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| 1 | Decrement of Sugar Consumption in Rice Young Panicle Under High Temperature Aggravates Spikelet Number Reduction显示文摘Two rice genotypes Huanghuazhan(HHZ, heat-resistant) and IR36(heat-susceptible) were subjected to high-temperature(HT, 40℃) and normal-temperature(NT, 32℃) treatments at the spikelet differentiation stage. HT treatment inhibited spikelet differentiation, aggravated spikelet degeneration, reduced spikelet size, and disordered carbohydrate allocation. Meanwhile, HT treatment increased nonstructural carbohydrate content in leaves, but decreased that in stems and young panicles, and the same tendencies of sucrose and starch contents were observed in leaves and stem. However, HT treatment significantly increased the sucrose content and sharply decreased the glucose and fructose contents in young panicles. Lower activity levels of soluble acid invertase(EC3.2.1.26) and sucrose synthase(EC2.4.1.13) were observed under HT treatment. Moreover, HT treatment reduced the activities of key enzymes associated with glycolysis and the tricarboxylic acid cycle, which indicated sucrose consumption was inhibited in young panicles under HT treatment. Exogenous glucose and fructose applied under HT treatment increased the spikelet number more than exogenous sucrose. In conclusion, the results demonstrated that the reduction of spikelet number under high temperature was more affected by the decrease in sugar consumption than the blocking of sucrose transport. The impairment of sucrose hydrolysis was the main reason for the inhibition of sugar utilization. | WANG Yaliang ZHANG Yikai SHI Qinghua CHEN Huizhe XIANG Jing HU Guohui CHEN Yanhua WANG Xiaodan WANG Junke YI Zihao ZHU Defeng ZHANG Yuping | 2020 | Rice science2020，27，1： | 6 |
| 2 | Nuclear reprogramming: the zygotic transcription program is established through an“erase-and-rebuild” strategy显示文摘卵母细胞显示母亲特定的基因表达式侧面,它被换到当染色质的一个单倍体集合被传递到发展成一个胚胎的受精卵时, zygotic 介绍。位于这抄写 reprogramming 下面的机制当前是未知的。等到当抄写在幼芽的泡卵母细胞被关掉时,一般抄写因素和 transcriptional 管理者的一个范围从染色质被分裂,这里,我们表明那。染色质因素(CF ) 的全球分离破坏在染色质和 CF 之间的物理接触并且在功能的水平导致母亲的抄写节目的檫除。与染色质论坛分开的批评抄写因素和管理者遗体延长了时期,并且立即在专业版以后与染色质成为 re-associated 原子形成。Thisis 由象 DNA 和抄写那样的原子功能的重建跟随了速度集合。我们建议母亲的抄写节目在卵子发生期间被擦掉产生相对天真的染色质, zygotic 抄写节目是在授精以后的重建的重新。这个过程作为“ erase-and-rebuild ”被称为过程,它被用来重设抄写节目,和最可能的其它原子过程也,从母亲的到胚胎的。我们进一步在伴随的纸出现(高 T,等,房间物件 2007;17:135-150 .) 一样的策略也被采用到改编 transcriptional,这在体细胞介绍原子转移和单性生殖,建议这当模特儿在早胚胎开始期间对 transcriptional reprogramming 的所有形式普遍适用。从染色质的 CF 的排水量也为抄写沉默的现象提供解释在期间对 zygotic 转变母亲。 | Feng Sun Haiyan Fang Ruizhen Li Tianlong Gao Junke Zheng Xuejin Chen Wenqin Ying Hui Z Sheng | 2007 | Cell Research2007，17，2： | 5 |
| 3 | Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport显示文摘 | Yong Cui Hongguang Nie Hong Ma Lei Chen Lin Zhang Junke Wang Honglong Ji Daniel T. Monaghan | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
| 4 | Immunotherapy in leukaemia显示文摘Leukaemia is the common name for a group of malignant diseases of the haematopoietic system with complex classifications and characteristics.Remarkable progress has been made in basic research and preclinical studies for acute leukaemia compared to that of the many other types/subtypes of leukaemia,especially the exploration of the biological basis and application of immunotherapy in acute myeloid leukaemia(AML)and B-cell acute lympho-blastic leukaemia(B-ALL).In this review,we summarize the basic approaches to immunotherapy for leukaemia and focus on the research progress made in immunotherapy development for AML and ALL.Importantly,despite the advances made to date,big challenges still exist in the effectiveness of leukaemia immunotherapy,especially in AML.Therefore,we use AML as an example and summarize the mechanisms of tumour cell immune evasion,describe recently reported data and known therapeutic targets,and discuss the obstacles in finding suitabie treatment targets and the results obtained in recent clinical trials for several types of single and combination immunotherapies,such as bispecific antibodies,cell therapies(CAR-T-cell treatment),and checkpoint blockade.Finally,we summarize novel immunotherapy strategies for treating lymphocytic leukaemia and clinical trial results. | Xingmei Mu Chumao Chen Loujie Dong Zhaowei Kang Zhixian Sun Xijie Chen Junke Zheng Yaping Zhang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，6： | 1 |
