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| 1 | Efficient genome editing in plants using a CRISPR/Cas system显示文摘 | Zhengyan Feng Botao Zhang Wona Ding Xiaodong Liu Dong-Lei Yang Pengliang Wei Fengqiu Cao Shihua Zhu Feng Zhang Yanfei Mao Jian-Kang Zhu | 2013 | Cell Research2013，23，10： | 211 |
| 2 | Chinese consensus guidelines for diagnosis and management of gastrointestinal stromal tumor显示文摘In order to further promote the standardization of diagnosis and treatment of gastrointestinal stromal tumor(GIST) in China, the members of Chinese Society of Clinical Oncology(CSCO) Expert Committee on GIST thoroughly discussed the key contents of the consensus guidelines, and voted on the controversial issue. In final, the Chinese consensus guidelines for the diagnosis and management of GIST(2017 edition) was formed on the basis of 2013 edition consensus guidelines, which is hereby announced. The consensus included the pathological diagnosis,recurrence risk classification evaluation, targeted agent therapy, surgery and principles of surveillance of GIST. | jian li yingjiang ye jian wang bo zhang shukui qin yingqiang shi yulong he xiaobo liang xiufeng liu ye zhou xin wu xinhua zhang ming wang zhidong gao tianlong lin hui cao lin shen | 2017 | Chinese Journal of Cancer Research2017，29，4： | 104 |
| 3 | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro显示文摘Dear Editor,In December 2019,a novel pneumonia caused by a previously unknown pathogen emerged in Wuhan,a city of 11 million people in central China.The initial cases were linked to exposures in a seafood market in Wuhan.1 As of January 27,2020,the Chinese authorities reported 2835 confirmed cases in China's Mainland,including 81 deaths.Additionally,19 confirmed cases were identified in Hong Kong,Macao and Taiwan,and 39 imported cases were identified in Thailand,Japan,South Korea,United States,Vietnam,Singapore,Nepal,France,Australia and Canada.The pathogen was soon identified as a novel coronavirus(2019-nCoV),which is closely related to sever acute respiratory syndrome CoV(SARS-CoV).2 Currently,there is no specific treatment against the new virus.Therefore,identifying effective antiviral agents to combat the disease is urgently needed. | Manli Wang Ruiyuan Cao Leike Zhang Xinglou Yang Jia Liu Mingyue Xu Zhengli Shi Zhihong Hu Wu Zhong Gengfu Xiao | 2020 | Cell Research2020，30，3： | 563 |
| 4 | Cancer statistics in China and United States,2022:profiles,trends,and determinants显示文摘Background:The cancer burden in the United States of America(USA)has decreased gradually.However,China is experiencing a transition in its cancer profiles,with greater incidence of cancers that were previously more common in the USA.This study compared the latest cancer profiles,trends,and determinants between China and USA.Methods:This was a comparative study using open-source data.Cancer cases and deaths in 2022 were calculated using cancer estimates from GLOBOCAN 2020 and population estimates from the United Nations.Trends in cancer incidence and mortality rates in the USA used data from the Surveillance,Epidemiology,and End Results program and National Center for Health Statistics.Chinese data were obtained from cancer registry reports.Data from the Global Burden of Disease 2019 and a decomposition method were used to express cancer deaths as the product of four determinant factors.Results:In 2022,there will be approximately 4,820,000 and 2,370,000 new