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| 1 | Identification of stably expressed QTL for resistance to black shank disease in tobacco(Nicotiana tabacum L.) line Beinhart 1000-1显示文摘Cigar line Beinhart 1000-1 has effective durable resistance to black shank(BS) and is considered one of the most resistant sources in tobacco(Nicotiana tabacum L.). To investigate the inheritance and identification of stable quantitative trait loci(QTL) for BS response, F2,BC1 F2 individuals and BC1 F2:3 lines were produced from a cross between Beinhart 1000-1 and Xiaohuangjin 1025. Two major quantitative trait loci(M-QTL) named qBS7 and qBS17 were repeatedly detected under different conditions. QTL qBS7 was mapped to the region between PT30174 and PT60621 and explained 17.40%–25.60% of the phenotypic variance under different conditions. The other QTL qBS17 in interval PT61564–PT61538 of linkage group 17 was detected in a BC1 F2 population in the field and in BC1 F2:3 in both the field and at the seedling stage, explaining 6.90% to 11.60% of the phenotypic variance. The results improve our understanding of the inheritance of resistance to BS and provide information that can be used in marker-assisted breeding. | Yusheng Zhang Xuan Guo Xingxing Yan Min Ren Caihong Jiang Yazeng Cheng Liuying Wen Dan Liu Yu Zhang Mingming Sun Quanfu Feng Aiguo Yang Lirui Cheng | 2018 | The Crop Journal2018，6，3： | 4 |
| 2 | SIMULATING THE SUPPLY DISRUPTION FOR THE COORDINATED SUPPLY CHAIN显示文摘在供应链操作系统有许多造成分裂的事故;完成供应链的协作是为供应链研究的主要目的。当造成分裂的事故逐渐地影响了供应链的协调操作时,供应链协作上的存在研究文学在静止环境正在设定。造成分裂的事故怎么影响协调供应链的答案在这篇论文被给。基于供应锁住被否定刺激机制协调的基准,我们由使用随机的变量的二个不同分发函数在被用来表示供应混乱的模拟途径在供应链系统上学习供应混乱的影响。在这二模拟结果之间的比较;在供应混乱下面的可能的协作机制被建议。从供应链风险管理的观点,我们为经理提供灵感。 | Hui YU Caihong SUN Jian CHEN | 2007 | Journal of Systems Science and Systems Engineering2007，16，3： | 4 |
| 3 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 4 | Combined incisional ropivacaine infiltration and pulmonary recruitment manoeuvre for postoperative pain relief after diagnostic hysteroscopy and laparoscopy显示文摘 | Liu Huili Ma Caihong Zhang Xiaoqing Yu Chen Yang Yan Song Xueling Tang Yi Guo Xiangyang | 2014 | Chinese Medical Journal2014，，5： | 3 |
| 5 | Rho-Associated Kinase Inhibitors Promote Microglial Uptake Via the ERK Signaling Pathway显示文摘Microglia are immunocompetent cells in the central nervous system that take up tissue debris and pathogens.Rho-associated kinase(ROCK) has been identified as an important regulator of uptake, proliferation, secretion, and differentiation in a number of cell types. Although ROCK plays critical roles in the microglial secretion of inflammatory factors,migration, and morphology, its effects on microglial uptake activity have not been well characterized. In the present study,we found that treatment of BV2 microglia and primary microglia with the ROCK inhibitors Y27632 and fasudil increased uptake activity and was associated with morphological changes. Furthermore, western blots showed that this increase in uptake activity was mediated through the extracellular-signal-regulated kinase(ERK) signaling cascade, indicating the importance of ROCK in regulating microglial uptake activity. | Peicai Fu Ronghua Tang Zhiyuan Yu Caihong Li Xue Chen Minjie Xie Wei Wang Xiang Luo | 2016 | Neuroscience Bulletin2016，32，1： | 2 |
| 6 | Screwdriver-like Pd-Ag heterostructures formed via selective deposition of Ag on Pd nanowires as efficient photocatalysts for solvent-free aerobic oxidation of toluene显示文摘Heterostructured bimetal nanocrystals with a component having localized surface plasmon resonance(LSPR)property are promising photocatalysts for a series of reactions.In this work,kinetic products of Pd-Ag with a screwdriver-like heterostructure have been successfully fabricated via the selective epitaxial growth of Ag on Pd nanowires(NWs).It was confirmed that the deposition rate(Vdeposition)of Ag is much more sensitive to the temperature,compared to the surface diffusion rate(Vdiffusion)which can be effectively reduced by the binding of poly(vinylpyrrolidone)(PVP)molecules.Then the magnitude of Vdeposition/Vdiffusion has been well tailored for the formation of a kinetic growth environment.The interactions between the components of the as-prepared Pd-Ag heterostructures resulted in intensified LSPR effects.As a result,they gained better photocatalytic performance toward solvent free aerobic oxidation of toluene than Pd NWs,Ag NWs and the mixture of them.Additionally,the Pd-Ag heterostructured nanocrystals exhibited excellent catalytic stability for recycling.This work not only presents an idea for realizing kinetic growth but also supports that LSPR effect is a good tool for improving the photocatalytic activity. | Caihong He Lingli Yu Na Lu Wenjing Wang Wei Chen Shaojie Lu Yun Yang Dekun Ma Shaoming Huang | 2020 | Nano Research2020，13，3： | 2 |
