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| 1 | An epidermal sEMG tattoo-like patch as a new human–machine interface for patients with loss of voice显示文摘Throat cancer treatment involves surgical removal of the tumor,leaving patients with facial disfigurement as well as temporary or permanent loss of voice.Surface electromyography(sEMG)generated from the jaw contains lots of voice information.However,it is difficult to record because of not only the weakness of the signals but also the steep skin curvature.This paper demonstrates the design of an imperceptible,flexible epidermal sEMG tattoo-like patch with the thickness of less than 10μm and peeling strength of larger than 1N cm−1 that exhibits large adhesiveness to complex biological surfaces and is thus capable of sEMG recording for silent speech recognition.When a tester speaks silently,the patch shows excellent performance in recording the sEMG signals from three muscle channels and recognizing those frequently used instructions with high accuracy by using the wavelet decomposition and pattern recognization.The average accuracy of action instructions can reach up to 89.04%,and the average accuracy of emotion instructions is as high as 92.33%.To demonstrate the functionality of tattoo-like patches as a new human–machine interface(HMI)for patients with loss of voice,the intelligent silent speech recognition,voice synthesis,and virtual interaction have been implemented,which are of great importance in helping these patients communicate with people and make life more enjoyable. | Huicong Liu Wei Dong Yunfei Li Fanqi Li Jiangjun Geng Minglu Zhu Tao Chen Hongmiao Zhang Lining Sun Chengkuo Lee | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 2 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 3 | Near-zero-dispersion soliton and broadband modulational instability Kerr microcombs in anomalous dispersion显示文摘The developing advances of microresonator-based Ker cavity solitons have enabled versatile applications ranging from communication,signal processing to high-precision measurements.Resonator dispersion is the key factor determining the Kerr comb dynamics.Near the zero group-velocity-dispersion(GVD)regime,low-noise and broadband microcomb sources are achievable,which is crucial to the application of the Kerr soliton.When the GVD is almost vanished,higher-order dispersion can significantly affect the Kerr comb dynamics.Although many studies have investigated the Kerr comb dynamics near the zero-dispersion regime in microresonator or fiber ring system,limited by dispersion profles and dispersion perturbations,the near-zero-dispersion soliton structure pumped in the anomalous dispersion side is still elusive so far.Here,we theoretically and experimentally investigate the microcomb dynamics in fiber-based Fabry-Perot microresonator with ultra-small anomalous GVD.We obtain 2/3-octave-spaning microcombs with~10 GHz spacing,>84 THz span,and>8400 comb lines in the modulational instability(MI)state,without any external nonlinear spectral broadening.Such widely-spanned Ml combs are also able to enter the soliton state.Moreover,we report the first observation of anomalous-dispersion based near-zero-dispersion solitons,which exhibits a local repetition rate up to 8.6 THz,an individual pulse duration<100 fs,a span>32 THz and>3200 comb lines.These two distinct comb states have their own advantages.The broadband MI combs possess high conversion efficiency and wide existing range,while the near-zero-dispersion soliton exhibits relatively low phase noise and ultra-high local repetition rate.This work complements the dynamics of Kerr cavity soliton near the zero-dispersion regime,and may stimulate cross-disciplinary inspirations ranging from dispersion-controlled microresonators to broadband coherent comb devices. | Zeyu Xiao Tieying Li Minglu Cai Hongyi Zhang Yi Huang Chao Li Baicheng Yao Kan Wu Jianping Chen | 2023 | Light(Science & Applications)2023，12，2： | 2 |
