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| 1 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 2 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 3 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 4 | Geochronology,Geochemistry and Petrogenesis of Diabase Dyke Swarms in East Tianshan,Xinjiang,NW China显示文摘Diabase dyke swarms are widespread in the East Tianshan and Beishan regions. LA-ICP-MS zircon U-Pb ages of these diabase vary from 305 Ma to 278 Ma, showing that these dykes were formed during Late Carboniferous-Early Permian magmatism. All diabase samples are subalkali calc-alkali, characterized by slight LREE and LILEs enrichment, and weak negative Ti, Nb and Ta anomalies. The diabase samples have positive εNd(t) values (>+3), high Sr isotopic compositions (initial 87Sr/86Sr values=0.7030-0.7097), and large variation of Pb isotopic compositions, indicating they were derived from a deplete mantle source. Regional geology and geochemistry evidences indicate that these diabase dyke swarms were generated in a lithosphere extensional setting and had the same magma sources. Initial magmas may be a mixture of depleted asthenosphere mantle and enriched lithospheric mantle during rapid magma ascending. | ZHANG Zuoheng CHAI Fengmei WANG Tuanhua CHENG Yanbo XU Lingang YUAN Shunda | 2012 | Acta Geologica Sinica(English Edition)2012，86，6： | 5 |
| 5 | Geochronology of the Gabbro-mafic Microgranular Enclaves-granite Associations in the Gejiu District, Yunnan Province and Their Geodynamic Significance显示文摘Many igneous rocks distribute in Gejiu tin polymetallic ore-field at Yunnan province, rocks including basalt, gabbro, mafic microgranular enclaves, granites (porphyritic granite and equigranular granite) and akaline rocks. The ages of the granites and akaline rocks which are considered to have genetic connecting with the mineralization have been comfirmed, but the gabbro- mafic microgranular enclaves-granite assemblage's ages are still unknown. By means of LA-ICP-MS zircon U-Pb dating, the data of Shenxianshui equigranular granite, the mafic microgranular enclave in Jiasha area, the host rock of the mafic microgranular enclaves and the Jiasha gabbro are around ~80 Ma. Besides the above mentioned data, a group of new ages at ~30 Ma were discovered in this study, which is from gabbro and mafic microgranular enclaves. Based on the previous data and the new data gained this time, we suggest the major geochronology framework of the magmatism and mineralization events in Gejiu area is ~80 Ma, which is consistent with the Late Cretaceous magmatism and mineralization events in the whole southeast Yunnan and west Guangxi area and they were suggested to belong to the same geotectonic setting in late Yenshannian. And the new ages of the ~30 Ma obtained in this study is considered to represent a responding to the complicate tectonic evolution history of the Tibetan orogenic events in Cenozoic. | CHENG Yanbo MAO Jingwen | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 5 |
| 6 | A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state显示文摘Dopamine(DA)level in the nucleus accumbens(NAc)is critical for reward and aversion encoding.DA released from the ventral mesencephalon(VM)DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons(D1-MSNs)in the NAc to enhance DA release and augment rewards.However,how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive.Here we report that the ventral pallidum(VP)projection of NAc D1-MSNs(D1^(NAc-VP))is inhibited by rewarding stimuli and activated by aversive stimuli.In contrast to the VM projection of D1-MSN(D1^(NAc-VM)),activation of D1^(NAc-VP) projection induces aversion,but not reward.D1^(NAc-VP) MSNs are distinct from the D1^(NAc-VM) MSNs,which exhibit conventional functions of D1-MSNs.Activation of D1^(NAc-VP) projection stimulates VM GABAergic transmission,inhibits VM DAergic neurons,and reduces DA release into the NAc.Thus,D1^(NAc-VP) and D1^(NAc-VM) MSNs cooperatively control NAc dopamine balance and reward-aversion states. | Zhiyuan Liu Qiumin Le Yanbo Lv Xi Chen Jian Cui Yiming Zhou Deqin Cheng Chaonan Ma Xiujuan Su Lei Xiao Ruyi Yang Jiayi Zhang Lan Ma Xing Liu | 2022 | Cell Research2022，32，2： | 2 |
