|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mathematical model of flow characteristic in multi-strand continuous casting tundishes显示文摘In this paper,the subject of mathematical model is a series of math expressions,which is used to calculate different regions volume fraction and analyze flow characterization in multi-strand tundish.But research about mathematical model for multi-strand tundish is few,and so far,there has been no acknowledged math model for multi-strand tundish to describe its flow characteristic.If Sahai s model,which is originally proposed for the case of single-strand tundish(proposed in reference[10],and this model is widely used in the world),is applied to describe flow feature in multi-strand tundish,the calculation results would be unreasonable.Based on the data of water-model experiment results,the sum of each strand s dead region s volume fraction is bigger than 100%,and this obviously doesn t agree with reality;and the value of dead region s volume fraction is calculated to be minus according to mathematical simulation results data in another case.What s more,Sahai s model does not propose the standard of plotting the RTD-curve,and this makes scholars around the world can t achieve consensus of views about plotting RTD-curve.And the model doesn t consider the bypass flow and can t calculate its volume fraction,but bypass flow is critical to tundish metallurgy.And through Sahai s model,the calculation result of plug flow region s volume fraction is also not reasonable,because the model doesn t well describe the essence of plug flow.So these suggest that it is not reliable to apply Sahai s single-strand tundish model to multi-strand tundish case.Then a new model is attempted to propose in this paper for your discussion.In the new model,the standard of plotting RTD curve is definitely proposed,and relative calculation method is also proposed;and the feature of dead region is carefully studied and the model proposes a new method to calculate its volume fraction,and the calculation formula about its volume fraction can be adjustable according the actual demand;what s more,the new model considers the bypass flow and proposes a method to calculate its volume fraction for the first time,and then volume fraction of plug flow region,backmix flow region,dead region and bypass flow can be calculated and obtained at the same time;and this new model can better capture the deviation of reality flow pattern from ideal plug flow pattern,and reffects the feature of plug flow. | Hongwei PAN Shusen CHENG | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，4： | 3 |
| 2 | Mathematical simulation of hot metal desulfurization during KR process coupled with an unreacted core model显示文摘A three-dimensional mathematical model was established to predict the multiphase flow,motion and dispersion of desulfurizer particles,and desulfurization of hot metal during the Kanbara reactor(KR)process.The turbulent kinetic energy-turbulent dissipation rate(k-ε)turbulence model,volume-of-fluid multiphase model,discrete-phase model,and unreacted core model for the reaction between the hot metal and particles were coupled.The measured sulfur content of the hot metal with time during the actual KR process was employed to validate the current mathematical model.The distance from the lowest point of the liquid level to the bottom of the ladle decreased from 3170 to2191 mm when the rotation speed increased from 30 to 110 r/min,which had a great effect on the dispersion of desulfurizer particles.The critical rotation speed for the vortex to reach the upper edge of the stirring impeller was 70 r/min when the immersion depth was 1500 mm.The desulfurization rate increased with the increase in the impeller rotation speed,whereas the influence of the immersion depth was relatively small.Formulas for different rotation parameters on the desulfurization rate constant and turbulent energy dissipation rate were proposed to evaluate the variation in sulfur content over time. | Yanyu Zhao Wei Chen Shusen Cheng Lifeng Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 2 |
| 3 | The time-dependent shift in the hepatic graft and recipient macrophage pool following liver transplantation显示文摘Liver transplantation(LT)provides a cure for various end-stage liver diseases.The liver graft becomes the recipient’s new metabolic center,and donor genetics plays a potent role in the development of complications in the recipient,such as metabolic disorders1 and even tumor recurrence.2 Notably,both the donor’s3 and recipient’s genetics4 contributes significantly to intrahepatic complications(e.g.,liver fibrosis and de novo steatosis).Therefore,crosstalk between donor and recipient tissue remodels the architecture and homeostasis of the transplanted liver,which is still a great challenge to explore. | Haitao Huang Xueyou Zhang Cheng Zhang Hui Chen Qi Ling Shusen Zheng | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 4 | Optimization for the structure of BF hearth bottom and the arrangement of thermal couples显示文摘The hearth of “heat transfer method” and the ceramic cup synthetic hearth bottom of “heart isolation method” are two most popular designs for blast furnace (BF). Although there are successful real examples, some disadvantages, for instance large heat loss and high