|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 3 | Gossypol: phytoalexin of cotton显示文摘Sesquiterpenoids are a class of 15-carbon secondary metabolites that play diverse roles in plant adaptation to environment.Cotton plants accumulate a large amount of sesquiterpene aldehydes(including gossypol)as phytoalexins against pathogens and herbivores.They are stored in pigment glands of aerial organs and in epidermal layers of roots.Several enzymes of gossypol biosynthesis pathway have been characterized,including 3-hydroxy-3-methylglutaryl coenzyme A reductase(HMGR)and farnesyl diphosphate synthase(FPS)that catalyze the formation of the precursor farnesyl diphosphate(FPP),(+)-δ-cadinene synthase(CDN)which is the first enzyme committed to gossypol biosynthesis,and the downstream enzymes of CYP706B1 and methyltransferase.Expressions of these genes are tightly regulated during cotton plants development and induced by jasmonate and fungi elicitors.The transcription factor Ga WRKY1 has been shown to be involved in gossypol pathway regulation.Recent development of new genomic platforms and methods and releases of diploid and tetraploid cotton genome sequences will greatly facilitate the elucidation of gossypol biosynthetic pathway and its regulation. | Xiu Tian Juxin Ruan Jinquan Huang Xin Fang Yingbo Mao Lingjian Wang Xiaoya Chen Changqing Yang | 2016 | Science China(Life Sciences)2016，59，2： | 10 |
| 4 | 基于体波有限频层析成像的青藏高原南部和中部下方印度大陆岩石层俯冲和撕裂的三维图像显示文摘使用TIBET-31N无源地震台阵以及以前临时地震台阵记录到的远震体波数据进行了有限频层析成像反演,对青藏高原南部及中部的三维速度结构成像。在喜马拉雅和拉萨地块下方存在向北倾角40°的高速体。我们把这些高速异常区域解释为俯冲的印度大陆岩石层(ICL)。印度大陆岩石层似乎在青藏高原中部比东部向北延伸更多——沿85°E在31°N到达350km深处,而沿91°E则是在30°N到达350km深度。P波和S波低速异常区在当惹雍错裂谷、亚东—谷露裂谷和错那裂谷下方从下地壳延伸至≥180km深度,这表明青藏高原南部的裂谷可能包含了整个岩石层的变形。当惹雍错裂谷下方的异常区向下延伸到约180km,而亚东—谷露裂谷西部和错那裂谷东部的异常延伸到了超过300km的深度。亚东—谷露裂谷西部的低速区上地幔延伸至最北,并且似乎与青藏高原中部下方广阔的上地幔低速区相连。于是,北向俯冲的印度板块沿着南北走向的裂缝撕裂。这些裂缝允许或者导致的软流层上涌同青藏高原北部上地幔相类似。 | Xiaofeng Liang Yun Chen Xiaobo Tian Yongshun John Chen James Ni Andrea Gallegos Simon L.Klemperer Minling Wang Tao Xu Changqing Sun Shaokun Si Haiqiang Lan Jiwen Teng 左思成 | 2016 | 世界地震译丛2016，47，6： | 8 |
| 5 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 6 | VARIATIONAL PRINCIPLFS OF NONLINEAR PIEZOTHERMOELASTIC MEDIA显示文摘Through the phenomenological approach,the nonlinear constitutive equations couplingthe electro/magnetic therrnoelastic media are derived.Several nonlinear variational principles forpiezothermoelastic continua are presented and employed to formulate the incremental variational princi-ples which are of important significance in practical applications such as the nonlinear finite elementanalysis,the buckling,postbuckling and dynamic stability analyses of piezoelectric smart structures. | Chen Changqing Shen Yapeng Tian Xiaogeng (Department of Engineering Mechanics,Xi’an Jiaotong University,Xi’an 710049,China) | 1998 | Acta Mechanica Solida Sinica1998，11，1： | 4 |
| 7 | Rapid intelligent evaluation method and technology for determining engineering rock mass quality显示文摘The evaluation of engineering rock mass quality is fundamental work for the engineering activities of rock mass.The increasing scale of rock mass engineering necessitates higher intelligence,timeliness,and accuracy in engineering rock mass quality evaluation.As the core aspects of engineering rock mass quality evaluation,the structural characteristics,mechanical characteristics,and quality classification of rock mass have been innovated in recent years.The non-contact measurement technology for rock mass structure and rapid interpretation of rock mass structure information enables the intelligent extraction and analysis of rock mass structure parameters.The modular backpack laboratory system of rock mechanics provides an effective means to acquire rock mechanical parameters on-site conveniently.The theory of statistical mechanics of rock mass(SMRM)integrates various factors such as the rock mass properties,geological