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| 1 | Ultra-broadband on-chip twisted light emitter for optical communications显示文摘On-chip twisted light emitters are essential components of orbital angular momentum(OAM)communication devices1,2.These devices address the growing demand for high-capacity communication systems by providing an additional degree of freedom for wavelength/frequency division multiplexing(WDM/FDM).Although whispering-gallery-mode-enabled OAM emitters have been shown to possess some advantages3–5,such as compactness and phase accuracy,their inherent narrow bandwidths prevent them from being compatible with WDM/FDM techniques.Here,we demonstrate an ultra-broadband multiplexed OAM emitter that utilizes a novel joint path-resonance phase control concept.The emitter has a micron-sized radius and nanometer-sized features.Coaxial OAM beams are emitted across the entire telecommunication band from 1,450 to 1,650 nm.We applied the emitter to an OAM communication with a data rate of 1.2 Tbit/s assisted by 30-channel optical frequency combs(OFCs).The emitter provides a new solution to further increase capacity in the OFC communication scenario. | Zhenwei Xie Ting Lei Fan Li Haodong Qiu Zecen Zhang Hong Wang Changjun Min Luping Du Zhaohui Li Xiaocong Yuan | 2018 | Light(Science & Applications)2018，7，1： | 7 |
| 2 | First light of the 1.8-m solar telescope–CLST显示文摘Large-aperture solar telescopes play an important role in solar observations and research,and require high temporal and spatial resolution[1].To solve some fundamental problems such as the solar dynamo,coronal heating,and the triggering of major solar eruptions,the spatial resolution for solar-atmosphere observation should reach at least 0.1 arcsec[2]. | ChangHui Rao NaiTing Gu XueJun Rao Cheng Li LanQiang Zhang JinLong Huang Lin Kong Ming Zhang YunTao Cheng Yi Pu Hua Bao YouMing Guo YangYi Liu JinSheng Yang LiBo Zhong ChangJun Wang Kai Fang XiaoJun Zhang DongHong Chen Cheng Wang XinLong Fan ZhiWu Yan KeLe Chen XiYa Wei Lei Zhu Hong Liu YongJian Wan Hao Xian WenLi Ma | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，10： | 6 |
| 3 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 4 | Research on the thermal property of powerful white LEDs显示文摘 | LEI Yong FAN Guanghan LIAO Changjun | 2006 | Journal of Optoelectronics Laser2006，17，94： | 1 |
| 5 | 纳米结构Pt/WO3薄膜的制备显示文摘 | Fan Xiaohua(范小花),Hou Changjun(侯长军),TangYike(唐一科) | 2008 | 表征及氢敏性能[J]2008，，1： | 1 |
| 6 | Strategy evaluation and optimization with an artificial society toward a Pareto optimum显示文摘Strategy evaluation and optimization in response to troubling urban issues has become a challenging issue due to increasing social uncertainty,unreliable predictions,and poor decision-making.To address this problem,we propose a universal computational experiment framework with a fine-grained artificial society that is integrated with data-based models.The purpose of the framework is to evaluate the consequences of various combinations of strategies geared towards reaching a Pareto optimum with regards to efficacy versus costs.As an example,by modeling coronavirus disease 2019 mitigation,we show that Pareto frontier nations could achieve better economic growth and more effective epidemic control through the analysis of real-world data.Our work suggests that a nation’s intervention strategy could be optimized based on the measures adopted by Pareto frontier nations through large-scale computational experiments.Our solution has been validated for epidemic control,and it can be generalized to other urban issues as well. | Zhengqiu Zhu Bin Chen Hailiang Chen Sihang Qiu Changjun Fan Yong Zhao Runkang Guo Chuan Ai Zhong Liu Zhiming Zhao Liqun Fang Xin Lu | 2022 | The Innovation2022，3，5： | 1 |
| 7 | A METHOD FOR CALCULATING THE LYAPUNOV EXPONENT SPECTRUM OF A PERIODICALLY EXCITED NON-AUTONOMOUS DYNAMICAL SYSTEM显示文摘The relation between the Lyapunov exponent spectrum of a periodically excited non-autono-mous dynamical system and the Lyapunov exponent spectrum of the corresponding autonomous system is givenand the validity of the relation is verified theoretically and computationally.A direct method for calculatingthe Lyapunov exponent spectrum of non-autonomous dynamical systems is suggested in this paper,whichmakes it more eonvenient to calculate the Lyapunov exponent spectrum of the dynamical system periodicallyexcited.Following the definition of the Lyapunov dimension DLAof the autonomous system,the definition ofthe Lyapunov dimension DL of the non-autonomous dynamical system is also given,and the difference be-tween them is the integer 1 namely,DLA-DL = 1.For a quasi-periodically excited dynamical system,similar conclusions are formed. | Cheng Changjun Fan Xiaojun | 2000 | Acta Mechanica Solida Sinica2000，13，3： | 1 |