| 7 | Efficacy of chuanxiongdingtong herbal formula granule in the treatment and prophylactic of migraine patients:a randomized,double-blind,multicenter,placebo-controlled trial显示文摘 | Fu Caihong Yu Lihua Zou Yihuai | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，96： | 1 |
| 8 | The experimental exploration of carbon nanofiber and carbon nanotube additives on thermal behavior of phase change materials显示文摘 | Cui Yanbin Liu Caihong Hu Shan Yu Xun | 2011 | Solar Energy Materials&Solar Cells2011，95，： | 1 |
| 9 | Efficacy of chuanxiong Ding Tong herbal formula granule in the treatment and prophylactic of migraine patients:a randomized,Double-Blind,multicenter,Placebo-Controlled trial显示文摘 | FU Caihong YU Lihua ZOU Yihuai | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，96： | 1 |
| 10 | Engineering the viscoelasticity of gelatin methacryloyl(GelMA)hydrogels via small“dynamic bridges”to regulate BMSC behaviors for osteochondral regeneration显示文摘The dynamic extracellular matrix(ECM)constantly affects the behaviors of cells.To mimic the dynamics of ECM with controllable stiffness and energy dissipation,this study proposes a strategy in which a small molecule,3,4-dihydroxybenzaldehyde(DB),was used as fast'dynamic bridges'to construct viscoelastic gelatin methacryloyl(GelMA)-based hydrogels.The storage modulus and loss modulus of hydrogels were independently adjusted by the covalent crosslinking density and by the number of dynamic bonds.The hydrogels exhibited self-healing property,injectability,excellent adhesion and mechanical properties.Moreover,the in vitro results revealed that the viscous dissipation of hydrogels favored the spreading,proliferation,osteogenesis and chondrogenesis of bone marrow mesenchymal stem cells(BMSCs),but suppressed their adipogenesis.RNA-sequencing and immunofluorescence suggested that the viscous dissipation of hydrogels activated Yes-associated protein(YAP)by stabilizing integrinβ1,and further promoted nuclear translocation of smad2/3 andβ-catenin to enhance chondrogenesis and osteogenesis.As a result,the viscoelastic GelMA hydrogels with highest loss modulus showed best effect in cartilage and subchondral bone repair.Taken together,findings from this study reveal an effective strategy to fabricate viscoelastic hydrogels for modulating the interactions between cells and dynamic ECM to promote tissue regeneration. | Changjiang Liu Qifan Yu Zhangqin Yuan Qianping Guo Xiting Liao Feng Han Tao Feng Guoping Liu Runze Zhao Zhuang Zhu Haijiao Mao Caihong Zhu Bin Li | 2023 | Bioactive Materials2023，，7： | 1 |
| 11 | Co-administration of platelet-rich plasma and small intestinal submucosa is more beneficial than their individual use in promoting acute skin wound healing显示文摘Background:Acute skin wounds may compromise the skin barrier,posing a risk of infection.Small intestinal submucosa(SIS)is widely used to treat acute and chronic wounds.However,the efficacy of SIS to accelerate wound healing still needs to be improved to meet clinical demands.To tackle this problem,platelet-rich plasma(PRP)is used due to its potency to promote proliferation,migration and adhesion of target cells.In this study,we applied PRP and SIS to skin wounds to explore their effects on wound healing by evaluating re-epithelialization,collagen production,angiogenesis and the inflammatory response.Methods:A1×1-cm full-thickness skin defectwas established in mice.Sixty mice were divided into four treatment groups:PRP+SIS,PRP,SIS and control.On days 3,5,7,10 and 14 post-surgery,tissue specimens were harvested.Haematoxylin and eosin,Masson’s trichrome,immunohistochemical and immunofluorescence double staining were used to visualize epidermal thickness,collagen and vascular regeneration and inflammation.Results:Wound contraction in the PRP and PRP+SIS groups was significantly greater,compared with the other groups,on days 3 and 5 post-surgery.A histological analysis showed higher collagen expression in the PRP and PRP+SIS groups on day 7,whichwas associated with a thicker epidermal layer on day 14.In addition,immunohistochemical staining showed that CD31-positive blood vessels and vascular endothelial growth factor expression in the PRP+SIS and PRP groups were significantly higher,compared with the control group.Furthermore,immunofluorescence double staining showed that the number of M1 and M2 macrophages