cancer cases,and 3,210,000 and 640,000 cancer deaths in China and the USA,respectively.The most common cancers are lung cancer in China and breast cancer in the USA,and lung cancer is the leading cause of cancer death in both.Age-standardized incidence and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently,but rates of liver cancer have increased slightly.Rates of stomach,liver,and esophageal cancer decreased gradually in China,but rates have increased for colorectal cancer in the whole population,prostate cancer in men,and other seven cancer types in women.Increases in adult population size and population aging were major determinants for incremental cancer deaths,and case-fatality rates contributed to reduced cancer deaths in both countries.Conclusions:The decreasing cancer burden in liver,stomach,and esophagus,and increasing burden in lung,colorectum,breast,and prostate,mean that cancer profiles in China and the USA are converging.Population aging is a growing determinant of incremental cancer burden.Progress in cancer prevention and care in the USA,and measures to actively respond to population aging,may help China to reduce the cancer burden. | Changfa Xia Xuesi Dong He Li Maomao Cao Dianqin Sun Siyi He Fan Yang Xinxin Yan Shaoli Zhang Ni Li Wanqing Chen | 2022 | Chinese Medical Journal2022，，5： | 827 |
| 5 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 6 | Investigation on emission factors of particulate matter and gaseous pollutants from crop residue burning显示文摘微粒物质(下午)的排放因素,元素碳( EC ),器官的碳( OC ), SO2 , NOx ,公司, CO2 ,和十个离子(Na+,NH4+,K+,Mg2+,Ca2+, F ?, Cl ?, NO2 ?, NO3 ?, SO42 ?)从在农村中国的通常生产的罪残茬的四种类型的国内烧被估计:稻秸,麦秸,玉米 stover,和棉花越过中国搜索区域,它从代表是镇定的。一个燃烧塔被设计模仿农民在农村中国在下面烧了他们的罪残茬的煮的条件,到措施排放因素。,结果证明那麦秸在四罪残茬之中有最高的排放因素彻底的下午(8.75 g/kg ) 玉米 stover 和麦秸分别地为 EC (0.95 g/kg ) 和 OC (3.46 g/kg ) 有最高的排放因素。玉米 stover 也作为有最高的排放因素介绍没有, NOx,和 CO2,麦秸,稻秸,和棉花梗分别地有 NO2, SO2,和公司的最高的排放因素。水溶性的离子, K+ 和 Cl ? ,从所有庄稼有最高的排放因素。麦秸有阳离子种类和 F 的一个相对更高的排放因素 ? , Cl ? , NO2 吗?比另外的残余。 | CAO Guoliang ZHANG Xiaoye GONG Sunling ZHENG Fangcheng | 2008 | Journal of Environmental Sciences2008，20，1： | 61 |
| 7 | Heavy metals in rice and garden vegetables and their potential health risks to inhabitants in the vicinity of an industrial zone in Jiangsu, China显示文摘Contamination of soil and agricultural products by heavy metals resulting from rapid industrial development has caused major concern. In this study, we investigated heavy metal (Cu, Zn, Pb, Cr, Hg and Cd) concentrations in rice and garden vegetables, as well as in cultivated soils, in a rural-industrial developed region in southern Jiangsu, China, and estimated the potential health risks of metals to the inhabitants via consumption of locally produced rice and garden vegetables. A questionnaire-based survey on dietary consumption rates of foodstuffs showed that rice and vegetables accounted for 64% of total foodstuffs consumed, and over 60% of rice and vegetables were grown in the local region. Average concentrations of Cr, Cu, Zn, Cd, Hg and Pb were 0.75, 2.64, 12.00, 0.014, 0.006 and 0.054 mg/kg dw (dry weight) in rice and were 0.67, 1.18, 4.34, 0.011, 0.002 and 0.058 mg/kg fw (fresh weight) in garden vegetables, respectively. These values were all below the maximum allowable concentration in food in China except for Cr in vegetables. Leafy vegetables had higher metal concentrations than solanaceae vegetables. Average daily intake of Cr, Cu, Zn, Cd, Hg and Pb through