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| 1 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2显示文摘Receptor recognition and subsequent membrane fusion are essential for the establishment of successful infection by SARS-CoV-2.Halting these steps can cure COVID-19.Here we have identified and characterized a potent human monoclonal antibody,HB27,that blocks SARS-CoV-2 attachment to its cellular receptor at sub-nM concentrations.Remarkably,HB27 can also prevent SARS-CoV-2 membrane fusion.Consequently,a single dose of HB27 conferred effective protection against SARS-CoV-2 in two established mouse models.Rhesus macaques showed no obvious adverse events when administrated with10 times the effective dose of HB27.Cryo-EM studies on complex of SARS-CoV-2 trimeric S with HB27 Fab reveal that three Fab fragments work synergistically to occlude SARS-CoV-2 from binding to the ACE2 receptor.Binding of the antibody also restrains any further conformational changes of the receptor binding domain,possibly interfering with progression from the prefusion to the postfusion stage.These results suggest that HB27 is a promising candidate for immuno-therapies against COVID-19. | Ling Zhu Yong-Qiang Deng Rong-Rong Zhang Zhen Cui Chun-Yun Sun Chang-Fa Fan Xiaorui Xing Weijin Huang Qi Chen Na-Na Zhang Qing Ye Tian-Shu Cao Nan Wang Lei Wang Lei Cao Huiyu Wang Desheng Kong Juan Ma Chunxia Luo Yanjing Zhang Jianhui Nie Yao Sun Zhe Lv Neil Shaw Qianqian Li Xiao-Feng Li Junjie Hu Liangzhi Xie Zihe Rao Youchun Wang Xiangxi Wang Cheng-Feng Qin | 2021 | National Science Review2021，8，3： | 3 |
| 2 | A fusion–fission hybrid reactor with water-cooled pressure tube blanket for energy production显示文摘 | Hongchun Wu Tiejun Zu Suizheng Qiu Xinli Gao Youqi Zheng Liangzhi Cao Wenxi Tian | 2012 | Progress in Nuclear Energy2012，，： | 1 |
| 3 | Auto MOC—A 2D neutron transport code for arbitrary geometry based on the method of characteristics and customization of AutoCAD显示文摘 | Qichang Chen Hongchun Wu Liangzhi Cao | 2008 | Nuclear Engineering and Design2008，，10： | 1 |
| 4 | An acceleration technique for 2D MOC based on Krylov subspace and domain decomposition methods显示文摘 | Hongbo Zhang Hongchun Wu Liangzhi Cao | 2011 | Annals of Nuclear Energy2011，，12： | 1 |
| 5 | FMSR: A code system for in-core fuel man- agement calculation of aqueous homogeneous so lution reactor显示文摘 | LI Yunzhao WU Hongchun CAO Liangzhi | 2010 | Nuclear Engineering and De- sign2010，240，： | 1 |
| 6 | Auto MOC-A 2D Neutron Transport Code for Arbitrary Geometry Based on the Method of Characteristics and Customization of AutoCAD显示文摘 | Chen Qichang Wu Hongchun Cao Liangzhi | 2008 | Nucl Eng Dis2008，238，10： | 1 |
| 7 | Fuel, core design and subcgannel analysis of a superfast reactor显示文摘 | CAO Liangzhi OKA Y ISHIWATARI Y | 2008 | J Nucl Sci Technol2008，45，2： | 1 |
| 8 | Fuel, core design and subchannel analysis of a super fast reactor显示文摘 | CAO Liangzhi OKA Y ISHIWATARI Y | 2008 | Nuclear Science and Tech nology2008，45，2： | 1 |
| 9 | Three-dimensional core analysis on a super fast reactor with negative local void reactivity 显示文摘 | CAO Liangzhi OKA Y ISHIWATARI Y | 2009 | Nuclear Engineering and Design2009，239，2： | 1 |
| 10 | Fuel, core design and subchannel analysis of a superfast reactor 显示文摘 | CAO Liangzhi OKA Y ISHIWATARI Y | 2008 | J Nucl Sei Technol2008，45，2： | 1 |
| 11 | A new three-dimensional method of character- istics for neutron transport calculation显示文摘 | LIU Zhouyu WU Hongchun CAO Liangzhi | 2011 | An- nals of Nuclear Energy2011，38，： | 1 |
| 12 | A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants显示文摘Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-Co V-2 variants.In this study,we developed a tetravalent COVID-19 vaccine SCTV01E,based on the trimeric Spike protein of SARS-Co V-2 variants Alpha,Beta,Delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant SCT-VA02B.In the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(D614G,Alpha,Beta,and Delta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the D614G booster regimen.Furthermore,SCTV01E vaccination elicited na?ve and central memory T cell responses to SARS-Co V-2 ancestral strain and Omicron spike peptides.Together,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 variants.SCTV01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m RNA vaccines(NCT05323461). | Rui Wang Hongpeng Huang Chulin Yu Chunyun Sun Juan Ma Desheng Kong Yalong Lin Dandan Zhao Shaozheng Zhou Jianbo Lu Sai Cao Yanjing Zhang Chunxia Luo Xuefeng Li Yang Wang Liangzhi Xie | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 13 | Transmission Probability Method for Soving Neutron Transport Equation in Three-Dimensional Triangular-z Geometry 显示文摘 | Liu Guoming Wu Hongchun Cao Liangzhi | 2008 | Nucl Eng Dis2008，238，9： | 1 |
| 14 | Burnup calculations of light water-cooled pressure tube blanket for a fusion-fission hybrid reactor显示文摘 | Tiejun Zu Hongchun Wu Youqi Zheng Liangzhi Cao | 2014 | Fusion Engineering and Design2014，，： | 1 |
| 15 | NAPTH: Neutronics analysis code system for the fusion–fission hybrid reactor with pressure tube type blanket显示文摘 | Tiejun Zu Hongchun Wu Youqi Zheng Liangzhi Cao Chao Yang | 2013 | Fusion Engineering and Design2013，，3： | 1 |
| 16 | Improvements of the subgroup resonance calculation code SUGAR显示文摘 | Lei He Hongchun Wu Liangzhi Cao Yunzhao Li | 2014 | Annals of Nuclear Energy2014，，： | 1 |
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