| 5 | Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy显示文摘The poor prognosis of triple negative breast cancer(TNBC)results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis,which is associated with high recurrence and short overall survival.Here we developed a strategy by employing tumor-targeted selfassembled nanoparticles to coordinately regulate BACH1(BTB domain and CNC homology 1)and mitochondrial metabolism.The BACH1 inhibitor hemin and mitochondria function inhibitor berberine derivative(BD)were used to prepare nanoparticles(BH NPs)followed by the modification of chondroitin sulfate(CS)on the surface of BH NPs to achieve tumor targeting(CS/BH NPs).CS/BH NPs were found to be able to inhibit tumor migration and invasion by significantly decreasing the amounts of tumor cell metabolites,glycolysis and metastasis-associated proteins,which were related to the inhibition of BACH1 function.Meanwhile,decreased mitochondrial membrane potential,activated caspase 3/9 and increased ROS production demonstrated coordinated regulation of BACH1 and mitochondrial metabolism.In a xenograft mice model of breast cancer,CS/BH NPs significantly inhibited tumor growth and metastasis due to the synergetic effect of hemin and BD without showing obvious toxicities for major organs.In sum,the results of efficacy and safety experiments suggest potential clinical significance of the prepared self-assembled CS/BH nanoparticles for the treatment of TNBC. | Xuan Yang Yalong Wang Junke Zhao Hehui Rong Yujun Chen Mengting Xiong Xiaoxing Ye Shihui Yu Haiyan Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 1 |
| 6 | Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23); MLL-MLLT10显示文摘 | Zhenjun Lou Cheng Cheng Zhang Carlos A. Tirado Tamara Slone Junke Zheng Charles M. Zaremba Dwight Oliver Weina Chen | 2010 | Leukemia Research2010，，8： | 1 |
| 7 | The Effect of Phacoemulsification on Intraocular Pressure in Glaucoma Patients:A Report by the American Academy of Ophthalmology显示文摘 | Chen P P Lin S C Junk A K | 2015 | Ophthalmology2015，122，7： | 1 |
| 8 | Alterations and Its Mechanisms of Wnt Signal Pathway in Human High-matastatatic Large Cell Lung Cancer Cell Line L9981 by Transfecting with Nm23-H1 Gene显示文摘Backgroud and Objective Tumor metastasis is not only the malignant marker and characteristics of lung cancer, but also the main cause of failure to cure and lose their life of the | Junke FU Zhe WANG Sen WEI Gang CHEN Zhigang LI Jun CHEN Hongyu LIU Zhihao WU Ke XU Qinghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 1 |
| 9 | Hematopoietic stem cell metabolism and stemness显示文摘Hematopoietic stem cells(HSCs)are considered to originate from the aorta-gonad-mesonephros,migrate into fetal liver for a rapid expansion,and eventually reside into a unique hypoxic bone marrow niche,where they maintain their homeostasis throughout their life span.HSCs have been widely used for the treatment of many begin or malignant hematopoietic disorders.However,the unavailability of sufficient amount of HSCs still impedes their applications in the clinic.It is urgent to understand how HSC stemness or cell fates are determined at different developmental stages.Although many intrinsic and extrinsic factors(niche components)have been identified in the regulation of HSC origination,expansion,migration,and localization,the underlying mechanisms remain largely unknown.In this article,we summarize current views on the metabolic profiles of HSCs and related regulatory networks,which shows that intrinsic metabolic regulation may be critical for the cell fate determinations of HSCs:HSCs utilize glycolysis as their major energy sources;mitochondrial respiration is also required for the homeostasis of HSCs;amino acids,lipids,or other nutrient metabolisms also have unique roles in sustaining HSC activities.Mechanistically,many important regulatory pathways,such as MEIS1/HIF1A,MYC,PPM1K/CDC20,and ROS signals,are identified to fine-tune the nutrient metabolisms and cell fate commitments in HSCs.Nevertheless,more effort is required for the optimization or establishment of sensitive and specific metabolic techniques/systems for the metabolism studies in HSCs with limited cell numbers and exploring the metabolic profiles and fundamental regulatory mechanisms of different types of nutrients at each developmental stage of HSCs. | Dan Huang Chiqi Chen Li Xie Zhuo Yu Junke Zheng | 2019 | Blood Science2019，1，1： | 0 |