the consumption of rice and garden vegetables were 5.66, 16.90, 74.21, 0.10, 0.04 and 0.43 μg/(kg·day), respectively. Although Hazard Quotient values of individual metals were all lower than 1, when all six metal intakes via self-planted rice and garden vegetables were combined, the Hazard Index value was close to 1. Potential health risks from exposure to heavy metals in self-planted rice and garden vegetables need more attention. | Hongbin Cao Jianjiang Chen Jun Zhang Hui Zhang Li Qiao Yi Men | 2010 | Journal of Environmental Sciences2010，22，11： | 61 |
| 8 | Evaluation of the traditional Chinese medicine Shensongyangxin capsule on treating premature ventricular contractions: a randomized, double-blind, controlled multicenter trial显示文摘背景早熟的室的收缩(PVC ) 是治疗为掉进窘境的心律不齐的最普通的类型之一。以前的临床的申请证明繁体中文药 Shensongyangxin (SSYX ) 囊为 PVC 的治疗是有效的。这使随机化的临床的试用试图进一步在对待 PVC.Methods 上评估 SSYX 囊的功效和安全有经常的 PVC 与或没有器官的心疾病和正常心脏的功能的题目在学习被注册。主要端点是在有 SSYX 囊的八星期的药以后的 PVC 数字的变化。包括的第二等的端点与 PVC 和 SSYX 囊的安全评估有关的临床的症状变化。完全, 188 个 PVC 病人随机在非器官的心疾病 PVC 试用被注册并且口头上地拿了 SSYX 囊或类似物(三每天预定, 4 囊一次) 。671 个 PVC 病人的一个总数随机在器官的心疾病 PVC 试用被注册,并且口头上地拿了任何一个 SSYX 囊(三每天预定, 4 囊一次) 或 mexiletine 药片(三每天预定, 150 mg 时间) 。PVC 与 24 小时的 Holter 心电图被监视并且计算。在有 SSYX capsule.Results SSYX 囊的药显著地减少了前后,平淡的血,肝和肾功能被测试 PVC 数字并且在病人减轻了相关症状与或没有器官的心疾病。在非器官的心疾病组, SSYX 囊和安慰剂减少了从 12561.34 猠潣敲?的 PVC ???????鷓???鮰?钱?????????????????颓陎???讂??????鶝???????錄?吗??????疞????鮪鴿?铳?????????????? T ?? | ZOU Jian-gang ZHANG Jian JIA Zhen-hua CAO Ke-jiang | 2011 | Chinese Medical Journal2011，，1： | 70 |
| 9 | Emission inventories of primary particles and pollutant gases for China显示文摘Detailed high-resolution emission inventories of primary particles(PM2.5,BC and OC) and pollutant gases(SO2,NOx,NH3,CO and VOCs) for China in 2007 were constructed on the basis of the latest fuel consumption data,mostly at the county level,and from socio-economic statistics and data on fossil and biomass fuels obtained from government agencies.New emission factors reflecting local features were also used.The calculated emissions were 13.212 Mt PM2.5,1.4 Mt BC,2.946 Mt OC,31.584 Mt SO2,23.248 Mt NOx,16.017 Mt NH3,164.856 Mt CO and 35.464 Mt VOCs.The national and regional emissions were gridded with 0.5°× 0.5° resolution for use in air quality models.Larger emissions were found in eastern and central China than in western China.The emissions estimated here are roughly equal to those obtained in previous studies,but with different contributions from because of seasonal changes in residential heating and biomass combustion.Finally,uncertainties in inventories were analyzed. | CAO GuoLiang ZHANG XiaoYe GONG SunLing AN XinQin WANG YaQiang | 2011 | Chinese Science Bulletin2011，56，8： | 64 |
| 10 | A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus显示文摘AIM:To determine the therapeutic effect of lamivudine in late pregnancy for the interruption of motherto-child transmission(MTCT) of hepatitis B virus(HBV).METHODS:Studies were identified by searching available databases up to January 2011.Inclusive criteria were HBV-carrier mothers who had been involved in randomized controlled clinical trials(RCTs) with lamivudine treatment in late pregnancy,and newborns or infants whose serum hepatitis B surface antigen(HBsAg),hepatitis B e antigen(HBeAg) or HBV DNA had been documented.The relative risks(RRs) for interruption of MTCT as indicated by HBsAg,HBV DNA or HBeAg of newborns or infants were calculated with 95% confidence