| 8 | Physiological Signals Based Fatigue Prediction Model for Motion Sensing Games显示文摘 | Ziyu Lu Ling Chen Changjun Fan | 2012 | Advances in Computer Entertainment Lecture Notes in Computer Science2012，7624，： | 1 |
| 9 | Effects of site conditions on growth and wood properties of Populus×euramericana cv.'74/76'显示文摘The growth and wood properties of 240 individual Populus×euramericana cv.’74/76’(hereafter poplar 107)trees planted in Hebei Plain,China was evaluated.Mean annual increments in height,breast height diameter and volume,as well as cellulose,hemicellulose and lignin contents,shrinkage,density,bending strength and modulus of elasticity in the heart wood and sap wood.Environmental factors influencing growth and wood properties were analyzed using correlation and stepwise regres sion.The results show that the coefficients of variation(CVs)of growth traits ranged from 10.6 to 22.4%.The CVs of the chemical properties of heartwood ranged from 4.3 to 30.2%,and for sap wood from 3.2 to 27.5%.The CVs of the physical and mechanical properties of heartwood ranged from 8.6 to 31.7%,and for sapwood from 6.4 to 29.9%.The results of one-way ANOVA showed that there were significant differences in growth traits and wood properties among sites.Soil pH,total and available phosphorus,total potassium,and soil organic matter were key soil factors affecting growth and wood properties of poplar 107,whereas mean annual ground temperatures and precipitation were the main climatic factors.To better cultivate poplar 107,area with less annual rainfall,slightly higher temperature and soil pH value close to neutral should be selected. | Jianmin Fan Changjun Ding Shijie Wang Changming Ma Chao Zhang Yongtan Li Jinmao Wang Minsheng Yang Xiaohua Su | 2023 | Journal of Forestry Research2023，34，2： | 0 |
| 10 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 11 | Real-time Energy Management of Low-carbon Ship Microgrid Based on Data-driven Stochastic Model Predictive Control显示文摘With increasing restrictions on ship carbon emis-sions,it has become a trend for ships to use zero-carbon energy such as solar to replace traditional fossil energy.However,uncer-tainties of solar energy and load affect safe and stable operation of the ship microgrid.In order to deal with uncertainties and real-time requirements and promote application of ship zero-carbon energy,we propose a real-time energy management strategy based on data-driven stochastic model predictive control.First,we establish a ship photovoltaic and load scenario set consid-ering time-sequential correlation of prediction error through three steps.Three steps include probability prediction,equal probability inverse transformation scenario set generation,and simultaneous backward method scenario set reduction.Second,combined with scenario prediction information and rolling op-timization feedback correction,we propose a stochastic model predictive control energy management strategy.In each scenario,the proposed strategy has the lowest expected operational cost of control output.Then,we train the random forest machine learn-ing regression algorithm to carry out multivariable regression on samples generated by running the stochastic model predictive control.Finally,a low-carbon ship microgrid with photovoltaic is simulated.Simulation results demonstrate the proposed strategy can achieve both real-time application of the strategy,as well as operational cost and carbon emission optimization performance close to stochastic model predictive control.Index Terms-Data-driven stochastic model predictive control,low-carbon ship microgrid,machine learning,real-time energy management,time-sequential correlation. | Hui Hou Ming Gan Xixiu Wu Kun Xie Zeyang Fan Changjun Xie Ying Shi Liang Huang | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 0 |