| 7 | Neighborhood,community and consumption:Study on the socio-spatial structure during two boosting epochs in Shanghai显示文摘The modernization of Shanghai has experienced two boosting periods.The first appeared in the 1930s,when it formed the civil society of Shanghai and initially facilitated the trade port into an international metropolis.The second started after the nation’s reform and opening-up,which attempted to promote the city into a global metropolis in the 2010s.In order to evaluate the socio-spatial transitions of communities in Shanghai during the process,Lilong historical neighborhoods in the 1930s and 2010s are successively chosen as research objects.Meanwhile,three specific neighborhoods in each period are selected for case study,so as to depict different symbiosis patterns of the socio-spatial structures under different spatiotemporal conditions by means of a cross-sectional analysis of the consumption level.By pointing out Shanghai in the 1930s was marked with social integration and local-based consumption,while it was inundated with administration tendency and global-oriented consumption in the 2010s,the article believes the dual integration of local-based and global-oriented consumptions is an alternative solution for Shanghai.Finally,the article proposes that Shanghai’s current urban regeneration should rely on the multi-centered symbiotic structure to create a compound network,during which territorial socio-spatial structures and basic living needs of the plebeian can be simultaneously preserved. | Xiang Zhou Yanbo Li Yuning Cheng | 2020 | Frontiers of Architectural Research2020，9，2： | 2 |
| 8 | Acidic buffer mechanism of cyclotriphosphazene and melamine cyanurate synergism system flame retardant epoxy resin显示文摘 | Yanbo Cheng Jiang Li Yueshan He | 2015 | Polymer Engineering & Science2015，55，5： | 1 |
| 9 | Protective effects of Ginkgo biloba extract on 6-hydroxydopamine-induced apoptosis in PC12 cells显示文摘The present study analyzed the protective effects of Ginkgo biloba extract against 6-hydroxydopamine-induced PC12 cell apoptosis in a model of Parkinson's disease. The results showed that Ginkgo biloba extract had a potent cytoprotective action and inhibited apoptosis of PC12 cells induced by 6-hydroxydopamine. Ginkgo biloba extract decreased the ratio of Bax to Bcl-2 and markedly inhibited the activation of p53 and caspase-3. These experimental findings indicate that Ginkgo biloba extract may significantly reduce the effects of oxidative stress induced by 6-hydroxydopamine in PC12 cells and suppress cell apoptosis. The potential effects of Ginkgo biloba extract might be greater than those of levodopa in the treatment of Parkinson's disease. | Jie Wang Yanbo Cheng Jiale Yin Qian LU Xingshun Xu Xiaoxing Yin | 2011 | Neural Regeneration Research2011，6，33： | 1 |
| 10 | Age and geochenfistry of granites in Gejiu area, Yunnan province, SW China: constraints on their petrogenesis and tectonic setting显示文摘 | Cheng Yanbo Man Jingwen | 2010 | Lithos2010，120，： | 1 |
| 11 | Age and geochemistry of granites in Gejiu area,Yunnan province,SW China:Constraints on their petrogenesis and tectonic setting显示文摘 | Cheng Yanbo Mao Jingwen | 2010 | Lithos2010，120，： | 1 |
| 12 | Major types and time-space distribution of Mesozoic ore deposits in South China and their geodynamic settings显示文摘 | Mao Jingwen Cheng Yanbo Chen Maohong | 2013 | Mineralium Deposita2013，48，3： | 1 |
| 13 | Fabrication of W-20wt%Cu alloys by powder injection molding 显示文摘 | Cheng Jigui Wan Lei Cai Yanbo et at | 2010 | Journal of Materials Processing Technology2010，210，1： | 1 |
| 14 | Age and geochemistry of granites in Gejiu area, Yunnan province, SW China: Constraints on their petrogene- sis and tectonic setting 显示文摘 | Cheng Yanbo Mao Jingwen | 2010 | Lithos2010，120，： | 1 |
| 15 | Age and geochemistry of gran- ites in Gejiu area, Yunnan Province, SW China: Constraints on their petrogenesis and tectonic setting 显示文摘 | Cheng Yanbo Mao Jingwen | 2010 | Lithos2010，120，34： | 1 |
| 16 | Age and geochemistry of granites in Gejiu area, Yunnan province, SW China: Constraints on their petrogenesis and tectonic setting显示文摘 | Cheng Yanbo Mao Jingwen | 2010 | LITHOS2010，，3： | 1 |
| 17 | Geology and molybdenite Re-Os age of the Dahutang grantite-related veinlets-disseminated tungsten ore filed in the Jiangxi Province,China显示文摘 | Zhihao Mao Yanbo Cheng Jiajun Liu | 2013 | Ore Geology Reviews2013，53，： | 1 |
| 18 | Fabrication of W–20<ce:hsp sp='0.25'/>wt.%Cu alloys by powder injection molding显示文摘 | Jigui Cheng Lei Wan Yanbo Cai Jinchuan Zhu Peng Song Jie Dong | 2009 | Journal of Materials Processing Tech2009，，1： | 1 |
| 19 | Dynamic Channel Allocation in TD-SCDMA显示文摘 | Cheng Xingqing Li Chengshu | 2003 | Proceedings of ICCT2003，，： | 1 |
| 20 | A numerical differentiation method and its application to reconstruction of discontinuity显示文摘 | Wang Yanbo Jia Xianzheng Cheng Jin | 2002 | Inverse Problems2002，18，： | 1 |
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