interval(CI) to estimate the efficacy of lamivudine treatment.RESULTS:Fifteen RCTs including 1693 HBV-carrier mothers were included in this meta-analysis.The overall RR was 0.43(95% CI,0.25-0.76;8 RCTs;Pheterogeneity = 0.04) and 0.33(95% CI,0.23-0.47;6 RCTs;Pheterogeneity = 0.93) indicated by newborn HBsAg or HBV DNA.The RR was 0.33(95% CI,0.21-0.50;6 RCTs;Pheterogeneity = 0.46) and 0.32(95% CI,0.20-0.50;4 RCTs;Pheterogeneity = 0.33) indicated by serum HBsAg or HBV DNA of infants 6-12 mo after birth.The RR(lamivudine vs hepatitis B immunoglobulin) was 0.27(95% CI,0.16-0.46;5 RCTs;Pheterogeneity = 0.94) and 0.24(95% CI,0.07-0.79;3 RCTs;P heterogeneity = 0.60) indicated by newborn HBsAg or HBV DNA,respectively.In the mothers with viral load < 106 copies/mL after lamivudine treatment,the efficacy(RR,95% CI) was 0.33,0.21-0.53(5 RCTs;Pheterogeneity = 0.82) for the interruption of MTCT,however,this value was not significant if maternal viral load was > 106 copies/mL after lamivudine treatment(P = 0.45,2 RCTs),as indicated by newborn serum HBsAg.The RR(lamivudine initiated from 28 wk of gestation vs control) was 0.34(95% CI,0.22-0.52;7 RCTs;Pheterogeneity = 0.92) and 0.33(95% CI,0.22-0.50;5 RCTs;Pheterogeneity = 0.86) indicated by newborn HBsAg or HBV DNA.The incidence of adverse effects of lamivudine was not higher in the mothers than in controls(P = 0.97).Only one study reported side effects of lamivudine in newborns.CONCLUSION:Lamivudine treatment in HBV carriermothers from 28 wk of gestation may interrupt MTCT of HBV efficiently.Lamivudine is safe and more efficient than hepatitis B immunoglobulin in interrupting MTCT.HBV MTCT might be interrupted efficiently if maternal viral load is reduced to < 106 copies/mL by lamivudine treatment. | Lei Han Hong-Wei Zhang Jia-Xin Xie Qi Zhang Hong-Yang Wang Guang- Wen Cao | 2011 | World Journal of Gastroenterology2011，17，38： | 61 |
| 11 | Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway显示文摘绝经后的骨质疏松症严重地使受危险人的健康。没有副作用,寻找治疗学的药必要性大。我们的学习被设计调查是否 resveratrol, SIRT1 的收缩筋,能在骨质疏松症上并且到有有利效果探索内在的机制。老鼠骨质疏松症模型(卵巢切除术组, OVX ) 被双边的卵巢切除术建立。resveratrol 的三不同剂量被使用:5 mg/kg/d (低剂量,物件 LD ), 25 mg/kg/d (开媒介,物件 MD ), 和 45 mg/kg/d (开高度,物件 HD ) 。结果显示出那物件 LD 没在 OVX 改变上显示出任何重要效果,当时物件 MD 和物件 HD 显著地提高了骨质疏松症导致的减少的骨头矿物质密度(物件 MD 0.205 吗? | Jing Feng Shuai Liu Sai Ma Jian Zhao Wei Zhang Wei Qi Pengchong Cao Zheng Wang Wei Lei | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 70 |
| 12 | WRKY transcription factors in plant responses to stresses显示文摘The WRKY gene family is among the largest families of transcription factors(TFs) in higher plants.By regulating the plant hormone signal transduction pathway,these TFs play critical roles in some plant processes in response to biotic and abiotic stress.Various bodies of research have demonstrated the important biological functions of WRKY TFs in plant response to different kinds of biotic and abiotic stresses and working mechanisms.However,very little summarization has been done to review their research progress.Not just important TFs function in plant response to biotic and abiotic stresses,WRKY also participates in carbohydrate synthesis,senescence,development,and secondary metabolites synthesis.WRKY proteins can bind to W-box(TGACC(A/T)) in the promoter of its target genes and activate or repress the expression of downstream genes to regulate their stress response.Moreover,WRKY proteins can interact with other TFs to regulate plant defensive responses.In the present review,we focus on the structural characteristics of WRKY TFs and the research progress on their functions in plant responses to a variety of stresses. | Jingjing Jiang Shenghui Ma Nenghui Ye Ming Jiang Jiashu Cao Jianhua Zhang | 2017 | Journal of Integrative Plant Biology2017，59，2： | 75 |
