 ) 和根的二个集合的效果调整建筑学的基因(iaaM 和 AtCKX ) ,在在 Nicotiana tabacum 的干旱忍耐上,植物使遭到了到不同条件。根特定的倡导者 PYK10 驾驶的 AtCKX3 的表示(此后指定了为 P10;P10 : AtCKX3 ) , 35S:AtCKX3,或 P10:iaaM 支持了根生长和开发。比作怀有 P10 的植物: 展出的 AtCKX3, 35S:AtCKX3, P10:iaaM,或空向量,那些带的 35S:AtDREB1B, 35S:AtCBL1,或 35S:iaaM 在控制实验室的条件下面增加了干旱忍耐。相反地,在地里,条件,与 35S:AtDREB1 转变的植物, 35S:AtCBL1,或 35S:iaaM 对干旱应力敏感。在地条件下面,干旱应力戏剧性地减少了生长和而它在带 P10 的植物上有小效果,怀有 35S:AtDREB1B, 35S:AtCBL1, 35S:iaaM,或空向量的植物的种子生产: AtCKX3, 35S:AtCKX3,或 P10:iaaM。这研究证明到有环境条件的干旱压力变化的植物忍耐,和我们的结果显示操作控制根建筑学的基因的表示可能为处于自然条件与改进干旱忍耐设计植物是重要的。 | Yuanhua Wang Ruihong Dang Jinxi Li Yu Han Ning Ding Xingliang Li Meiru Jia Ziqiang Li Lingzhi Wei Jinzhu Jiang Yijuan Fan Bingbing Li Wensuo Jia | 2015 | Science Bulletin2015，60，6： | 3 |
| 4 | Databases and Web Tools for Cancer Genomics Study显示文摘Publicly-accessible resources have promoted the advance of scientific discovery. The era of genomics and big data has brought the need for collaboration and data sharing in order to make effective use of this new knowledge. Here, we describe the web resources for cancer genomics research and rate them on the basis of the diversity of cancer types, sample size, omics data comprehensiveness, and user experience. The resources reviewed include data repository and analysis tools; and we hope such introduction will promote the awareness and facilitate the usage of these resources in the cancer research community. | Yadong Yang Xunong Dong Bingbing Xie Nan Ding Juan Chen Yongjun Li Qian Zhang Hongzhu Qu Xiangdong Fang | 2015 | Genomics, Proteomics & Bioinformatics2015，13，1： | 3 |
| 5 | Highly active sites of low spin Fe^(Ⅱ)N_(4)species:The identification and the ORR performance显示文摘Over recent years,catalytic materials of Fe-N-C species have been recognized being active for oxygen reduction reaction(ORR).However,the identification of active site remains challenging as it generally involves a pyrolysis process and mixed components being obtained.Herein Fe_(3)C/C and Fe_(2)N/C samples were synthesized by temperature programmed reduction of Fe precursors in 15%CH_(4)/H_(2)and pure NH_(3),respectively.By acid leaching of Fe_(2)N/C sample,only single sites of FeN_(4)species were presented,providing an ideal model for identification of catalytic functions of the single sites of FeN_(4)in ORR.A correlation was conducted between the concentration of Fe^(Ⅱ)N_(4)in low spin state by Mossbauer spectra and the kinetic current density at 0.8 V in alkaline media,and such a structure-performance correlation assures the catalytic roles of low spin Fe^(Ⅱ)N_(4) species as highly active sites for the ORR. | Huizhu Cai Bingbing Chen Xiao Zhang Yuchen Deng Dequan Xiao Ding Ma Chuan Shi | 2021 | Nano Research2021，14，1： | 2 |
| 6 | Photo-controllable room-temperature phosphorescence of organic photochromic polymers based on hexaarylbiimidazole显示文摘Pure organic room-temperature phosphorescent(RTP)materials have been attracting widespread attention due to the unique properties and broad applications.However,RTP materials with the adjustable photochromic property are still a challenge.Based on this,two polymers containing hexaarylbiimidazole are strategically designed with dual emission of both fluorescence and phosphorescence.Furthermore,both polymers show sensitive photochromic responses from faint yellow to brown upon exposure to ultraviolet light.This study can enrich pure organic luminescent systems and provide new ideas for functional RTP materials. | Yuanhao Li Fan Gu Bingbing Ding Lei Zou Xiang Ma | 2021 | Science China Chemistry2021，64，8： | 2 |
| 7 | Experimental Study on the Improvement of Yaw Stability by Coordination Control between the Caudal Fin and Anal Fin显示文摘Due to the unique locomotion,the head-shaking problem of biomimetic robotic fish inevitably occurs during rectilinear locomotion,which strongly hinders its practical applications.In this paper,we experimentally study this problem by proposing the method of coordination control between the caudal fin and anal fin.First,an untethered biomimetic robotic fish,equipped with an anal fin,a caudal fin and two pectoral fins,is developed as the experimental platform.Second,a Central Pattern Generator(CPG)-based controller is used to coordinate the motions of the anal fin and caudal fin.Third,extensive experiments are conducted to explore different combinations of the flapping frequencies,the flapping amplitudes,and the phase differences between the anal fin and caudal fin.Notably,through proper control of the anal fin,the amplitude of the yaw motion can be as small as 4.32°,which sees a 65%improvement compared to the scenario without anal fin,and a 57%improvement compared to that with a stationary anal fin.This paper provides a novel way to alleviate the head-shaking problem for biomimetic robotic fish,and first test this method on an untethered,freely swimming robotic platform,which can shed light on the development of underwater robotics. | Jiang Ding Changzhen Zheng Chaocheng Song Qiyang Zuo Yaohui Xu Bingbing Dong Jiaxu Cui Kai He Fengran Xie | 2022 | Journal of Bionic Engineering2022，19，5： | 1 |