cost, still exist for these designs. According to the theory of heat transfer, based on the calculation of temperature distribution of the hearth bottom, it is elucidated that all brick layers at the hearth bottom may not be considered as the only reason why different structures exhibited different temperature distributions although total heat resistance is the same, and then based on the effect of hot metal and cold water on different temperature distribution ranges, the concepts of “heat resistance” and “cooling enhancement” are put forth. Based on this, the disadvantages and the factors affecting temperature distribution, of the two types of hearth bottoms were illustrated. On the basis of these analyses, a novel structure for BF hearth bottom designing that can easily form “self-protecting” slag layer stably, called “the method of gradient brick layout that has an optimum combination of cooling enhancement and heat resistance” was proposed; it can not only prolong the hearth bottom longevity but also reduce the cost and heat loss. Also, the optimum arrangement of thermal couples in hearth bottom was suggested based on the previous studies on erosion prediction carried out by the author. | ZHAO Hongbo CHENG Shusen | 2006 | 北京科技大学学报2006，28，12： | 2 |
| 5 | Mitofusin-2 is a novel direct target of p53显示文摘 | Weilin Wang Xiaofei Cheng Jianju Lu Jianfeng Wei Guanghou Fu Feng Zhu Changku Jia Lin Zhou Haiyang Xie Shusen Zheng | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 1 |
| 6 | Hepatitis B virus X protein inhibits p53-mediated upregulation of mitofusin-2 in hepatocellular carcinoma cells显示文摘 | Weilin Wang Dongkai Zhou Jianfeng Wei Zehui Wu Xiaofei Cheng Qiang Sun Haiyang Xie Lin Zhou Shusen Zheng | 2012 | Biochemical and Biophysical Research Communications2012，，2： | 1 |
| 7 | Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma显示文摘 | Baiye Jin Guanghou Fu Hao Pan Xiaofei Cheng Lin Zhou Jia Lv Geming Chen Shusen Zheng | 2011 | Medical Oncology2011，，1： | 1 |
| 8 | Discussion about model of residual time distribution for tundish显示文摘 | Pan Hongwei Cheng Shusen Cheng Zijian | 2008 | Journal of Iron and Steel Research International2008，15，1： | 1 |
| 9 | NDRG1 as a biomarker for metastasis, recurrence and of poor prognosis in hepatocellular carcinoma显示文摘 | Jun Cheng Hai-Yang Xie Xiao Xu Jian Wu Xuyong Wei Rong Su Wu Zhang Zhen Lv Shusen Zheng Lin Zhou | 2011 | Cancer Letters2011，，1： | 1 |
| 10 | Tempera- ture Field of Lining and Cooling Apparatus显示文摘 | Cheng Shusen Xue Qingguo Yang Tianjun et ai | 2000 | Journal of U- niversity of Science and Technology Beijing2000，7，1： | 1 |
| 11 | Optimization for the structure of BF hearth bottom and the arrangement of thermal couples显示文摘The hearth of “heat transfer method” and the ceramic cup synthetic hearth bottom of “heart isolation method” are two most popular designs for blast furnace (BF). Although there are successful real examples, some disadvantages, for instance large heat loss and high cost, still exist for these designs. According to the theory of heat transfer, based on the calculation of temperature distribution of the hearth bottom, it is elucidated that all brick layers at the hearth bottom may not be considered as the only reason why different structures exhibited different temperature distributions although total heat resistance is the same, and then based on the effect of hot metal and cold water on different temperature distribution ranges, the concepts of “heat resistance” and “cooling enhancement” are put forth. Based on this, the disadvantages and the factors affecting temperature distribution, of the two types of hearth bottoms were illustrated. On the basis of these analyses, a novel structure for BF hearth bottom designing that can easily form “self-protecting” slag layer stably, called “the method of gradient brick layout that has an optimum combination of cooling enhancement and heat resistance”was proposed; it can not only prolong the hearth bottom longevity but also reduce the cost and heat loss. Also, the optimum arrangement of thermal couples in hearth bottom was suggested based on the previous studies on erosion prediction carried out by the author. | Hongbo Zhao Shusen Cheng | 2006 | Journal of University of Science and Technology Beijing2006，13，6： | 0 |
| 12 | Application of biocompatible custom ceria nanoparticles in improving the quality of liver grafts for transplantation显示文摘Liver transplantation(LT),an ultimate and vital method for treating end-stage liver disease,is often accompanied by ischemiareperfusion injury(IRI)resulting from warm or cold ischemia of the donor liver.Organ protection techniques are used to improve the quality of liver grafts(from retrieval to implantation).Reactive oxygen species(ROS)cause oxidative stress,which is considered a crucial factor in IRI after LT.Nano antioxidants capable of scavenging ROS alleviate IRI in multiple types of organs and tissues.In this study,we synthesized ceria nanoparticles(NPs)with antioxidant properties using a pyrolysis method and covered them with phospholipid-polyethylene glycol to improve their biocompatibility in vivo.We investigated the potential organprotective effect of ceria NPs and the underlying mechanisms.Ceria NPs promoted liver function recovery after LT by attenuating IRI in liver grafts in vivo.The protective effect of ceria NPs on liver grafts was investigated by applying hypothermic oxygenated machine perfusion ex vivo.Ceria NPs attenuated hypoxia reoxygenation-or H_(2)O_(2)-induced hepatocyte injury by enhancing mitochondrial activity and ROS scavenging in vitro.These effects may be associated with the activation of the nuclear factor erythroid-derived 2-related factor 2(Nrf2)/Kelch-like ECH-associated protein 1(Keap1)/heme oxygenase 1(HO-1)signaling pathway.In conclusion,ceria NPs may serve as a promising antioxidant agent for the treatment of hepatic IRI after LT. | Yinbiao Qiao Jianhui Li Suchen Bian Chenyue Zhan Jia Luo Li Jiang Haoyu Li Hao Wu Cheng Zhang Shusen Zheng Haiyang Xie Penghong Song | 2023 | Nano Research2023，16，4： | 0 |