| 13 | Soluble triggering receptor expressed on myeloid cell-1 (sTREM- 1): a potential biomarker for the diagnosis of infectious diseases显示文摘为传染疾病的诊断和预后的敏感、有用的 biomarkers 广泛地被开发了。这些 biomarkers 的一个例子正在触发在 myeloid cell-1 (TREM-1 ) 上表示的受体,它是在单核白血球 / 巨噬细胞和 neutrophils 上表示的房间表面受体。TREM-1 由激活 TREM-1/DAP12 小径放大发炎。这条小径被细菌的 lipopolysaccharide 被和 ligands 或刺激的 TREM-1 的相互作用触发。因而,支持 inflammatory cytokines 和 chemokines 被分泌。可溶的 TREM-1 (sTREM-1 ) 是能直接为传染疾病在人的身体液体和著名 biomarker 被测试的 TREM-1 的一种特殊形式。 sTREM-1 水平能潜在地为早诊断和一些传染疾病的预后预言被使用,包括传染肋膜的流出,肺感染,败血,细菌的脑膜炎,病毒的感染(例如,克里米亚半岛的刚果出血性的发烧和登革热发烧),真菌的感染(例如,曲霉属菌感染),并且灼伤相关的感染。sTREM-1 比传统的索引是更敏感、特定的 biomarker,例如 C 反应的蛋白质和 procalcitonin 层次,为这些传染疾病。因此, sTREM-1 是为指向的治疗和传染疾病的快速、早的诊断的可行 biomarker。 | Changlin Cao Jingxian Gu Jingyao Zhang | 2017 | Frontiers of Medicine2017，11，2： | 62 |
| 14 | Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma显示文摘Primary liver cancer is an important cause of cancer death,and hepatocellular carcinoma(HCC) accounts for 70%-85% of total liver cancer worldwide.Chronic hepatitis B virus(HBV) infection contributes to > 75% of HCC cases.High serum viral load is the most reliable indicator of viral replication in predicting development of HCC.HBV genotype C is closely associated with HCC in cirrhotic patients aged > 50 years,whereas genotype B is associated with development of HCC in non-cirrhotic young patients and postoperative relapse of HCC.Different HBV subgenotypes have distinct patterns of mutations,which are clearly associated with increased risk of HCC.Mutations accumulate during chronic HBV infection and predict occurrence of HCC.Chronic inflammation leads to increased frequency of viral mutation via cellular cytidine deaminase induction.Mutations are negatively selected by host immunity,whereas some immuno-escaped HBV mutants are active in hepatocarcinogenesis.Inflammatory pathways contribute to the inflammation-necrosis-regeneration process,ultimately HCC.Their hallmark molecules can predict malignancy in HBV-infected subjects.Continuing inflammation is involved in hepatocarcinogenesis and closely related to recurrence and metastasis.HBV load,genotype C,viral mutations and expression of inflammatory molecules in HBV-related HCC tissues are significantly associated with poor prognosis.Imbalance between intratumoral CD8+ T cells and regulatory T cells or Th1 and Th2 cytokines in peritumoral tissues can predict prognosis of HBV-related HCC.These factors are important for developing active prevention and surveillance of HBV-infected subjects who are more likely to develop HCC,or for tailoring suitable treatment to improve survival or postpone postoperative recurrence of HCC. | Yi-Fang Han Jun Zhao Li-Ye Ma Jian-Hua Yin Wen-Jun Chang Hong-Wei Zhang Guang-Wen Cao | 2011 | World Journal of Gastroenterology2011，17，38： | 54 |