| 4 | Study on coordinated control and hardware system of a mobile manipulator显示文摘 | Yingshu Chen Libing Liu Minglu Zhang ect | 2006 | Proceedings of the 6th world congress on intelligent control and automation2006，，6： | 1 |
| 5 | Polyamidoamine (PAMAM)dendrimers as biocompatible carriers of quinolone antimicrobials:An in vitro study显示文摘 | Chen Yiyun Qu Haiou Ma Minglu | 2007 | Eur J Med Chem2007，42，： | 1 |
| 6 | Blind zone-suppressed hybrid beam steering for solid-state Lidar显示文摘We demonstrate a blind zone-suppressed and flash-emitting solid-state Lidar based on lens-assisted beam-steering technology.As a proof-of-concept demonstration,with the design of a subwavelength-gap 1D long-emitter array and multiwavelength flash beam emitting,the device was measured to have 5%blind zone suppression,0.06°/point-deflection step,and 4.2μs scanning speed.In time-of-flight ranging experiments,Lidar systems have a field of view of 11.3°×8.1°(normal device)or 0.9°×8.1°(blind-zone suppressed device),far-field number of resolved points of 192,and a detection distance of 10 m.This work demonstrates the possibility that a new integrated beam-steering technology can be implemented in a Lidar without sacrificing other performance. | CHAO LI XIANYI CAO KAN WU GAOFENG QIU MINGLU CAI GUANGJIN ZHANG XINWAN LI JIANPING CHEN | 2021 | Photonics Research2021，9，9： | 1 |
| 7 | Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials:An in vitro study显示文摘 | Chen Yiyun Qu Haiou Ma Minglu | 2007 | Eur J Med Chem2007，42，： | 1 |
| 8 | Comparison of NOM removal and microbial properties in up-flow/down-flow BAC filter显示文摘 | Lineng Han Wenjun Liu Mo Chen Minglu Zhang Shuming Liu Ruilin Sun Xiangqin Fei | 2013 | Water Research2013，，： | 1 |
| 9 | Efficient control of chronic LCMV infection by a CD4 T cell epitope-based heterologous prime-boost vaccination in a murine model显示文摘CD4^(+)T cells are essential for sustaining CD8^(+)T cell responses during a chronic infection.The adoptive transfer of virus-specific CD4^(+)T cells has been shown to efficiently rescue exhausted CD8^(+)T cells.However,the question of whether endogenous virus-specific CD4^(+)T cell responses can be enhanced by certain vaccination strategies and subsequently reinvigorate exhausted CD8^(+)T cells remains unexplored.In this study,we developed a CD4^(+)T cell epitope-based heterologous prime-boost immunization strategy and examined the efficacy of this strategy using a mouse model of chronic lymphocytic choriomeningitis virus(LCMV)infection.We primed chronically LCMV-infected mice with a Listeria monocytogenes vector that expressed the LCMV glycoprotein-specific I-Ab-restricted CD4^(+)T cell epitope GP61–80(LM-GP61)and subsequently boosted the primed mice with an influenza virus A(PR8 strain)vector that expressed the same CD4^(+)T cell epitope(IAV-GP61).This heterologous prime-boost vaccination strategy elicited strong anti-viral CD4^(+)T cell responses,which further improved both the quantity and quality of the virusspecific CD8^(+)T cells and led to better control of the viral loads.The combination of this strategy and the blockade of the programmed cell death-1(PD-1)inhibitory pathway further enhanced the anti-viral CD8^(+)T cell responses and viral clearance.Thus,a heterologous prime-boost immunization that selectively induces virus-specific CD4^(+)T cell responses in conjunction with blockade of the inhibitory pathway may represent a promising therapeutic approach to treating patients with chronic viral infections. | Ran He Xinxin Yang Cheng Liu Xiangyu Chen Lin Wang Minglu Xiao Jianqiang Ye Yuzhang Wu Lilin Ye | 2018 | Cellular & Molecular Immunology2018，15，9： | 1 |
| 10 | A global reliability assessment method oil aging offshore platforms with corrosion and cracks显示文摘 | Ji Chunyan Li Shanshan Chen Minglu | 2009 | Chinese Ocean Engineering2009，23，2： | 1 |