| 8 | Pillared-layer microporous metal-organic frameworks constructed by robust hydrogen bonds, synthesis, characterization, and magnetic and adsorption properties of 2,2'-biimidazole and carboxylate complexes 显示文摘 | Ding Bingbing Weng Yanqin Mao Zongwan | 2005 | Inorg Chem2005，44，24： | 1 |
| 9 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 10 | pH-Responsive amorphous room-temperature phosphorescence polymer featuring delayed fluorescence based on fluorescein显示文摘Numerous researchers have paid attention to achieve metal-free phosphorescence by exploring new structures or new mechanisms.Herein,a facile way is introduced to endow a common fluorescence dye,tetrabromofluorescein(4 Br-Flu),some fabulous optical characteristics such as dual emission including thermally activated delayed fluorescence,room-temperature phosphorescence(RTP),and the excellent pH-sensitivity.Shortly,4 Br-Flu with good light-emitting properties is composed into the polymer system.The multiple bromine atoms promote the spin-orbit coupling effect and facilitate triplet excitation.Especially,the hydrogen bonding network of the polymer restricts the molecular motion of4 Br-Flu so that the system can emit long-wavelength RTP when 4 Br-Flu is doped into polyvinyl alcohol or co-polymerized with acrylamide.Due to the reversible transformation of protonation and deprotonation,the 4 Br-Flu based polymer responded to acid and alkali like a phosphorescent switch which makes it an excellent hydrogen chloride/ammonia gas leak detector in dry environment. | Guanghui Wang Zifei Wang Bingbing Ding Xiang Ma | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 11 | Achieving room temperature phosphorescence from organic small molecules on amino acid skeleton显示文摘Room temperature phosphorescence(RTP)generated by small molecules has attracted great attention due to their unique potentials for biosensor,bioimaging and security protection.While,the design of RTP materials is extremely challenging for organic small molecules in non-crystalline solid state.Herein,we report a new strategy for achieving non-crystalline organic small molecules with RTP emission by modifying different phosphors onto diphenylalanine or phenylalanine derivatives.Benefiting from the skeletal structure of the amino acid derivatives,there are intermolecular hydrogen bond formation and rigidification effect,thereby minimizing the intermolecular motions and enhancing their RTP performance. | Zifei Wang Teng Li Bingbing Ding Xiang Ma | 2020 | Chinese Chemical Letters2020，31，11： | 0 |
| 12 | Multidimensional regulation of Ti-Zr-Cr-Mn hydrogen storage alloys via Y partial substitution显示文摘High density and safe storage of hydrogen are the preconditions for the large-scale application of hydrogen energy.Herein,the hydrogen storage properties of Ti_(0.6)Zr_(0.4)Cr_(0.6)Mn_(1.4) alloys are systematically studied by introducing Y element instead of Ti element through vacuum arc melting.After the partial substitution of Y,a second phase of rare earth oxide is added in addition to the main suction hydrogen phase,C14 Laves phase.Thanks to the unique properties of rare earth elements,the partial substitution of Y can not only improve the activation properties and plateau pressure of the alloys,but also increase the effective hydrogen storage capacity of the alloys.The comprehensive properties of hydrogen storage alloys are improved by multidimensional regulation of rare earth elements.Among them,Ti_(0.552)Y_(0.048)Zr_(0.4)Cr_(0.6)Mn_(1.4) has the best comprehensive performance.The alloy can absorb hydrogen without activation at room temperature and 5 MPa,with a maximum hydrogen storage capacity of 1.98 wt.%.At the same time,it reduces the stability of the hydride and the enthalpy change value,making it easier to release hydrogen.Through theoretical analysis and first-principle simulation,the results show that the substitution of Y element reduces the migration energy barrier of hydrogen and the structural stability of the system,which is conducive to hydrogen evolution.The alloy has superior durability compared to the original alloy,and the capacity retention rate was 96.79%after 100 hydrogen absorption/desorption cycles. | Haixiang Xiu Wanqiang Liu Dongming Yin Nan Ding Wenfeng Qiao Shaolei Zhao Long Liang Cong Liu Shaohua Wang Qingshuang Wang Bingbing Chen Limin Wang Yong Cheng | 2024 | Nano Research2024，17，5： | 0 |