in the PRP+SIS and PRP groups was higher,compared with the control and SIS groups alone,on day 3.However,on day 7,the number of M1 macrophages dramatically decreased in the PRP+SIS and PRP groups.The ratio of M2 to M1 macrophages in the PRP+SIS and PRP groups was 3.97 and 2.93 times that of the control group and 4.56 and 3.37 times that of the SIS group,respectively.Conclusion:Co-administration of SIS and PRP has a better effect on promoting angiogenesis,reepithelialization and collagen regeneration in managing acute wound healing than either agent alone. | Xiaoxuan Lei Liuhanghang Cheng Yu Yang Mengru Pang Yunqing Dong Xuanru Zhu Caihong Chen Zexin Yao Gang Wu Biao Cheng Tymour Forouzanfar | 2021 | Burns & Trauma2021，9，1： | 1 |
| 12 | The experimental exploration of carbon nanofiber and carbon nanotube additives on thermal behavior of phase change materials显示文摘 | Yanbin Cui Caihong Liu Shan Hu Xun Yu | 2011 | Solar Energy Materials and Solar Cells2011，，4： | 1 |
| 13 | Optimization on preparation conditions of Rehmannia glutinosa polysaccharide liposome and its immunological activity显示文摘 | Yee Huang Caihong Wu Zhenguang Liu Yuanliang Hu Cheng Shi Yun Yu Xiaojuan Zhao Cui Liu Jiaguo Liu Yi Wu Deyun Wang | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 14 | Genetic Variation Dissection of Rice Blast Resistance Using an Indica Population显示文摘Rice blast disease,caused by fungus pathogen Magnaporthe oryzae,is one of the most destructive diseases that impact rice farming.In the worldwide,rice harvests lose 10%to 30%of the total production because of blast infection,which is estimated to be enough for feeding 60 million people(Skamnioti and Gurr,2009). | ZHANG Mengchen WEI Zhonghua YUAN Xiaoping WANG Caihong WANG Shan NIU Xiaojun XU Xin XU Qun FENG Yue YU Hanyong WANG Yiping ZHU Zhiwei ZHAI Rongrong YANG Yaolong WEI Xinghua | 2020 | Rice science2020，27，4： | 1 |
| 15 | Efficacy of chuanxiong ding tong herbal formula granule in the treatment and prophylactic of migraine patients:A randomized,double-blind,multicenter,placebo-controlled trial显示文摘 | Fu Caihong Yu Lihua Zou Yihuai | | 0，，： | 1 |
| 16 | Persistent luminescence phosphor as in-vivo light source for tumoral cyanobacterial photosynthetic oxygenation and photodynamic therapy显示文摘Tumor oxygenation level has been regarded as an attractive target to elevate the efficiency of photodynamic therapy(PDT).Cyanobacterial photosynthesis-mediated reversal of tumor hypoxia could enable an oxygen-boosted PDT,but is limited by scant penetration depth and efficiency of external light.Herein,aiming at the dual purposes of reducing biological toxicity induced by long-term light irradiation and alleviating hypoxia,we here introduce a novel-designed CaAl2O4:Eu,Nd blue persistent luminescence material(PLM)as the in vivo light source after pre-excited in vitro.The ingenious construction of blue-emitting PLM with“optical battery”characteristics activates cyanobacterial cells and verteporfin simultaneously,which performs the successive oxygen supply and singlet oxygen generation without the long-term external excitation,resulting in the modulated tumor hypoxic microenvironment and enhanced photodynamic tumor proliferation inhibition efficiency.Both in vitro cellular assessment and in vivo tumor evaluation results affirm the advantages of self-produced oxygen PDT system and evidence the notable antineoplastic outcome.This work develops an irradiation-free photosynthetic bacteria-based PDT platform for the optimization of both oxygen production capacity and light utilization efficiency in cancer treatment,which is expected to promote the clinical progress of microbial-based photonic therapy. | Meiqi Chang Wei Feng Li Ding Hongguang Zhang Caihong Dong Yu Chen Jianlin Shi | 2022 | Bioactive Materials2022，7，4： | 0 |
| 17 | Extraction,chemical components,bioactive functions and adulteration identification of walnut oils:A review显示文摘Walnut oil is a functional wood oil known to researchers that may potentially be a large source of Chinese edible oils.There are various extraction methods for walnut oil,including traditional(pressing,solvent-and enzymeassisted extraction)and novel methods(microwave,ultrasound,supercritical CO_(2),subcritical and other extraction technologies).Walnut oil is rich in nutrients,including phytosterols,tocopherols,polyphenols,squalene and minerals.It provides many health benefits,such as antioxidant,antitumor,anti-inflammatory,antidiabetic and lipid metabolism-related functions.In addition,the authentication of walnut oil has received much research attention.The present review provides detailed research on walnut oil extraction,composition,health benefits and adulteration identification methods.The path toward further walnut oil improvement in the context of the market value of walnut oil is also discussed. | Yuan Gao Jia Hu Xia Su Qi Li Caihong Su Yongling Li Gaiqin Ma Siyu Zhang Xiuzhu Yu | 2024 | Grain & Oil Science and Technology2024，7，1： | 0 |
