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| 1 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 2 | Preparation,structural characterization of a novel egg-shell palladium sulfide catalyst and its application in selective reductive alkylation reaction显示文摘有核心和钯硫化物的膜被 sulphidizing Pd/C 与 H2S 作为表面准备了的钯金属的新奇卵壳 PdS 催化剂。这催化剂是有效的让 p 氨基的二苯胺(PADPA ) 和 methylisobutyl 酉同类(MIBK ) 的减少的完化负担得起 N-(1,3-dimethylbutyl ) 有直到 99.42% 的变换和到 97.46% 的选择的 -N-phenyl-p-phenylenedianine (DBPPD ) 。与另外的普通的钯硫化物催化剂作比较,表面上的硫化物和钯金属的核心在更低的硫协作在新催化剂的表面上引起 Pd 的钯的膜,它改进它的活动。我们的结果显示这新卵壳 PdS/C 是有效加氢催化剂。 | Qun Feng Zhang Jia Chun Wu Chang Su Feng Feng Qiao Ling Ding Zhao Lian Yuan Hong Wang Lei Ma Chun Shan Lu Xiao Nian Li | 2012 | Chinese Chemical Letters2012，23，10： | 5 |
| 3 | 5-氟尿嘧啶和卡培他滨对中国患者的心脏毒性:一项前瞻性研究显示文摘背景与目的已有许多研究报道5-氟尿嘧啶(5-Fluorouracil,5-FU)和卡培他滨相关的心脏毒性,严重程度从无症状心电图(electrocardiography,ECG)异常到严重心肌梗塞而不同。目前为止,对中国恶性肿瘤患者的这种心脏毒性尚无研究。本研究旨在前瞻性地对多个中心招募的癌症患者进行5-FU和卡培他滨相关心脏毒性的发生率和临床表现进行评估。方法在完成研究的527例患者中,196例接受基于5-FU的化疗,331例接受基于卡培他滨的化疗并以其为一线或辅助治疗。在治疗期间和长达28 d的随访期间对所发生的不良反应进行记录。疗效测量指标包括心电图、心肌酶、心肌肌钙蛋白、脑钠肽和超声心动图。使用单因素分析和logistic回归方法进行亚组分析和鉴定与两种药物的心脏毒性相关的显著性独立变量。结果 527例患者中有161例(30.6%)出现心脏毒性。卡培他滨组的心脏毒性发生率为33.8%(112/331),显著高于5-FU组25%(49/196)的发生率(P=0.0042)。110/527患者(20.9%)发生心律失常,105/527(19.9%)发生缺血性改变,而只有20/527患者(3.8%)出现心力衰竭,6/527患者(1.1%)出现心肌梗塞。既往的心脏病、高血压、卡培他滨为基础的化疗和治疗时间被确定为与心脏毒性相关的显著风险因素。优势比分别为15.7(心脏病史vs.无病史)、1.86(卡培他滨vs. 5-FU)、1.06(5–8个化疗周期vs. 1–4个化疗周期)和1.58(高血压vs.无高血压)。结论氟嘧啶类药物在中国人群中引起的心脏毒性可能在临床实践中被低估。建议密切监测患者,尤其是对心脏毒性高风险的患者。可能的风险因素包括治疗持续时间、基于卡培他滨的化疗、既往心脏病史和高血压史。 | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | 癌症2018，37，10： | 3 |
| 4 | Study on the response of wheat to lead, cadmium and zinc显示文摘Studyontheresponseofwheattolead,cadmiumandzincMengLing,TanDeyong,WangHuanxiao,DuanChangqun,DuanPeishang,GaoShangyiDepar... | Meng Ling *, Tan De yong, Wang Huan xiao, Duan Chang qun, Duan Pei shang, Gao Shang yi Department of Biology, Yunnan University, Kunming 650091,China | 1998 | Journal of Environmental Sciences1998，10，2： | 2 |
| 5 | Comparison of Clinical Characteristics and Outcomes of Pediatric and Adult Patients with Coronavirus Disease 2019 in Shenzhen,China显示文摘Objective Here we aimed to investigate the difference in clinical characteristics and outcomes between pediatric and adult patients with COVID-19.Methods A total of 333 consecutive patients with laboratory-confirmed SARS-CoV-2 infection treated in the departments of Internal medicine of Shenzhen Third People’s Hospital from January 11 th to February 10 th,2020 were included.The data were obtained from electronic medical records.The epidemiological data,clinical characteristics,length of hospital stays,and outcomes of pediatric and adult patients were compared.Results Compared with adult patients,pediatric patients had a shorter time of symptom onset to hospitalization than adults[median time,1(IQR,1.0-1.0)d vs.3(IQR,2.0-6.0)d,P<0.001],milder or fewer symptoms,less severe chest CT findings.The clinical severity classification of children was less severe than adults.Up to 15 th March,the end of the follow-up,33(100%)children and 292(97.3%)adult patients had been discharged from hospital.Only 2(0.7%)adult patients died,with an overall case mortality of 0.6%.The median length of hospital stay of pediatric patients was shorter than that of adult patients[19(95%CI:16.6-21.4)d vs.21(95%CI:19.9-22.1)d,P=0.024].Conclusion Pediatric patients with COVID-19 had milder or less clinical symptoms,less evident pulmonary imaging changes,better prognosis,and shorter length of hospital stay. | WANG Fang LAI Chang Xiang HUANG Peng Yu LIU Jia Ming WANG Xian Feng TANG Qi Yuan ZHOU Xuan XIAN Wen Jie CHEN Rui Kun LI Xuan LI Zhi Yu LIAO Li Qun HE Qing LIU Lei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 2 |
| 6 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
| 7 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | The Lancet2013，，9887： | 1 |
| 8 | Source localization using a sparse representation framework to achieve superresolution显示文摘 | Xiansheng Guo Qun Wan Chunqi Chang Edmund Y. Lam | 2010 | Multidimensional Systems and Signal Processing2010，，4： | 1 |