| 11 | Research and Development of Ceramic Filtration Membrane显示文摘Ceramic filter membrane plays an irreplaceable role in many fields because of its unique advantages. However, the complicated preparation process and high cost still limit the large scale application of ceramic fi lter membrane. Therefore, to improve the preparation process of ceramic fi lter membrane, optimize the membrane system structure is the ceramic fi lter membrane industry is facing major problems. In this paper, the structure, separation principle, preparation technology and application of ceramic fi lter membrane are introduced. | Minglu Deng Rong Chen Sirong Liu | 2018 | Ceramic Sciences and Engineering2018，1，1： | 1 |
| 12 | Intermetallic CuAu nanoalloy for stable electrochemical CO_(2) reduction显示文摘Copper is one of the most efficient catalysts widely investigated in electrochemical CO_(2) reduction, however, the further development of copper-based catalysts is constrained by severe stability problems. In this work, we developed a method for the synthesis of highly ordered Cu Au intermetallic nanoalloys(o-CuAu) under mild conditions(< 250℃), which can convert carbon dioxide to carbon monoxide with high selectivity and can operate stably for 160 h without current decay. The improved stability is believed to be due to the increased mixing enthalpy and stronger atomic interactions between Cu and Au atoms in the intermetallic nanoalloy. In addition, XPS results, Tafel slope and in situ IR spectroscopy demonstrate that high valence gold atoms on o-CuAu surface promote the reduction of CO_(2). In contrast, the disordered CuAu nanoalloy(d-CuAu) underwent atomic rearrangement to form a Cu-rich structure on the surface, leading to reduced stability. These findings may provide insight into the rational design of stable CO_(2) RR electrocatalysts through proper structural engineering. | Siyu Kuang Minglu Li Xiaoyi Chen Haoyuan Chi Jianlong Lin Zheng Hu Shi Hu Sheng Zhang Xinbin Ma | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 13 | 蛋白磷酸酶PTENα通过调节CaMKⅡ通路调控恐惧记忆及空间学习能力显示文摘文章简介PTEN基因作为强大的抑癌基因而闻名于世,其在神经系统中也发挥重要调控作用。PTEN基因缺失小鼠表现出多种与神经相关的疾病表型,包括自发性癫痫、自闭症谱系障碍、小脑共济失调等。同时,临床研究显示携带PTEN基因突变的病人容易发生癫痫、自闭症等神经疾病。 | Pan Wang Fan Mei Jiapan Hu Minglu Zhu Hailong Qi Xi Chen Ruiqi Li Michael A.McNutt 尹玉新 | 2018 | 科学新闻2018，0，4： | 0 |
| 14 | Super-assembled sandwich-like Au@MSN@Ag nanomatrices for high-throughput and efficient detection of small biomolecules显示文摘Small biomolecules(m/z<500)are the material basis of organisms and participate in life activities,but their comprehensive and accurate detection in complex samples remains a challenge.Matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)is a powerful detection tool for molecular analysis with high throughput.The development of a new matrix is essential to improve the efficiency of the MALDI-MS for molecular compound detection.In this work,the sandwich-like gold nanoparticles@mesoporous silica nanocomposite@silver nanoparticles(Au@MSN@Ag)nanospheres were prepared by layer-by-layer super-assembly strategy,and can be used as a novel matrix for the quantitative detection and enrichment of small biomolecules by LDI-MS.The sandwich-like nanospheres form a unique plasma resonant cavity that effectively absorbs the laser energy,while the homogeneous mesoporous structure of MSN can lock the analyte,which is essential for efficient LDI of small molecules.Compared to traditional matrices,Au@MSN@Ag shows the advantages of low background,wide application range,high sensitivity,super high salt and protein tolerance,and good stability.For example,the detection limit of glucose was as low as 5 fmol,and showed a good linear relationship in the range of 1−750μg/mL.Au@MSN@Ag assisted LDI-MS allows the enrichment and detection of small molecules in traditional Chinese medicine(TCM)without derivatization and purification,classification of herbs using the accurate quantitative results oligosaccharides,and identification of gelatin by amino acid content.This research could help in designing more efficient nanostructure matrices and further explored the application of LDI-MS. | Dantong Zhao Chunxia Ma Meng Gao Yong Li Bo Yang Hui Li Runhao Zhang Minglu Hao Jing Huang Kang Liang Pu Chen Lei Xie Rong Rong Biao Kong | 2022 | Nano Research2022，15，3： | 0 |