| 10 | Interannual evolution of the chemical composition,sources and processes of PM_(2.5)in Chengdu,China:Insights from observations in four winters显示文摘The air quality in China has improved significantly in the last decade and,correspondingly,the characteristics of PM_(2.5)have also changed.We studied the interannual variation of PM_(2.5)in Chengdu,one of the most heavily polluted megacities in southwest China,during the most polluted season(winter).Our results show that the mass concentrations of PM_(2.5)decreased significantly year-by-year,from 195.8±91.0μg/m~3in winter 2016 to 96.1±39.3μg/m^(3)in winter 2020.The mass concentrations of organic matter(OM),SO_()4^(2-),NH_(4)^(+)and NO_(3)^(-)decreased by 49.6%,57.1%,49.7% and 28.7%,respectively.The differential reduction in the concentrations of chemical components increased the contributions from secondary organic carbon and NO_(3)^(-)and there was a larger contribution from mobile sources.The contribution of OM and NO_(3)^(-)not only increased with increasing levels of pollution,but also increased year-by-year at the same level of pollution.Four sources of PM_(2.5)were identified:combustion sources,vehicular emissions,dust and secondary aerosols.Secondary aerosols made the highest contribution and increased year-by-year,from 40.6%in winter 2016 to 46.3% in winter 2020.By contrast,the contribution from combustion sources decreased from 14.4% to 8.7%.Our results show the effectiveness of earlier pollution reduction policies and emphasizes that priority should be given to key pollutants(e.g.,OM and NO_(3)^(-))and sources(secondary aerosols and vehicular emissions)in future policies for the reduction of pollution in Chengdu during the winter months. | Junke Zhang Jiaqi Li Yunfei Su Chunying Chen Luyao Chen Xiaojuan Huang Fangzheng Wang Yawen Huang Gehui Wang | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 11 | Author correction to'Coordinated regulation of BACH1 and mitochondrial metabolism through tumor targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy'[Acta Pharmaceutica Sinica B 12(2022)3934-3951]显示文摘The authors regret that there are two errors in the article Fig.4A and Fig.5C due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading. | Xuan Yang Yalong Wang Junke Zhao Hehui Rong Yujun Chen Mengting Xiong Xiaoxing Ye Shihui Yu Haiyan Hu | 2023 | Acta Pharmaceutica Sinica B2023，13，11： | 0 |
| 12 | Anisotropic Fermat’s principle for controlling hyperbolic van der Waals polaritons显示文摘Transformation optics(TO)facilitates flexible designs of spatial modulation of optical materials via coordinate transformations,thus,enabling on-demand manipulations of electromagnetic waves.However,the application of TO theory in control of hyperbolic waves remains elusive due to the spatial metric signature transition from(+,+)to(−,+)of a two-dimensional hyperbolic geometry.Here,we proposed a distinct Pythagorean theorem,which leads to establishing an anisotropic Fermat’s principle.It helps to construct anisotropic geometries and is a powerful tool for manipulating hyperbolic waves at the nanoscale and polaritons.Making use of absolute instruments,the excellent collimating and focusing behaviors of naturally in-plane hyperbolic polaritons in van der Waals��α–MoO_(3)layers are demonstrated,which opens up a new way for polaritons manipulation. | SICEN TAO TAO HOU YALI ZENG GUANGWEI HU ZIXUN GE JUNKE LIAO SHAN ZHU TAN ZHANG CHENG-WEI QIU HUANYANG CHEN | 2022 | Photonics Research2022，10，10： | 0 |