environment,and engineering disturbance,providing a theoretical basis for accurately evaluating the weakening and anisotropy of rock mass.The cloud computing platform established based on SMRM can provide technical support for the rapid calculation of rock mass parameters and instant evaluation of the rock mass quality.The development of intelligent evaluation method and technology is altering the conventional technical state of qualitative and semi-quantitative evaluation of engineering rock mass quality,supporting the realization of rock mass engineering construction with intellectualization and informatization. | Faquan Wu Jie Wu Han Bao Zhongxi Bai Lei Qiao Fang Zhang Bo Li Fuan Si Lei Yu Shenggong Guan Peng Sha Deheng Kong Zhenzhong Dai Kun Chen Yun Tian Changqing Liu | 2023 | Rock Mechanics Bulletin2023，2，2： | 3 |
| 8 | Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs显示文摘Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effects of fibroblast injection on intervertebral disc degeneration(IDD) in a preclinical setting. Compared with the IDD group, the fibroblast treatment group demonstrated effective maintenance of IVD height, reduced endplate degeneration, and improved nuclear magnetic resonance signals and overall histological structure. In doing so, fibrotic IVDs maintained the stability and biomechanics of the vertebra. This finding is in agreement with clinical findings that human nucleus pulposus(NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy(PELD). Mechanistically, we demonstrated that injected fibroblasts not only proliferated but also induced NP cells to adopt a fibrotic phenotype via the secretion of TGF-β.Finally, to better mimic human conditions, the efficacy of autologous fibroblast injection in the treatment of IDD was further examined in a nonhuman primate cynomolgus monkey model due to their capacity for upright posture. We showed that the injection of fibroblasts could maintain the IVD height and rescue IVD signals in cynomolgus monkeys. Taken together, the results of our study reveal that autologous fibroblast injection can enhance the natural process of fibrosis during acute and subacute stages of stress-induced IDD. Fibrotic IVDs can maintain the stability, biological activity, and mechanical properties of the intervertebral space, thus providing a new direction for the treatment of intervertebral space-derived lumbar degenerative diseases. | Chen Chen Tangjun Zhou Xiaojiang Sun Chen Han Kai Zhang Changqing Zhao Xunlin Li Haijun Tian Xiao Yang Yifan Zhou Zhiqian Chen An Qin Jie Zhao | 2020 | Bone Research2020，8，1： | 3 |
| 9 | Disruption of the bHLH transcription factor Abnormal Tapetum 1 causes male sterility in watermelon显示文摘Although male sterility has been identified as a useful trait for hybrid vigor utilization and hybrid seed production,its underlying molecular mechanisms in Cucurbitaceae species are still largely unclear.Here,a spontaneous male-sterile watermelon mutant,Se18,was reported to have abnormal tapetum development,which resulted in completely aborted pollen grains.Map-based cloning demonstrated that the causal gene Citrullus lanatus Abnormal Tapetum 1(ClATM1)encodes a basic helix-loop-helix(bHLH)transcription factor with a 10-bp deletion and produces a truncated protein without the bHLH interaction and functional(BIF)domain in Se18 plants.qRT–PCR and RNA in situ hybridization showed that ClATM1 is specifically expressed in the tapetum layer and in microsporocytes during stages 6–8a of anther development.The genetic function of ClATM1 in regulating anther development was verified by CRISPR/Cas9-mediated mutagenesis.Moreover,ClATM1 was significantly downregulated in the Se18 mutant,displaying a clear dose effect at the transcriptional level.Subsequent dual-luciferase reporter,β-glucuronidase(GUS)activity,and yeast one-hybrid assays indicated that ClATM1 could activate its own transcriptional expression through promoter binding.Collectively,ClATM1 is the first male sterility gene cloned from watermelon,and its self-regulatory activity provides new insights into the molecular mechanism underlying anther development in plants. | Ruimin Zhang Jingjing Chang Jiayue Li Guangpu Lan Changqing Xuan Hao Li Jianxiang Ma Yong Zhang Jianqiang Yang Shujuan Tian Li Yuan Xian Zhang Chunhua Wei | 2021 | Horticulture Research2021，8，1： | 3 |