| 15 | A New Modified Two-Subgradient Extragradient Algorithm for Solving Variational Inequality Problems显示文摘In this paper,we propose a modified two-subgradient extragradient algorithm(MTSEGA)for solving monotone and Lipschitz continuous variational inequalities with the feasible set being a level set of a smooth convex function in Hilbert space.The advantage of MTSEGA is that all the projections are computed onto a half-space per iteration.Moreover,MTSEGA only needs one computation of the underlying mapping per iteration.Under the same assumptions with the known algorithm,we show that the sequence generated by this algorithm is weakly convergent to a solution of the concerned problem. | Jiaxin CHEN Minglu YE | 2022 | Journal of Mathematical Research with Applications2022，42，4： | 0 |
| 16 | Relationship between the expression of TLR4 and TIRAP and sepsis in peripheral blood显示文摘Objective:To explore the relationship between the expression of TLR4 and TIRAP and sepsis severity.Methods:The study selected 30 healthy examinees as the control group and 53 patients with sepsis as the observation group.The patients in the observation group were assessed by Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ).40 patients with APACHE Ⅱ score≤20,were classified into the low-score sepsis group;13 patients with APACHE Ⅱ score>20,were classified into the high-score sepsis group.The levels of TLR4 and TIRAP in venous serum were detected in all subjects by enzyme-linked immunosorbent assay(ELISA).Results:The levels of TLR4 and TIRAP in serum were 0.886±0.058 ng/ml and 5.216±0.410 ng/ml in the control group;2.253±0.379 ng/ml and 9.540±2.294 ng/ml in the low-score sepsis group;4.494±0.709 ng/ml and 19.206±1.755 ng/ml in the high-score sepsis group.The observation group(low-score and high-score sepsis groups)was significantly different from the control group(p=.000),and the low-score sepsis group was significantly different from the high-score sepsis group(p=.000).With APACHE II score of 20 as the cut-off point,the low-score sepsis group was consisted of low-risk patients and the high-score group was consisted of the high-risk,which can indicate the sepsis severity.According to Pearson’s correlation analysis,the level of TLR4 was positively correlated with sepsis severity(r=0.931,p<.05),the level of TIRAP was also positively correlated with the sepsis severity(r=0.972,p<.05);the level of TLR4 was positively correlated with the level of TIRAP(r=0.936,p<.05).Conclusions:The levels of TLR4 and TIRAP in septic patients can be used to predict and determine the severity of sepsis. | Minglu Qi Jingping Yang Xue Yin Si Chen Xiyuan Xu | 2016 | Discussion of Clinical Cases2016，3，4： | 0 |
| 17 | Search by shortcuts in P2P scientific collaboration system显示文摘A P2P scientific collaboration is a P2P network whose members can share documents, co-compile papers and codes, and communicate with each other instantly. From the simulation experiment we found that P2P collaboration system is a power-law network with a tail between -2 and -3.We utilized the algorithm that searches by high-degree shortcuts to improve the scalability of p2p collaboration system. The experimental result shows that the algorithm works better than random walk algorithm. | Deng Qianni(邓倩妮) Chen Li Lu Xinda Li Minglu | 2005 | High Technology Letters2005，11，3： | 0 |
| 18 | Spatio-temporal characteristics of human activities using location big data in Qilian Mountain National Park显示文摘Human activities significantly impact the environment.Understanding the patterns and distribution of these activities is crucial for ecological protection.With location-based technology advancement,big data such as location and trajectory data can be used to analyze human activities on finer temporal and spatial scales than traditional remote sensing data.In this study,Qilian Mountain National Park(QMNP)was chosen as the research area,and Tencent location data were used to construct time series data.Time series clustering and decomposition were performed,and the spatio-temporal distribution characteristics of human activities in the study area were analyzed in conjunction with GPS trajectory data and land use data.The study found