| 18 | A fructose receptor gene influences development and feed intake in Helicoverpa armigera显示文摘Gustatory receptors(GRs)are critical for multiple life activities of insects.Owing to the rapid development of genome and transcriptome sequencing,numerous insect GRs have been identified.However,the expression patterns and functions of these receptors are poorly understood.In this study,we analyzed the expression pattern of GRs in Helicoverpa armigera and found that the fructose receptor HarmGR9 was highly expressed in the foregut and abdomen.The function of HarmGR9 was identified using the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system.Knockout of the HarmGR9 gene shortened the developmental period of the larval stages and increased food consumption in both larvae and adults.This study revealed the tissue distribution of sugar-sense-related receptors in H.armigera and thereby expanded the understanding of insect feeding regulation. | Dong Ai Chenxi Dong Bin Yang Caihong Yu Guirong Wang | 2022 | Insect Science2022，29，4： | 0 |
| 19 | Oxygen-evolving photosynthetic cyanobacteria for 2D bismuthene radiosensitizer-enhanced cancer radiotherapy显示文摘The local hypoxic tumor environment substantially hampers the therapeutic efficiency of radiotherapy, which typically requires the large X-ray doses for tumor treatment but induces the serious side effects. Herein, a bio-mimetic radiosensitized platform based on a natural in-situ oxygen-evolving photosynthetic cyanobacteria combined with two-dimensional (2D) bismuthene with high atomic-number (Z) components, is designed and engineered to effectively modulate the radiotherapy-resistant hypoxic tumor environment and achieve sufficient radiation energy deposition into tumor. Upon the exogenous sequential irradiation of 660 nm laser and X-ray beam, continuous photosynthetic oxygen evolution by the cyanobacteria and considerable generation of reactive oxygen species by the 2D bismuthene radiosensitizer substantially augmented the therapeutic efficacy of radiotherapy and suppressed the in vivo tumor growth, as demonstrated on both LLC-lung tumor xenograft-bearing C57/B6 mice model and 4T1-breast tumor xenograft-bearing Balb/c mice model, further demon-strating the photosynthetic hypoxia-alleviation capability and radiosensitization performance of the engineered biomimetic radiosensitized platform. This work exemplifies a distinct paradigm on the construction of microorganism-enabled tumor-microenvironment modulation and nanoradiosensitizer-augmented radiotherapy for efficient tumor treatment. | Rong Chai Luodan Yu Caihong Dong Yipengchen Yin Sheng Wang Yu Chen Qin Zhang | 2022 | Bioactive Materials2022，7，11： | 0 |
| 20 | RIS-enhanced multi-cell downlink transmission using statistical channel state information显示文摘This paper considers a multi-cell downlink transmission system,where a reconfigurable intelligent surface(RIS)is deployed to support the connectivity of users in blind areas(i.e.,at the cell edges).In order to reduce the instantaneous channel state information(CSI)acquisition overhead at each base station(BS),only statistical CSI is considered at both the BSs and the RIS.Particularly,each BS has only statistical CSI within its own cell.Under these assumptions,we first obtain the approximated ergodic spectral efficiency(SE)for each user.Then,we investigate the BSs beamforming and RIS phase shift joint optimization under different criteria.For the approximated ergodic weighted sum SE maximization criteria,a sub-optimal algorithm is proposed,based on complex circle manifold,to design the RIS phase shift while the statistical maximum ratio transmission beamforming is employed at each BS.To ensure fairness,we adopt the projected subgradient-based algorithm in order to optimize the approximated minimum ergodic user SE.Simulation results demonstrate that the approximated ergodic SE expression matches well with the exact expression,whilst the superiority of the weighted sum SE and fairness performance of the proposed algorithms are verified. | Xiao LI Luoluo JIANG Caihong LUO Yu HAN Michail MATTHAIOU Shi JIN | 2023 | Science China(Information Sciences)2023，66，11： | 0 |
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