| 10 | Start-up Characteristics of Linear Compressors in a Refrigeration System显示文摘This work investigates the start-up characteristics of linear compressors in a refrigeration system through experiment and simulation.Experiments are carried out by a refrigeration test system with a linear compressor controlled by a LabVIEW platform.A simulation model that considers the nonlinear process of gas force is set up on the basis of Runge-Kutta method for linear compressors.Compared with the experimental results,the simulation errors are within 15%,including the unstable state.The influences of ambient temperature and power frequency on linear compressors are studied through experiments.Unstable phenomena exist at 25℃ ambient temperature compared with the designed ambient temperature of 35℃.The unsteadiness mechanism is analyzed by simulation.Simulation analysis indicated that two sensitive stages of linear compressors,namely,starting to pump and touching top dead center,are unstable.Furthermore,properly increasing equivalent mass (approximately 3%) or spring stiffness doring the design stage can be a practical method to improve the stability of linear compressors. | ZOU Huiming LI Xuan TANG Mingsheng TIAN Changqing | 2021 | Journal of Thermal Science2021，30，2： | 1 |
| 11 | A direct finite element method study of general- ized thermoelastic problems 显示文摘 | TIAN Xiaogeng SHEN Yapeng CHEN Changqing | 2006 | International Journal of Solids and Structures2006，43，78： | 1 |
| 12 | Wavelet-based image fusion and quality assessment显示文摘 | Wenzhong Shi ChangQing Zhu Yan Tian Janet Nichol | 2004 | International Journal of Applied Earth Observations and Geoinformation2004，，3： | 1 |
| 13 | Wavelet - based image fusion and Quality assessment显示文摘 | Shi WenZhong Zhu ChangQing Tian Yah | 2005 | International Journal of Applied Earth Observation and Geoinformation2005，6，3： | 1 |
| 14 | Transient behavior evaluation of an automotive air conditioning system with a variable displacement compressor显示文摘 | Tian Changqing Li Xiangting | 2005 | Applied Thermal Engineering2005，25，13： | 1 |
| 15 | Wavelet-based image fusion and quality assessment显示文摘 | Shi Wenzhong Zhu Changqing Tian Yan | 2005 | International Journal of Applied Earth Observation and Geoinformation2005，6，3： | 1 |
| 16 | International Competitiveness of the Chinese Publishing Industry 显示文摘 | ] Xianrong Huang Changqing Tian | 2014 | Publish- ing Research Quarterly2014，30，1： | 1 |
| 17 | Expression of Human Peroxisome Proliferator-Activated Receptors Ligand Binding Domain- Maltose Binding Protein Fusion Protein in Escherichia coli:A Convenient and Reliable Method for Preparing Receptor for Screening Ligands显示文摘 | LI Changqing TIAN Mi YUAN Ye | 2008 | ASSAY and Drug Development Technologies2008，6，6： | 1 |
| 18 | Performance Characteristics Around the TDC of Linear Compressor Based on Whole-process Sim- ulation显示文摘 | Huiming Zou Mingsheng Tang Hongbo Xu Shuangquan Shao Changqing Tian | 2014 | International Journal of Applied Electromagnet- ics and Mechanics2014，28，10： | 1 |
| 19 | Waveletbased image fusion and quality assessment 显示文摘 | Shi Wenzhong Zhu Changqing Tian Yan | 2005 | International Journal of Applied Earth Observation and Geoinformation2005，6，34： | 1 |
| 20 | Wavelet-based image fusion and quality assessment显示文摘 | Shi Wenzhong Zhu ChangQing Tian Yan | 2005 | International Journal of Applied Earth Observation and Geoinformation2005，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员