| 15 | Evolution of planetary boundary layer under different weather conditions,and its impact on aerosol concentrations显示文摘一个领域实验在天津被进行,从 2010 年 9 月 930 日的中国,在表面空气污染物质上集中了于行星的边界层(PBL ) 和它的影响的进化。实验使用了三台遥感仪器,风侧面雷达( WPR ),微波辐射计( MWR )和微脉搏的激光雷达( MPL ),到检测风,温度,和喷雾器 backscattering 系数并且到的垂直侧面测量表面污染物质的垂直侧面(喷雾器,公司, SO2 , NOx ),并且也从 255-m 收集了声音的风速表数据气象学的塔。把大小基于这些, PBL 的进化被估计。平均 PBL 高度在夜间期间在 noon/afternoon-time,和 200300 m 期间是大约 10001300 m。PBL 高度和喷雾器集中是相关反的在期间清楚并且薄雾条件。当平均喷雾器集中分别地是在薄雾和晴朗天空条件下面的 52 和 17 g/m3 时,平均最大的 PBL 高度是 1.08 和 1.70 km。太阳的放射上的喷雾器和云的影响基于从 255-m 收集的声音的风速表数据被观察气象学的塔。当 PBL 的镇压结构进一步削弱了污染物质的散开时,热流动被发现被薄雾(重污染) 或云显著地减少了,它趋于压抑 PBL 的发展,导致重污染。这个可能的积极反馈周期(更多的喷雾器降低 PBL 高度更多的喷雾器) 将在大城市为重地面污染导致一个加速过程。 | Jiannong Quan Yang Gao Qiang Zhang Xuexi Tie Junji Cao Suqin Han Junwang Meng Pengfei Chen Delong Zhao | 2013 | Particuology2013，11，1： | 51 |
| 16 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 17 | Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients显示文摘AIM:To evaluate the performance of a novel non-invasive controlled attenuation parameter(CAP)to assess liver steatosis.METHODS:This was a multi-center prospective cohort study.Consecutive patients(aged≥18 years)who had undergone percutaneous liver biopsy and CAP measurement were recruited from three Chinese liver centers.Steatosis was categorized as S0:<5%;S1:5%-33%;S2:34%-66%;or S3:≥67%,according to the nonalcoholic fatty liver disease(NAFLD)activity score.The FibroScan?502 equipped with the M probe(Echosens,Paris,France)was used to capture both CAP and liver stiffness measurement values simultaneously.Receiver operating characteristic curves were plotted,and the areas under the curves were calculated to determine the diagnostic efficacy.The accuracy of the CAP values at the optimal thresholds was defined by maximizing the sum of sensitivity and specificity(maximum Youden index).RESULTS:A total of 152 patients were recruited,including 52(34.2%)patients with NAFLD and 100(65.8%)with chronic hepatitis B(CHB)virus infection.After adjustment,the steatosis grade(OR=37.12;95%CI:21.63-52.60,P<0.001)and body mass index(BMI,OR=6.20;95%CI:2.92-9.48,P<0.001)were found independently associated with CAP by multivariate linear regression analysis.CAP was not influenced by inflammation,fibrosis or aetiology.The median CAP values and interquartile ranges among patients with S0,S1,S2 and S3 steatosis were 211(181-240)dB/m,270(253-305)dB/m,330(302-360)dB/m,and 346(313-363)dB/m,respectively.The cut-offs for the CAP values in all patients with steatosis≥5%,≥34%and≥67%were 253 dB/m,285 dB/m and 310 dB/m,respectively.The areas under the curves were 0.92,0.92and 0.88 for steatosis≥5%,≥34%and≥67%,respectively.No significant differences were found in the CAP values between the NAFLD group and the CHB group in each steatosis grade.CONCLUSION:CAP appears to be a promising tool for the non-invasive detection and quantification of hepatic steatosis,but is limited by BMI. | Feng Shen Rui-Dan Zheng Yu-Qiang Mi Xiao-Ying Wang Qin Pan Guang-Yu Chen Hai-Xia Cao Ming-Li Chen Liang Xu Jian-Neng Chen Yi Cao Rui-Nan Zhang Lei-Ming Xu Jian-Gao Fan | 2014 | World Journal of Gastroenterology2014，20，16： | 55 |
| 18 | Oxidative stress and DNA damages induced by cadmium accumulation显示文摘试验性的证据证明然而,镉( Cd )能在动物房间导致氧化压力 andthen 原因 DNA 损坏如此的效果是否在植物存在,是 stillunclear.In 现在的学习, Vicia faba 植物为 4 d toinvestigate 暴露于 5 和 10 mg/L Cd 在植物的 Cd 的分发,在 leaves.Cd 的房间类脂化合物, antioxidativeenzymes 和 DNA 损坏上的金属效果在叶子和提高的 concen 在类脂化合物 peroxidation 的 plants.An enhancedlevel 在 Cd | LIN Ai-jun ZHANG Xu-hong CHEN Mei-mei CAO Qing | 2007 | Journal of Environmental Sciences2007，19，5： | 47 |