| 12 | Effect of Tongxinluo on basic fibroblast growth factor mRNA after cerebral ischemia/reperfusion injury显示文摘BACKGROUND: Basic fibroblast growth factor (bFGF) can cause proliferation and differentiation of plentiful cells which are derived from mesoblast and neural ectoblast. Previous researches suggested that Tongxinluo could promote differentiation from neural stem cells (NSCs) to neurons and astrocytes after cerebral ischemia/reperfusion injury. OBJECTIVE: To observe the effect of Tongxinluo on bFGF mRNA of rats after cerebral ischemia/reperfusion injury and analyze its dosage-dependence. DESIGN: Randomized controlled study. SETTING: Department of Neurology, Nanfang Hospital of Southern Medical University. MATERIALS: The experiment was carried out in Neurological Department of Nanfang Hospital affiliated to Southern Medical University from May 2005 to March 2006. A total of 192 healthy Wistar rats, weighing (200±20) g, of SPF grade, of both gender by half, were provided by Experimental Animal Center of Nanfang Hospital Affiliated to Southern Medical University. Tongxinluo was consisted of renshen, wugong, quanxie, shuizhi, chishao, bingpian, etc. and was provided by Shijiazhuang Yiling Pharmaceutical Co., Ltd. (batch number: 9906115). Main reagents: Agarose, DEPC-treated water, total RNA purification kit and one-step reverse transcription polymerase chain reaction (RT-PCR) kit were provided by Beijing Saibaisheng Gene Technique Co., Ltd. METHODS: All rats were randomly divided into 4 groups, including high-dosage Tongxinluo group, low-dosage Tongxinluo group, model group and sham operation group with 48 in each group. Rats in the former three groups were observed at 3, 5, 7, 14, 21 and 30 days after ischemia/reperfusion. In addition, rats in sham operation group were selected at the relevant time points. Every 8 rats were selected from each group for once. ① Right middle cerebral artery occlusion-reperfusion models were induced by Koizumi method and modified; moreover, neurological impairment was evaluated with Zealonga method. Except rats in sham operation group, rats in other three groups were involved in the final analysis, if scores of neurological impairment were higher than 2 at 6 hours after modeling. ② Administration: Rats in high-dosage Tongxinluo group were perfused with 150 g/L 1 g/(kg·d) Tongxinluo suspension; rats in low-dosage Tongxinluo group were perfused with 75 g/L 0.5 g/(kg·d) Tongxinluo suspension; rats in sham operation group and control group were perfused with the same volume of distilled water. Rats in each group were administrated at the wakeful time after reperfusion immediately. ③ Preparation of brain tissue: Rats were anesthetized at 3, 5, 7, 14, 21 and 30 days after perfusion to obtain their brains, separate brain tissue on ischemic site, extract total RNA, perform RT-PCR and semi-quantitative analysis and detect expression of bFGF mRNA at ischemic brain tissue. ④ Statistical analysis: Intensity at each time point was measured with analysis of variance and F test. MAIN OUTCOME MEASURES: Changes of bFGF mRNA during proliferation and differentiation of NSCs in ischemic brain tissue at each time point after cerebral ischemia/reperfusion injury. RESULTS: All 192 rats were involved in the final analysis. Expression of bFGF mRNA was hardly measured at focal side of rats in sham operation group. Otherwise, expression of bFGF mRNA was measured at various time points at ischemic side of rats in model group; moreover, the expression was the strongest on the 7th day, decreased on the 14th day and fallen down to the basic value on the 30th day. At 5, 7, 14, 21 and 30 days after modeling, expressions of bFGF mRNA at focal side were 0.86±0.04, 0.87±0.04; 0.88±0.02, 0.87±0.02; 0.79±0.02, 0.81±0.03; 0.52±0.04, 0.54±0.04; 0.46±0.03, 0.45±0.03 in high-dosage Tongxinluo group and low-dosage Tongxinluo group, respectively, which were stronger than those in model group (0.62±0.06, 0.63±0.05, 0.52±0.06, 0.43±0.06, 0.19±0.04, P < 0.05). Expression of bFGF mRNA at each time point was similar in high-dosage Tongxinluo group to that in low-dosage Tongxinluo group. In addition, expression of bFGF mRNA was the strongest at focal side in high-dosage Tongxinluo group and low-dosage Tongxinluo group on the 7th day after modeling; meanwhile, the expression was still stronger within 30 days after ischemia. CONCLUSION: ① Tongxinluo can strengthen the expression of bFGF mRNA at ischemic side; meanwhile, the expression may last for 30 days. ② This effect does not show as dosage-dependence. | Ruixue Yin Bingxun Lu Lixin Wang Jianzhong Fan Changjun Lu Hongzhen Zhou | 2006 | Neural Regeneration Research2006，1，6： | 0 |