| 13 | Advances in the Application of Perovskite Materials显示文摘Nowadays, the soar of photovoltaic performance of perovskite solar cells has set off a fever in the study of metal halide perovskite materials. The excellent optoelectronic properties and defect tolerance feature allow metal halide perovskite to be employed in a wide variety of applications. This article provides a holistic review over the current progress and future prospects of metal halide perovskite materials in representative promising applications, including traditional optoelectronic devices(solar cells, light-emitting diodes, photodetectors, lasers), and cutting-edge technologies in terms of neuromorphic devices(artificial synapses and memristors) and pressure-induced emission. This review highlights the fundamentals, the current progress and the remaining challenges for each application, aiming to provide a comprehensive overview of the development status and a navigation of future research for metal halide perovskite materials and devices. | Lixiu Zhang Luyao Mei Kaiyang Wang Yinhua Lv Shuai Zhang Yaxiao Lian Xiaoke Liu Zhiwei Ma Guanjun Xiao Qiang Liu Shuaibo Zhai Shengli Zhang Gengling Liu Ligang Yuan Bingbing Guo Ziming Chen Keyu Wei Aqiang Liu Shizhong Yue Guangda Niu Xiyan Pan Jie Sun Yong Hua Wu‑Qiang Wu Dawei Di Baodan Zhao Jianjun Tian Zhijie Wang Yang Yang Liang Chu Mingjian Yuan Haibo Zeng Hin‑Lap Yip Keyou Yan Wentao Xu Lu Zhu Wenhua Zhang Guichuan Xing Feng Gao Liming Ding | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 14 | Genomic evolution during locoregional recurrence in colorectal cancer determined by whole-exome sequencing: a retrospective observational study显示文摘Objective:The genomic landscapes of metastatic colorectal cancer(mCRC)have been extensively studied;however,the genetic mechanisms underlying the locoregional recurrence(LR)of CRC remain unclear.The objective of our study was to investigate genomic evolution during LR in CRC using high-throughput sequencing.Methods:Twenty-three CRC patients with matched primary and LR tissues were recruited from Nanfang Hospital and Zhejiang Cancer Hospital between January 2011 and December 2018.The last date of follow-up was March 2020.Tissue samples were analyzed by whole-exome sequencing and the genomic profiles were depicted by single nucleotide variation,mutational signature,copy number variation,clonal architecture,and other features.The evolutionary process was speculated with comparison of the genetic variations between primary and LR lesions.The disseminating clusters from primary to LR lesions were identified by variant allele frequency dynamics.Furthermore,the early-recurrent biomarker was explored by comparing the indel signature between early-and late-recurrent patients.The study was approved by the Institutional Review Board of Nanfang Hospital of Southern Medical University(approval No.2020010)on September 11,2020.Results:The results highlighted distinct origins of LR between patients with high microsatellite instability and microsatellite stability.LR lesions evolved independently in patients with high microsatellite instability,while LR lesions were highly clonally related to the primary lesions in patients with microsatellite stability.Late-acquired variations in LR lesions encompassed a wide range of driver genes involved in histone methylation,DNA replication,T cell activation,PDCD1 gain,and LMNA loss.Furthermore,clonal analysis of the disseminating cells identified a dominant polyclonal seeding pattern during LR.The indel signature ID4 was associated with significantly shorter disease-free survival in patients with relapsed CRC according to a public dataset.Conclusion:These findings pose a challenge for the development of new approaches targeting the interactions of multiple clones in the establishment of LR and in terms of optimizing the clinical management of susceptible patients. | Xiaoliang Lan Xiaoxiao Wu Chao Zhang Genxia Wei Bingbing Li Weihao Qiu Danyi Li Huanwen Wu Yanqing Ding Jie Yuan Zaixian Tai Zuoquan Yang Zhiyong Liang Dan Su Li Liang | 2022 | Journal of Bio-X Research2022，5，4： | 0 |
| 15 | On fracture behavior of inner enamel:a numerical study显示文摘The ingenious hierarchical structure of enamel composed of rods and protein produces excellent fracture resistance.However,the fracture resistance mechanism in the inner enamel is unknown.The micromechanical models of enamel are constructed to numerically analyze the mechanical behaviors of the inner enamel with different decussation angles and different decussation planes.The results show that the manner of crack propagation in the inner enamel,including crack bridging,crack deflection,and crack bifurcation,is determined by both the rod decussation angle and the decussation plane.In the case of the strong decussation plane,the fracture strength and the required energy dissipation with the decussation angles of 15°and 30°are much higher than those without decussation,demonstrating that decussation is an important mechanism in improving the fracture resistance of enamel.The maximum tensile stress of enamel with the decussation angle of 15°is slightly higher than that of enamel with the decussation angle of 30°,illustrating that an optimal decussation angle exists which balances the strength and toughness.The synergetic mechanism of the decussation angle and the decussation plane on the crack propagation provides a new design hint for bionic composites. | Siyong LIU Yuanzhi XU Richeng LIAO Ge HE Li DING Bingbing AN Dongsheng ZHANG | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，6： | 0 |