| 19 | Phytoplankton community structure and environmental parameters in aquaculture areas of Daya Bay,South China Sea显示文摘Environmental characteristics and phytoplankton community structure were investigated in two aquaculture areas in Dapeng Cove of Daya Bay,South China Sea,between April 2005 and June 2006.Phytoplankton abundance ranged between 5.0 and 8877.5 cells/mL,with an average of 751.8 cells/mL.The seasonal cycle of phytoplankton were demonstrated by frequent oscillations,with recurrent high abundances from late spring to autumn and a peak stage in late winter.Diatoms were the predominant phytoplankton group,accounting for 93.21%of the total abundance.The next most abundant group was the dinoflagellates,which made up only 1.24%of total abundance. High concentrations of Alexandrium tamarense(Lebour) Balech with a maximum of 603.0 cells/mL were firstly recorded in this area known for high rates of paralytic shellfish poisoning(PSP) contamination.Temperatures and salinities were within the suitable values for the growth of phytoplankton,and were important in phytoplankton seasonal fluctuations.The operation of the Daya Bay Nuclear Power Station(DNPS) exerts influences on the phytoplankton community and resulted in the high abundances of toxic dinoflagellate species during the winter months.Dissolved inorganic nitrogen(DIN) and dissolved silicate(DSi) were suffcient,and rarely limited for the growth of phytoplankton.Dissolved inorganic phosphorus(DIP) was the most necessary element for phytoplankton growth. The enriched environments accelerated the growth of small diatoms,and made for the shift in predominant species from large diatom Rhizosolenia spp.to chain-forming diatoms such as Skeletonema costatum,Pseudo-nitzschia spp.and Thalassiosira subtilis. | WANG Zhaohui ZHAO Jiangang ZHANG Yujuan CAO Yu | 2009 | Journal of Environmental Sciences2009，21，9： | 44 |
| 20 | Variations between rice cultivars in iron and manganese plaque on roots and the relation with plant cadmium uptake显示文摘To understand certain mechanisms causing variations between rice cultivars with regard to cadmium uptake and tolerance,pot soil experiments were conducted with two rice cultivars of different genotypes under different soil Cd levels.The relationships between plant Cd uptake and iron/manganese(Fe/Mn) plaque formation on roots were investigated.The results showed that rice cultivars di?ered markedly in Cd uptake and tolerance.Under soil Cd treatments,Cd concentrations and accumulations in the cultivar Shanyou 63(the genotype indica) were significantly higher than those in the cultivar Wuyunjing 7(the genotype japonica)(P < 0.01,or P < 0.05),and Shanyou 63 was more sensitive to Cd toxicity than Wuyunjing 7.The differences between the rice cultivars were the largest at relatively low soil Cd level(i.e.,10 mg/kg).Fe concentrations in dithionite-citrate-bicarbonate root extracts of Shanyou 63 were generally lower than that of Wuyunjing 7,and the difference was the most significant under the treatment of 10 mg Cd/kg soil.The results indicated that the formation of iron plaque on rice roots could act as a barrier to soil Cd toxicity,and may be a 'buffer' or a 'reservoir' which could reduce Cd uptake into rice roots.And the plaque may contribute,to some extent,to the genotypic differences of rice cultivars in Cd uptake and tolerance. | Jianguo Liu Changxun Cao Minghung Wong Zhijun Zhang Yuhong Chai | 2010 | Journal of Environmental Sciences2010，22，7： | 43 |
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