| 13 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 14 | BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes显示文摘Brain-specific serine/threonine-protein kinase 2(BRSK2)plays critical roles in insulin secretion andβ-cell biology.However,whether BRSK2 is associated with human type 2 diabetes mellitus(T2DM)has not been determined.Here,we report that BRSK2 genetic variants are closely related to worsening glucose metabolism due to hyperinsulinemia and insulin resistance in the Chinese population.BRSK2 protein levels are significantly elevated inβcells from T2DM patients and high-fat diet(HFD)-fed mice due to enhanced protein stability.Mice with inducibleβ-cell-specific Brsk2 knockout(βKO)exhibit normal metabolism with a high potential for insulin secretion under chow-diet conditions.Moreover,βKO mice are protected from HFD-induced hyperinsulinemia,obesity,insulin resistance,and glucose intolerance.Conversely,gain-of-function BRSK2 in matureβcells reversibly triggers hyperglycemia due toβ-cell hypersecretion-coupled insulin resistance.Mechanistically,BRSK2 senses lipid signals and induces basal insulin secretion in a kinase-dependent manner.The enhanced basal insulin secretion drives insulin resistance andβ-cell exhaustion and thus the onset of T2DM in mice fed an HFD or with gain-of-function BRSK2 inβcells.These findings reveal that BRSK2 links hyperinsulinemia to systematic insulin resistance via interplay betweenβcells and insulin-sensitive tissues in the populations carrying human genetic variants or under nutrient-overload conditions. | Rufeng Xu Kaiyuan Wang Zhengjian Yao Yan Zhang Li Jin Jing Pang Yuncai Zhou Kai Wang Dechen Liu Yaqin Zhang Peng Sun Fuqiang Wang Xiaoai Chang Tengli Liu Shusen Wang Yalin Zhang Shuyong Lin Cheng Hu Yunxia Zhu Xiao Han | 2023 | Journal of Molecular Cell Biology2023，15，5： | 0 |
| 15 | SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation显示文摘Background:Liver cancer is a malignancy with high morbidity and mortality rates.Serpin family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many tumors.In this study,we aimed to investigate the potential mechanism of SERPINE2 in liver cancer metastasis.Methods:The Cancer Genome Atlas database(TCGA),including DNA methy-lation and transcriptome sequencing data,was utilized to identify the crucial oncogene associated with DNA methylation and cancer progression in liver can-cer.Data from the TCGA and RNA sequencing for 94 pairs of liver cancer tissues were used to explore the correlation between SERPINE2 expression and clin-ical parameters of patients.DNA methylation sequencing was used to detect the DNA methylation levels in liver cancer tissues and cells.RNA sequencing,cytokine assays,immunoprecipitation(IP)and mass spectrometry(MS)assays,protein stability assays,and ubiquitination assays were performed to explore the regulatory mechanism of SERPINE2 in liver cancer metastasis.Patient-derived xenografts and tumor organoid models were established to determine the role of SERPINE2 in the treatment of liver cancer using sorafenib.Results:Based on the public database screening,SERPINE2 was identified as a tumor promoter regulated by DNA methylation.SERPINE2 expression was significantly higher in liver cancer tissues and was associated with the dismal prognosis in patients with liver cancer.SERPINE2 promoted liver cancer metas-tasis by enhancing cell pseudopodia formation,cell adhesion,cancer-associated fibroblast activation,extracellular matrix remodeling,and angiogenesis.IP/MS assays confirmed that SERPINE2 activated epidermal growth factor receptor(EGFR)and its downstream signaling pathways by interacting with EGFR.Mechanistically,SERPINE2 inhibited EGFR ubiquitination and maintained its protein stability by competing with the E3 ubiquitin ligase,c-Cbl.Additionally,EGFR was activated in liver cancer cells after sorafenib treatment,and SER-PINE2 knockdown-induced EGFR downregulation significantly enhanced the therapeutic efficacy of sorafenib against liver cancer.Furthermore,we found that SERPINE2 knockdown also had a sensitizing effect on lenvatinib treatment.Conclusions:SERPINE2 promoted liver cancer metastasis by preventing EGFR degradation via c-Cbl-mediated ubiquitination,suggesting that inhibition of the SERPINE2-EGFR axis may be a potential target for liver cancer treatment. | Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu Wenfeng Song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong Song | 2024 | Cancer Communications2024，44，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员