| 13 | Dithizone-functionalized C18 online solid-phase extraction-HPLC-ICP-MS for speciation of ultra-trace organic and inorganic mercury in cereals and environmental samples显示文摘A simple and efficient dithizone-functionalized solid-phase extraction(SPE)procedure,online coupled with high-performance liquid chromatography(HPLC)-inductively coupled plasma mass spectrometry,was developed for the first time for enrichment and determination of ultra-trace mercury(Hg)species(inorganic divalent Hg(Hg(Ⅱ)),methylmercury(CH_(3)Hg(Ⅱ))and ethylmercury(C_(2)H_(5)Hg(Ⅱ))in cereals and environmental samples.In the proposed method,functionalization of the commercial C_(18) column with dithizone,enrichment,and elution of the above Hg species can be completed online with the developed SPE device.A simple solution of 2-mercaptoethanol(1%(V/V))could be used as an eluent for both the SPE and HPLC separation of Hg species,significantly simplifying the method and instrumen-tation.The online SPE method was optimized by varying dithizone dose,2-mercaptoethanol concentration,and sample volume.In addition,the effect of pH,coexisting interfering ions,and salt effect on the enrichment was also discussed.Under the optimized conditions,the detection limits of Hg species for 5 mL water sample were 0.15 ng/L for Hg(Ⅱ),0.07 ng/L for CH_(3)Hg(Ⅱ),and 0.04 ng/L for C_(2)H_(5)Hg(Ⅱ)with recoveries in the range of 85%-100%.The developed dithizone-functionalized C_(18) SPE column can be reused after a single function-alization,which significantly simplifies the enrichment step.Moreover,the stability of Hg species enriched on the SPE column demonstrated its suitability for field sampling of Hg species for later laboratory analysis.This environment-friendly method offers a robust tool to detect ultra-trace Hg species in cereals and environmental samples. | Ying Wang Ailing Zhu Yingying Fang Changjun Fan Yanli Guo Zhiqiang Tan Yongguang Yin Yong Cai Guibin Jiang | 2022 | Journal of Environmental Sciences2022，34，5： | 0 |
| 14 | Pathogenic Characterization and Full Length Genome Sequence of a Reassortant Infectious Bursal Disease Virus Newly Isolated in Pakistan显示文摘Dear Editor,Infectious bursal disease (IBD) is one of the most important diseases of the poultry. The IBD virus (IBDV), a nonenveloped virus belonging to the Birnaviridae family with a genome consisting of two segments of double-stranded RNA (segments A and B), targets B lymphocytes of bursa of Fabricious leading to immunosuppression. In Pakistan,poultry farming is the second biggest industry and IBD is the second biggest disease threating the poultry sector.However. | Altaf Hussain Tiantian Wu Hui Li Linjin Fan Kai Li Li Gao Yongqiang Wang Yulong Gao Changjun Liu Hongyu Cui Qing Pan Yanping Zhang Asim Aslam Khan Muti-Ur-Rehman Muhammad Munir Salman Latif Butt Xiaomei Wang Xiaole Qi | 2019 | Virologica Sinica2019，34，1： | 0 |
| 15 | Highly efficient and aberration-free off-plane grating spectrometer and monochromator for EUV—soft X-ray applications显示文摘We demonstrate a novel flat-field,dual-optic imaging EUV—soft X-ray spectrometer and monochromator that attains an unprecedented throughput efficiency exceeding 60%by design,along with a superb spectral resolution ofλ/Δλ>200 accomplished without employing variable line spacing gratings.Exploiting the benefits of the conical diffraction geometry,the optical system is globally optimized in multidimensional parameter space to guarantee optimal imaging performance over a broad spectral range while maintaining circular and elliptical polarization states at the first,second,and third diffraction orders.Moreover,our analysis indicates minimal temporal dispersion,with pulse broadening confined within 80 fs tail-to-tail and an FWHM value of 29 fs,which enables ultrafast spectroscopic and pump-probe studies with femtosecond accuracy.Furthermore,the spectrometer can be effortlessly transformed into a monochromator spanning the EUV—soft X-ray spectral region using a single grating with an aberration-free spatial profile.Such capability allows coherent diffractive imaging applications to be conducted with highly monochromatic light in a broad spectral range and extended to the soft X-ray region with minimal photon loss,thus facilitating state-of-the-art imaging of intricate nano-and bio-systems,with a significantly enhanced spatiotemporal resolution,down to the nanometer–femtosecond level. | Jie Li Kui Li Xiaoshi Zhang Dimitar Popmintchev Hao Xu Yutong Wang Ruixuan Li Guangyin Zhang Jiyue Tang Jin Niu Yongjun Ma Runyu Meng Changjun Ke Jisi Qiu Yunfeng Ma Tenio Popmintchev Zhongwei Fan | 2024 | Light(Science & Applications)2024，13，1： | 0 |