| 16 | Dual-Responsive Thermally Activated Delayed Fluorescence of Spiropyran Derivatives显示文摘For the first time,a series of photochromic dyes SP1-3 with dual-responsive thermally activated delayed fluorescence(TADF)characteristics were reported in this research.Benefitting from the reversible light-responsive property of SP1-3,the eigen TADF of these compounds could be regulated between 588 and 678 nm or turned on/off by different wavelengths of light irradiation in a polyvinylpyrrolidone(PVP)matrix.The emission lifetime of the spiropyran derivative was prolonged to millisecond level for the first time.Moreover,the delayed fluorescence of SP1 and SP3 could also be manipulated by mechanical force because of the mechanochromistic properties of SP1 and SP3.This research is a significant breakthrough for photochromic materials and may broaden its scope. | Liangwei Ma Guanghui Wang Bingbing Ding Xiang Ma | 2022 | CCS Chemistry2022，4，6： | 0 |
| 17 | Effects of forest cover type and ratio changes on runoff and its components显示文摘Changes in forest cover can affect not only the total runoff from a watershed,but also the runoff components(e.g.,surface runoff,interflow,groundwater flow).In this study,based on the WetSpa model simulation method and the recursive digital filtering(RDF)method,the Banchengzi watershed in the mountainous region of Beijing,China,was selected to investigate how changes in forest cover type and cover percentage affect total runoff,surface runoff,interflow,and groundwater flow through scenario settings.Our results show that the difference between the WetSpa model and the RDF method for separating runoff components is small,with only 4.7%and 0.4%difference between the calibration and validation periods.Total runoff in different forest types followed the order shrub forest>coniferous forest>mixed forest>broadleaf forest.Regarding runoff components,the proportions of baseflow(sum of interflow and groundwater flow)to total runoff were 61.1%and 60.8%for broadleaf and mixed forests,which was significantly higher than those of 53.0%and 43.1%for coniferous and shrub forests.However,the proportion of shrub forest baseflow was high in wet years,and that of broadleaf forest baseflow was high in normal and dry years.The proportions of interflow and groundwater flow from various forest cover types to total runoff continued to increase with increasing forest cover rate.Our results have important implications for the implementation of afforestation projects and forest conservation programs,contributing to water resource regulation and ecosystem protection in watersheds. | Bingbing Ding Yonge Zhang Xinxiao Yu Guodong Jia Yousheng Wang Yusong Wang Pengfei Zheng Zedong Li | 2022 | International Soil and Water Conservation Research2022，10，3： | 0 |
| 18 | Effects of BMP-2 Patterns on Bovine Chondrocytes Adhesion and Alignment显示文摘Striped bone morphogenetic protein-2(BMP-2) patterns are created on polystyrene(PS) surfaces by microcontact printing(μCP) to investigate the influences of the protein patterns on bovine chondrocytes behaviors. Due to the excellent ability of BMP-2 to recruit cells and the limited ability of blank PS areas to bind cells, bovine chondrocytes preferentially attach on the protein areas, leading to formation of cell patterns and elongated cell morphologies to some degree. The BMP-2 protein stripe can guide bovine chondrocytes adhesion and alignment. The pattern dimensions can significantly affect the cell adhesion and spread. The protein stripe width mainly controls the cell elongation and orientation while the pattern spacing mainly affects the cell spread towards neighboring stripes. Therefore, the cell morphology and distribution direction can be controlled by precisely designing the pattern shapes and sizes. We believe that the present study could find applications for surface modification of biomaterials' surfaces to create the bioactive patterns to control chondrocytes adhesion, spreading and even cell function. It may be helpful for the development of novel biomaterials for cartilage repair. | 潘长江 ZHANG Bingbing ZHANG Man DONG Yunxiao DING Hongyan | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，5： | 0 |
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