| 13 | Alterations in the Cytoskeleton and Biological Behavior in Human Lung Cancer Cell Line L9981 by Nm23-H1 gene Transfection显示文摘Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known | Zhe WANG Junke FU Zhihao WU Hongyu LIU Jun CHEN Liya SUN Q inghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 14 | Aerodynamic optimization of a high-lift system with adaptive dropped hinge flap显示文摘The Adaptive Dropped Hinge Flap(ADHF) is a novel trailing edge high-lift device characterized by the integration of downward deflection spoiler and simple hinge flap, with excellent aerodynamic and mechanism performance. In this paper, aerodynamic optimization design of an ADHF high-lift system is conducted considering the mechanism performance. Shape and settings of both takeoff and landing configurations are optimized and analyzed, with considering the kinematic constraints of ADHF mechanism, and the desired optimization results were obtained after optimization. Sensitivity analysis proves the robustness of the optimal design. Comparison shows that the ADHF design has better comprehensive performance of both mechanism and aerodynamics than the conventional Fowler flap and simple hinge flap design. | Qiang JI Yufei ZHANG Haixin CHEN Junke YE | 2022 | Chinese Journal of Aeronautics2022，35，11： | 0 |
| 15 | Characterization of Fe-containing particles in Chengdu,southwest China,using single-particle aerosol mass spectrometry显示文摘Single-particle aerosol mass spectrometry was used to study the characteristics of Fecontaining particles during winter in Chengdu,southwest China.The mass concentrations of PM_(2.5)and PM_(10)during the study period were 64±38 and 89±49μg/m~3,respectively,and NO_(2)and particulate matter were high compared with most other regions of China.The Fecontaining particles were divided into seven categories with different mass spectra,sources and aging characteristics.The highest contribution was from Fe mixed with carbonaceous components(Fe-C,23.1%)particles.Fe was more mixed with sulfate than nitrate and therefore the contribution of Fe mixed with sulfate(Fe-S,20.7%)particles was higher than that of Fe mixed with nitrate(Fe-N,12.5%)particles.The contributions from Fe-containing particles related to primary combustion were high in the small particle size range,whereas aged Fecontaining particles and dust-related particles were mostly found in the coarse particle size range.The air masses mainly originated from the west and east of Chengdu,and the corresponding PM_(2.5)concentrations were 79±36 and 55±36μg/m~3,respectively.The west and east air masses showed stronger contributions of Fe-containing particles related to biomass burning(Fe-B)and fossil fuel combustion(Fe-C and Fe-S)particles,respectively.The southwest area contributed the most Fe-containing particles.Future assessments of the effects of Fe-containing particles during heavy pollution period should pay more attention to Fe-C and Fe-S particles.Emission-reduction of Fe-containing particles should consider both local emissions and short-distance transmission from the surrounding areas. | Renjiang He Junke Zhang Luyao Chen Wei Zhang Yingwei Xi | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 16 | Real-time,single-particle chemical composition,volatility and mixing state measurements of urban aerosol particles in southwest China显示文摘To investigate the volatility of atmospheric particulates and the evolution of other particulate properties(chemical composition,particle size distribution and mixing state)with temperature,a thermodenuder coupled with a single particle aerosol mass spectrometer was used to conduct continuous observations of atmospheric fine particles in Chengdu,southwest China.Because of their complex sources and secondary reaction processes,the average mass spectra of single particles contained a variety of chemical components(including organic,inorganic and metal species).When the temperature rose from room temperature to280℃,the relative areas of volatile and semi-volatile components decreased,while the relative areas of less or non-volatile components increased.Most(>80%)nitrate and sulfate existed in the form of NH_(4)NO_(3)and(NH_(4))_(2)SO_(4),and their volatilization temperatures were50–100℃and 150–280℃,respectively.The contribution of biomass burning(BB)and vehicle emission(VE)particles increased significantly at 280℃,which emphasized the important role of regional biomass burning and local motor vehicle emissions to the core of particles.With the increase in temperature,the particle size of the particles coated with volatile or semi-volatile components was reduced,and their mixing with secondary inorganic components was significantly weakened.The formation of K-nitrate(KNO_(3))and K-sulfate(KSO_(4))particles