two distinct human activity patterns,Pattern A and Pattern B,in QMNP.Compared to Pattern B,Pattern A had a higher volume of location data and clear nighttime peaks.By incorporating land use and trajectory data,we conclude that Pattern A and Pattern B represent the activity patterns of the resident and tourist populations,respectively.Moreover,the study identified seasonal variations in human activities,with human activity in summer being approximately two hours longer than in winter.We also conducted an analysis of human activities in different counties within the study area. | Minglu Che Yanyun Nian Siwen Chen Hao Zhang Tao Pei | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 19 | Co-delivery of mitochondrial targeted lonidamine and PIN1 inhibitor ATRA by nanoparticulate systems for synergistic metastasis suppression显示文摘Mitochondria are highly involved in the metastasis of cancer cells.However,tumor cells impede the efficiency of mitochondrial targeted drugs by protecting mitochondria through an intrinsic and adaptive antioxidant mechanism.We aim to disturb the redox homeostasis by prolyl-isomerase PIN1 inhibitor all-trans retinoic acid(ATRA)to improve the therapeutic efficacy of mitochondrial targeted lonidamine(TL).The combination of ATRA and TL with a ratio of 2:1 was found to have the best synergistic effect in inhibiting the proliferation and metastasis of metastatic 4T1 breast cancer cells.Dual-drug loaded nanoparticles(TL-ATRA NPs)were further developed by self-assembly and were observed to disturb the redox homeostasis drastically and triggered a robust mitochondrial disruption on metastatic 4T1 breast cancer cells.The molecular mechanism was related to the downregulation of nuclear factor E2-related factor 2(NRF2),a critical transcription factor that regulated antioxidant responses,and its downstream molecules.As a result,TL-ATRA NPs significantly suppressed the growth of primary tumors and the formation of lung metastasis nodes.Collectively,our findings showed that sensitizing mitochondria to anti-cancer drugs by disturbing redox homeostasis achieved a satisfactory therapeutic effect to inhibit tumor growth and metastasis. | Cheng Chen Qiuyi Li Liyun Xing Minglu Zhou Chaohui Luo Shujie Li Lian Li Yuan Huang | 2022 | Nano Research2022，15，4： | 0 |
| 20 | Design and motion control analysis of double helix wall climbing robot显示文摘For the detection environment of complex walls such as high-rise buildings,a double helix wall climbing robot(DHWCR)with strong adsorption force and good stability is designed and developed,which uses symmetrical propellers to provide adsorption force.The symmetrical driving structure can provide smooth thrust for the DHWCR,so that the robot can be absorbed to the wall surface with different roughness.A left and right control frame with multiple degrees of freedom is designed,which can adjust the fixed position of the brushless propeller motor in the front and back directions,realize the continuous adjustable thrust direction of the robot,and improve the flexibility of the robot movement.Using the front wheel steering mechanism with universal joint,the steering control of the DHWCR is realized by differential control.In the vertical to ground transition,the front and rear brushless motors can provide the pull up and oblique thrust,so that the DHWCR can smoothly transition to the vertical wall.The motion performance and adaptability of the DHWCR in the horizontal ground and vertical wall environment are tested.The results show that the DHWCR can switch motion between the horizontal ground and vertical wall,and can stably adsorb on the vertical wall with flexible attitude control.The DHWCR can move at a fast speed.The speed on the horizontal ground is higher than that on the vertical wall,which verifies the feasibility and reliability of the DHWCR moving stably on the vertical wall. | Jinzhan WANG Minglu CHI Yue MA Qinchao REN Mengqing HUANG Yibo CHEN Ruihua REN Jinyu WANG Si LIU | 2022 | Mechanical Engineering Science2022，4，1： | 0 |
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