| 16 | Corrigendum to“Dithizone-functionalized C18 online solid-phase extraction-HPLC-ICP-MS for speciation of ultra-trace organic and inorganic mercury in cereals and environmental samples”Journal of Environmental Science 115(2022)403-410显示文摘The authors regretThe authors would like to apologize for any inconvenience caused. | Ying Wang Ailing Zhu Yingying Fang Changjun Fan Yanli Guo Zhiqiang Tan Yongguang Yin Yong Cai Guibin Jiang | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 17 | Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer显示文摘Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical field.However,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy.Though photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration depth.Here,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction.The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated.Moreover,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis. | Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu | 2021 | Research2021，，1： | 0 |
| 18 | The Greenhouse Climate Records from Organic Carbon Isotope Excursions During the Toarcian (Early Jurassic) Sediments in the Shuanghu Area, Qianghai-Tibetan Plateau显示文摘Objective The organic-matter-rich oil shales outcropped at the Biluo Co area of the Qiangtang Basin in Tibet are of the Toarcian(Early Jurassic)based on the ammonite fauna(Yi et al.,2003).We first proposed its sedimentary age to be the Early Toarcian and correlated with the Posidonia shales and the early Toarcian Oceanic Anoxic Event(TOAE)(Chen et al.,2005).The carbon isotopes excursions and Buchi bivalves suggest that these oil shales at the Biluo Co section are represent of T-OAE in the Asian Tethyan regions. | YI Haisheng JI Changjun DA Xuejuan YI Fan XIA Guoqing LI Gaojie CHEN Lan JIAO Haijing WU Chihua | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 0 |
| 19 | In vivo spatial-spectral photoacoustic microscopy enabled by optical evanescent wave sensing显示文摘In addition to offering morphological visualizations via capture of the spatial distributions of optical absorption,photoacoustic imaging technology can reveal abundant physical information about biological particles,including their orientation,density,and viscoelasticity,through analysis of the pressure transients in the spectral domain.However,the low-amplitude wideband photoacoustic signals of intrinsic microscopic optically-absorbing objects under the action of confined photoacoustic excitation power continue to hinder simultaneous photoacoustic structural imaging and spectroscopic analysis of the nonfluorescent chromophores in living biological tissues because of the inadequate responses to photoacoustic impulses observed in most photoacoustic imaging setups that include piezoelectric transducers.Building upon a recently-developed optical evanescent wave sensor that can respond to ultrasound with high sensitivity over a broad frequency range,we propose in vivo spatial-spectral photoacoustic microscopy for recovery of structural imaging in three dimensions and characterization of anatomical features in the acoustic frequency domain.Label-free photoacoustic images of a living zebrafish are acquired in which spectroscopically-resolved differentiation of the microarchitecture is accessed,along with isometric micrometer-scale volumetric visualizations.The proposed imaging technology could potentially provide more comprehensive evaluations of the physiopathological status of living small animals. | Fan Yang Yushu Dong Changjun Min Yejun He Siwei Zhu Hao Liu Wei Song Xiaocong Yuan | 2023 | Medicine in Novel Technology and Devices2023，，2： | 0 |
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