was dominated by liquid-phase processes and photochemical reactions,respectively.Reducing KNO_(3)and BB particles is the key to improving visibility.These new results are helpful towards better understanding the initial sources,pollution formation mechanisms and climatic effects of fine particulate matter in this megacity in southwest China. | Luyao Chen Junke Zhang Jiaqi Li Xiaojuan Huang Yuzheng Xiang Jing Chen Tingru Pan Wei Zhang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 17 | Application of Metabolomics Approach to Study on Chemical Constituents in Cultivated and Wild Pinellia ternate (Thunb.) Breit. and Typhonium flagelliforme (Lodd.) Blume Based on UPLC-ESI-HRMS^n显示文摘[Objectives] The aim was to study chemical components of cultivated and wild Pinellia ternate(Thunb.) Breit and Typhonium flagelliforme(Lodd.) Blume by metabolomics technology based on UPLC-ESI-HRMS^n. [Methods] Chemical components of 27 samples of cultivated and wild P. ternate and T. flagelliforme were detected by using UPLC-ESI-HRMS^ntechnology. Differential markers between P. ternate and T. flagelliforme as well as cultivated and wild P. ternate were screened and identified by principal component analysis(PCA) and orthogonal partial least square-discriminate analysis(OPLS-DA). [Results]12 components of P. ternate(cultivated and wild variety) and T.flagelliforme and three components of cultivated and wild P. ternate were screened and identified by OPLS-DA. N-Acetyl-6-hydroxy-L-tryptophan and N-Phenylacetylglutamic were not detected in P. ternate,and these two components can be used as potential markers of P. ternate and T. flagelliforme. [Conclusions]UPLC-ESI-HRMS^n-based metabolomics technology could be used to quickly identify the chemical constituents of P. ternate and effectively distinguish P. ternate and T. flagelliforme,which has reference significance for the quality control of P. ternate. | Yanfang LI Gang KUANG Ainuan LI Junke CHEN Hui SUN Rui ZENG Xin LI | 2019 | Medicinal Plant2019，10，1： | 0 |
| 18 | The Coupling Coordination Evolution Research of Economy - Ecology - Society System in Xinjiang:Based on the Interaction Perspective of Water Resources显示文摘Under the water resources perspective,coupling coordination of economy-ecology-society system in Xinjiang was taken as the research object. By building the coupling evaluation index system of the water resources-economy-ecology-society system,quantitative evaluation and analysis of the coupling coordination of the water resources-economy-ecology-society system from 2001 to 2014 were conducted. The results showed that benefit indexes of economic system and social system grew rapidly,while benefit indexes of water resources system and ecosystem fluctuated smoothly from 2001 to 2014; coupling state of the whole system was at rival stage,and coupling coordination was reluctant coordination type,and the coupling index was slightly higher than the coupling coordination index. Moreover,it showed that the more the coupling systems,the lower indices of coupling and the coupling coordination. | Chen Junke Li Hong Wang Xibo Ma Yongren | 2017 | Meteorological and Environmental Research2017，8，5： | 0 |
| 19 | Fabrication of Porous Nitrogen-Doped Carbon Materials as Anodes for High-Performance Lithium Ion Batteries显示文摘层次多孔的做氮的碳材料(HNC ) 被使用作为碳来源包含明胶的氮准备, nano 硅石作为模板由一条简单火焰合成途径获得了。所有作为与商业石墨相比同样获得的 HNC 给高级得多的李看存储能力。明确地,体积和最高的氮满足的有最大的 micropore 的 HNC-700 甚至在 3.72 A·g −1(10 C ) 在 37.2 mA·g −1(0.1 C ) 和 309 mAh·g −1 的当前的密度展出了 1084 mAh·g −−1 的最佳的可逆能力。这结果建议 HNC 应该是在高率的锂离子电池(解放) 的阳极材料的一个有希望的候选人。 | Junke Ou Lin Yang YongzhiZhang Li Chen Yong Guo Dan Xiao | 2015 | Chinese Journal of Chemistry2015，33，11： | 0 |
| 20 | 微束电源控制系统升级显示文摘A new power supplies control system was developed at the high energy heavy ion microbeam facility in the Institute of Modern Physics(IMP),CAS.The system comprises AO modules from ICP DAS and AI modules from Advantech for different types of power supply interfaces.This paper introduces the hardware configuration,software design and running status of the power supplies system. | Liu Xiaojun Zhang Wei An Shi Wang Pengpeng Chang Jianjun Wu Junqi Liu Junke Chen Yun | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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