| 9 | Three-Dimension ISAR Imaging Based on Antenna Array显示文摘 | MA Chang zheng YEO Tat-soon ZHANG Qun | 2008 | IEEE Trans on Geoscience and Remote Sensing2008，45，2： | 1 |
| 10 | 1-(2-Formamidoethyl)-3-phenylurea functionalized activated carbon for selective solid-phase extraction and preconcentration of metal ions显示文摘 | Zhifeng Tu Qun He Xijun Chang Zheng Hu Ru Gao Lina Zhang Zhenhua Li | 2009 | Analytica Chimica Acta2009，，2： | 1 |
| 11 | Chemically modified silica gel with p -dimethylaminobenzaldehyde for selective solid-phase extraction and preconcentration of Cr(III), Cu(II), Ni(II), Pb(II) and Zn(II) by ICP-OES显示文摘 | Yuemei Cui Xijun Chang Xiangbing Zhu Haixia Luo Zheng Hu Xiaojun Zou Qun He | 2007 | Microchemical Journal2007，，1： | 1 |
| 12 | Source localization using a sparse representation framework to achieve superresolution 显示文摘 | Xiansheng Guo Qun Wan Chunqi Chang etal | 2010 | Mulitidimensional Systems and Signal Processing2010，21，4： | 1 |
| 13 | Study on the Binding Effect between Cordycepin and Calf Thymus DNA by Circular Dichroism显示文摘Binding of cordycepin to the double helical DNA with a high affinity was investigated by CD spectra in this paper. The results proved that uncoiling, unbinding and denaturation of DNA proceeded continuously upon the increase of the concentration of cordycepin. | Jian Ya LING Jian Qun LIN Guo Ying ZHANG Chang Kai ZHANG | 2006 | Chinese Chemical Letters2006，17，10： | 1 |
| 14 | Selective solid-phase extraction of trace mercury(II) using a silica gel mod-ilied with diethylenetriamine and thiourea显示文摘 | Yin Jiang Huatang Zhang Qun He Zheng Hu Xijun Chang | 2012 | Microchim Acta2012，178，： | 1 |
| 15 | MoS_(2) on topological insulator Bi_(2)Te_(3) thin films:Activation of the basal plane for hydrogen reduction显示文摘2H-MoS_(2) is a well-studied and promising non-noble metal electrocatalyst for heterogeneous reactions,such as the hydrogen evolution reaction(HER).The performance is largely limited by the chemically inert basal plane,which is unfavorable for surface adsorption and reactions.Herein,we report a facile method to boost the HER activities of 2H-MoS_(2) by coupling with epitaxial Bi2Te3 topological insulator films.The as-obtained MoS_(2)/Bi2Te3/SrTiO3 catalyst exhibits prominent HER catalytic activities compared to that of pure MoS_(2) structures,with a 189 mV decrease in the overpotential required to reach a current density of 10 mA cm^(−2) and a low Tafel slope of 58 mV dec−1.Theoretical investigations suggest that the enhanced catalytic activity originates from the charge redistribution at the interface between the Bi2Te3topological insulator films and the MoS_(2) layer.The delocalized sp-derived topological surface states could denote electrons to the MoS_(2) layer and activate the basal plane for hydrogen adsorption.This study demonstrates the potential of manipulating topological surface states to design high-performance electrocatalysts. | Guowei Lia Jue Huang Qun Yang Liguo Zhang Qingge Mu Yan Sun Stuart Parkin Kai Chang Claudia Felser | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 16 | Adsorption of chromium(III), mercury(II) and lead(II) ions onto 4-aminoantipyrine immobilized bentonite显示文摘 | Qihui Wang Xijun Chang Dandan Li Zheng Hu Ruijun Li Qun He | 2010 | Journal of Hazardous Materials2010，，2： | 1 |
| 17 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | The Lancet . 2013 (9887)2013，，9887： | 1 |
| 18 | Degradation of Modulation Transfer Function in Push-broom Camera Caused by MechanicalVibration显示文摘 | Peng X Qun H Chang N H | 2003 | Optics&Laser Technology2003，35，： | 1 |
| 19 | Synthesis and ap- plications of surface- grafted Th( IV ) -imprinted polymers for selective solid-phase extraction of thorium (IV) 显示文摘 | He Qun Chang Xijun Wu Qiong | 2007 | Analytica Chimica Acta2007，605，2： | 1 |
| 20 | Source locali- zation Using a Sparse Representation Framework to Achieve Super Resolution显示文摘 | GUO XIANSHENG WAN QUN CHANG C | 2010 | Multi-Dimensional Systems and Sig- nal Processing2010，21，4： | 1 |
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